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不同品种燕麦种子活力鉴定与耐贮藏性评价

草业学报 2024年第6期33卷 165-174页

作者：张昭伏莹莹孙浩文孙逢雪闫慧芳青岛农业大学草业学院山东青岛266109 黄河三角洲草地资源与生态国家林业和草原局重点实验室山东青岛266109 青岛市滩涂盐碱地特色植物种质创制与利用重点实验室山东青岛266109 青岛农业大学动物科技学院山东青岛266109

为探究不同品种燕麦种子活力与耐贮藏性差异,筛选具有高活力且耐贮藏的优异种质,本研究以8个品种燕麦种子为试验材料,采用45℃、100%相对湿度人工老化法模拟种子贮藏,通过测定老化0 d(即未老化,对照CK)、老化4 d两种条件下11个种子萌发... 详细信息

为探究不同品种燕麦种子活力与耐贮藏性差异,筛选具有高活力且耐贮藏的优异种质,本研究以8个品种燕麦种子为试验材料,采用45℃、100%相对湿度人工老化法模拟种子贮藏,通过测定老化0 d(即未老化,对照CK)、老化4 d两种条件下11个种子萌发与幼苗生长特性相关指标变化,运用耐老化系数、综合耐老化系数、主成分分析、隶属函数、综合评价值(D值)和系统聚类分析方法对供试种子耐贮藏性进行综合评价,以期为燕麦高活力强耐贮藏性种质筛选与新品种培育提供理论参考。结果表明:人工老化条件下,除平均发芽时间呈延长趋势外,发芽势、发芽率、发芽指数、种子活力指数、成苗率和幼苗活力指数在所有供试燕麦品种中均呈下降趋势。通过主成分分析,可将11个单项测定指标转换为3个相互独立的综合指标。根据耐贮藏性综合评价D值和系统聚类分析,将8个品种燕麦种子耐贮藏性划分为4个类型,即强耐贮藏性、中耐贮藏性、弱耐贮藏性和极弱耐贮藏性,并筛选出强耐贮藏性品种为“贝勒Ⅱ”、极弱耐贮藏性品种为“海威”,为燕麦高活力强耐贮藏性种质筛选、关键候选基因挖掘及新种质创制与利用提供了理论依据。

关键词：燕麦种子活力人工老化耐贮藏性隶属函数

Synthesis and in vitro-Anti-hepatitis B Virus Activities of Several Ethyl 5-Hydroxy-1H-indole-3-carboxylates

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Chemical Research in Chinese Universities 2006年第5期22卷 577-583页

作者： ZHAO Chun-shen ZHAO yan-fang CHAI hui-fang GONG Ping Liaoning Province Key Laboratory of Innovative Medicine Research and Design Shenyang Pharmaceutical University Shenyang 110016 P. R. China

A series of ethyl 5-hydroxyindole-3-earboxylates 6a-10r was designed and synthesized. The structures of all the compounds were confirmed by IR, ^1H NMR, and MS and their anti-hepatitis B virus （HBV） activities were evaluated in 2.2.15 cells. Among them, compound 7g { ethyl 5-hydroxy-2- [ （ 3-methoxyphenylsulfinyl ） methyl ] -1-methyl-4- [ （4-methylpiperazin-1-yl） methyl ]-1H-indole-3-carboxylate} displays a significant anti-HBV activity, which is more potent than the positive control lamivudine.

关键词： Ethyl 5-hydroxy-1H-indole-3-carboxylates Synthesis Anti-hepatitis B virus activity

Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing

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Chinese Chemical Letters 2024年第3期35卷 87-95页

作者： Peiwen Liu hui Jin yan Chen Derong Wang Haohui yan Mingzhao Wu fang Zhao Weiping Zhu State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

The pharmaceutical industry is now paying increased attention to continuous *** the revolution to continuous and automated manufacturing is deepening in most of the top pharma companies in the world,the advancement of automated pharmaceutical continuous manufacturing in China is relatively slow due to some key challenges including the lack of knowledge on the related technologies and shortage of qualified *** this review,emphasis is given to two of the crucial technologies in automated pharmaceutical continuous manufacturing,i.e.,process analytical technology(PAT)and self-optimizing *** work published in recent 5 years employing advanced PAT tools and self-optimization algorithms is introduced,which represents the great progress that has been made in automated pharmaceutical continuous manufacturing.

关键词： Pharmaceutical continuous manufacturing Automation Process analytical technology Self-optimization algorithm

Enhancing personalized exercise recommendation with student and exercise portraits

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Journal of Electronic Science and Technology 2024年第2期22卷 91-109页

作者： Wei-Wei Gao hui-fang Ma yan Zhao Jing Wang Quan-Hong Tian College of Computer Science and Engineering Northwest Normal UniversityLanzhou730070China Computer Center of Gansu Province Lanzhou730070China

The exercise recommendation system is emerging as a promising application in online learning scenarios,providing personalized recommendations to assist students with explicit learning *** solutions generally follow a collaborative filtering paradigm,while the implicit connections between students(exercises)have been largely *** this study,we aim to propose an exercise recommendation paradigm that can reveal the latent connections between student-student(exercise-exercise).Specifically,a new framework was proposed,namely personalized exercise recommendation with student and exercise portraits(PERP).It consists of three sequential and interdependent modules:Collaborative student exercise graph(CSEG)construction,joint random walk,and recommendation list ***,CSEG is created as a unified heterogeneous graph with students’response behaviors and student(exercise)***,a joint random walk to take full advantage of the spectral properties of nearly uncoupled Markov chains is performed on CSEG,which allows for full exploration of both similar exercises that students have finished and connections between students(exercises)with similar ***,we propose to optimize the recommendation list to obtain different exercise *** analyses of two public datasets,the results demonstrated that PERP can satisfy novelty,accuracy,and diversity.

关键词： Educational data mining Exercise recommend Joint random walk Nearly uncoupled Markov chains Optimization Personalized learning

Adhesion property of AlCrNbSiTi high-entropy alloy coating on zirconium:experimental and theoretical studies

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Nuclear Science and Techniques 2024年第8期35卷 79-91页

作者： Bao‑Liang Zhang Wen‑Guan Liu Meng‑He Tu Can fang yan Liu Yu‑hui Wang Yong Hu hui Wang China Institute of Atomic Energy Beijing 102413China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China

Experimental scratch tests and first-principles calculations were used to investigate the adhesion property of AlCrNbSiTi high-entropy alloy(HEA)coatings on zirconium *** HEA and Cr coatings were deposited on Zr alloy substrates using multi-arc ion plating technology,and scratch tests were subsequently conducted to estimate the adhesion property of the *** results indicated that Cr coatings had better adhesion strength than HEA coatings,and the HEA coatings showed *** special quasi-random structure approach was used to build HEA models,and Cr/Zr and HEA/Zr interface models were employed to investigate the cohesion between the coatings and Zr substrate using first-principles *** calculated interface energies showed that the cohesion between the Cr coating and the Zr substrate was stronger than that of the HEA coating with *** contrary to Al or Si in the HEA coating,Cr,Nb,and Ti atoms binded strongly with Zr *** on the calculated elastic constants,it was found that low Cr and high Al content decreased the mechanical performances of HEA ***,this study demonstrated the utilization of a combined approach involving first-principles calculations and experimental studies for future HEA coating development.

关键词： High-entropy alloy coating Cr coating Adhesion property Scratch test First-principles calculation

Bibliometric analysis of hotspots and trends of global myopia research

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 940-950页

作者： Xing-yang Wu hui-hui fang yan-Wu Xu yan-Ling Zhang Shao-Chong Zhang Wei-Hua yang Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina School of Future Technology South China University of TechnologyGuangzhou 510641Guangdong ProvinceChina

AIM:To gain insights into the global research hotspots and trends of ***:Articles were downloaded from January 1,2013 to December 31,2022 from the Science Core Database website and were mainly statistically analyzed by bibliometrics ***:A total of 444 institutions in 87 countries published 4124 *** 2013 and 2022,China had the highest number of publications(n=1865)and the highest H-index(61).Sun Yat-sen University had the highest number of publications(n=229)and the highest H-index(33).Ophthalmology is the main category in related *** from 2020 to 2022 highlight keywords of options and reference,child health(pediatrics),myopic traction mechanism,public health,and machine learning,which represent research ***:Myopia has become a hot research *** and Chinese institutions have the strongest academic influence in the field from 2013 to *** main driver of myopic research is still medical or *** study highlights the importance of public health in addressing the global rise in myopia,especially its impact on children’s *** present,a unified theoretical system is still *** surgical and therapeutic solutions must be proposed for people with different characteristics to manage and intervene refractive *** addition,the benefits of artificial intelligence(AI)models are also reflected in disease monitoring and prediction.

关键词： bibliometric analysis myopia global trends

Occupational Exposure to Indium of Indium Smelter Workers

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Biomedical and Environmental Sciences 2016年第5期29卷 379-384页

作者： DING Chun Guang WANG Huan Qiang SONG Han Bo LI Zhi hui LI Xiao Ping YE Shao Se ZHANG Fu Gang CUI Shi Wei yan hui fang LI Tao National Institute of Occupational health and Poison Control Chinese Center for Disease Control and Prevention Beijing 100050 China North China University of Science and Technology Tangshan 063009 Hebei China Guangxi Zhuang Autonomous Region Academy for the Prevention and Treatment of Occupational Diseases Nanning 530021 Guangxi China

Case reports of indium-related lung disease in workers have raised public concern to the human toxicity of indium （In） and its compounds. However, studies evaluating the exposure or health of workers in In smelting plants are rare. Therefore, in this study, we focused on four In smelting plants, with the main objective of characterizing In in smelter plants in China and discussing the potential exposure biomarkers of In exposure.

关键词： Occupational Exposure to Indium of Indium Smelter Workers than Office In

Trudinger–Moser Inequalities on a Closed Riemann Surface with a Symmetric Conical Metric

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2263-2284页

作者： Yu fang Yun yan yanG College of Teacher Education Quzhou UniversityQuzhou 324003P.R.China Department of Mathematics Renmin University of ChinaBeijing 100872P.R.China

This is a continuation of our previous work(*** ***.,20,1295–1324,2020).Let(Σ,g)be a closed Riemann surface,where the metric g has conical singularities at finite *** G is a group whose elements are isometries acting on(Σ,g).Trudinger–Moser inequalities involving G are established via the method of blow-up analysis,and the corresponding extremals are also *** extends previous results of Chen(***.,1990),Iula–Manicini(Nonlinear Anal.,2017),and the authors(2020).

关键词： Trudinger-Moser inequality blow-up analysis conical singularity

Immune Blot Analysis on Expression of the Mammalian Target of Rapamycin in Goat Fetal Fibroblasts with Recombinant Polyclonal Antibody

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Journal of Integrative Agriculture 2012年第6期11卷 1002-1008页

作者： LIANG yan LI Shu-yu WANG Xiao-jing WU Man-lin yanG Jiao-fu LI Jie HAO Xi-yan HAO hui-fang BA Yin-ma CHEN Xian-wei WANG Zhi-gang College of Life Science lnner Mongolia UniversityHohhot 010021P.R.China

To detect the mammalian target of rapamycin （mTOR） expressed in Cashmere goat fetal fibroblasts （GFb）, mTOR gene was cloned from Inner Mongolia Cashmere goat （Capra hircus） and expressed in Escherichia coli followed by immunizing mice with the purified recombinant protein as an irnmunogen to produce the anti-goat mTOR recombinant polyclonal antibody. Antiserum was collected from the immunized mice after the fifth immunization and its titer was determined with enzyme-linked immunosorbent assay （ELISA）. The results showed that the recombinant polyclonal antibody had a titer 1：200000 and could react with the roTOR expressed in GFb cells with a specific and sensitive affinity. Western blot showed that mTOR expression and phospho-mTOR （Ser 2448） activity were inhibited when GFb cells were treated with CCI-779, an mTOR specific inhibitor.

关键词： prokaryotic expression recombinant antibody goat mTOR CCI-779