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Future temperature changes over the critical Belt and Road region based on CMIP5 models

Advances in Climate Change Research 2018年第1期9卷 57-65页

作者： dong Tian-Yun dong Wen-Jie GUO yan CHOU Jie-Ming yanG Shi-Li TIAN Di yan dong-dong State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China School of Atmospheric Sciences Sun Yat-Sen UniversityGuangzhou 510275China Zhuhai Joint Innovative Center for Climate-Environment-Ecosystem Future Earth Research InstituteBeijing Normal UniversityZhuhai 519087China Business School Beijing Normal UniversityBeijing 100875China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyHangzhou310012China

Based on data of 22 models from the Coupled Model Inter-comparison Project Phase 5(CMIP5),the performance of climate simulation is assessed and future changes under RCP2.6,RCP4.5 and RCP8.5 are projected over critical Belt and Road *** with observations,the CMIP5 models simulate the linear trend and spatial distribution of the annual mean surface air temperature(SAT)better in the north(NBR)and south(SBR)of the Belt and Road *** trend of the 22-model ensemble mean(CMIP5 MME)is 0.70/0.50 C per 100 years from 1901 to 2005,and the observed trend is 1.11/0.77 C per 100 years in the NBR/SBR *** 1971,the relative error between CMIP5 MME and observations is 22%/15%in the NBR/SBR ***/nine models are selected in the NBR/SBR to project future SAT changes under three RCP *** 2081e2100,warming in the NBR/SBR is projected to be(1.16±0.29)/(0.72±0.32)C,(2.41±0.54)/(1.55±0.44)C,and(5.23±1.02)/(3.33±0.65)C for RCP2.6,RCP4.5,and RCP8.5,*** the RCP scenarios,the NBR region shows greater warming than the SBR *** most significant warming is expected in Kazakhstan and the northern part of the *** associated uncertainty generally increases with time under the three RCP ***,increases in warming over the Belt and Road region are more remarkable under higher-emission scenarios than lower-emission ones.

关键词： CMIP5 models The Belt and Road region Temperature projection RCPs

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Immunotoxicity assessment of cadinene sesquiterpenes from Eupatorium adenophorum in mice

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Journal of Integrative Agriculture 2016年第10期15卷 2319-2325页

作者： OUyanG Can-bin LIU Xiao-man yan dong-dong LI Yuan WANG Qiu-xia CAO Ao-cheng GUO mei-xia Institute of Plant Protection Chinese Academy of Agricultural Sciences/State Key Laboratory for Biology of Plant Disease and Insect Pest

Sesquiterpenes in Eupatorium adenophorum are abundant in leaves and have great development potential as biopesticides. The toxicity of sesquiterpenes in immune cells and their corresponding immune functions are not fully understood. We evaluated the immunotoxicity of two cadinene sesquiterpenes 2-deoxo-2-（acetyloxy）-9-oxoageraphorone（DAOA） and 9-oxo-10,11-dehydro-agerophorone（ODA） by using histopathology and toxicology methods in vitro and in vivo in lymphocytes and natural killer cells in Kunming mice. The mice were given single doses of 75, 150 and 300 mg kg^-1 body weight（BW） of DAOA/ODA every day for a week. S erious damage to the thymus and spleen was found in tissue images with clear lysis reduction numbers and a loosened arrangement of splenocytes and thymocytes to the mice treated with 150–300 mg kg^-1 DAOA/ODA. Mice cytology was also affected with significant cellular alterations, increased splenocytes apoptosis rates（P〈0.01）, proliferation reduction（P〈0.05） and natural killer cells activities reduction（P〈0.05） when given 150–300 mg kg^-1 DAOA/ODA, the severities of which were dose-dependent. Howev er, a 75 mg kg^-1 dose of DAOA/ODA showed no change in tissue or cytology after the 7 day treatment, and therefore was considered to be within acceptable safety parameters. Taken together, cadinene sesquiterpenes, as a type of toxic botanical component, have low environmental risks in small doses and should be further studied for their use as biopesticides.

关键词： histop athology splenocytes 2-deoxo-2-(acetyloxy)-9-oxoageraphorone immunotoxicity Eupato rium adenophorum

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A model of 3D-structure of H+, K+-ATPase catalytic subunit derived by homology modeling

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Acta Pharmacologica Sinica 2004年第4期25卷 76-81页

作者： dong yan, Yuan-dong HU1, Song LI1, Mao-sheng CHENG2 Shenyang Pharmaceutical University, Shenyang 110016 1Academy of Military Medical Sciences, Beijing 100850, China Shenyang Pharmaceutical University cademy of Military Medical Sciences

AIM: To build a model of 3D-structure of H+, K+-ATPase catalytic subunit for theoretical study and anti-ulcer drug design. METHODS: The model was built on the basis of structural data from the Ca2+-ATPase. Structurally conserved regions were defined by amino acid sequence comparisons, optimum interconnecting loops were se- lected from the protein databank, and amino (N)- and carboxyl (C)-terminal ends were generated as random coil structures. Applying molecular mechanics method then minimized the model energy. Molecular dynamics tech- nique was used to do further structural optimization. RESULTS: The model of 3D-structure of H+, K+-ATPase was derived. The model is reasonable according to several validation criteria. There were ten transmembrane helices (TM1-TM10) in the model and inhibitor-binding site was identified on the TM5-8 riched negatively charged residues. CONCLUSION: The 3D-structure model from our study is informative to guide future molecular biology study about H+, K+-ATPase and drug design based on database searching.

关键词： peptic ulcer H(+)-K(+)-exchanging ATPase protein structural homology drug design

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The synergistic advantage of combining chloropicrin or dazomet with fosthiazate nematicide to control root-knot nematode in cucumber production

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Journal of Integrative Agriculture 2019年第9期18卷 2093-2106页

作者： HUANG Bin WANG Qian GUO Mei-xia FANG Wen-sheng WANG Xiao-ning WANG Qiu-xia yan dong-dong OUyanG Can-bin LI Yuan CAO Ao-cheng Institute of Plant Protection Chinese Academy of Agricultural SciencesBeijing 100193P.R.China Beijing Innovation Consortium of Agriculture Research System Beijing 100193P.R.China

The highly-damaging root-knot nematode(Meloidogyne spp.,RKN)cannot be reliably controlled using only a nematicide such as fosthiazate because of increasing pest *** laboratory and greenhouse trials,we showed that chloropicrin(CP)or dazomet(DZ)synergized the efficacy of fosthiazate against *** combination significantly extended the degradation half-life of fosthiazate by an average of about 1.25 *** or DZ with fosthiazate reduced the time for fosthiazate to penetrate the RKN cuticle compared to fosthiazate *** or DZ combined with low or medium rate of fosthiazate increased the total cucumber yield,compared to the use of each product alone.A low-dose fosthiazate with DZ improved total yield more than a low dose fosthiazate with *** the half-life of fosthiazate and reducing the time for fosthiazate or fumigant to penetrate the RKN cuticle were the two features that gave the fumigant-fosthiazate combination its synergistic advantage over these products used *** synergy provides the opportunity for farmers to use a low dose of fosthiazate which lowers the risk of RKN *** could combine DZ at 30 g m^-2 with fosthiazate at a low rate of 0.375 g m^-2 to control RKN and adequately control two major soil-borne diseases in cucumber greenhouses.

关键词： dazomet chloropicrin fosthiazate cucumber root-knot nematode

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Evaluation of soil flame disinfestation(SFD) for controlling weeds,nematodes and fungi

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Journal of Integrative Agriculture 2020年第1期19卷 164-172页

作者： WANG Xiao-ning CAO Ao-cheng yan dong-dong WANG Qian HUANG Bin ZHU Jia-hong WANG Qiu-xia LI Yuan OUyanG Can-bin GUO Mei-xia WANG Qian Institute of Plant Protection Chinese Academy of Agricultural SciencesBeijing 100193P.R.China Foreign Economic Cooperation Office Ministry of Ecological EnvironmentBeijing 100035P.R.China

Soil flame disinfestation(SFD) is a form of physical disinfestation that can be used both in greenhouses and on field crops. Its use for soil disinfestation in different crop growing conditions makes it increasingly attractive for controlling soilborne pathogens and weeds. But little is known about the effect on weeds and soilbrone diseases. This study reports on greenhouses and field crops in China that determined the efficacy of SFD to control weeds, nematodes and fungi. It also determined the impact of SFD on the soil physical and chemical properties(water content, bulk density, NO3^–-N content, NH4^+-N content, conductivity and organic matter) in three field trials. A second generation SFD machine was used in these trials. SFD treatment significantly reduced weeds(>87.8%) and root-knot nematodes(Meloidogyne incognita)(>98.1%). Plant height and crop yield was significantly increased with SFD treatment. NO3^–-N and NH4^+-N increased after the SFD treatment, and there was also an increase in soil conductivity. Water content, bulk density and organic matter decreased significantly in the soil after the SFD treatment compared to the control. Soil flame disinfestation is a potential technique for controlling weeds and diseases in greenhouses or in fields. SFD is a non-chemical, safe, environmentally-friendly soil disinfection method.

关键词： soil flame disinfestation weeds pests control soil properties field application sustainable

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Application of the combination of 1,3-dichloropropene and dimethyl disulfide by soil injection or chemigation: effects against soilborne pests in cucumber in China

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Journal of Integrative Agriculture 2016年第1期15卷 145-152页

作者： MAO Lian-gang WANG Qiu-xia yan dong-dong LIU Peng-fei SHEN Jin FANG Wen-sheng HU Xiao-mei LI Yuan OUyanG Can-bin GUO Mei-xia CAO Ao-cheng Department of Pesticides Institute of Plant Protection Chinese Academy of Agricultural Sciences State Key Laboratory for Biology of Plant Diseases and Insect Pests Ministry of Agriculture

The combination of 1,3-dichloropropene＋dimethyl disulfide （1,3-D＋DMDS）, which forms a pre-plant soil fumigant, can provide a substitute for the environmentally unfriendly methyl bromide （MB）. Three greenhouse trials were performed to evaluate the root-knot nematode and soilborne fungi control efficacy in the suburbs of Beijing in China in 2010-2014. Randomized blocks with three replicates were designed in each trial. The combination of 1,3-D＋DMDS （10＋30 g m-2） significantly controlled Meloidogyne incognita, effectively suppressed the infestation of Fusarium oxysporum and Phytophthora spp., and successfully provided high commercial fruit yields （equal to MB but higher than 1,3-D or DMDS）. The fumigant soil treatments were significantly better than the untreated controls. These results indicate that 1,3-D＋DMDS soil treatments can be applied by soil injection or chemigation as a promising MB alternative against soilborne pests in cucumber in China.

关键词： soil fumigation 1,3-dichloropropene dimethyl disulfide soilborne pest cucumber

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Gelatin encapsulation of chloropicrin and 1,3-dichloropropene as fumigants for soilborne diseases in the greenhouse cultivation of cucumber and tomato

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Journal of Integrative Agriculture 2017年第8期16卷 1758-1766页

作者： yan dong-dong WANG Qiu-xia LI Yuan OUyanG Can-bin GUO Mei-xia Jim Xinpei Huang John Busacca Jong Neng Shieh Alisa Ye Yu Phil Howard Don Williams CAO Ao-cheng Key Laboratory of Integrated Pest Management in Crops Ministry of Agriculture/Institute of Plant Protection Chinese Academy of Agricultural Sciences Dow Agro Sciences R&D

Combined use of chloropicrin （Pic） and 1,3-dicloropropene （1,3-D） is as effective as methyl bromide （MB） at controlling soilborne diseases in many trials and commercial uses. However, Pic and 1,3-D are both highly volatile and may pose strong exposure risks to humans and the environment. A gelatin capsule formulation containing Pic and 1,3-D has been developed to reduce exposure risks to workers and bystanders and improved application safety. We conducted two experiments in tomato and cucumber greenhouses located in Beijing and Qingdao, China, to study the efficacy of Pic plus 1,3-D gelatin capsules applied at different dosages and soil depths. Results indicated that both injection and gelatin capsules of Pic plus 1,3-D provided good control of soil nematodes and reduced disease index of Fusarium wilt and root-knot nematode. Plant yield of tomato and cucumber treated with gelatin capsules was similar to MB treatment. Based on our results, gelatin capsules applied at a soil depth of 15 cm provided better control of soilborne diseases and led to higher fruit yield compared to an application depth of 5 cm. In conclusion, a gelatin capsule of Pic plus 1,3-D is a promising and novel formulation, which not only shows good efficacy in controlling soilborne diseases, but also reduces potential exposure risks of fumigants.

关键词： soil fumigation chloropicrin 1,3-dichloropropene gelatin capsule formulation efficacy application depth

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低轨预警卫星引导下的相控阵雷达搜索区域研究

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电子科技大学学报 2016年第6期45卷 911-916页

作者：严冬冬李智徐灿装备学院研究生管理大队北京怀柔区101416 装备学院航天指挥系北京怀柔区101416 装备学院航天装备系北京怀柔区101416

在弹道导弹防御过程中,相控阵雷达在预警卫星的引导下能否快速捕获并跟踪目标是开展拦截的关键。该文针对低轨预警卫星引导精密跟踪雷达搜索探测弹道导弹的搜索区域确定问题开展研究。以美国STSS低轨预警卫星为研究对象,首先分析了双星... 详细信息

在弹道导弹防御过程中,相控阵雷达在预警卫星的引导下能否快速捕获并跟踪目标是开展拦截的关键。该文针对低轨预警卫星引导精密跟踪雷达搜索探测弹道导弹的搜索区域确定问题开展研究。以美国STSS低轨预警卫星为研究对象,首先分析了双星联合观测时的探测精度,提出以定位误差克拉美罗界作为跟踪卫星的定位精度,进而研究了测量误差在不同坐标系下的表达式及传递形式。最后,结合相控阵雷达搜索方式,提出并确定了相控阵雷达在指向坐标系下的搜索范围。仿真结果表明,采用该文的分析方法将有助于减小相控阵雷达搜索范围,提高雷达搜索针对性。

关键词：低轨预警卫星相控阵雷达雷达指向坐标系搜索区域

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微乳液脱除油泥砂中的原油

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高等学校化学学报 2012年第8期33卷 1777-1781页

作者：闫栋栋杜娜侯万国山东大学环境研究院济南250100 山东大学国家胶体材料工程技术研究中心济南250100

以煤油为油相,十二烷基苯磺酸钠(SDBS)为主表面活性剂,正戊醇为助表面活性剂,通过改变NaCl浓度分别制备出上相、中相和下相3种类型的微乳液,研究了其对油泥砂中原油的脱除效率,考察了微乳液类型、油泥砂处理量、时间和温度等的影响.结... 详细信息

以煤油为油相,十二烷基苯磺酸钠(SDBS)为主表面活性剂,正戊醇为助表面活性剂,通过改变NaCl浓度分别制备出上相、中相和下相3种类型的微乳液,研究了其对油泥砂中原油的脱除效率,考察了微乳液类型、油泥砂处理量、时间和温度等的影响.结果表明,油相在下相微乳液中的脱油效率最高,在中相中次之,在上相中最低,且油相脱油率与油泥砂处理量间具有良好的线性关系;在所考察的时间(10～60 min)和温度(20～70℃)范围内,脱油效率变化幅度不显著,表明该体系可对油泥砂进行常温快速脱油处理.

关键词：微乳液油泥砂原油回收

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衔接蛋白p66Shc在心肌缺血再灌注损伤中的作用研究进展

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解放军医学杂志 2023年第4期48卷 456-460页

作者：王沛剡冬冬彭瑜张钲兰州大学第一临床医学院甘肃兰州730000 兰州大学第一医院心脏中心甘肃兰州730000 甘肃省心血管病重点实验室甘肃兰州730000

缺血性心脏病是全世界死亡率较高的疾病之一,长期危害着人类的健康,其首选治疗策略再灌注可导致心肌缺血恶化及加速损伤,即心肌缺血再灌注损伤(MIRI),严重影响临床疗效及患者预后。目前MIRI的预防和治疗仍是临床尚未解决的难题。大量研... 详细信息

缺血性心脏病是全世界死亡率较高的疾病之一,长期危害着人类的健康,其首选治疗策略再灌注可导致心肌缺血恶化及加速损伤,即心肌缺血再灌注损伤(MIRI),严重影响临床疗效及患者预后。目前MIRI的预防和治疗仍是临床尚未解决的难题。大量研究表明,衔接蛋白p66Shc在包括MIRI对内的多种疾病的发生发展具有重要的调控作用。本文针对衔接蛋白p66Shc在MIRI氧化应激、炎症反应和血管内皮功能障碍中的调节作用机制,以及以p66Shc为靶点的相关治疗策略进行综述,以期为MIRI的预防和治疗提供进一步的参考。

关键词：缺血性心脏病心肌缺血再灌注损伤 p66Shc 氧化应激

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