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The effect of fasting plasma glucose on in-hospital mortality after acute myocardial infarction in patients with and without diabetes:findings from a prospective,nationwide,and multicenter registry

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Journal of Geriatric Cardiology 2024年第5期21卷 523-533页

作者： Rui FU Ying-Xuan ZHU Kong-Yong CUI Jin-Gang yanG hai-yan XU Dong YIN Wei-Hua SONG Hong-Jian WANG Cheng-Gang ZHU Lei FENG Wei WU Kai-HongCHEN yan-yan ZHAO Ye LU Ke-Fei DOU Yue-Jin yanG on behalf of the CAMI Registry Investigators Cardiometabolic Medicine Center Fuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Medical Research&Biometrics Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Coronary Heart Disease Center Fuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Guangzhou Traditional Chinese Medical College First Affiliated HospitalGuangdong ProvinceChina Department of Cardiology Longyan Hospital First HospitalFujian ProvinceChina 不详

OBJECTIVES To evaluate the predictive value of fasting plasma glucose(FPG)for in-hospital mortality in patients with acute myocardial infarction(AMI)with different glucose metabolism *** We selected 5,308 participants with AMI from the prospective,nationwide,multicenter CAMI registry,of which 2,081 were diabetic and 3,227 were *** were divided into high FPG and low FPG groups according to the optim-al cutoff values of FPG to predict in-hospital mortality for diabetic and nondiabetic cohorts,*** primary endpoint was in-hospital *** Overall,94 diabetic patients(4.5%)and 131 nondiabetic patients(4.1%)died during hospitalization,and the optimal FPG thresholds for predicting in-hospital death of the two cohorts were 13.2 mmol/L and 6.4 mmol/L,*** with individuals who had low FPG,those with high FPG were significantly associated with higher in-hospital mortality in diabet-ic cohort(10.1%vs.2.8%;odds ratio[OR]=3.862,95%confidence interval[CI]:2.542-5.869)and nondiabetic cohort(7.4%vs.1.7%;HR=4.542,95%CI:3.041-6.782).After adjusting the potential confounders,this significant association was not ***-more,FPG as a continuous variable was positively associated with in-hospital mortality in single-variable and multivariable models regardless of diabetic *** FPG to the original model showed a significant improvement in C-statistic and net reclassification in diabetic and nondiabetic *** This large-scale registry indicated that there is a strong positive association between FPG and in-hospital mor-tality in AMI patients with and without *** might be useful to stratify patients with AMI.

关键词： patients fasting infarction

Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

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Chinese Journal of Integrative Medicine 2024年第2期30卷 171-180页

作者： ZHAO Wen-xiao WANG Tong ZHANG Ya-nan CHEN Qian WANG Yuan XING yan-qing ZHENG Jun DUAN Chen-chen CHEN Lijun ZHAO hai-jun WANG Shijun School of Nursing Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJi'nan(250355)China Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula Shandong University of Traditional Chinese MedicineJi'nan(250355)China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan(250355)China

The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver *** extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and *** alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides *** addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut *** review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.

关键词： Chinese medicine polysaccharides gut microbiota short-chain fatty acids lipopolysaccharides gut-organaxis synergistic actions

Large eddy simulation study of 3D wind field in a complex mountainous area under different boundary conditions

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第7期25卷 541-556页

作者： yan LI Lei yan Xuhui HE School of Civil Engineering Central South UniversityChangsha410075China National Engineering Research Center for High-speed Railway Construction Changsha410075China Hunan Provincial Key Laboratory for Disaster Prevention and Mitigation of Rail Transit Engineering Structures Changsha410075China

Large eddy simulations generally are used to predict 3D wind field characteristics in complex mountainous *** simulation boundary conditions,such as the height and length of the computational domain or the characteristics of inflow turbulence,can significantly impact the quality of *** this study,we examined these boundary conditions within the context of the mountainous terrain around a long-span cable-stayed bridge using a wind tunnel *** sizes of computational domains and turbulent incoming wind velocities were used in large eddy *** results show that when the height of the computational domain is five times greater than the height of the terrain model,there is minimal influence from the top wall on the wind field characteristics in this complex mountainous *** the length of the wake region of the computational domain has negligible effects on the wind *** in the inlet boundary reduces the length of the wake region on a leeward hill with a low slope,but has less impact on the mean wind velocity of steep hills.

关键词： Large eddy simulation(LES) Spectral representation method Recycling method High mountainous canyon Wind characteristics Atmospheric boundary layer Computational domain

Helicobacter pylori infection alters gastric microbiota structure and biological functions in patients with gastric ulcer or duodenal ulcer

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World Journal of Gastroenterology 2024年第24期30卷 3076-3085页

作者： Ling-Xiao Jin Yu-Peng Fang Chen-Mei Xia Teng-Wei Cai Qian-Qian Li Yu-Yin Wang hai-Fan yan Xia Chen Department of Gastroenterology Wenling Hospital of Wenzhou Medical University(The First People’s Hospital of Wenling)Wenling 317500Zhejiang ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is closely associated with gastrointestinal *** preliminary studies have indicated that *** infection had a significant impact on the mucosal microbiome structure in patients with gastric ulcer(GU)or duodenal ulcer(DU).AIM To investigate the contributions of *** infection and the mucosal microbiome to the pathogenesis and progression of ulcerative *** Patients with *** infection and either GU or DU,and healthy individuals without *** infection were *** or duodenal mucosal samples was obtained and subjected to metagenomic *** compositions of the microbial communities and their metabolic functions in the mucosal tissues were *** Compared with that in the healthy individuals,the gastric mucosal microbiota in the ***-positive patients with GU was dominated by ***,with signi-ficantly reduced *** intergroup differential functions,which were enriched in the ***-positive GU patients,were all derived from ***,particularly those concerning transfer RNA queuosine-modification and the synthesis of demethylmenaquinones or menaquinones.A significant enrichment of the uibE gene was detected in the synthesis *** was no significant difference in microbial diversity between the ***-positive DU patients and healthy *** *** infection significantly alters the gastric microbiota structure,diversity,and biological functions,which may be important contributing factors for GU.

关键词： Helicobacter pylori Gastric ulcer Duodenal ulcer Metagenomic sequencing Transfer RNA queuosine-modification Menaquinones

角度补偿同步平均的二级行星齿轮箱行星轮故障特征提取方法

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振动工程学报 2024年第5期37卷 896-902页

作者：晏云海郭瑜昆明理工大学机电工程学院云南昆明650550

加窗同步平均克服了行星齿轮传动引起的振动传递路径时变性问题,可有效应用于单级行星齿轮箱齿轮故障特征提取。但二级行星齿轮箱存在两级行星结构共用传动轴引起的振动耦合问题,该方法不易有效提取第一级行星轮的故障特征,为此本文提... 详细信息

加窗同步平均克服了行星齿轮传动引起的振动传递路径时变性问题,可有效应用于单级行星齿轮箱齿轮故障特征提取。但二级行星齿轮箱存在两级行星结构共用传动轴引起的振动耦合问题,该方法不易有效提取第一级行星轮的故障特征,为此本文提出一种角度补偿同步平均的二级行星齿轮箱行星轮故障特征的提取方法。通过等角度重采样消除转速波动的影响;采用角度补偿同步平均分离重采样振动中存在的第二级太阳轮的干扰,并通过差运算将其从重采样振动中消除;提取残余振动的包络信号;通过加窗同步平均构建第一级行星轮的合成包络信号,并采用包络同步平均提取第一级行星轮的故障特征。通过二级行星齿轮箱实验台实测信号分析验证,所提方法能够有效地提取第一级行星轮的故障特征。

关键词：故障特征提取二级行星齿轮箱加窗振动分离包络分析角度补偿同步平均

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Advanced hepatocellular carcinoma in a patient with neurofibromatosis type 1 and malignant peripheral nerve sheath tumor

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 530-532页

作者： Ahmad Alhaskawi yan-Zhao Dong Xiao-Di Zou Sohaib Hasan Abdullah Ezzi Ze-Wei Wang hai-Ying Zhou Sahar Ahmed Abdalbary Hui Lu Department of Orthopedics the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Chinese Medicine the Second Affiliated HospitalZhejiang Chinese Medical UniversityHangzhou 310005China Department of Orthopedics the Third Xiangya HospitalCentral South UniversityChangsha 410083China Zhejiang University School of Medicine Hangzhou 310000China Department of Orthopedic Physical Therapy Faculty of Physical TherapyNahda University in Beni SuefBeni SuefEgypt

To the Editor: Neurofibromatosis type 1(NF-1), or Von Recklinghausen disease, is a genetic disorder inherited in an autosomal dominant pattern. It is caused by a mutation in the neurofibromin gene located on chromosome 17, accounting for 96% of all neurofibromatosis cases. This condition can affect multiple systems and often leads to the formation of tumors along the nervous system [1]. Patients with NF-1 may exhibit various symptoms, including Lisch nodules, neurofibromas, scoliosis, café au lait spots, learning disabilities, vision disorders, and epilepsy.

关键词： epilepsy hepatocellular malignant

Electromagnetic characteristic analysis and design of a linear motor used for ultra-high-speed EMS maglev train

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Science China(Technological Sciences) 2024年第6期67卷 1957-1973页

作者： GAO Han SHI TingNa GAO XinMai LEI yanXiao yan Dong GUO Liyan yan yan College of Electrical Engineering Zhejiang UniversityHangzhou310027China Zhejiang University Advanced Electrical Equipment Innovation Center Hangzhou311107China State Key Laboratory of High-speed Maglev Transportation Technology Qingdao266100China CRRC Qingdao Sifang Co.Ltd. Qingdao266111China

The operating speed of the commercial electromagnetic suspension(EMS)maglev train has been over 430 km/h,making it the fastest means of land *** the increasing demands of people traveling,it is necessary to further improve the operating speed of maglev *** to examine whether the existing EMS system can meet the requirements of ultra-highspeed operation(more than 600 km/h),the electromagnetic characteristics of an EMS linear motor under the operating speed of 600–1000 km/h fed by a square-wave voltage supply is investigated in this ***,an electromagnetic field model of the EMS system under the square-wave voltage supply is established to investigate its electromagnetic performance,e.g.,the characteristics of phase current,the magnetic flux density,and the electromagnetic ***,the relationship between the harmonic components of the air-gap magnetic flux density and electromagnetic force is investigated using the two-dimensional fast Fourier transform(2D-FFT)to reveal the mechanism of electromagnetic force ***,to address the issues of excessive armature current density and significant electromagnetic force ripple,the linear motor is re-designed by enlarging the stator slot area and reshaping the mover's main magnetic ***,the Taguchi method is used to further improve the electromagnetic characteristics of the linear electric ***,the effectiveness of the proposed optimal design is validated by the finite-element analysis(FEA)based co-simulation.

关键词： ultra-high-speed maglev transportation electromagnetic suspension(EMS) linear motor electromagnetic force ripple suppression

Research on Modeling and Parameter Identification of Comprehensive Load Model of Distribution Network in Industrial Park

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Chinese Journal of Electronics 2024年第1期33卷 264-273页

作者： Tingling WANG Xiaohe yan School of Electric Engineering North China University of Water Resources and Electric Power Wenzhou Polytechnic

With the rapid development of industrial parks, its load model research has become a hot spot. In order to study the load of power system in industrial park, based on the characteristics of the industrial park load, a comprehensive load admittance static model with full voltage range adaptability is considered, and a comprehensive load model of distribution network of the industrial park is established. A complete parameter identification of the model is carried out through chaos particle swarm optimization. The simulation results show that the model can effectively describe the load characteristics of the distribution network in industrial parks.

关键词： Chaos Adaptation models Analytical models Parameter estimation Induction motors Simulation Distribution networks

Thermal and mechanical behavior of casting copper alloy wheel during wheel and belt continuous casting process

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China Foundry 2024年第1期21卷 82-90页

作者： Kun Gao yan Peng School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina

To investigate the thermal and mechanical behavior of casting wheel,a two-dimensional thermoelastic-plastic finite element model was used to predict the temperature,stress and distortion distribution of the casting wheel during the wheel and belt continuous casting *** effects of grinding thickness and casting speed on the thermal and mechanical behaviors of the center of the hot face of the casting wheel were discussed in *** each rotation,the casting wheel passes through four different spray *** results show that the temperature distribution of the casting wheel in different spray zones is similar,the temperature of the hot face is the highest and the temperature reaches the peak in the spray zoneⅢ.The stress and distortion depend on the temperature distribution,and the maximum stress and distortion of the hot face are 358.2 MPa and 1.82 mm,*** temperature at the center of the hot face decreases with increasing grinding thickness and increases with increasing casting speed.

关键词： casting wheel finite element model grinding thickness casting speed hot face spray zones