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Can mosapride citrate reduce the volume of lavage solution for colonoscopy preparation?

World Journal of Gastroenterology 2013年第5期19卷 727-735页

作者： Masahiro Tajika Yasumasa Niwa Vikram Bhatia Shinya Kondo Tsutomu Tanaka Nobumasa Mizuno Kazuo Hara Susumu Hijioka Hiroshi Imaoka Koji Komori Kenji yamao Department of Endoscopy Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Medical Hepatology Institute of Liver and Biliary SciencesNew Delhi 110070India Department of Gastroenterology Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Gastroenterological surgery Aichi Cancer Center HospitalNagoya 464-8681Japan

AIM:To evaluate the possibility of reducing the volume of polyethylene glycol(PEG)-electrolyte solution using adjunctive mosapride citrate for colonoscopy preparation. METHODS:This was a single-center,prospective, randomized,investigator-blinded,non-inferiority study involving 252 patients of both sexes,aged from 20 to 80 years,scheduled for screening or diagnostic colonoscopy in our department.A total of 126 patients was randomized to receive 1.5 L PEG-electrolyte solution plus 15 mg of mosapride(1.5 L group),and 126 received 2 L PEG-electrolyte solution plus 15 mg of mosapride(2 L group).Patients completed a questionnaire on the acceptability and tolerability of the bowel preparation *** efficacy of bowel preparation was assessed using a 5-point scale based on the Aronchick *** primary end point was adequate bowel preparation rates(score of excellent/good/fair) vs(poor/inadequate).Acceptability and tolerability,as well as disease detection,were secondary end points. RESULTS:A total of 244 patients was included in the *** were no significant differences between the 2 L and 1.5 L groups in age,sex,body mass index, number of previous colonoscopies,and the preparation method used *** adequate bowel preparation rates were 88.5%in the 2 L group and 82.8%in the 1.5 L group[95%lower confidence limit(LCL)for the difference=-14.5%,non-inferiority P=0.019]in the right *** the left colon,the adequate bowel preparation rates were 89.3%in the 2 L group and 81.1%in the 1.5 L group(95%LCL=-17.0%,non-inferiority P=0.066).Compliance,defined as complete (100%)intake of the PEG solution,was significantly higher in the 1.5 L group than in the 2 L group(96.8% vs 85.7%,P=0.002).The proportion of abdominal distension(none/mild/moderate/severe)was significantly lower in the 1.5 L group than in the 2 L group (36/65/22/3 vs 58/48/18/2,P=0.040).Within the subgroup who had undergone colonoscopy previously, a significantly higher number of patients in t

关键词： Mosapride citrate Bowel preparation Polyethylene glycol-electrolyte solution Prokinetics Colonoscopy

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利用超声内镜引导的细针抽吸法对胰腺癌和局灶性胰腺炎进行鉴别诊断

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世界核心医学期刊文摘（胃肠病学分册） 2005年第6期1卷 42-43页

作者： Takahashi K. yamao K. Okubo K. 赵丽娜 Department of Gastroenterology Aichi Cancer Center Hospital 1-1 Kanokoden Chikusa-ku Nagoya 464-0021 Japan Dr.

Despite advances in diagnostic imaging techniques, the differentiation between pancreatic cancer and focal pancreatitis remains difficult. This study evaluated the effectiveness of EUS-guided FNA in the differential diagnosis between pancreatic cancer and focal pancreatitis, with particular reference to detection of the K-ras point mutation. The study included 62 consecutive patients with pancreatic ductal cancer and 15 patients with focal pancreatitis demonstrated as a pancreatic mass lesion by EUS. Sensitivity, specificity, overall accuracy, positive predictive value, and negative predictive value of cytopathologic diagnosis were 82%, 100%, 86%, 100%, and 58%, respectively. Sensitivity, specificity, overall accuracy, positive predictive value, and negative predictive value of histopathologic diagnosis were 44%, 100%, 55%, 100%, and 32%, respectively. The K-ras point mutation was found in 74%of pancreatic cancers and 0%of focal pancreatitis lesions. No complication of EUS-guided FNA was observed. EUS-guided FNA is useful for the differential diagnosis of pancreatic mass lesions caused by pancreatic cancer and focal pancreatitis. Analysis for the K-ras point mutation in specimens obtained by EUS-guided FNA may enhance diagnostic accuracy in indeterminate cases.

关键词：鉴别诊断超声内镜预计值病理学诊断点突变特异性

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日本Sakuragien-青森养老院

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现代装饰 2021年第2期 62-67页

作者： Kazuma yamao Juri Haramiishi Yuki Nakamura Koji Kobayashi 范嘉苑日本waiwai设计事务所 Spiral

Sakuragien养老院位于青森县,坐落在日本主岛的北部边界上。养老院建成于40多年前,日本waiwai设计事务所受业主委托,近年对养老院进行了重建。尽管关于日本人口老龄化的争论有很多,但目前日本的老年人赡养问题主要还是依赖于用公共资源...

Sakuragien养老院位于青森县,坐落在日本主岛的北部边界上。养老院建成于40多年前,日本waiwai设计事务所受业主委托,近年对养老院进行了重建。尽管关于日本人口老龄化的争论有很多,但目前日本的老年人赡养问题主要还是依赖于用公共资源来解决。项目一方面旨在将自然景观,包括冬季大雪和当地居民赖以生存的林地都融入于建筑空间之中;另一方面,希望通过新的空间设计与布局改善养老院看护人员的工作环境。为了让每位长者都获得个性化的体验,一层的房间与场地周边的自然环境充分融合,让居住者可以尽情欣赏林地景观与冬季雪景。

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endoscopic ultrasonography-guided biliary drainage:Who,when,which,and how?

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World Journal of Gastroenterology 2016年第3期22卷 1297-1303页

作者： Kazuo Hara Kenji yamao Nobumasa Mizuno Susumu Hijioka Hiroshi Imaoka Masahiro Tajika Tutomu Tanaka Makoto Ishihara Nozomi Okuno Nobuhiro Hieda Tukasa Yoshida Yasumasa Niwa Department of Gastroenterology Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Endoscopy Aichi Cancer Center HospitalNagoya 464-8681Japan

Both endoscopic ultrasonography(EUS)-guided choledochoduodenostomy( EUS- CDS) and EUS-guided hepaticogastrostomy(EUS-HGS) are relatively well established as alternatives to percutaneous transhepatic biliary drainage(PTBD). Both EUSCDS and EUS-HGS have high technical and clinical success rates(more than 90%) in high-volume centers. Complications for both procedures remain high at 10%-30%. Procedures performed by endoscopists who have done fewer than 20 cases sometimes result in severe or fatal complications. When learning EUSguided biliary drainage(EUS-BD), we recommend a mentor's supervision during at least the first 20 cases. For inoperable malignant lower biliary obstruction, a skillful endoscopist should perform EUS-BD before EUS-guided rendezvous technique(EUS-RV) and PTBD. We should be select EUS-BD for patients having altered anatomy from malignant tumors before balloon-enteroscope-assisted endoscopic retrograde cholangiopancreatography, EUS-RV, and PTBD. If both EUS-CDS and EUS-HGS are available, we should select EUS-CDS, according to published data. EUSBD will potentially become a first-line biliary drainage procedure in the near future.

关键词： endoscopic ultrasonography endoscopicultrasonography-guided biliary drainage Interventionalendoscopic ultrasonography endoscopic ultrasonography-guided choledochoduodenostomy endoscopicultrasonography-guided rendezvous technique

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Cholangiocarcinoma developed in a patient with IgG4-related disease

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World Journal of Gastrointestinal Oncology 2013年第8期5卷 181-185页

作者： Akitoshi Douhara Akira Mitoro Emi Otani Masanori Furukawa Kosuke Kaji Masakazu Uejima Masayoshi Sawai Motoyuki Yoshida Hitoshi Yoshiji Junichi yamao Hiroshi Fukui Department of Gastroenterology and Endocrinology Nara Medical University

A 77-year-old man with jaundice and a pancreatic head tumor was referred to our hospital in *** initial laboratory tests,computed tomography(CT)scan,magnetic resonance imaging(MRI),and endoscopic retrograde cholangiopancreatography suggested IgG4-related cholangitis and autoimmune *** prednisolone(PSL)was then *** treatment reduced the size of the pancreatic parenchyma,and the lower common bile duct(CBD)returned to its normal ***,the oral PSL was gradually tapered to a maintenance *** February 2010,a CT scan and MRI showed segmental wall thickening and stenosis of the middle CBD,the progression of which led to extrahepatic obstructive *** suspected the emergence of a cholangiocarcinoma rather than the exacerbation of the IgG4-related sclerosing cholangitis because the stricture of the CBD was short and ***,a percutaneous transhepatic biliary drainage was *** biopsy specimens obtained via the percutaneous transhepatic tract indicated an abnormal glandular formation,suggesting the presence of a moderate,well-differencated *** gross examination,microscopic examination and immunohistochemical analysis of the pancreaticoduodenectomy specimen suggested that a cholangiocarcinoma developed from the IgG4-related sclerosing cholangitis.

关键词： IgG4 Sclerosing cholangitis Autoimmune pancreatitis Cholangiocarcinoma

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奥氏体晶粒度对高Si油回火钢丝疲劳强度的影响

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金属制品 2004年第B5期30卷 4-6页

作者： Hiromu Izumida Norihito yamao Nozomu Kawabe Teruyuki Murai 李居强姜岩

Cr-Si油淬火-回火钢丝作为气门簧钢丝已被广泛使用.对于抗拉强度为1 400～1 800 MPa的中碳钢,奥氏体晶粒愈细,疲劳强度愈高.本文对抗拉强度＞2 100 MPa高Si油回火钢丝的奥氏体晶粒度对疲劳强度的影响进行研究.

关键词：油淬火回火钢丝奥氏体晶粒度力学性能

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超声内镜引导下行胃部的细针抽吸活检诊断胃肠间质瘤

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 56-57页

作者： Okubo K. yamao K. Nakamura T. 姜建涛 Department of Gastroenterology Aichi Cancer Center Hospital 1-1 Kanokoden Chikusa-ku Nagoya 464-8681 Japan

Background. For the diagnosis of gastric submucosal tumors (SMTs), endoscopic ultrasound (EUS) alone does not reveal the complete pathology, such as the degre e of malignancy, and EUS-guided fine-needle aspiration biopsy (EUS-FNAB) has been reported to be more useful. Recently, most cases initially diagnosed as lei omyosarcomas have received further study with immunohistochemical staining and h ave been given the new diagnosis of gastrointestinal stromal tumors (GISTs). The degree of malignancy of GISTs differs widely in clinical aspects. In this study , we examined whether EUS-FNAB was useful in diagnosing GISTs and differentiati ng their degrees of malignancy. Methods. From January 1997 to March 2002,21 case s of gastric GISTs were diagnosed from the immunohistochemical staining of speci mens resected at Aichi Cancer Center Hospital. Of these 21 patients, 14 (5 with high-grade malignancy and 9 with lowgrade malignancy) underwent EUS-FNAB preop eratively, and were examined further: their EUS-FNAB specimens were submitted f or additional immunohistochemical testing. Results. The EUS-FNAB specimens from all patients were positive for c-kit and CD34 immunohistochemical testing, coi nciding with the staining results of the resected specimens. The MIB-1 labeling indic es in specimens of high-grade malignancy were significantly higher than those o f low-grade malignancy. If we assumed that a tumor with an MIB-1 labeling inde x of more than 5%was a high-grade malignancy, the diagnostic, accuracy was 85. 7%. Conclusions. The EUS-FNAB procedure is a useful tool for diagnosing GISTs of the stomach with immunohistochemical staining. When used with MIB-1 staining , the proceduremay indicateGIST prognosis and influence decisions regarding ther apeutic strategies.

关键词：胃肠间质瘤细针抽吸活检超声内镜黏膜下肿瘤恶性程度免疫组化染色标记指数平滑肌肉瘤病理特性癌症中心

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西南地区辣椒干制品中黄曲霉毒素污染状况及风险评估

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中国酿造 2023年第2期42卷 126-131页

作者：杨雅茂尹礼国陈露张超杜科黎宜宾学院农林与食品工程学部四川宜宾644000 固态发酵资源利用四川省重点实验室四川宜宾644000

为分析来自西南地区(四川、重庆和云南)辣椒干制品中黄曲霉毒素(AFB_(1)、AFB_(2)、AFG_(1)和AFG_(2))的污染情况和暴露风险,购自西南地区的超市、农贸市场和零售店的干辣椒和辣椒粉样品经研碎、过筛、提取、衍生等前处理后,采用高效液... 详细信息

为分析来自西南地区(四川、重庆和云南)辣椒干制品中黄曲霉毒素(AFB_(1)、AFB_(2)、AFG_(1)和AFG_(2))的污染情况和暴露风险,购自西南地区的超市、农贸市场和零售店的干辣椒和辣椒粉样品经研碎、过筛、提取、衍生等前处理后,采用高效液相色谱(HPLC)法测定黄曲霉毒素含量。结果表明,该方法的精密度及准确度较好,AFB_(1)、AFG_(1)的检出限和定量限均分别为0.05 ng/mL、0.15 ng/mL;AFB_(2)、AFG_(2)的检出限和定量限均分别为0.03 ng/mL、0.10 ng/mL。四川、重庆和云南地区辣椒干制品中黄曲霉毒素的阳性率分别为15%、10%和5%;干辣椒和辣椒粉中黄曲霉毒素的阳性率均分别为6.67%和13.33%;来自农贸市场和零售店的辣椒干制品阳性率(分别为15%、10%)比超市(5%)高。样品中黄曲霉毒素的膳食暴露量为0.001455 ng/(kg体质量·d),西南地区人群暴露率为0.15%,表明存在一定的暴露风险。

关键词：干辣椒辣椒粉黄曲霉毒素西南地区污染高效液相色谱

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采用步进加载的桥梁刚度量化识别方法

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交通运输工程学报 2014年第6期14卷 10-16,43页

作者：牛艳伟郝景贤苏英平山尾敏孝黄平明长安大学公路学院陕西西安710064 山西省交通科学研究院黄土地区公路建设与养护技术交通行业重点实验室山西太原030006 中交公路规划设计院有限公司北京100088 西安市政设计研究院有限公司陕西西安710068 熊本大学熊本县熊本市860-8555

针对桥梁刚度识别问题,在常规桥梁荷载试验的基础上,提出一种将试验加载车沿桥梁纵向逐步前进加载进行桥梁刚度量化识别的方法。引入刚度影响因子矩阵,采用步进加载及有限元模型分别建立实测挠度变化矩阵和计算挠度变化矩阵,并建立控制... 详细信息

针对桥梁刚度识别问题,在常规桥梁荷载试验的基础上,提出一种将试验加载车沿桥梁纵向逐步前进加载进行桥梁刚度量化识别的方法。引入刚度影响因子矩阵,采用步进加载及有限元模型分别建立实测挠度变化矩阵和计算挠度变化矩阵,并建立控制偏差逼近水平从而对刚度影响因子进行识别的方法及流程。以一座系杆拱桥为例,验证了单一区域及多区域损伤的识别准确性。试验结果表明:拱脚外区域识别精度可达到6.6%;采用步进加载方法可以对混凝土桥梁的刚度进行定位与量化识别;采用多项式拟合对测量结果进行修正后,可提高识别精度,逼近水平提高18%。

关键词：桥梁工程混凝土桥梁步进加载刚度量化识别

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外置钢管补强圆形钢桥墩的抗震性能

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沈阳建筑大学学报（自然科学版） 2009年第1期25卷 34-38页

作者：王占飞孙宝芸隋伟宁山尾敏孝沈阳建筑大学土木工程学院辽宁沈阳110168 熊本大学自然科学研究科日本熊本860-8555

目的研究钢管径厚比和桥墩柱长细比参数对外置钢管补强圆形钢桥墩承载力、延性和吸收能量的影响.方法在确定数值分析与实验数据吻合的基础上,采用MARC有限元程序,对外置钢管补强的圆形柱7个试件进行非线性数值分析.结果得到了在一定垂... 详细信息

目的研究钢管径厚比和桥墩柱长细比参数对外置钢管补强圆形钢桥墩承载力、延性和吸收能量的影响.方法在确定数值分析与实验数据吻合的基础上,采用MARC有限元程序,对外置钢管补强的圆形柱7个试件进行非线性数值分析.结果得到了在一定垂直荷载和水平往复荷载作用下荷载-位移滞回曲线.明确了外钢管的设置改善桥墩具有良好抗震性能的机理:当内钢管底部变形达到两管间的Dgap时,外钢管阻止了内钢管局部变形的发展,提高了结构的延性和承载力.结论除了λ=0.15试件,其他的试件都是在5yδ时达到最大承载力,并且其大小变化不大.结构延性随着λ(或Rt)的增大而减少.

关键词：外置钢管钢桥墩延性吸收能量

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