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Subsequent pregnancy outcomes and fertility rates in the case series that underwent bilateral hypogastric artery ligation(BHGAL)due to severe postpartum hemorrhage

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Asian pacific Journal of Reproduction 2024年第1期13卷 28-33页

作者： OKUTUCU Gulcan EVSEN Mehmet S PEKER Nurullah yaman tunc senem ICEN Mehmet S Department of Obstetrics and Gynecology Division of PerinatologyTurkish Ministry of Health Ankara City HospitalAnkaraTurkey Department of Obstetrics and Gynecology Dicle UniversitySchool of MedicineDiyarbakirTurkey

Objective:To evaluate the effect of bilateral hypogastric artery ligation(BHGAL)on women's pregnancy outcomes and fertility rates in cases with severe postpartum ***:Patients hospitalized in a tertiary care center between 2007 and 2018 were included in the *** records of cases were obtained from the hospital database,*** demographic data,morbidities or complications associated with BHGAL surgery,any additional haemostatic interventional or surgical procedures,preoperative admission and lowest postoperative haematocrit-hemoglobin values,blood products given,type of anaesthesia,intensive care unit(ICU)and length of hospital stay were *** cases without surgical sterilization,future fertility and subsequent pregnancy outcomes were assessed for at least two years after *** was obtained through face-to-face or telephone interviews with patients whose long-term fertility and subsequent pregnancy outcomes were ***:Sixty-eight patients with BHGAL surgery history were included in the study.26 Of 37 cases(70%)that did not undergo surgical sterilization had a desire for pregnancy after the *** of these cases(23%)were diagnosed with secondary *** fertility rate of these cases was 77%,and subsequent pregnancy was detected in 20 women.A total of 25 pregnancies,including first and second pregnancies,developed,and 15 of these pregnancies resulted in term delivery,six preterm births,one stillbirth,and three ***:The postoperative pregnancy rate was found to be higher than the rate of women with infertility problems,and this surgery does not seem to adversely affect pregnancy *** is a tertiary center experience and cohort studies with large patient series are needed.

关键词： Fertility Iliac artery Ligations Postpartum hemorrhage Pregnancy outcomes

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Effects of Melatonin on Ischemia-Reperfusion Injury in Rat Ovary:Histopathologic and Immunohistochemical Study

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Open Journal of Obstetrics and Gynecology 2015年第11期5卷 639-645页

作者： Deniz Balsak Cihan Togrul Cenap Ekinci Kerem Doga Seckin Mehmet Fatih Karsli Aysun Ekinci Ali Emre Tahaoglu Hanefi Bademkiran Zuat Acar senem yaman tunc Engin Deveci Günsen Kirman Department of Obstetrics and Gynecology School of Medicine Hospital University of Halic Istanbul Turkey Department of Obstetrics and Gynecology School of Medicine University of Hitit Corum Turkey Department of Histology and Embryology School of Medicine Hospital University of Dicle Diyarbakir Turkey Department of Obstetrics and Gynecology Kanuni Sultan Süleyman Education and Research Hospital Istanbul Turkey Department of Obstetrics and Gynecology Dr. Sami Ulus Education and Research Hospital Ankara Turkey Department of Biochemistry Faculty of Medicine University of Dicle Diyarbakir Turkey Department of Obstetrics and Gynecology Diyarbakir Gazi Yasargil Education and Research Hospital Diyarbakir Turkey Department of Obstetrics and Gynecology Diyarbakir Obstetrics and Gynecology Hospital Diyarbakir Turkey Department of Obstetrics and Gynecology Memory Hospital Diyarbakir Turkey Department of Obstetrics and Gynecology School of Medicine Hospital University of Dicle Diyarbakir Turkey

Aim: To investigate the effect of melatonin on ischemia–reperfusion (I/R) injury in rat ovary. Material and Method: A total of 24 Wistar rats were divided into four groups. The rats were first numbered randomly and then randomly divided into four equal groups: sham, torsion, detorsion and melatonin groups. In group I (n = 6) sham, as well as in group II ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. In group IV, melatonin was dissolved in 1% ethanol just before use. Melatonin was injected 1 hour before torsion to the torsion plus melatonin group. Right ovaries were surgically removed in all groups. Result: Malondialdehyde (MDA) levels were measured. We suggested that administration of melatonin would be in treating ovaries from torsion/detorsion induced damage in humans. The histopathological changes such as vascular congestion, edema, hemorrhage, and follicular degeneration were found to be decreased in the melatonin + ischemia-reperfusion group. Ischemia-reperfusion group: PECAM-I expression is positive in vessel of the stromal area. The follicles and interfolicular area infiltrated with CD68 positive cells were increased in a time of ischemia-reperfusion exposure dependent manner. Conclusions: Melatonin after ischemia-reperfusion CD31 and CD68 expressions is weak, due to the reduction of the inflammatory effects and hemorrhage is thought that melatonin is effective.

关键词： Ischemia-Reperfusion Ovary Rat CD31 CD68

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