检索结果-南通市图书馆

Retinitis pigmentosa and stem cell therapy

International Journal of Ophthalmology(English edition) 2024年第7期17卷 1363-1369页

作者： Xin-ya qi Chen-Hui Mi De-Rui Cao Xie-Qun Chen Peng Zhang School of Medicine Department of Life Sciences and MedicineNorthwest UniversityXi’an 710069Shaanxi ProvinceChina The Third Hospital of Xi’an Affiliated Hospital of Northwest UniversityXi’an 710021Shaanxi ProvinceChina

Retinitis pigmentosa(RP)is a group of genetic disorders characterized by progressive degeneration of photoreceptors and retinal pigment epithelium(RPE)*** main clinical manifestations include night blindness and progressive loss of peripheral vision,making it a prevalent debilitating eye disease that significantly impacts patients’quality of *** exhibits significant phenotypic and genetic *** instance,numerous abnormal genes are implicated in RP,resulting in varying clinical presentations,disease progression rates,and pathological characteristics among different ***,gene therapy for RP poses challenges due to these ***,stem cells have garnered considerable attention in the field of RPE therapy since both RPE cells and photoreceptors can be derived from stem *** recent years,a large number of animal experiments and clinical trials based on stem cell transplantation attempts,especially cord blood mesenchymal stem cell(MSC)transplantation and bone marrow-derived MSC transplantation,have confirmed that stem cell therapy can effectively and safely improve the outer retinal function of the RP-affected ***,stem cell therapy also has certain limitations,such as the fact that RP patients may involve multiple types of retinal cytopathia,which brings great challenges to stem cell transplantation therapy,and further research is needed to solve various problems faced by this approach in the *** comprehensive analysis of the etiology and histopathological changes associated with RP,this study substantiates the efficacy and safety of stem cell therapy based on rigorous animal experimentation and clinical trials,while also highlighting the existing limitations that warrant further investigation.

关键词： retinitis pigmentosa photoreceptor stem cell therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global research trends and hotspots in overweight/obese comorbid with depression among children and adolescents: A bibliometric analysis

引用

World Journal of Psychiatry 2024年第8期14卷 1267-1284页

作者： ya-qi Wang Tao-Tao Wu yan Li Shi-En Cui Ying-Shuai Li College of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310051Zhejiang ProvinceChina National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Overweight/obesity combined with depression among children and adolescents(ODCA)is a global *** bidirectional relationship between depression and overweight/obesity often leads to their *** and adolescence represent critical periods for physical and psychological development,during which the comorbidity of overweight/obesity and depression may increase the risk of adverse health *** To evaluate the relationship between ODCA,we conduct a bibliometric analysis to aid in formulating prevention and treatment *** From 2004 to 2023,articles related to ODCA were selected using the Science Citation Index Expanded from the Web of Science Core *** analysis of relevant publications,including countries/regions,institutions,authors,journals,references,and keywords,was conducted using the online bibliometric analysis platforms,CiteSpace,VOSviewer,and *** Between 2004 and 2023,a total of 1573 articles were published on *** United States has made leading contributions in this field,with Harvard University emerging as the leading contributor in terms of research output,and Tanofsky being the most prolific *** J Adolescent Health has shown significant activity in this *** on the results of the keyword and reference analyses,inequality,adverse childhood experiences,and comorbidities have become hot topics in ***,the impact of balancedrelated behavior and exploration of the biological mechanisms,including the potential role of key adipocytokines and lipokines,as well as inflammation in ODCA,have emerged as frontier *** The trend of a significant increase in ODCA publications is expected to *** research findings will contribute to elucidating the pathogenic mechanisms of ODCA and its prevention and treatment.

关键词： Children Adolescents Overweight Obesity Depression Bibliometric analysis Research trends

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interaction between ozone and paternal smoking on fetal congenital heart defects among pregnant women at high risk a multicenter maternal-fetal medicine study

引用

World Journal of Pediatrics 2024年第6期20卷 621-632页

作者： Huan Wang yan-Ping Ruan Sheng Ma ya-qi Wang Xiao-Yu Wan Yi-Hua He Jing Li Zhi-Yong Zou Institute of Child and Adolescent Health School of Public HealthNational Health Commission Key Laboratory of Reproductive HealthPeking UniversityNo.38 Xueyuan RdHaidian DistrictBeijing 100191China Echocardiography Medical Center Beijing Anzhen Hospital.Capital Medical UniversityMaternal-Fetal Medicine center in Fetal Heart DiseaseBeijing Anzhen HospitalNo.2 Anzhen RdChaoyang DistrictBeijing 100029China

Background Evidence remains limited on the association between maternal ozone(O,)exposure and congenital heart defects(CHDs)in offspring,and few studies have investigated the interaction and modification of paternal smoking on this *** Using a sample including pregnant women at high risk of fetal CHD(with metabolic disease,first-trimester viral infection,family history of CHD,etc.)from a maternal-fetal medicine study covering 1313 referral hospitals in China during 2013-2021,we examined the associations between maternal O_(3)exposure during 3-8 weeks of gestational age and fetal CHD in offspring and investigated the interaction and modification of paternal smoking on this *** was diagnosed by fetal echocardiograms,maximum daily 8-hour average O,exposure data at a 10 km×10 km spatial resolution came from the Tracking Air Pollution in China dataset,and paternal smoking was collected using *** regression models were used to estimate adjusted odds ratios(ORs)and 95%confidence intervals(CIs).Results Among 27,834 pregnant women at high risk of fetal CHD,17.4%of fetuses were diagnosed with *** 10μg/m^(3)increase in maternal O_(3)exposure was associated with a 17%increased risk of CHD in offspring(OR=1.17,95%CI=1.14-1.20).Compared with paternal nonsmoking and maternal low O_(3)exposure,the ORs(95%CI)of CHD for smoking and low O_(3)exposure,nonsmoking and high O_(3)exposure,and smoking and high O_(3)exposure were 1.25(1.08-1.45),1.81(1.56-2.08),and 2.23(1.84-2.71),*** smoking cessation seemingly mitigated the increased risk of *** Maternal O_(3)exposure and paternal smoking were interactively associated with an increased risk of fetal CHD in offspring,which calls for effective measures to decrease maternal exposure to O_(3)pollution and secondhand smoke for CHDprevention.

关键词： Congenital heart defects Fetal heart development Ozone exposure Tobacco smoking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy and safety of yangxinshi tablet for chronic heart failure:A systematic review and meta-analysis

引用

World Journal of Clinical Cases 2024年第13期12卷 2218-2230页

作者： Sheng-Hua Lu Yun-Feng Yu Si-Si Dai ya-qi Hu Jian-He Liu The First Clinical College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Branch of National Clinical Research Center for Chinese Medicine Cardiology The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

BACKGROUND The specific benefits of yangxinshi tablet(YXST)in the treating chronic heart failure(CHF)remain *** To systematically evaluate the efficacy and safety of YXST in the treatment of *** Randomized controlled trials(RCTs)investigating YXST for CHF treatment were retrieved from eight public databases up to November ***-analyses of the included clinical studies were conducted using Review Manager *** Twenty RCTs and 1845 patients were *** meta-analysis results showed that the YXST combination group,compared to the conventional drug group,significantly increased the clinical efficacy rate by 23%[relative risk(RR)=1.23,95%CI:1.17-1.29],(P<0.00001),left ventricular ejection fraction by 6.69%[mean difference(MD)=6.69,95%CI:4.42-8.95,P<0.00001]and 6-min walk test by 49.82 m(MD=49.82,95%C:38.84-60.80,P<0.00001),and reduced N-terminal pro-Btype natriuretic peptide by 1.03 ng/L[standardized MD(SMD)=-1.03,95%CI:-1.32 to-0.74,P<0.00001],brain natriuretic peptide by 80.95 ng/L(MD=-80.95,95%CI:-143.31 to-18.59,P=0.01),left ventricular end-diastolic diameter by 3.92 mm(MD=-3.92,95%CI:-5.06 to-2.78,P<0.00001),and left ventricular endsystolic diameter by 4.34 mm(MD=-4.34,95%CI:-6.22 to-2.47,P<0.00001).Regarding safety,neither group reported any serious adverse events during treatment(RR=0.54,95%CI:0.15-1.90,P=0.33).In addition,Egger's test results indicated no significant publication bias(P=0.557).CONCLUSION YXST effectively improves clinical symptoms and cardiac function in patients with CHF while maintaining a favorable safety profile,suggesting its potential as a therapeutic strategy for CHF.

关键词： yangxinshi tablet Chronic heart failure Cardiac function Systematic evaluation Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy

引用

Chinese Chemical Letters 2024年第7期35卷 377-382页

作者： Mengjuan Sun Muye Zhou Yifang Xiao Hailei Tang Jinhua Chen Ruitao Zhang Chunjiayu Li qi ya qian Chen Jiasheng Tu qiyue Wang Chunmeng Sun NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients China Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 211198China Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityNanjing 211198China Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics China Pharmaceutical UniversityNanjing 210009China School of Pharmaceutical Science Nanjing Tech UniversityNanjing 211816China

Size is one of the most important characteristics of nanoparticles to influence their biodistribution and antitumoral *** with large sizes have difficulty in deep tumor penetration,while small particles are easily removed from tumor tissues due to the high tumor interstitial fluid *** address these issues,an intelligent core-crosslinked polyion complex micelle(cPCM)with a reversibly sizeswitchable feature was engineered in this *** micelles are consisting of methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer(mPEG-PLA),mPEG-PLA-(HE)6CC,and mPEG-PLA-(RG)6CC at an optimal mass ratio of 6:1:1 with an antiangiogenic compound,dabigatran etexilate(DE),*** net charge inside the micelles is switchable when exposed to different pH conditions,thereby leading to revisable size-change of ***-loaded micelles(DE@cPCM)can swell and release drugs at the tumor sites with a mildly acidic pH,while they shrink and protect the cargo from leaking into the blood circulation with a neutral *** indicated that DE@cPCM can inhibit tumor angiogenesis in vitro and in vivo,thereby efficiently restraining tumor growth in a 4T1-bearing mouse ***,the sizeswitchable cPCM is a promising nanoplatform for targeting delivery of anticarcinogens into the matrix of tumor tissues.

关键词： Polyion complex micelle Size-switchable Revisable size-change pH response Antiangiogenic cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新质生产力全域赋能:智能媒体高质量发展新路向

引用

编辑之友 2024年第6期 74-83页

作者：漆亚林中国社会科学院大学新闻传播学院北京102401

“奇点临近”之际,人工智能技术的创新应用与迭代升级必将成为推动传媒业结构性改革和高质量发展的新动能,促进智能媒体不断优化跃迁,进入信息传播的新赛道。文章在厘清智能媒体辞屏尺度的基础上,从知识涌现与溢出的角度考察智能媒体高... 详细信息

“奇点临近”之际,人工智能技术的创新应用与迭代升级必将成为推动传媒业结构性改革和高质量发展的新动能,促进智能媒体不断优化跃迁,进入信息传播的新赛道。文章在厘清智能媒体辞屏尺度的基础上,从知识涌现与溢出的角度考察智能媒体高质量发展的内在机理。智能媒体有两条基本型构路向:数智平台的知识创新与媒体化建设、主流媒体的智能化与平台化建设。发展基于科技创新与高质量运维的传媒新质生产力是智能媒体高质量发展的未来朝向。智能媒体的新质生产力以知识生产主体、生产资料、生产对象及其优化组合的跃升为主要特征和发展逻辑,并在智能采集、智能生产、智能分发、智能经营、智能管理等应用场景中进行全域赋能。

关键词：新质生产力智能媒体基础架构智能传播未来展望

来源：

维普期刊数据库博看期刊

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inhibitory effect of saffron on head and neck squamous cell carcinoma via targeting of ESR1 and CCND1 by its active compound crocetin

引用

Traditional Medicine Research 2024年第7期9卷 25-34页

作者： Xiao-Jie Wang Ming-Jun Zhang Li-Mei Cui Zhe-Ying Song ya-qi Wang Yu-Teng yang Xiang-Kun Zhao ya-Kui Mou Yu-Mei Li Xi-Cheng Song School of Clinical Medicine Weifang Medical UniversityWeifang 261042China. Department of Otorhinolaryngology Head and Neck SurgeryYantai Yuhuangding HospitalQingdao UniversityYantai 264000China. Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases Yantai 264000China. yantai Key Laboratory of Otorhinolaryngologic Diseases Yantai Yuhuangding HospitalYantai 264000China. The 2nd Medical College of Binzhou Medical University Yantai 264000China.

Background:Traditional Chinese medicine is promising for managing challenging and complex disorders,including cancer,and in particular,saffron is applied in treating various cancer ***,its potential therapeutic efficacy and active components in managing squamous cell carcinoma of the head and neck(HNSCC)remain unclear ***:Using network pharmacology approaches,active ingredients of saffron,their target genes,and HNSCC-related genes were *** analyses were conducted for determining molecular functions and pathways enriched by genes that overlapped between the saffron target gene set and the HNSCC gene *** the four known active ingredients of saffron,crocetin was found to have the strongest inhibitory impact on HNSCC,based on the findings of cell viability and migration ***,the potential target genes of crocetin in HNSCC cells were examined using molecular docking experiments and were confirmed by *** s:Four active ingredients of saffron and 184 of their target genes were ***,a total of 34 overlapping saffron-/HNSCC-associated targets related to the four active ingredients were screened,and crocetin was chosen for further investigation because it had the strongest inhibitory effect on HNSCC *** docking experiments indicated that ESR1 and CCND1 were the target genes of *** results were confirmed through qPCR analysis,in which crocetin was found to lower the expression of the ESR1 and CCND1 genes in AMC-HN-8 and FaDu ***:According to our results,crocetin is a primary active anti-cancer component of saffron that may have potential in the development of novel HNSCC-treating ***,more thorough molecular research is necessary for confirming these results and elucidating the anti-cancer mechanism underlying saffron.

关键词： saffron hub genes crocetin network pharmacology analysis HNSCC ESR1 CCND1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国春季复合极端低温多雨事件的年代际变化及成因分析

引用

气候变化研究进展 2024年第1期20卷 1-9页

作者：周晶孙燕齐雅静江苏省气象科学研究所南京210019 南京信息工程大学大气科学学院南京210044

利用1961—2020年中国553站逐日最低气温、降水资料和ERA5再分析资料,探讨了我国春季复合极端低温多雨事件的年代际变化特征及可能成因。结果表明,春季复合极端低温多雨事件整体呈现出南多北少的分布型,并且高频次中心在西南和华南地区... 详细信息

利用1961—2020年中国553站逐日最低气温、降水资料和ERA5再分析资料,探讨了我国春季复合极端低温多雨事件的年代际变化特征及可能成因。结果表明,春季复合极端低温多雨事件整体呈现出南多北少的分布型,并且高频次中心在西南和华南地区,年平均超过了5 d。全国绝大部分地区春季复合极端低温多雨事件近60年呈现减少趋势,在1990年代末期出现了由多转少的全国范围的年代际突变,并以我国东南部季风区的减少最为显著。进一步分析发现,我国北方至白令海峡地区的异常气旋性环流和我国东南侧西北太平洋上的异常反气旋性环流是引起年代际突变的两个关键环流系统。

关键词：复合极端低温多雨事件年代际异常环流背景

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

财政透明度对企业税收遵从的影响——来自新《预算法》实施的证据

引用

当代财经 2024年第6期 43-56页

作者：肖鹏王亚琪中央财经大学财政税务学院北京102206

财政公开透明作为现代预算制度的重要特征,不仅是推进国家治理体系和治理能力现代化的重要抓手,还是影响企业经营行为和税收遵从的重要因素。以新《预算法》的实施为切入点,基于2013—2021年我国地级市和A股上市公司的数据,实证分析了... 详细信息

财政公开透明作为现代预算制度的重要特征,不仅是推进国家治理体系和治理能力现代化的重要抓手,还是影响企业经营行为和税收遵从的重要因素。以新《预算法》的实施为切入点,基于2013—2021年我国地级市和A股上市公司的数据,实证分析了财政透明度对企业税收遵从的影响及其作用机制。研究表明:财政透明度能够显著地提高企业税收遵从度,表明财政透明度作为一种治理工具,在企业税收决策中发挥了重要作用。机制分析发现,从社会维度看,财政透明度通过提高财政支出的有效性,提高企业纳税意愿;从政治维度看,财政透明度通过减少政府官员腐败和企业政治关联,减小企业避税空间;从经济维度看,财政透明度通过改善营商环境,降低企业避税动机。异质性分析发现,在信息化程度高、财政压力小的城市,财政透明度能够明显地提高企业税收遵从度。因此,要建立预算公开长效机制,提高预算公开与其他预算改革举措的系统性和协调性,优化财政资源配置,强化财政透明度的经济社会治理效应,以便提高企业税收遵从度。

关键词：财政透明度企业税收遵从新《预算法》现代预算制度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Building and characterizing a stylus ion-trap system

引用

Chinese Physics B 2024年第4期33卷 122-127页

作者：崔太豪魏雅琪李冀袁泉戴双晴李沛东周飞张建奇郑驻军陈亮冯芒 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy of Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of the Chinese Academy of Sciences Beijing 100049China Laboratory of Quantum Science and Engineering South China University of TechnologyGuangzhou 510641China Research Center for Quantum Precision Measurement Guangzhou Institute of Industry TechnologyGuangzhou 511458China Department of Physics Zhejiang Normal UniversityJinhua 321004China

Cold trapped ions can be excellent sensors for ultra-precision detection of physical quantities,which strongly depends on the measurement situation at *** stylus ion trap,formed by two concentric cylinders over a ground plane,holds the promise of relatively simple structure and larger solid angle for optical access and fluorescence collection in comparison with the conventional ion *** we report our fabrication and characterization of the first stylus ion trap constructed in China,aiming for studying quantum optics and sensing weak electric fields in the *** have observed the stable confinement of the ion in the trapping potential for more than two hours and measured the heating rate of the trap to be dε/dt=7.10±0.13 meV/s by the Doppler recooling *** work starts a way to building practical quantum sensors with high efficiency of optical collection and with ultimate goal for contributing to future quantum information technology.

关键词： stylus ion trap electric-field noises Doppler recooling method heating rate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：