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Clinical Evaluation of the Safety and Efficacy of the Phytomedicine APIVIRINE Based on Aqueous Extracts of Dichrostachys glomerata (Forssk.). Chiov. (D. cinerea) in COVID-19 Patients without Signs of Severity

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International Journal of Clinical Medicine 2023年第6期14卷 302-318页

作者： Daouda ouédraogo Grissoum Tarnagda Jean Claude Romaric Pingdwindé ouédraogo Amed Héma Simon Tiendrebéogo Salfo ouédraogo Geoffroy Gueswindé ouédraogo Lazare Belemnaba Noufou ouédraogo Félix Dit Bondo Kini zékiba Tarnagda Martial ouédraogo Sylvin ouédraogo Service de Pneumologie/Centre Hospitalier Universitaire yalgado ouédraogo (CHU-yO) Ouagadougou Burkina Faso Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouaga-dougou Burkina Faso

Background: Since the appearance of the COVID-19 pandemic, several drugs have also been proposed for the treatment of the COVID-19, but the therapeutic effectiveness of those drugs is not satisfactory. This situation has led to the search for therapeutic solutions based on recipes from traditional medicine. Aims: This study aimed to evaluate the clinical safety, efficacy and tolerability of the phytomedicine APIVIRINE in patients with non-severe COVID-19. Methods: Patients were included following defined criteria and followed on an outpatient basis until recovery in accordance with national guidelines for the management of single cases of COVID-19 in Burkina Faso. Vital signs, anthropometric parameters as well as electrocardiographic, hematological and biochemical examinations were measured on D4, D7, D14 and D21. Adverse events were recorded during maintenance. Results: The present study included 45 patients. The clinical signs present at inclusion were mostly cough (44.44%), asthenia (42.22%), headache (40%), and anosmia (35.55%). Dyspnoea and chest pain were less represented in 05 (11.11%) and 06 (13.33%) patients. Cough, dyspnoea, chest pain, fever, sore throat, headache, and nasal obstruction present at inclusion disappeared before Day 4 of treatment. Anosmia and asthenia disappeared before Day 7. At the inclusion visit (Day 1), CRP, WBC, and blood glucose were abnormal in 15 (33.33%), 13 (28.89%), and 11 (24.44%) patients respectively. In addition, 3 (6.66%) patients had elevated creatinine levels. Transaminases Alanine aminotransferase (ALAT) were elevated in 05 (11.11%) patients while Aspartate aminotransferase (ASAT) was elevated in 04 (8.89%) patients. After 4 days of treatment, the cure rate was 33.33% of patients and 48.89% after 7 days. The cumulative cure rate was 86.67% after 14 days of treatment. Conclusion: No serious side effects or allergic reactions were observed during treatment. No clinical complications were observed and all symptoms present r

关键词： APIVIRINE COVID-19 Clinical Study Safety

Joint effects of microwave and chromium trioxide on root tip cells of Vicia faba

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Journal of zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第3期7卷 221-227页

作者： QIAN Xiao-wei LUO Wei-hua zHENG ou-xiang School of Life and EnvironmentalScience Wenzhou University Wenzhou 325003 China

The mutagemc effects of microwave and chromium trioxide （CrO3） on Vicia faba root tip were studied. Micronucleus assay and chromosomal aberration assay were used to determine the mitotic index, the micronucleus frequency and chromosomal aberration frequency of Vicia faba root tip cells induced by microwave and CrO3. The results showed that the micronucleus frequency decreased, and that the mitotic index and chromosomal aberration frequency showed linear dose responses to CrO3, in treatment of microwave for 5 s. In microwave of 25 s, the mitotic index decreased, the micronucleus frequency and chromosomal aberration frequency increased with increase of CrO3 concentration. We concluded that microwave and CrO3 had antagonistic effect on the mitotic index of Vicia faba root tip cells, but had synergetic effect on micronucleus frequency and chromosomal aberration frequency of Viciafaba root tip cells.

关键词： Microwave Chromium trioxide (CrO3) Antagonistic effect Synergetic effect

武夷肉桂加工中挥发性成分糖苷结合物和香气品质形成研究

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茶叶科学 2024年第1期44卷 84-100页

作者：吴宗杰欧晓西林宏政余欣茹程守悦吴晴阳李鑫磊孙云福建农林大学园艺学院福建福州350002 茶学福建省高校重点实验室福建福州350002 福建省农业科学院茶叶研究所福建福州350012

肉桂是武夷岩茶主栽品种,具有馥郁的花果香和辛锐的桂皮味特征。为明确武夷肉桂关键呈香物质和挥发性成分糖苷结合物(GBVs)对香气的贡献,采用超高效液相色谱四极杆/静电场轨道阱质谱仪系统(UHPLC-Q-Exactive/MS)和顶空固相微萃取-气相色... 详细信息

肉桂是武夷岩茶主栽品种,具有馥郁的花果香和辛锐的桂皮味特征。为明确武夷肉桂关键呈香物质和挥发性成分糖苷结合物(GBVs)对香气的贡献,采用超高效液相色谱四极杆/静电场轨道阱质谱仪系统(UHPLC-Q-Exactive/MS)和顶空固相微萃取-气相色谱-质谱联用(HS-SPME-GC-MS)技术对武夷肉桂加工过程GBVs和香气物质动态变化进行研究。结果表明,共检测到武夷肉桂11个不同加工阶段的276种香气物质,这些香气物质包括酯类、醇类、杂环化合物类、酮类、醛类、萜类等多种组分,其中杂环化合物类、酯类、萜类和醇类香气组分含量较高。正交偏最小二乘法判别分析(OPLS-DA)发现,武夷肉桂中30种特征香气物质变量重投影要性值和香气活度值均大于1,其中具有青味的(z)-3-己烯醇和(E)-2-己烯醛含量在加工过程中下降,呈花香或果香的芳樟醇、苯甲醇、苯乙醛、香叶醇和β-罗勒烯含量在加工过程中上升,脱氢芳樟醇和α-石竹烯具有辛香的特征,可能是肉桂品种特征香气桂皮辛香的主要贡献物。在武夷肉桂毛茶中芳樟醇、苯乙醛、苯甲醇、2-乙氧基-3-甲基吡嗪和(E,E)-3,5-辛二烯-2-酮等物质香气特征影响值大于1,说明这些物质是武夷肉桂加工过程中关键呈香物质。在武夷肉桂中鉴定到10种GBVs,在加工过程中,葡萄糖苷的含量呈上升趋势,而樱草糖苷的含量呈下降趋势,GBVs总含量上保持相对稳定。在做青后期,葡萄糖苷和樱草糖苷的含量都呈现下降趋势,特别是苯甲基樱草糖苷、2-苯乙基樱草糖苷、香叶基樱草糖苷、芳樟基樱草糖苷和香叶基葡萄糖苷显著下降,结果表明GBVs参与了武夷肉桂花果香和甜香的形成。研究结果阐明武夷肉桂特征香气成分以及GBVs在武夷肉桂香气形成中的作用,有利于更好地提升武夷肉桂香气品质,提质增效。

关键词：武夷肉桂代谢组学加工过程香气挥发性成分糖苷结合物

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基于交叉偏置磁场的单光束三轴原子磁力仪

激光与光电子学进展 2024年第5期61卷 253-259页

作者：吴梓楠张佳龙何孟阳任博康王子隆欧中华岳慧敏周晓军刘永电子科技大学光电科学与工程学院电子薄膜与集成器件国家重点实验室四川成都610054

报道了一种基于交叉偏置磁场的单光束单调制三轴原子磁力仪。基于Bloch方程研究了单光束泵浦探测结构实现三轴磁场检测的理论,提出使用交叉偏置磁场来旋转原子自旋极化方向实现三轴磁场探测的方案,并通过实验进行了验证。仅采用单一调... 详细信息

报道了一种基于交叉偏置磁场的单光束单调制三轴原子磁力仪。基于Bloch方程研究了单光束泵浦探测结构实现三轴磁场检测的理论,提出使用交叉偏置磁场来旋转原子自旋极化方向实现三轴磁场探测的方案,并通过实验进行了验证。仅采用单一调制磁场,在抑制低频噪声的前提下避免了磁场串扰问题。实验结果表明:在零磁场环境下,系统对X轴方向待测磁场的响应带宽为90 Hz,系统灵敏度为21 fT/(Hz^(1/2));在z轴方向施加34 nT的偏置磁场时,系统对y轴方向待测磁场的响应带宽为130 Hz,系统灵敏度为26 fT/(Hz^(1/2));在y轴方向施加38 nT的偏置磁场时,系统对z轴方向待测磁场的响应带宽为128 Hz,系统灵敏度为29 fT/(Hz^(1/2))。该三轴原子磁力仪体积小、结构简单且制作成本低,有望应用于生物医疗等领域。

关键词：原子磁力仪三轴磁场灵敏度无自旋交换弛豫弱磁检测

Magnetic Inertial Confinement Fusion(MICF)

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Plasma Science and Technology 2016年第11期18卷 1055-1063页

作者： MIAO Feng zHENG Xianjun DENG Baiquan LIU Wei ou Wei HUANG yi Institute of Atomic and Molecular Physics Sichuan University Chengdu 610065 China HOPE Innovations Inc. Ontario L4W0A5 Canada Southwestern Institute of Physics Chengdu 610041 China Southwest University for Nationalities Chengdu 610041 China Institute of Nuclear Science and Technology Sichuan University Chengdu 610064 China

t Based on the similarity in models of the early Sun and the 3-D common focal region of the micro-pinch in X-pinch experiments, a novel hybrid fusion configuration by continuous focusing of multiple z-pinched plasma beams on spatially symmetric plasma is proposed. By replacing gravity with Lorentz force with subsequent centripetal spherical pinch, the beam- target fusion reactivity is enhanced in a quasi-spherical converging region, thus achieving MICF. An assessment, presented here, suggests that a practical fusion power source could be achieved using deuterium alone. Plasma instabilities can be suppressed by fast rotation resulting from an asymmetric tangential torsion in the spherical focal region of this configuration. Mathematical equivalence with the Sun allows the development of appropriate equations for the focal region of MICF, which are solved numerically to provide density, temperature and pressure distributions that produce net fusion energy output. An analysis of MICF physics and a preliminary experimental demonstration of a single beam are also carried out.

关键词： MICF centripetal spherical pinch beam-target enhancement

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血浆神经丝蛋白轻链与帕金森病亚型的相关性

中华行为医学与脑科学杂志 2024年第9期33卷 783-789页

作者：梁晓静乙红艳李天天许富贵王丽君欧洲佟强南京医科大学附属淮安第一医院神经内科淮安223300

目的探讨帕金森病(Parkinson disease,PD)患者血浆总α-突触核蛋白(α-synuclein,α-syn)、磷酸化-α-突触核蛋白(phosphorylatedα-synuclein,p-α-syn)、神经丝蛋白轻链(neurofilament light chain,NfL)与不同亚型的关系。方法连续收集2021年9月至2023年1月在南京医科大学附属淮安第一医院神经内科就诊的62例PD患者(PD组),进行H-y分期(Hoehn-yahr,H-y)、统一帕金森病评定量表Ⅲ(unified Parkinson''s disease rating scaleⅢ,UPDRS-Ⅲ)、左旋多巴每日等效剂量(levodopa equivalent daily dosage,LEDD)、简易精神状态量表(mini-mental state examination,MMSE)、帕金森病生活质量问卷39项(Parkinson disease quality of life questionnaire 39,PDQ-39)、日常生活活动能力(activities of daily living,ADL)等评分。同期选择年龄、性别匹配的健康志愿者25例作为对照组(HC组)。收集临床资料,采集血样标本,利用ELISA技术检测PD组和HC组血浆α-syn、p-α-syn、NfL水平。根据UPDRS-Ⅲ评分将PD患者分为震颤型(tremor dominant,TD;n=27)和少动-强直型(akinetic rigid dominant,AR;n=35)。使用SPSS 25.0软件进行统计分析,应用Logistic回归分析PD亚型的影响因素,绘制受试者工作特征曲线(receiver operating characteristic,ROC)判断血浆NfL在临床上区分PD的TD与AR间的最佳切点。结果PD组血浆α-syn、p-α-syn、NfL水平均高于HC组,差异有统计学意义(z=-2.537,-6.580,-7.101,均Py分期、UPDRS-Ⅲ评分、LEDD、MMSE评分方面均差异有统计学意义(z=-2.503,-3.021,-2.025,-2.086,-2.409,均Pyn、p-α-syn水平与TD组差异无统计学意义(z=-0.341,-0.085,均P>0.05),但AR组血浆NfL水平[92.79(16.84,117.53)pg/mL]显著高于TD组[12.10(6.99,100.17)pg/mL](z=-2.236,P<0.05)。血浆NfL水平与强直得分(r=0.438,P<0.001)、UPDRS-Ⅲ运动评分(r=0.337,P<0.05)和运动亚型(r=0.286,P<0.05)相关。多因素Logistic回归分析显示,NfL是AR发生的独立影响因素(B=0.002,OR=1.002,95%CI=1.001~1.003,P=0.017)。ROC曲线分析显示血浆NfL预测PD不同亚型的ROC曲线下面积为0.667,最佳截断值为26.527。结论血浆NfL水平升高与PD患者AR的发生存在相关性,揭示了神经损伤可能参与了PD不同运动亚型的发生和发展。

关键词：帕金森病神经丝蛋白轻链运动亚型 α-突触核蛋白相关分析

酱油腐败细菌的分离鉴定及天然抑菌物的抑菌研究

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食品科技 2024年第1期49卷 275-281页

作者：李碧怡陈南娟李彤罗晓莹欧幼玲郑蔓萍李琳电子科技大学中山学院材料与食品学院广东中山528402

以腐败广式酱油为研究对象,对其腐败细菌进行分离鉴定,并考察2株芽孢杆菌的耐盐特性。比较了不同抑菌物质(丁香油、柠檬醛、Nisin、乳酸、山梨酸钾)对解淀粉芽孢杆菌、贝莱斯芽孢杆菌的最小抑制浓度(Minimum inhibitory concentration,M... 详细信息

以腐败广式酱油为研究对象,对其腐败细菌进行分离鉴定,并考察2株芽孢杆菌的耐盐特性。比较了不同抑菌物质(丁香油、柠檬醛、Nisin、乳酸、山梨酸钾)对解淀粉芽孢杆菌、贝莱斯芽孢杆菌的最小抑制浓度(Minimum inhibitory concentration,MIC);在此基础上,以低盐广式原油为研究对象,探究不同抑菌剂对酱油原油的抑菌效果。结果表明:腐败广式原油中分离的细菌主要为蜡样芽孢杆菌、解淀粉芽孢杆菌、贝莱斯芽孢杆菌和沙氏芽孢杆菌;解淀粉芽孢杆菌与贝莱斯芽孢杆菌均具有耐盐性,12%的食盐可在细菌生长初期抑制其生长;抑菌剂Nisin z、乳酸对解淀粉芽孢杆菌和贝莱斯芽孢杆菌的MIC分别为0.2、1 mg/mL;在低盐酱油原油中添加抑菌剂组合(0.02%Nisin z和0.05%乳酸)可较好控制酱油原油的品质。

关键词：天然抑菌物酱油低盐酱油腐败细菌芽孢杆菌

Burst-like first-order transition in La(Fe,Si)13 giant magnetocaloric materials

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Burst-like first-order transition in La(Fe,Si)13 giant magne...

48例原因不明矮身材儿童临床特征和致病基因分析

中国稀土学会第四届青年学术会议

作者： F.Guillou H.yibole O.Tegus z.Q.ou J.y.Xu V.Hardy College of Physics and Electronic Information Inner Mongolia Key Laboratory for Physics and Chemistry of Functional Materials Inner Mongolia Normal University

While magnetization measurements are by far the most commonly used method to quantify the magnetocaloric effect, they may overlook some exotic phenomena sometimes occurring at first-order magnetic transitions. These features actually require thermal methods to be observed. La(Fe,Si)13 is one of the archetypical example of alloys with a giant magnetocaloric effect associated to a first-order magnetic transition. Recent Peltier cell calorimetry studies have revealed that the exchange of latent heat at the transition can take the form of a succession of individual peaks as a function of time. Here, using various thermal techniques such as Peltier cell calorimetry, commercial differential scanning calorimeter, semi-adiabatic calorimetry and thermal analyses;we show that the first-order transition can also be accompanied by other unusual features including recalescence/anti-recalescence(a burst-like temperature change at the beginning of the transformation), reverse trend(a general cooling of the sample when heating across the transition) or a two-step transition(a burst-like acceleration near the end of the transformation) [1-3]. In all cases, a basic requirement is a large latent heat confined within a small temperature range, which can lead to a transition profile very different from an ideal first-order transition, see Figure 1. We will discuss the conditions for the observation of these particular thermal responses, which also raise questions on dynamical aspects of the transition, i.e. how the first-order transition of La(Fe,Si)13 develop in time and space.

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中山大学学报（医学科学版） 2024年第1期45卷 127-135页

作者：侯乐乐林少汾李晓娟刘祖霖欧辉张丽娜孟哲梁立阳中山大学孙逸仙纪念医院儿童医学中心广东广州510289 中山大学孙逸仙纪念医院细胞分子诊断中心广东广州510289

【目的】总结原因不明矮身材儿童的临床特征并探讨其致病基因,为临床精准诊疗提供依据。【方法】收集我院儿科内分泌专科2018年1月至2022年8月就诊的未能明确诊断的矮身材儿童临床表现、实验室检查及全外显子组测序(WES)结果进行回顾性... 详细信息

【目的】总结原因不明矮身材儿童的临床特征并探讨其致病基因,为临床精准诊疗提供依据。【方法】收集我院儿科内分泌专科2018年1月至2022年8月就诊的未能明确诊断的矮身材儿童临床表现、实验室检查及全外显子组测序(WES)结果进行回顾性分析,根据不同作用机制对致病基因进行归纳总结。【结果】纳入患儿48例(男性30例,女性18例),年龄(7.73±3.97)岁,身高标准差分值为-3.63±1.67;临床表现:特殊面容33例(68.8%),体型或骨骼系统异常31例(64.6%),围产期异常26例(54.2%,其中61.5%为小于胎龄儿),内分泌系统异常24例(50.0%,其中87.5%生长激素(GH)峰值低于正常),矮身材家族史21例(43.8%);实验室检查:GH激发试验峰值(9.72±7.25)ng/mL,IGF-1标准差分值为-0.82±1.42,骨龄与年龄差值(-0.93±1.39)岁;WES共发现相关基因变异者25例,其中14例(56.0%)为致病变异,6例(24.0%)为可能致病变异,5例(20.0%)为意义未明变异;评价为致病及可能致病变异的基因共14个,其中影响细胞内信号通路10个(PTPN11、RAF1、RIT1、ARID1B、ANKRD11、CSNK2A1、SRCAP、CUL7、SMAD4和FAM111A),影响细胞外基质(ECM)4个(ACAN、FBN1、COL10A1和COMP)。【结论】临床上表现为严重矮身材伴特殊面容、非匀称体型、骨骼系统异常、小于胎龄儿、GH峰值低于正常和矮身材家族史等特征的儿童,其病因需考虑罕见单基因疾病的可能,WES是提高单基因性矮小症诊断效能的重要手段。本组患儿致病基因中,主要致病机制是影响细胞内信号通路和ECM组分或功能,进一步研究有助于发现和研究新的矮小症致病变异和基因功能。

关键词：矮身材儿童临床特征全外显子组测序基因变异致病基因