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Light-powered self-rolling of a liquid crystal elastomer-based dicycle

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Applied Mathematics and Mechanics(English Edition) 2025年第2期46卷 253-268页

作者： kai LI Chongfeng ZHAO yunlong QIU yuntong DAI school of Civil Engineering Anhui Jianzhu University

Conventional liquid crystal elastomer (LCE)-based robots are limited by the need for complex controllers and bulky power supplies, restricting their use in microrobots and soft robots. This paper introduces a novel light-powered dicycle that uses an LCE rod, enabling self-rolling by harvesting energy from the environment. The LCE rod serves as the driving force, with energy being supplied by a line light source. Employing a dynamic LCE model, we calculate the transverse curvature of the LCE rod after deformation, as well as the driving moment generated by the shift in a rod’s center of gravity,which allows the dicycle to roll on its own. Through extensive numerical simulations,we identify the correlations between the angular velocity of the dicycle and the key system parameters, specifically the light intensity, LCE rod length, light penetration depth,overall mass of the dicycle, rolling friction coefficient, and wheel radius. Further, the experimental verification is the same as the theoretical result. This proposed light-powered self-rolling dicycle comes with the benefits of the simple structure, the convenient control,the stationary light source, and the small luminous area of the light source. It not only demonstrates self-sustaining oscillations based on active materials, but also highlights the great potential of light-responsive LCE rods in applications such as robotics, aerospace,healthcare, and automation.

关键词： self-rolling dicycle liquid crystal elastomer (LCE) rod light-powered O322 O323

Visible-light-induced ring-opening cross-coupling of cycloalcohols with vinylazaarenes and enones via β-C-C scission enabled by proton-coupled electron transfer

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Chinese Chemical Letters 2025年第02期36卷 400-405页

作者： Qinghong Zhang Qiao Zhao Xiaodi Wu Li Wang kairui shen yuchen Hua Cheng Gao yu Zhang Mei Peng kai Zhao Institute of Advanced synthesis School of Chemistry and Molecular EngineeringJiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech University College of Chemical Engineering Nanjing Forestry University College of Pharmacy Hengyang Medical SchoolUniversity of South China school of Chemistry and Chemical Engineering Henan Normal University

Pyridyl-based ketones and 1,6-diketones are both attractive and invaluable scaffolds which play pivotal roles in the construction and structural modification of a plethora of synthetically paramount natural products, pharmaceuticals, organic materials and fine chemicals. In this context, we herein demonstrate an unprecedented, robust and generally applicable synthetically strategy to deliver these two crucial ketone frameworks via visible-light-induced ring-opening coupling reactions of cycloalcohols with vinylazaarenes and enones, respectively. A plausible mechanism involves the selective β-C-C bond cleavage of cycloalcohols enabled by proton-coupled electron transfer and ensuing Giese-type addition followed by single electron reduction and protonation. The synthetic methodology exhibits broad substrate scope,excellent functional group compatibility as well as operational simplicity and environmental friendliness.

关键词： 1,6-Diketone C-C Bond cleavage Proton-coupled electron transfer Pyridyl-based ketone Ring-opening coupling

Dynamic intelligent prediction approach for landslide displacement based on biological growth models and CNN-LsTM

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Journal of Mountain science 2025年第1期22卷 71-88页

作者： WANG Ziqian FANG Xiangwei ZHANG Wengang WANG Luqi WANG kai CHEN Chao school of Civil Engineering Chongqing UniversityChongqing 400045China Nanjiang Hydro-geology and Engineering Geology Team of Chongqing Geology Mineral Bureau Chongqing 401147China China Coal Technology and Engineering Chongqing Design and Research Institute(Group)Co. Ltd.Chongqing 400016China

Influenced by complex external factors,the displacement-time curve of reservoir landslides demonstrates both short-term and long-term diversity and dynamic *** is difficult for existing methods,including Regression models and Neural network models,to perform multi-characteristic coupled displacement prediction because they fail to consider landslide creep *** paper integrates the creep characteristics of landslides with non-linear intelligent algorithms and proposes a dynamic intelligent landslide displacement prediction method based on a combination of the Biological Growth model(BG),Convolutional Neural Network(CNN),and Long shortTerm Memory Network(LsTM).This prediction approach improves three different biological growth models,thereby effectively extracting landslide creep characteristic ***,it integrates external factors(rainfall and reservoir water level)to construct an internal and external comprehensive dataset for data augmentation,which is input into the improved CNN-LsTM ***,harnessing the robust feature extraction capabilities and spatial translation invariance of CNN,the model autonomously captures short-term local fluctuation characteristics of landslide displacement,and combines LsTM's efficient handling of long-term nonlinear temporal data to improve prediction *** evaluation of the Liangshuijing landslide in the Three Gorges Reservoir Area indicates that BG-CNN-LsTM exhibits high prediction accuracy,excellent generalization capabilities when dealing with various types of *** research provides an innovative approach to achieving the whole-process,realtime,high-precision displacement predictions for multicharacteristic coupled landslides.

关键词： Reservoir landslides Displacement prediction CNN LsTM Biological growth model

Impact of spinal Manipulative Therapy on Brain Function and Pain Alleviation in Lumbar Disc Herniation:A Resting-state fMRI study

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Chinese Journal of Integrative Medicine 2025年第2期31卷 108-117页

作者： ZHOU Xing-chen WU shuang WANG kai-zheng CHEN Long-hao WEI Zi-cheng LI Tao HUA Zi-han XIA Qiong LyU Zhi-zhen LyU Li-jiang Department of spine The Third Affiliated Hospital of Zhejiang Chinese Medicine UniversityHangzhou(310053)China Department of spine The Third School of Clinical MedicineZhejiang Chinese Medicine UniversityHangzhou(310053)China Research Institute of Tuina(spinal Disease) Zhejiang Chinese Medicine UniversityHangzhou(310053)China

Objective:To elucidate how spinal manipulative therapy(sMT)exerts its analgesic effects through regulating brain function in lumbar disc herniation(LDH)patients by utilizing resting-state functional magnetic resonance imaging(rs-f MRI).Methods:From september 2021 to september 2023,we enrolled LDH patients(LDH group,n=31)and age-and sex-matched healthy controls(HCs,n=28).LDH group underwent rs-f MRI at 2 distinct time points(TPs):prior to the initiation of sMT(TP1)and subsequent to the completion of the sMT sessions(TP2).sMT was administered once every other day for 30 min per session,totally 14 treatment sessions over a span of 4 *** did not receive sMT treatment and underwent only one f MRI ***,participants in LDH group completed clinical questionnaires on pain using the Visual Analog scale(VAs)and the Japanese Orthopedic Association(JOA)score,whereas HCs did not undergo clinical scale *** effects on the brain were jointly characterized using the amplitude of low-frequency fluctuations(ALFF)and regional homogeneity(Re Ho).Correlation analyses were conducted between specific brain regions and clinical ***:Following sMT treatment,pain symptoms in LDH patients were notably alleviated and accompanied by evident activation of effects in the *** comparison to TP1,TP2 exhibited the most significant increase in ALFF values for Temporal_sup_R and the most notable decrease in ALFF values for Paracentral_Lobule_L(voxelwise Psters>30;FDR correction).Additionally,the most substantial enhancement in Re Ho values was observed for the Cuneus_R,while the most prominent reduction was noted for the Olfactory_R(voxelwise Psters>30;FDR correction).Moreover,a comparative analysis revealed that,in contrast to HCs,LDH patients at TP1 exhibited the most significant increase in ALFF values for Temporal_Pole_sup_L and the most notable decrease in ALFF values for Frontal_Mid_L(voxelwise Psters>30;FDR correction).Fur

关键词： functional magnetic resonance imaging lumbar disc herniation spinal manipulative therapy pain

Deep view of composite sNR CTA1 with LHAAsO in γ-rays up to 300 TeV

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science China(Physics,Mechanics & Astronomy) 2025年

作者： Zhen Cao F.Aharonian Axikegu y.X.Bai y.W.Bao D.Bastieri X.J.Bi y.J.Bi W.Bian A.V.Bukevich Q.Cao W.y.Cao Zhe Cao J.Chang J.F.Chang A.M.Chen E.s.Chen H.X.Chen Liang Chen Lin Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen s.Chen s.H.Chen s.Z.Chen T.L.Chen y.Chen N.Cheng y.D.Cheng M.C.Chu M.y.Cui s.W.Cui X.H.Cui y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan J.H.Fan y.Z.Fan J.Fang J.H.Fang K.Fang C.F.Feng H.Feng L.Feng s.H.Feng X.T.Feng y.Feng y.L.Feng s.Gabici B.Gao C.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge T.T.Ge L.s.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo J.Guo X.L.Guo y.Q.Guo y.y.Guo y.A.Han O.A.Hannuksela M.Hasan H.H.He H.N.He J.y.He y.He y.K.Hor B.W.Hou C.Hou X.Hou H.B.Hu Q.Hu s.C.Hu C.Huang D.H.Huang T.Q.Huang W.J.Huang X.T.Huang X.y.Huang y.Huang y.y.Huang X.L.Ji H.y.Jia K.Jia H.B.Jiang K.Jiang X.W.Jiang Z.J.Jiang M.Jin M.M.Kang I.Karpikov D.Khangulyan D.Kuleshov K.Kurinov B.B.Li C.M.Li Cheng Li Cong Li D.Li F.Li H.B.Li H.C.Li Jian Li Jie Li K.Li s.D.Li W.L.Li W.L.Li X.R.Li Xin Li y.Z.Li Zhe Li Zhuo Li E.W.Liang y.F.Liang s.J.Lin B.Liu C.Liu D.Liu D.B.Liu H.Liu H.D.Liu J.Liu J.L.Liu M.y.Liu R.y.Liu s.M.Liu W.Liu y.Liu y.N.Liu Q.Luo y.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao Z.Min W.Mitthumsiri H.J.Mu y.C.Nan A.Neronov K.C.y.Ng L.J.Ou P.Pattarakijwanich Z.y.Pei J.C.Qi M.y.Qi B.Q.Qiao J.J.Qin A.Raza D.Ruffolo A.sáiz M.saeed D.semikoz L.shao O.shchegolev X.D.sheng F.W.shu H.C.song yu.V.stenkin V.stepanov y.su D.X.sun Q.N.sun X.N.sun Z.B.sun J.Takata P.H.T.Tam Q.W.Tang R.Tang Z.B.Tang W.W.Tian L.H.Wan C.Wang C.B.Wang G.W.Wang H.G.Wang H.H.Wang J.C.Wang kai Wang kai Wang L.P.Wang L.y.Wang P.H.Wang R.Wang W.Wang X.G.Wang X.y.Wang y.Wang y.D.Wang y.J.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei y.J.Wei T.Wen C.y.Wu H.R.Wu Q.W.Wu s.Wu X.F.Wu y.s.Wu s.Q.Xi J.Xia G.M.Xiang D.X.Xiao G.Xiao y.L.Xin y.Xing D.R.Xiong Z.Xiong D.L.Xu R.F.Xu R.X.Xu W.L.Xu L.Xue D.H.yan J.Z.yan T.yan C.W.yang C.y.yang F.yang F.F.yang L.L.yang M.J.yang R.Z.yang W.X.yang y.H.yao Z.G.yao L.Q.yin N.yin X.H.you Z.y.you y.H southwest Jiaotong University school of Astronomy and space science Nanjing University Center for Astrophysics Guangzhou University Tsung-Dao Lee Institute & school of Physics and Astronomy shanghai Jiao Tong University Institute for Nuclear Research of Russian Academy of sciences Hebei Normal University University of science and Technology of China LHAAsO Collaboration state Key Laboratory of Particle Detection and Electronics Key Laboratory of Dark Matter and space Astronomy & Key Laboratory of Radio Astronomy Purple Mountain Observatory Chinese Academy of sciences Research Center for Astronomical Computing Zhejiang Laboratory Key Laboratory for Research in Galaxies and Cosmology shanghai Astronomical Observatory Chinese Academy of sciences school of Physics and Astronomy Key Laboratory of Particle Astrophysics & Experimental Physics Division & Computing Center yunnan University Key Laboratory of Cosmic Rays (Tibet University) Ministry of Education Department of Physics The Chinese University of Hong Kong Key Laboratory of Radio Astronomy and Technology National Astronomical Observatories Chinese Academy of sciences school of Physics and Astronomy (Zhuhai) & school of Physics (Guangzhou) & sino-French Institute of Nuclear Engineering and Technology (Zhuhai) sun yat-sen University Institute of High Energy Physics Institute of Frontier and Interdisciplinary science shandong University APC Université Paris Cité CNRs/IN2P3 CEA/IRFU Observatoire de Paris Department of Engineering Physics & Department of Astronomy Tsinghua University school of Physics and Microelectronics Chinese Academy of sciences Zhengzhou University yunnan Observatories Chinese Academy of sciences China Center of Advanced science and Technology College of Physics sichuan University school of Physics Peking University Guangxi Key Laboratory for Relativistic Astrophysics school of Physical science and Technology University of Chinese Academy of sciences Guangxi University Department of Physics Faculty of science Mahidol University Moscow Institute

The ultra-high-energy（UHE） gamma-ray source 1LHAAsO J0007+7303u is positionally associated with the composite sNR CTA1 that is located at high Galactic Latitude b ≈ 10.5°. This provides a rare opportunity to spatially resolve the component of the pulsar wind nebula（PWN） and supernova remnant（sNR） at UHE. This paper conducted a dedicated data analysis of 1LHAAsO J0007+7303u using the data collected from December 2019 to July 2023. This source is well detected with significances of 21σ and 17σ at 8-100 TeV and >100 TeV, respectively. The corresponding extensions are determined to be 0.23°±0.03°and 0.17°±0.03°. The emission is proposed to originate from the relativistic electrons accelerated within the PWN of PsR J0007+7303. The energy spectrum is well described by a power-law with an exponential cutoff function dN/dE =（42.4 ± 4.1）(E/（20 TeV）)-2.31±0.11exp(-E/（110±25 TeV）) TeV-1cm-2s-1in the energy range from 8 to 300 TeV, implying a steady-state parent electron spectrum dNe/dEe∝(Ee/（100 TeV）)-3.13±0.16exp[(-Ee/（373±70 TeV）)2] at energies above ≈ 50 TeV. The cutoff energy of the electron spectrum is roughly equal to the expected current maximum energy of particles accelerated at the PWN terminal shock. Combining the X-ray and gamma-ray emission, the current space-averaged magnetic field can be limited to≈ 4.5 μG. To satisfy the multi-wavelength spectrum and the γ-ray extensions, the transport of relativistic particles within the PWN is likely dominated by the advection process under the free-expansion phase assumption.

关键词：

LHAAsO detection of very-high-energy γ-ray emission surrounding PsR J0248+6021

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science China(Physics,Mechanics & Astronomy) 2025年

We report the detection of an extended very-high-energy(VHE) γ-ray source coincident with the location of middle-aged(62.4 kyr) pulsar PsR J0248+6021, by using the LHAAsO-WCDA data of live 796 d and LHAAsO-KM2A data of live 1216d. A significant excess of γ-ray induced showers is observed both by WCDA in energy bands of 1-25 Te V and KM2A in energy bands of >25 TeV with 7.3σ and 13.5σ, respectively. The best-fit position derived through WCDA data is R.A. = 42.06°± 0.12°and Dec. = 60.24°± 0.13°with an extension of 0.69°±0.15°and that of the KM2A data is R.A.= 42.29°± 0.13°and Dec. =60.38°± 0.07°with an extension of 0.37°±0.07°. No clear extended multiwavelength counterpart of this LHAAsO source has been found from the radio band to the GeV band. The most plausible explanation of the VHE γ-ray emission is the inverse Compton process of highly relativistic electrons and positrons injected by the pulsar. These electrons/positrons are hypothesized to be either confined within the pulsar wind nebula or to have already escaped into the interstellar medium, forming a pulsar halo.

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Observation of the γ-ray emission from W43 with LHAAsO

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science China(Physics,Mechanics & Astronomy) 2025年

In this paper, we report the detection of the very-high-energy (VHE, 100 Ge V100 TeV) γ-ray emissions from the direction of the young star-forming region W43, observed by the Large High Altitude Air shower Observation (LHAAsO). The extended γ-ray source was detected with a significance of～16σby KM2A and～17σby WCDA, respectively. The angular extension of this γ-ray source is about 0.5 degrees, corresponding to a physical size of about 50pc. We discuss the origin of the γ-ray emission and possible cosmic ray acceleration in the W43 region using multi-wavelength data. Our findings suggest that W43 is likely another young star cluster capable of accelerating cosmic rays (CRs) to at least several hundred TeV.

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胃癌治疗的新靶点:铁死亡

海军军医大学学报 2025年第1期46卷 95-102页

作者：徐袁谢伟印慨海军军医大学(第二军医大学)第一附属医院胃肠外科上海200433

胃癌是我国人口死亡的主要原因之一,近年来确诊为早期胃癌的患者数量逐年上升,然而肿瘤细胞耐药性的产生严重限制了手术和化学治疗的效果,极有必要探索胃癌治疗的新靶点。铁死亡是一种铁依赖性细胞程序性死亡方式,其显著特征是细胞内脂... 详细信息

胃癌是我国人口死亡的主要原因之一,近年来确诊为早期胃癌的患者数量逐年上升,然而肿瘤细胞耐药性的产生严重限制了手术和化学治疗的效果,极有必要探索胃癌治疗的新靶点。铁死亡是一种铁依赖性细胞程序性死亡方式,其显著特征是细胞内脂质过氧化。胃癌细胞对细胞内铁代谢水平非常敏感,铁死亡在胃癌的发生、进展、治疗及耐药机制中发挥着至关重要的作用。胃癌细胞内铁死亡相关基因和非编码RNA与胃癌转移、耐药和预后密切相关,近年来关于铁死亡对胃癌细胞增殖的调节作用研究已获得一定的进展,因此,靶向铁死亡可能是胃癌的有效治疗策略。本文通过阐述铁死亡在胃癌细胞增殖、侵袭、转移及耐药机制中的作用,总结与铁死亡相关的靶点基因,并对靶向调节铁死亡在胃癌治疗中的前景进行展望。

关键词：胃肿瘤铁死亡肿瘤侵袭肿瘤转移细胞增殖肿瘤抗药性预后

Comparative Effect of Balance Rhythm Dance and Aerobics on Motor Function Rehabilitation in Elderly Women

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Journal of Clinical and Nursing Research 2025年第1期9卷 132-138页

作者： shanshan Zhang Xiuli yu kai Gao Runli yang Liu Ren ye yuan Xuefan Li Jun shen Chongqing Vocational College of Nursing Chongqing 402673China Chongqing Medical University Chongqing 400016China Qinggang Geriatric Care Center The First Affiliation Hospital of Chongqing Medical UniversityChongqing 402673China Chongqing College of Traditional Chinese Medicine Chongqing 402760China Chongqing Traditional Chinese Medicine Hospital Chongqing 400021China

Objective: To investigate the effect of a self-developed balance rhythm dance program on the rehabilitation of motor function and the reduction of fall risk in elderly women with diminished balance function. Methods: Fifty elderly women with reduced balance function, admitted to the Qingbar Elderly Care Center of Chongqing Medical University from December 2022 to December 2023, were randomly selected and divided into two groups. The aerobic exercise group (25 patients) received traditional treatment and rehabilitation nursing, while the balance rhythm dance intervention group (25 patients) received the balance rhythm dance intervention in addition to traditional treatment and rehabilitation nursing. The Unified Parkinson’s Disease Rating scale (UPDRs) and Berg Balance scale (BBs) were used as evaluation indicators to compare the intervention effects between the two groups. Results: The data revealed that the balance rhythm dance intervention significantly improved the motor ability and balance function of elderly women in the intervention group (P statistically significant differences observed. Conclusion: The balance rhythm dance program plays a critical role in promoting the rehabilitation of motor function and balance ability in elderly women, effectively enhancing their quality of life.

关键词： Balance rhythm dance Fall risk Eldery women Motor function