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Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus

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Acta Pharmaceutica Sinica B 2024年第2期14卷 437-454页

作者： Jiamei le yilong Chen Wei yang Ligong Chen Jianping ye Shanghai Key Laboratory of Molecular Imaging Zhoupu HospitalShanghai University of Medicine and Health SciencesShanghai 201318China School of Health Science and engineering University of Shanghai for Science and TechnologyShanghai 200093China Metabolic Disease Research Center Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou 450007China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Solute carriers(SLCs) constitute the largest superfamily of membrane transporter *** transporters, present in various SLC families, play a vital role in energy metabolism by facilitating the transport of diverse substances, including glucose, fatty acids, amino acids, nucleotides, and *** actively participate in the regulation of glucose metabolism at various steps, such as glucose uptake(e.g., SLC2A4/GLUT4), glucose reabsorption(e.g., SLC5A2/SGLT2), thermogenesis(e.g., SLC25A7/UCP-1), and ATP production(e.g., SLC25A4/ANT1 and SLC25A5/ANT2). The activities of these transporters contribute to the pathogenesis of type 2 diabetes mellitus(T2DM). Notably, SLC5A2 has emerged as a valid drug target for T2DM due to its role in renal glucose reabsorption, leading to groundbreaking advancements in diabetes drug discovery. Alongside SLC5A2, multiple families of SLC transporters involved in the regulation of glucose homeostasis hold potential applications for T2DM therapy. SLCs also impact drug metabolism of diabetic medicines through gene polymorphisms, such as rosiglitazone(SLCO1B1/OATP1B1) and metformin(SLC22A1-3/OCT1-3 and SLC47A1, 2/MATe1, 2). By consolidating insights into the biological activities and clinical relevance of SLC transporters in T2DM, this review offers a comprehensive update on their roles in controlling glucose metabolism as potential drug targets.

关键词： Solute carriers(SLCs) energ ymetabolism ATP production Type 2 diabetes mellitus(T2DM) Glucose homeostasis Polymorphisms

A study on wildfire impacts on greenhouse gas emissions and regional air quality in South of Orléans,France

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Journal of environmental Sciences 2024年第1期135卷 521-533页

作者： Chaoyang Xue Gisèle Krysztofiak yangang Ren Min Cai Patrick Mercier Frédéric le Fur Corinne Robin Benoit Grosselin Véronique Daele Max RMcGillen yujing Mu Valéry Catoire Abdelwahid Mellouki Laboratoire de Physique et Chimie de l’environnement et de l’espace(LPC2e) CNRS–UniversitéOrléans–CNES(UMR 7328)Orléans Cedex 245071France Institut de Combustion AérothermiqueRéactivitéEnvironnement(ICARE)CNRSOrléans Cedex 245071France Research Centre for eco-environmental Sciences Chinese Academy of SciencesBeijing 100085China Lig’Air-Association de surveillance de la qualitéde l’air en région Centre-Val de Loire Saint-Cyr-en-Val 45590France Mohammed V University RabatMorocco

Wildfire events are increasing globally which may be partly associated with climate change,resulting in significant adverse impacts on local,regional air quality and global *** September 2020,a small wildfire(burned area:36.3 ha)event occurred in Souesmes(Loiret-Cher,Sologne,France),and its plume spread out over 200 km on the following day as observed by the MODIS *** on measurements at a suburban site(~50 km northwest of the fire location)in Orléans and backward trajectory analysis,young wildfire plumes were *** increases in gaseous pollutants(CO,CH_(4),N_(2)O,VOCs,etc.)and particles(including black carbon)were found within the wildfire plumes,leading to a reduced air *** factors,defined as eF(X)=ΔX/ΔCO(where,X represents the target species),of various trace gases and black carbon within the young wildfire plumes were determined accordingly and compared with previous *** in the ambient ions(such as ammonium,sulfate,nitrate,chloride,and nitrite in the particle-and gasphase)and aerosol properties(e.g.,aerosol water con.ent,aerosol p H)were also quantified and ***,we estimated the total carbon and climate-related species(e.g.,CO_(2),CH_(4),N_(2)O,and BC)emissions and compared them with fire emission *** biomass burning emission inventories have uncertainties in estimating small fire burned areas and *** instance,we found that the Global Fire Assimilation System(GFAS)may underestimate emissions(e.g.,CO)of this small wildfire while other inventories(GFeD and FINN)showed significant *** that it is the first time to record wildfire plumes in this region,related atmospheric implications are presented and discussed.

关键词： Wildfire Air quality emission factor emission inventory VOLTAIRe supersite

Self-actuating protection mechanisms for safer lithium-ion batteries

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Journal of energy Chemistry 2024年第7期94卷 181-198页

作者： yang Luo Chunchun Sang Kehan le Hao Chen Hui Li Xinping Ai Hubei Key Lab of electrochemical Power Sources College of Chemistry&Molecular ScienceWuhan UniversityWuhan 430072HubeiChina state Key Laboratory of New Textile Materials&Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200HubeiChina

Safety issue is still a problem nowadays for the large-scale application of lithium-ion batteries(LIBs)in electric vehicles and energy storage *** unsafe behaviors of LIBs arise from the thermal run-away,which is intrinsically triggered by the overcharging and *** improve the safety of LIBs,various protection strategies based on self-actuating reaction control mechanisms(SRCMs)have been proposed,including redox shuttle,polymerizable monomer additive,potential-sensitive separator,thermal shutdown separator,positive-temperature-coefficient electrode,thermally polymerizable addi-tive,and reversible thermal phase transition *** build-in protection mechanisms,these meth-ods can sensitively detect either the temperature change inside battery or the potential change of the electrode,and spontaneously shut down the electrode reaction at risky conditions,thus preventing the battery from going into thermal *** their advantages in enhancing the intrinsic safety of LIBs,this paper overviews the research progresses of SRCMs after a brief introduction of thermal runaway mechanism and limitations of con.entional thermal runaway mitigating *** importantly,the current states and issues,key challenges,and future developing trends of SRCTs are also discussed and outlined from the viewpoint of practical application,aiming at providing insights and guidance for developing more effective SRCMs for LIBs.

关键词： Li-ion battery Safety Thermal runaway Thermal protection Overcharge protection

Perpendicular-Cutdepth:Perpendicular Direction Depth Cutting Data Augmentation Method

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Computers, Materials & continua 2024年第4期79卷 927-941页

作者： le Zou Linsong Hu yifan Wang Zhize Wu Xiaofeng Wang Anhui Provincial engineering Laboratory of Big Data Technology Application forUrban Infrastructure School ofArtificial Intelligence and Big DataHefei UniversityHefei230601China Institute of Applied Optimization School of Artificial Intelligence and Big DataHefei UniversityHefei230601China

Depth estimation is an important task in computer *** data at scale for monocular depth estimation is challenging,as this task requires simultaneously capturing RGB images and depth ***,data augmentation is crucial for this *** data augmentationmethods often employ pixel-wise transformations,whichmay inadvertently disrupt edge *** this paper,we propose a data augmentationmethod formonocular depth estimation,which we refer to as the Perpendicular-Cutdepth *** method involves cutting realworld depth maps along perpendicular directions and pasting them onto input images,thereby diversifying the data without compromising edge *** validate the effectiveness of the algorithm,we compared it with existing convolutional neural network(CNN)against the current mainstream data augmentation ***,to verify the algorithm’s applicability to Transformer networks,we designed an encoder-decoder network structure based on Transformer to assess the generalization of our proposed *** results demonstrate that,in the field of monocular depth estimation,our proposed method,Perpendicular-Cutdepth,outperforms traditional data *** the indoor dataset NyU,our method increases accuracy from0.900 to 0.907 and reduces the error rate from0.357 to *** the outdoor dataset KITTI,our method improves accuracy from 0.9638 to 0.9642 and decreases the error rate from 0.060 to 0.0598.

关键词： Perpendicular depth estimation data augmentation

An efficient improved Gradient Boosting for strain prediction in Near-Surface Mounted fiber-reinforced polymer strengthened reinforced concrete beam

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Frontiers of Structural and Civil engineering 2024年第8期18卷 1148-1168页

作者： Abdelwahhab KHATIR Roberto CAPOZUCCA Samir KHATIR erica MAGAGNINI Brahim BeNAISSA Thanh CUONG-le Structural Section DICeA Polytechnic University of MarcheAncona 60131Italy Centre for engineering Application&Technology Solutions Ho Chi Minh City Open UniversityHo Chi Minh City 70000Vietnam Design engineering Laboratory Toyota Technological InstituteNagoya 468-8511Japan

The Near-Surface Mounted(NSM)strengthening technique has emerged as a promising alternative to traditional strengthening methods in recent *** the past two decades,researchers have extensively studied its potential,advantages,and applications,as well as related parameters,aiming at optimization of construction ***,there is still a need to explore further,both from a static perspective,which involves accounting for the noncon.ervation of the contact section resulting from the bond-slip effect between fiber-reinforced polymer(FRP)rods and resin and is typically neglected by existing analytical models,as well as from a dynamic standpoint,which involves studying the trends of vibration frequencies to understand the effects of various forms of damage and the efficiency of *** address this gap in knowledge,this research involves static and dynamic tests on simply supported reinforced concrete(RC)beams using rods of NSM carbon fiber reinforced polymer(CFRP)and glass fiber reinforced polymer(GFRP).The main objective is to examine the effects of various strengthening *** research conducts bending tests with loading cy.les until failure,and it helps to define the behavior of beam specimens under various damage degrees,including concrete *** analysis by free vibration testing enables tracking of the effectiveness of the reinforcement at various damage levels at each stage of the loading *** addition,application of Particle Swarm Optimization(PSO)and Genetic Algorithm(GA)is proposed to optimize Gradient Boosting(GB)training performance for concrete strain prediction in NSM-FRP *** GB using Particle Swarm Optimization(GBPSO)and GB using Genetic Algorithm(GBGA)systems were trained using an experimental data set,where the input data was a static applied load and the output data was the con.equent *** models of GBPSO and GBGA have been shown to provide highly accurate results for predicting *** model

关键词： NSM technique fiber-reinforced polymer rods static and dynamic analysis GB PSO GA finite element analysis

Polycomb and trithorax:Their yin-yang dynamics in plants

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Molecular Plant 2024年第6期17卷 845-847页

作者： Fan Xu Daolei Zhang Liang le Li Pu Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China School of Life Science Inner Mongolia UniversityHohhot 010021China

Polycomb(PcG)and trithorax(trxG)are two groups of con.erved epigenetic complexes that maintain active and repressive states of target genes by altering their chromatin states to regulate plant development and stress *... 详细信息

关键词： maintain complexes states

Understanding Surface Water-Groundwater con.ersion Relationship and Associated Hydrogeochemistry evolution in the Upper Reaches of Luan River Basin, North China

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Journal of earth Science 2024年第3期35卷 1010-1023页

作者： le Zhao Chunli Su Wenbo Liu Xianjun Xie School of environmental Studies China University of GeosciencesWuhan 430078China State environmental Protection Key Laboratory of Source Apportionment and control of Aquatic Pollution Ministry of Ecology and EnvironmentWuhan 430078China China Geological environmental Monitoring Institute Beijing 100081China

Luan River is the main water source in Beijing-Tianjin-Hebei region,northern China,where the groundwater system is vulnerable and pollution issue is *** is significant for regional groundwater resources protection to identify the hydrogeochemistry evolution and affecting factors along flow direction occurred in the upper reaches,especially the surface water-groundwater(SWGW)con.ersion *** this study,recharge,con.ersion and geochemistry evolution of SW and GW were elucidated based on physical-hydrochemical indicators and stable isotopes in 36 GW samples and 20 SW samples,which were collected in July 2019 and July *** factor analysis was further utilized to determine the main factors responsible for regional hydrogeochemical *** indicate that GW recharged SW in plateau area,and SW and GW recharged each other in typical Alpine valley *** hydrochemical types are HCO3-Ca·Mg and HCO3-Ca,and the hydrochemical evolution is dominated by weathering of silicate and carbonate *** cation exchange adsorption has minor impact on groundwater *** rise of SO42-and NO3-con.ents in groundwater is related to industrial and agricultural *** main controlling factors of SW hydrochemical components included recharge from groundwater,industrial and mining activities,explaining 90.04%of data ***,water-rock interaction,agricultural and domestic sewage are responsible for GW quality,accounting for 83.38%.

关键词： groundwater water sources con.ersion relationship hydrogeochemical characteristics evolutional processes water-rock interaction factor analysis Luan River Basin.

Self-assembly of tau fragments as a key pathologic event in tauopathies

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Neural Regeneration Research 2024年第12期19卷 2565-2566页

作者： Ly Thi Huong Luu le Jung Hoon lee Min Jae lee Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea

Tau protein is encoded by the microtubuleassociated protein tau(MAPT)gene and stabilizes microtubules in the *** has unique biophysical properties that make it both highly water-soluble and positively *** tau is an intrinsically disordered protein lacking defined secondary structures,it can acquire highly organized-sheet structures and stack into a filamentous inclusion such as a paired helical filament(PHF).

关键词： tau pathologic assembly

experimental Study on Towing Characteristics of Composite Bucket Wellhead Platform

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China Ocean engineering 2024年第3期38卷 531-542页

作者： ZHANG Pu-yang LIU ying-fei le cong-huan DING Hong-yan BAI yu State Key Laboratory of Hydraulic engineering Intelligent construction and Operation Tianjin UniversityTianjin 300072China

With the rapid development of large-scale development of marginal oilfields in China,simple wellhead platforms that are simple in structure and easy to install have become an inevitable choice in the process of oilfield ***,traditional simple wellhead platforms are often discarded after a single *** pursuit of a more costeffective approach to developing marginal oilfields,this paper proposes a new offshore oil field development facility—an integrated bucket foundation for wellhead *** verify the safety of its towing behavior and obtain the dynamic response characteristics of the structure,this paper takes a bucket integrated bucket foundation for wellhead platform with a diameter of 40 m as the research *** combining physical model tests and numerical simulations,it analyzes the static stability and dynamic response characteristics of the structure during towing,complete with the effects of the draft,wave height,wave period,and towing point height,which produce the dynamic responses of the structure under different influence factors,such as roll angle,pitch angle,heave acceleration and towing force as well as the sensibility to transport *** results show that the integrated bucket foundation for wellhead platform is capable of self-floating towing,and its movement is affected by the local environment,which will provide a reference for actual projects.

关键词： composite bucket foundation wellhead platform air flotation towing model test