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Interacting with α7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages

Acta Pharmaceutica Sinica B 2020年第10期10卷 1926-1942,2020页

作者： Etta y.l.liu yingjie Xia Xiangpeng Kong Maggie S.S.Guo Anna X.D.yu Brody Z.y.Zheng Shinghung Mak Miranda l.Xu Karl W.K.Tsim Key laboratory of Food Quality and Safety of Guangdong Province College of Food ScienceSouth China Agricultural UniversityGuangzhou 510642China Shenzhen Key laboratory of Edible and Medicinal Bioresources the Hong Kong University of Science and TechnologyShenzhen 518057China Division of life Science Center for Chinese Medicinethe Hong Kong University of Science and TechnologyHong kongChina

Acetylcholine(ACh)regulates inflammation viaα7 nicotinic acetylcholine receptor(α7 nAChR).Acetylcholinesterase(AChE),an enzyme hydrolyzing ACh,is expressed in immune cells suggesting non-classical function in inflammatory ***,the expression of PRiMA-linked G4 AChE was identified on the surface of *** lipopolysaccharide-induced inflammatory processes,AChE was upregulated by the binding of NF-κB onto the ACHE ***,the overexpression of G4 AChE inhibited ACh-suppressed cytokine release and cell migration,which was in contrast to that of applied AChE ***,a DNA construct without enzymatic activity,was adopted to identify the protein role of AChE in immune *** of G4 AChEmt induced cell migration and inhibited ACh-suppressed cell *** co-localization ofα7 nAChR and AChE was found in macrophases,suggesting the potential interaction ofα7 nAChR and ***,immunoprecipitation showed a close association ofα7 nAChR and AChE protein in cell ***,the novel function of AChE in macrophage by interacting withα7 nAChR was *** with hydrolysis of ACh,AChE plays a direct role in the regulation of inflammatory *** such,AChE could serve as a novel target to treat age-related diseases by antiinflammatory responses.

关键词： Macrophage AChE Cholinergic anti-inflammatory pathway α7 nAChR

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Turbulent Modeling of Wall-Bounded Flow with Memory Effects

Turbulent Modeling of Wall-Bounded Flow with Memory Effects

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The 16th Annual Conference of Hong Kong Society of Theoretical and Applied Mechanics 2012、The 1st Mainland-Hong Kong youth Forum on Mechanics 2012、The 8th Shanghai-Hong Kong Forum on Mechanics and Its Application 2012

作者： X.Qiu J.P.luo y.l.liu School of Science Shanghai Institute of Technology School of Mechanical Engineering Shanghai Institute of Technology Shanghai Institute of Applied Mathematics and Mechanics Shanghai University

Memory effects have been recognized to be very important in turbulent shear *** turbulent flows of Newtonian fluids have already been compared with non-Newtonian laminar flows. In this paper the analogy between these classes of flows is explored,and a new approach to derive a turbulent model concerning memory effects based on a nonlinear constitutive equation is *** order to reach this aim,opened DNS databases of turbulent channel flows are used and analyzed in the light of the classical parameters of non-Newtonian constitutive *** Reynolds stress tensor is expressed in terms of a set of basis tensors based on a projection of a nonlinear *** coefficients of the model are given as functions of the intensity of the mean strain *** apparent turbulent viscosity,the first and second normal stress difference,are presented in function of the shear rate.A turbulent Weissenberg number,based on a characteristic turbulent time ratio of the first normal stress difference to the apparent viscosity is also *** material functions, exhibiting a shear-thinning behavior,are fitted with the power law(the Carreau-type) *** range of the Reynolds number investigated was 180≤Reτ≤*** of the advantages of the new algebraic nonlinear power law constitutive equation derived in the paper is that its dependence is only on the mean velocity gradient and can be integrated up to the wall.

关键词： Turbulent Modeling of Wall-Bounded Flow with Memory Effects

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Effects of dietary energy density on plasma glucose and lipid profile,morphological aspects and chemical characteristics of adipose tissue in finishing pigs

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Journal of Animal Science and Biotechnology 2010年第1期1卷 25-34页

作者： J.Chao y.l.liu y.l.yin y.Q.Hou H.l.Zhu X.FKong HubeiKeylaboratoryofAnimalNutritionandFeedScience WuhanPolytechnicUniversityWuhanHubci430023China InstituteofSubtropicalAgriculture theChineseAcademyofSciencesChangshaHunan410125China

ABSTRACT： Peroxisome proliferator-activated re- ceptor-Υ （PPAR-T） plays a pivotal role in controlling adipogenesis. We hypothesized that changes in dietary energy density might alter fat deposition in finishing pigs via modulation of the expression of PPAR-Υ . To test this hypothesis, thirty female finishing pigs were fed diets containing low （ lD ）, medium （ MD ） or high （HD） energy density. Blood samples were col- lected on day 53, and then the pigs were sacrificed to collect samples of the dorsal subcutaneous （ ST）, ab- dominal （AT） and mesenteric （MT） adipose tissue. Compared with pigs fed the MD diet, malate dehydro- genase activity was increased in the ST and MT of pigs fed the HD diet, while activity was decreased in the MT of pigs fed the lD diet （P 〈 0.05）. Glucose- 6-phosphate dehydrogenase activity was increased in all three fat depots of pigs fed the HD diet （P 〈0.05） in comparison with pigs fed the MD diet. Both HD and lD diets increased the size of the adipocytes in the AT and MT （ P 〈 0.05 ）. Pigs fed the HI） diet had a higher cell proliferation index in the ST com- pared with pigs fed the other two diets （P 〈 0.05 ）. Compared with pigs fed the MD diet, a decreased ap- optosis index was seen in the ST of pigs fed the HD diet, and in the AT of pigs fed the lD diet, as well as in the MT of both HD and lD fed pigs （ P 〈 0.05）. PPAR-Υ positive percentage was elevated in the ST and MT of HD fed pigs compared with pigs fed the MD and lD diets, while it was decreased in the ST of lD compared with MD fed pigs （ P 〈 0.05 ）. These results suggest that dietary energy density may regu- late fat deposition in fmishing pigs. It is possible that feeding a high energy diet may induce fat deposition via up-regulation of PPAR-Υ expression.

关键词： adipocyte morphology adipose tissue energy density finishing pigs peroxisome proliferator-activated receptor-~/

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Study on real-gas state equations of hydrogen

Study on real-gas state equations of hydrogen

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第九届全国氢能学术会议

作者： H.G.Chen,J.y Zheng,P Xu,l.li,y.l.liu,H.y.Bie Zhejiang University,China

＜正＞Currently,high pressure hydrogen storage has been an important transportation channel in areas of new energy development and *** hydrogen demonstrations require to explore the physical and chemical properties in detail before the practical employment,which is completely different from the ideal gas under high pressure ***,the

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Fatigue lifetime evaluation of high pressure hydrogen storage vessel for fuel cell vehicles

Fatigue lifetime evaluation of high pressure hydrogen storag...

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第九届全国氢能学术会议

作者： H.y.Bie,J.y Zheng,P.Xu,y.l.liu,H.G Chen Zhejiang University,China

＜正＞The fatigue failure properties of the lightweight high pressure hydrogen storage vessel for fuel cell vehicle（FCV） which consists of the Al liner-carbon/epoxy composite laminates largely affect its reliability and *** a finished hydrogen vessel,many factors such as the pressure cyclic range,the cyclic frequency,the temperature and humidity are related with

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai l.P.An R.Aliberti Q.An X.Z.Bai y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.y.Chen H.Chen H.X.Chen J.F.Chen K.Chen l.l.Chen P.Chen S.l.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.Q.Chen H.y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai l.y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding l.y.Dong W.H.Dong V.Druzhinin D.S.Du y.J.Du Z.G.Du l.M.Duan D.Epifanov y.l.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng y.T.Feng J.l.Fu J.Gao y.N.Gao P.S.Ge C.Q.Geng l.S.Geng A.Gilman l.Gong T.Gong B.Gou W.Gradl J.l.Gu A.Guevara l.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo y.P.Guo Z.H.Guo A.Guskov K.l.Han l.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He y.l.He Z.B.He Z.X.Heng B.l.Hou T.J.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.y.Huang W.Q.Huang X.T.Huang X.J.Huang y.B.Huang y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.l.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.lei E.levichev C.H.li C.li D.y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.l.li J.M.li J.li l.li l.li l.y.li N.li P.R.li R.H.li S.li T.li W.J.li X.li X.H.li X.Q.li X.H.li y.li y.y.li Z.J.li H.liang J.H.liang y.T.liang G.R.liao l.Z.liao y.liao C.X.lin D.X.lin X.S.lin B.J.liu C.W.liu D.liu F.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.y.liu K.liu l.liu Q.liu S.B.liu T.liu X.liu y.W.liu y.liu y.l.liu Z.Q.liu Z.y.liu Z.W.liu I.logashenko y.long C.G.lu J.X.lu N.lu Q.F.lü y.lu y.lu Z.lu P.lukin F.J.luo T.luo X.F.luo y.H.luo H.J.lyu X.R.lyu J.P.Ma P.Ma y.Ma y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev y.Nefedov S.l.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan y.Pan E.Passemar y.P.Pei H.P.Peng l.Peng X.y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi y.Q.Qi W.B.Qian y.Qian C.F.Qiao J.J.Qin J.J.Qin l.Q.Qin X.S.Qin T.l.Qiu J.Rademacker C.F.Redmer H.y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de lausanne(EPFl) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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Experiment and numerical simulation on the temperature rise in the fill process of hydrogen for 150 l 35 MPa composite storage cylinders

Experiment and numerical simulation on the temperature rise ...

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第九届全国氢能学术会议

作者： y.l.liu~1,J.y.Zheng~1,y.Z.Zhao~1,P.Xu~1,l.F.Zhang~2,H.Zhao~2,T.Xie~2,R.H.Sheng~2 ~1 Zhejiang University,China ~2 Beijing lvNeng power sources corporation,China

As a high fill velocity of hydrogen is needed to full fill the storage cylinders,it may lead to temperature rise and heterogeneity inside *** this research,experiments for temperature rise test in the process of fast ...

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3D steady Model and simulation considered the porosity of diffusion layer for a proton exchange membrane fuel cell performance

3D steady Model and simulation considered the porosity of di...

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第九届全国氢能学术会议

作者： y.S.Wei~1,H.Zhu~1,y.l.liu~1,Z.F.Huang~1,M.Wang~1,X.W.Zhang~(1,2),B.l.yi~2 1 Beijing Jiaotong University,China 2Dalian Institute of Chemical Physics,China

＜正＞A three-dimensional,steady-state non-isotherm mathematical Model for proton exchange membrane fuel cell was *** model takes into accounts simultaneously the mass, momentum,energy,species,charge conservation equation and combines electrochemistry reaction inside the *** performance of the fuel cell,current density distribution,

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Two stage column leaching of uranium from uraninite ore

Two stage column leaching of uranium from uraninite ore

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中国核学会2011年学术年会

作者： D.X.Ding,y.l.liu,G.y.li,N.Hu,y.D.Wang (Key Discipline laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China,Hengyang of Hunan Prov.421001,P.R.China)

The leaching process of uraninite ore was divided into the acidification and bacterial leaching stages,and the two stage leaching experiments and the control were conducted with 3 columns,each being charged with 20 kg uraninite *** ore contained 0.113%uranium,1.859%iron and large amounts of silica and *** the acidification stage,high to low concentration sulfuric acid solutions were used to acidify the uranium ore in each column until the pH of the pregnant leach solution from each column was maintained at *** acidification lasted for 18 d and the uranium recoveries for the three columns reached about 70%.In the bacterial leaching stage,column 1,as the control,continued to be leached with sulfuric acid solution with pH = 2.0,column 2,with the bacterial solution based on the indirect leaching mechanism,and column 3,with the bacterial solution based on the direct leaching *** leaching in this stage was continued until the concentrations of the uranium in the pregnant leach solutions from the three columns amounted to less than 50 mg/*** stage lasted for 20 d and the final uranium recoveries for columns 1,2 and 3 reached 73.72%,78.97%and 75.79%,respectively.

关键词： Acidification Bacterial leaching Acidithiobacillus ferrooxidans Ferric ions Uraninite ore

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Microwave heated polyol synthesis of carbon supported PtAuSn/C nanoparticles for ethanol electrooxidation

Microwave heated polyol synthesis of carbon supported PtAuSn...

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第九届全国氢能学术会议

作者： H.Zhu~1,y.l.liu~2,H.J.Wang~2,Z.J.Guo~1,X.W.Zhang~1,Z.F.Huang~1,y.S.Wei~1 1 Beijing Jiaotong University,China 2 Henan Normal University,China 3 National Research Council Canada,Cadana

＜正＞Carbon supported PtAuSn/C catalysts with different Sn content were prepared within a few minutes by using a microwave-polyol *** catalysts are characterized by transmission electron microscopy and X-ray diffract...

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