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Novel heating-and deformation-induced phase transitions and mechanical properties for multicomponent Zr_(50)M_(50),Zr_(50)(M,Ag)_(50)and Zr_(50)(M,Pd)_(50)(M=Fe,Co,Ni,Cu)amorphous alloys

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Journal of Materials Science & Technology 2022年第9期104卷 109-118页

作者： J.Ding A.Inoue F.l.Kong S.l.Zhu y.l.pu E.Shalaan A.A.Al-Ghamdi A.l.Greer School of Materials Science and Engineering Tianjin UniversityTianjin 300072China International Institute of Green Materials Josai International UniversityTogane 283-8555Japan Institute of Massive Amorphous Alloy Science China University of Mining TechnologyXuzhou 221116China Department of Physics King Abdulaziz UniversityJeddah 22254Saudi Arabia MISiS National University of Science and TechnologyMoscow 119049Russia School of Materials Science and Engineering Lanzhou Jiaotong UniversityLanzhou 730070China Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK

Multicomponent alloys of Zr_(50)M_(50),Zr_(50)(M,Ag)_(50)and Zr_(50)(M,Pd)_(50)(M=Fe,Co,Ni,Cu)can be melt-spun to obtain amorphous *** maximum thickness for fully amorphous ribbons varies with composition in the range 34-53μ*** contrast,fully amorphous ribbons are not obtainable for binary Zr_(50)Ni_(50)or ternary Zr_(50)(Ni,Cu)_(50)***-induced crystallization occurs through:two stages of amorphous[am]→[~(am')+B2]→[B2+B33]for Zr_(50)M_(50);and[am]→[am'+B2]→[B2+AgZr]for Zr_(50)(M,Ag)_(50);and a single stage of[am]→[B2]for Zr_(50)(M,Pd)_(50),while no B2 phase is formed for the binary and ternary Zr_(50)Q_(50)(Q=Ni or/and Cu)***-spun amorphous ribbons have good bending ***,Zr_(50)M_(50)ribbons in tension show 0.22-0.28%plastic elongation and work-hardening(the yield stress is~820 MPa,the fracture stress is~1200 MPa).When cold-rolled at room temperature to 30%reduction in thickness,Zr_(50)M_(50)ribbons show 10%increase in hardness,while retaining good bending ***-rolling induces precipitation of spheroidal B2 and irregular B33 particles,while deformation in tension induces B2,B33 and also plate-like monoclinic *** B2 and B33 particles form by polymorphic transformation,and include a high density of internal *** novel deformationinduced precipitation has not been recognized for any Zr_(50)Q_(50)binary or ternary *** new multicomponent systems are encouraging for future progress as structural amorphous alloys.

关键词： Multicomponent Microstructure Mechanical properties Phase transition Amorphous alloy

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A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping pu yu Wu Zhongjie Zhu Hongwei Zhao Donghong Cui Shanghai Key laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

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NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao lin Changzhou ying Xiaoli Si Naijia Xue yi liu Ran Zheng ying Chen Jiali pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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Effects of Bifidobacterium lactis Bla80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang ying Zhu pu Chen Tong Zhou Zhe-yi Han Jun Xiao Jian-Feng Ma Wen Ma Peng Zang ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)Bla80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** Bla80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/ml,and each rat was 1 ml/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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Social function scores and influencing factors in patients with residual depressive symptoms

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World Journal of Psychiatry 2025年第1期15卷 117-127页

作者： Zong-ling liao Xiao-li pu Zhi-yi Zheng Jie luo Department 1 of Psychiatry Gele Mountain Hospital of Chongqing Mental Health CenterChongqing 400030China Department of Psychology Chongqing Jiangjin District Psychiatric HospitalChongqing 402260China Department of Psychiatry Chongqing Third Social Welfare InstituteChongqing 400036China Women and Children’s Mental Health Center Affiliated Hospital of Chongqing Population and Family Planning Research InstituteChongqing 400020China

BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still *** depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on *** the influencing factors of their social function is of great *** To explore the social function score and its influencing factors in patients with residual depressive *** This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December *** functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between *** influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESUlTS The SDS scores of the 158 patients with depressive symptoms were 11.48±*** with the control group,the SDS scores and all items in the case group were *** scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥*** history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(Pl functional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.C

关键词： Depressive Residual symptoms Social function Influence factors

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Physical rehabilitation for sensorineural hearing loss in childhood:Progress and challenges

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World Journal of Clinical Cases 2025年第7期13卷 57-62页

作者： lu Zhang pu-Jue Huang Xue Deng Jiao Tang yang Zhai Tao Wang Department of Pediatrics Luzhou Maternal and Child Health HospitalLuzhou 646600Sichuan ProvinceChina Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pediatrics The First People's Hospital of Longquanyi DistrictChengdu 610100Sichuan ProvinceChina Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Chengdu 610041Sichuan ProvinceChina Department of Pediatrics Chengdu Women’s and Children’s Central HospitalChengdu 610000Sichuan ProvinceChina

Early intervention for sensorineural hearing loss(SNHl)in childhood is crucial for auditory and language *** recent years,innovative auditory stimulation techniques and speech therapy strategies,such as middle ear implants,cochlear implants,auditory brainstem implants,and midbrain implants,have provided new avenues for improving patient ***,basic research advancements in cell reprogramming and regeneration,stem cell therapy,and targeted drug delivery offer promising approaches to meet the individualized needs of children with ***,many challenges and unresolved issues remain in the treatment of *** article comments on the case report,which describes a female pediatric patient with SNHl who underwent foot reflexology which led to the normalization of hearing *** is considered to have potential benefits in physical rehabilitation,but its efficacy in hearing restoration requires further scientific validation through rigorous clinical trials and large-scale prospective studies.

关键词： Sensorineural hearing loss Childhood Physical rehabilitation therapy Recent advances in rehabilitation techniques Reflexology

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RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-yu Chen Pei-yao Wang Bang liu yang-pu Jia Zhao-Xiong Zhang Xin liu Dao-Han Wang yong-Jia yan Wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai Qian Zhang Zi-Han li yi-Xin Zhang Rong-Xuan Xu Wei Wu Zhi-Han yao Chun-Wen pu Xiao-Feng li School of public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,Plated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONClUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study linear Mixed-Effect Mode Joint Modelling of longitudinal and Survival data

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Dermatitis bullosa caused by the immune checkpoint inhibitor camrelizumab:A case report

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World Journal of Clinical Cases 2025年第8期13卷 15-21页

作者： yuan-Jing Jiang lu Wu Xiao yang yu pu Bing-Jie Ning Na Peng Xiao-Ju Zhu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Since the advent of the 20th century,alongside the progression of medical science and technological advancements,immunotherapy has emerged as a pivotal thera-peutic approach for tumor patients subsequent to undergoing radiotherapy and ***(camrelizumab),a flagship drug in the realm of immuno-therapy,functions as a monoclonal antibody specifically targeting the progra-mmed death protein 1(PD-1).This drug engages with the human PD-1 receptor,effectively inhibiting the PD-1/programmed death ligand 1 signaling *** inhibition results in the restoration of T cell activity and the induction of an anti-tumour ***,it is noteworthy that such interference could lead to immune-related adverse events resembling autoimmune *** grow-ing availability and clinical use of immune checkpoint inhibitors have raised sig-nificant clinical concerns regarding their *** instances of immune-related adverse reactions and the associated management strategies have been extensively *** identification and diagnosis,coupled with multidi-sciplinary consultation and the prompt administration of immunosuppressants,can effectively address severe immune-related adverse *** SUMMARy Arimab(camrelizumab),a monoclonal antibody targeting programmed death protein 1(PD-1),disrupts the PD-1/programmed death ligand 1(PD-l1)inter-action,reactivating T cell function and triggering anti-tumor ***,this disruption may trigger immune-mediated adverse events akin to autoim-mune *** 2.8%of such events manifest as immune-related dermatologic reactions,with 0.7%classified as grade 3,which are infrequently ***,this study describes a case of grade 3 bullous dermatitis occur-ring 15 days after initiating camrelizumab *** patient,a 67-year-old male with oesophageal squamous cell carcinoma,received camrelizumab plus paclitaxel alongside chemotherapy and radiotherapy in early ***

关键词： Camrelizumab Anti-programmed cell death protein-1 blockade Skin-related adverse events Immune-related dermatitis Case report

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-yan Huang yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-yun Ma Peng-Peng li Hai-Wei pu Xin-yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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