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Deuterium Retention and Physical Sputtering of Low Activation Ferritic Steel

Plasma Science and Technology 2005年第2期7卷 2737-2740页

作者： T.Hino K.yamaguchi y.yamauchi y.Hirohata K.Tsuzuki y.kusama Department of Nuclear Engineering Hokkaido University Sapporo060-8628 JapanDepartment of Nuclear Engineering Hokkaido UniversitySapporo060-8628 JapanDepartment of Nuclear Engineering Hokkaido UniversitySapporo060-8628 JapanDepartment of Nuclear Engineering Hokkaido UniversitySapporo060-8628 JapanJapan Atomic Energy Research Institute NakaIbaraki-ken311-0193 JapanJapan Atomic Energy Research Institute NakaIbaraki-ken311-0193 Japan

Low activation materials have to be developed toward fusion demonstrationreactors. Ferritic steel, vanadium alloy and SiC/SiC composite are candidate materials of the firstwall, vacuum vessel and blanket components, respectively. Although changes of mechanical-thermalproperties owing to neutron irradiation have been investigated so far, there is little data for theplasma material interactions, such as fuel hydrogen retention and erosion. In the present study,deuterium retention and physical sputtering of low activation ferritic steel, F82H, wereinvestigated by using deuterium ion irradiation apparatus. After a ferritic steel sample wasirradiated by 1.7 keV D^+ ions, the weight loss was measured to obtain the physical sputteringyield. The sputtering yield was 0.04, comparable to that of stainless steel. In order to obtain theretained amount of deuterium, technique of thermal desorption spectroscopy (TDS) was employed to theirradiated sample. The retained deuterium desorbed at temperature ranging from 450 K to 700 K, inthe forms of DHO, D_2, D_2O and hydrocarbons. Hence, the deuterium retained can be reduced by bakingwith a relatively low temperature. The fluence dependence of retained amount of deuterium wasmeasured by changing the ion fluence. In the ferritic steel without mechanical polish, the retainedamount was large even when the fluence was low. In such a case, a large amount of deuterium wastrapped in the surface oxide layer containing O and C. When the fluence was large, the thickness ofsurface oxide layer was reduced by the ion sputtering, and then the retained amount in the oxidelayer decreased. In the case of a high fluence, the retained amount of deuterium became comparableto that of ferritic steel with mechanical polish or SS 316 L, and one order of magnitude smallerthan that of graphite. When the ferritic steel is used, it is required to remove the surface oxidelayer for reduction of fuel hydrogen retention. Ferritic steel sample was exposed to the envi

关键词： ferritic steel fuel hydrogen retention sputtering yield first wall fusionreactor

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A case of quadruple primary cancer including lip cancer

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中国口腔颌面外科杂志 2008年第B5期6卷 141-142页

作者： Masako yamashita yoshinori Jinbu Masaki Hiratsuka Hiroto Itoh Mikio kusama Department of Dentistry Oral and Maxillofacial Surgery JichiMedical University3311-1 Yakushiji Shimotsuke-shi Tochigi 329-0498 Japan

In recent years, the frequency of occurrence of multiple cancers has tended to increase in association with the progression of diagnostic techniques and the treatment of malignancy or the aging of society。We experienced a case of quadruple cancer (prostate cancer, gastric cancer, larynx cancer, and lip cancer) which developed in a 73-year-old male。Patient: 73-year-old male。First visit: October 4, 2006。Chief complaint: Pain in the lower lip。Past medical history: Radiation therapy for prostate cancer in 1983。A total gastrectomy for gastric cancer in 2004。Laryngomicrosurgery in 2005 and radiation therapy in 2007 for larynx cancer Current medical history: The patient felt pain in his lower lip about 1 month before visiting the hospital。He had been initially treated at a dental clinic in his neighborhood, but the symptoms did not ameliorate, so he visited our department on October 4, 2006, by referral。Present status: Erosion with redness detected in the lower lip。Clinical diagnosis: Leukoplakia of the lower lip。Treatment and progression: On October 5, 2006, the patient had a biopsy taken of his lower lip, and was diagnosed to have differentiated squamous cell cancer based on a histopathological diagnosis。The patient's lower lip was irradiation with 57.5 Gy as part of radiation therapy from December 2006 to January 29, 2007。He is currently being followed up by conservative observations but is making satisfactory progress with no findings that would be indicative of a recurrence。The frequency of occurrence of quadruple cancer is low。Among all cases of malignancy, reported cases that include oral cancer are particularly rare, accounting for only 18 cases in Japan, including the present case。These cases constitutes 12 males and 6 females, with ages ranging from 47 to 86 years old and an average age of 63.7 years old。Among oral cancers, tongue cancer was observed most frequently, accounting for 5 cases, followed by gingival cancer。In other part of cancer, gastric cancer, esop

关键词：嘴唇重复癌治疗方法临床分析

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高效液相色谱法测定tRNA^(Ile)的核苷酸组成

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第一军医大学学报 1993年第3期13卷 208-211页

作者：彭朝晖 Kuniko kusama-Eguchi KazueiIgarashi 第一军医大学生物化学教研室日本千叶大学

用高效液相色谱法(HPLC)分析了纯化的牛肝tRNA^(He)核苷酸组成成份,并根据各成份的峰的面积计算了它们的近似数量。实验表明牛肝tRNA^(He)有76个核苷酸,其中含9种14个稀有碱基。t^6A不能被发现。

关键词：牛肝核苷酸高效液相色谱 tRNA

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Relation of stathmin expression with tumor invasion in human tongue cancer

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中国口腔颌面外科杂志 2008年第B5期6卷 130-131页

作者： Hiroto Itoh yoshinori Jinbu yuri Obi Mikio kusama Keiichi Tsukinoki Jichi Medical University Tochigi Japan Kanagawa DentalCollege Kanagawa Japan

Background: Stathmin is a cytosolic phosphoprotein expressed at high levels in most human cancer cells。Stathmin expression and phosphorylation are linked to the control of cell differentiation and proliferation。However, few studies of stathmin expression in human oral squamous cell carcinoma have been reported。We performed immunohistochemical staining of stathmin and analyzed the relation with the mode of invasion in human tongue cancer。Methods: Oral biopsy specimens of 42 cases of tongue cancer were used。Paraffin sections were deparaffinized and primary antibody (anti-stathrnin monoclonal antibody) was added。The mode of invasion was divided into five types from grades 1 to 4d according to yamamoto (Cancer51;2175-80,1983)。Of these 42cases,29were grades 2+3 and 13 were grades 4c+4d。Results: No obvious immunostaining of stathmin was observed in normal tongue epithelium。Positive expression of stathmin in tumor cell was detected in all 42 cases of tongue cancer。However, the expression pattern was clearly different depending on mode of invasion。In cases of grades 2+3, stathmin expression observed in cancer cells located inside of the cancer nests。In cases of grade 4c+4d, strong positive staining for stathmin was detected throughout the small cancer nests。Extensive staining was observed in tumor cells invading diffusely into the deepest portion of the tissue。Conclusions: Expression of stathmin in human tongue cancer cells correlates with the mode of invasion。Thus, stathmin may play an important role in the invasion of tongue cancer。

关键词：舌癌治疗方法病因鳞状细胞癌

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Podoplanin expression in human pleomorphic adenomas

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中国口腔颌面外科杂志 2008年第B5期6卷 124-125页

作者： yuka Oku Akio Tanaka Patricia Gonzalez Alva Hideaki Sakashita Kaoru kusama Division of Oral and Maxillofacial Surgery 11 Department of Diagnostic and Therapeutic Sciences Meikai University School of Dentistry. Saitama 350-8310 Japan Division of Pathology Department of Diagnostic and Therapeutic Sciences Meikai University School of Dentistry. Saitama 350-8310 Japan

Purpose: To examine podoplanin expression in human pleomorphic adenomas (PA)。Methods: Immunohistochemical analysis was performed in 28 cases of PA。Results: Podoplanin expression was detected in limited modified myoepithelial elements in all cases。Strong reaction for podoplanin was observed in epitheloid and spindle cells。Conclusion: Expression of podoplanin by the limited modified myoepithelial elements may reflect the progression of PA。

关键词：多形性腺瘤治疗方法临床分析免疫组织化学

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家山黧豆提取物的神经毒性

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国际中医中药杂志 2007年第2期29卷 127-128页

作者： kusama-Eguchi K[英] 李小丽(摘) 阴赪宏(校)

家山黧科豆（ Lathyrus sativus ）含有神经细胞毒性物质L-β-L-酰二氨基丙酸（ODAP），过量食用会引起下肢痉挛性瘫痪。本次通过大鼠原代神经元细胞和神经胶质细胞，比较探讨了孟加拉、加拿大的家山黧豆提取物的毒性。

关键词：神经毒性提取物下肢痉挛性瘫痪原代神经元细胞细胞毒性物质神经胶质细胞二氨基丙酸过量食用

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二环组活塞环在汽油机中的实际运用

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汽车与新动力 1998年第3期 52-58页

作者： Hideki yoshida Hiroyuki Sugihara Kazunorr kusama 施谦陈友英

通过对二环组活塞环的试验和改进设计,减小了汽油机工作时活塞环产生的摩擦力,降低了燃油耗和机油耗,节约了能源,降低了废气排放,以达到保护环境的目的。

关键词：活塞环汽油机改进

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牛肝tRNA^（Ile）的序列分析和二级结构

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生物化学与生物物理进展 1994年第1期21卷 72-73页

作者：彭朝晖广州第一军医大学生物化学教研室

用随机降解法和Ｄｏｎｉｓ－Ｋｅｌｌｅｒ酶分析法，测定了牛肝ｔＲＮＡ￣（Ｉｌｅ）序列。牛肝ｔＲＮＡ￣（Ｉｌｅ）长７７个碱基；Ｇ５·Ｇ６９不配对为其显著特征。依据ｔＲＮＡ螺旋区和环区自由能大小及Ｈｏｌｌｅｙ模型，确定了ｔ... 详细信息

用随机降解法和Ｄｏｎｉｓ－Ｋｅｌｌｅｒ酶分析法，测定了牛肝ｔＲＮＡ￣（Ｉｌｅ）序列。牛肝ｔＲＮＡ￣（Ｉｌｅ）长７７个碱基；Ｇ５·Ｇ６９不配对为其显著特征。依据ｔＲＮＡ螺旋区和环区自由能大小及Ｈｏｌｌｅｙ模型，确定了ｔＲＮＡ￣（Ｉｌｅ）的二级结构。

关键词： tRNA^Ile 序列二级结构 RNA 牛肝

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Three cases of malignant iymphoma occurred in the oral and maxillofaciai region

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中国口腔颌面外科杂志 2008年第B5期6卷 144-144页

作者： Junichiha yasaka Hiroto Ito yoshinori Jinbu Mikio kusama Department of Dentistry Oral and Maxillofacial Surgery JichiMedical University3311-1 Yakushiji Shimotsuke-shi Tochigi329-0498 Japan

Purpose: We report three cases of malignant lymphoma arising in the oral and Maxillofacial region. Methods: Case 1,The patient was 57 year-old-man, complaining of swelling at the right mandibular gingiva and paresthesia of mandible. He had 43 x3 l mm mass on the right mandibular gingiva and erosive lesion on the left mandibular gingiva. CT scan showed bone resorption of the right mandible and MR/ revealed mandibular invasion of the lesions. The pathological diagnosis was malignant lymphoma (Diffuse large B-cell lymphoma). Case 2, The patient was 68 year-old-woman, complaining of the fever and multiple cervical lymphadenopathy. She was hospitalized with a clinical diagnosis of the necrosis-related lymphadenitis. Because of clinical exacerbation, lymph node biopsy was performed. The pathological diagnosis was malignant lymphoma. Further examination using immuno-histochemical method disclosed T-cell lymphoma (Angioimmunoblastic T-cell lymphoma). The patient received chemotherapy with R-CHOP. Case 3,The patient was 63 year-old-woman, complaining of swelling at the left palate. She had 48×35mm mass. CT scan showed bone resorption of the left maxilla. FDG-PET revealed hot lesions in the right axillary lymph nodes and inguinal lymph node. Pathological examination of biopsy revealed malignant lymphoma (Diffuse large B-cell lymphoma). Conclusion:

关键词：口腔溃疡临床分析治疗方法齿龈

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Epithelial-mesenchymal transition in squamous cell carcinoma of the oral cavity

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中国口腔颌面外科杂志 2008年第B5期6卷 204-204页

作者： Akio Tanaka yuka Oku Patricia Gonzalez Alva Hideaki Sakashita Kaoru kusama Division of Pathology Department of Diagnostic & Therapeutic Sciences Meikai University School of Dentistry Saitoma 350-8310 Japan Division of Oral and Maxillofacial Surgery H Department of Diagnostic & Therapeutic Sciences Meikai University School of Dentistry Saitoma 350-8310 Japan

Purpose: Epithelial-mesenchymal transition was examined in oral squamous cell carcinoma (OSCC)。Methods: The expression of TGF-b, Snail, E-cadherin and vimentin was examined in 57 OSCCs。Results: Reduced expression of E-cadherin was correlated with tumor grade and IFG。Conclusion: Reduced E-cadherin expression may be involved in the progression of OSCC, and the association of TGF-b is suggested。

关键词：鳞状细胞癌上皮间叶细胞口腔治疗方法

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