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现代雷达 1990年第4期12卷 134-143页

作者： y.konishi l.Awai y.Fukuoka M.Nakajima 林南枝 Uniden Corporation Electronics Department Kyoto University

在主电路板上再设置一块印制电路板,可以构成一种新型的定向耦合器。实验结果与用边界元法计算的结果相当吻合。在一个很宽的耦合参数范围内,都可以设计出这种紧凑和低成本定向耦合器。

关键词：定向耦合器平面电路耦合器

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红麻原料机械化生产体系的开发

中国麻业科学 2007年第4期29卷 233-236页

作者： M.Suzuki M.Ito y.Sasaki M.Takano y.konishi 吕江南

日本新泻县是一个气候温暖,冬季多雪的地区,为了在那里大规模、低成本地种植红麻,我们研发了一个以拖拉机为主要机械的红麻机械化栽培体系。这个体系是在已有的机械化栽培体系基础上开发的,使用这个机械化栽培体系,红麻种植从耕地到收... 详细信息

日本新泻县是一个气候温暖,冬季多雪的地区,为了在那里大规模、低成本地种植红麻,我们研发了一个以拖拉机为主要机械的红麻机械化栽培体系。这个体系是在已有的机械化栽培体系基础上开发的,使用这个机械化栽培体系,红麻种植从耕地到收获的所有作业步骤均可使用机械完成。从1999年开始,我们研究了红麻机械化收获体系使用过程中所遇到的问题,并提出了解决方法。研究结果表明,红麻实行机械化栽培是完全可能的。

关键词：机械化收获生产体系开发原料红麻栽培体系机械化栽培新泻县

Design improvement of the conversion mechanism from balloon inflation to bending motion for inflatable film actuators

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Microsystems & Nanoengineering 2023年第3期9卷 159-170页

作者： y.Hori S.konishi Graduate School of Science and Engineering Ritsumeikan UniversityShigaJapan Department of Mechanical Engineering Ritsumeikan UniversityShigaJapan Ritsumeikan Advanced Research Academy KyotoJapan Ritsumeikan Global Innovation Research Organization KyotoJapan

Various soft actuators have been investigated to overcome the drawbacks of conventional solid machines and explore the applications of soft *** particular,and because they are expected to be applicable in minimally invasive medicine because of their safety,soft inflatable microactuators using an actuation conversion mechanism from balloon inflation to bending motion have been proposed for high-output bending *** microactuators could be applied to create an operation space by safely moving organs and tissues;however,the conversion efficiency could be further *** study aimed to improve conversion efficiency by investigating the design of the conversion *** contact conditions between the inflated balloon and conversion film were examined to improve the contact area for force transmission,with the contact area dependent on the length of the contact arc between the balloon and force conversion mechanism and on the amount of balloon *** addition,surface contact friction between the balloon and film,which affects actuator performance,was also *** generated force of the improved device is 1.21 N at 80 kPa when it bends 10 mm,which is 2.2 times the generated force of the previous *** improved soft inflatable microactuator is expected to assist in performing operations in a limited space,such as in endoscopic or laparoscopic operations.

关键词： film mechanism operations

Simultaneous detection of the shuttling motion of liquid metal droplets in channels under alternating pressure and capacitive sensor signals

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Microsystems & Nanoengineering 2024年第2期10卷 83-90页

作者： Shinji Bono Ryotaro Nakai Satoshi konishi Research Organization of Science and Technology Ritsumeikan UniversityShigaJapan Ritsumeikan Advanced Research Academy KyotoJapan Ritsumeikan Global Innovation Research Organization Ritsumeikan UniversityShigaJapan Graduate School of Science and Engineering Ritsumeikan UniversityShigaJapan

Implementing a signal-switching mechanism for the selective use of integrated sensors and actuators plays a crucial role in streamlining the functionality of miniaturized ***,a liquid metal droplet(LMD)-based signal-switching mechanism is introduced to achieve such *** modulation with a 100-μm spatial resolution enabled precise control of the position of the LMDs within a *** integrating the channel with asymmetrically structured electrodes,the effect of the shuttle-like movement of LMD on the temporal changes in the overall capacitance was ***,analysis of the capacitive peaks revealed the directional movement of the LMDs,enabling estimation of the position of the LMDs without direct *** addition,we achieved successful signal extraction from the capacitive sensor that was linked to the activated electrodes,thereby enabling selective data *** proposed signal-switching mechanism method achieved a detection accuracy of~0.1 *** sensor’s ability to simultaneously detect the LMD position and generate a signal underscores its significant potential for multiplexing in multisensing systems,particularly in concealed environments,such as in vivo settings.

关键词： liquid thereby integrating

Coupled alkali feldspar dissolution and secondary mineral precipitation in batch systems: 5. Results of K-feldspar hydrolysis experiments

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Chinese Journal Of Geochemistry 2015年第1期34卷 1-12页

作者： Peng Lu Hiromi konishi Eric Oelkers Chen Zhu Department of Geological Sciences Indiana University EXPEC Advance Research Center Saudi Aramco Oil Company Department of Geology Faculty of Science Niigata University Laboratoire de Geochimie CNRS 38 Rue Des Trente-Six Ponts31400 Toulouse France Earth Sciences University College London Department of Earth Sciences Zhejiang University

This paper explores how dissolution and precipitation reactions are coupled in batch reactor experimental systems at elevated temperatures. This is the fifth paper in our series of ‘‘Coupled Alkali Feldspar Dissolution and Secondary Mineral Precipitation in Batch Systems.'' In the previous four papers we presented batch experiments of alkali-feldspar hydrolysis and explored the coupling of dissolution and precipitation reactions(Fu et al. in Chem Geol91:955–964, 2009; Zhu and Lu in Geochim Cosmochim Acta 73:3171–3200, 2009; Zhu et *** Geochim Cosmochim Acta 74:3963–3983, 2010; Lu et al. in Appl Geochem30:75–90, 2013). Here, we present the results of additionalK-rich feldspar hydrolysis experiments at 150 °C. Our solution chemistry measurements have constrained feldspar dissolution rates, and our high resolution transmission electron microscopy work has identified boehmite precipitation. Reaction path modeling of K-feldspar dissolution and boehmite precipitation simulated the coupled reactions, but only with forced changes of boehmite rate law in the middle of experimental duration. The results which are reported in this article lend further support to our hypothesis that slow secondary mineral precipitation explains part of the wellknown apparent discrepancy between lab measured and field estimated feldspar dissolution rates(Zhu et al. in Water–rock interaction, 2004).

关键词：沉淀反应水解实验长石溶解批处理系统次生矿物碱性长石钾长石高分辨透射电子显微镜

Progress and challenges in CRISPR-mediated therapeutic genome editing for monogenic diseases

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The Journal of Biomedical Research 2021年第2期35卷 148-162页

作者： Colin T.konishi Chengzu Long Leon H.Charney Division of Cardiology New York University Grossman School of MedicineNew YorkNY 10016USA Helen and Martin Kimmel Center for Stem Cell Biology New York University Grossman School of MedicineNew YorkNY 10016USA Department of Neurology New York University Grossman School of MedicineNew YorkNY 10016USA Department of Neuroscience and Physiology New York University Grossman School of MedicineNew YorkNY 10016USA

There are an estimated 10000 monogenic diseases affecting tens of millions of individuals *** application of CRISPR/Cas genome editing tools to treat monogenic diseases is an emerging strategy with the potential to generate personalized treatment approaches for these ***/Cas-based systems are programmable and sequence-specific genome editing tools with the capacity to generate base pair resolution manipulations to DNA or *** complexity of genomic insults resulting in heritable disease requires patientspecific genome editing strategies with consideration of DNA repair pathways,and CRISPR/Cas systems of different types,species,and those with additional enzymatic capacity and/or delivery *** this review we aim to discuss broad and multifaceted therapeutic applications of CRISPR/Cas gene editing systems including in harnessing of homology directed repair,non-homologous end joining,microhomology-mediated end joining,and base editing to permanently correct diverse monogenic diseases.

关键词： gene editing CRISPR-associated protein 9 CRISPR-Cas system genetic disease medical genetics genetic therapy

Molecular biomarkers for the detection of metastatic colorectal cancer cells

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World Journal of Gastroenterology 2014年第27期20卷 8928-8938页

作者： Hidenori Kamiyama Hiroshi Noda Fumio konishi Toshiki Rikiyama Department of Surgery Saitama Medical Center Jichi Medical University Department of Surgery Chichibu Municipal Hospital

Approximately half of all patients with colorectal cancer develop local recurrence or distant metastasis during the course of their illness. Recently, the molecular detection of metastatic cancer cells in various types of clinical samples, such as lymph nodes, bone marrow, peripheral blood, and peritoneal lavage fluid, has been investigated as a potential prognostic marker. The prognostic value of molecular tumor cell detection was independent of the type of detection method used. As assays become more sensitive and quantitative, a more thorough assessment of the cancer status of patients will be based on molecular markers alone. At present, it is difficult to conclude that one specific molecular marker is superior to others. Comparative analyses are recommended to assess the prognostic impact of molecular analyses in the same patient and determine the biomarkers that provide the most accurate prognostic information.

关键词： Molecular biomarker Metastatic colorectal cancer cell Circulating tumor cell Disseminated tumor cell Peritoneal lavage fluid Colorectal cancer

Implementation of soft microfingers for a hMSC aggregate manipulation system

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Microsystems & Nanoengineering 2016年第1期2卷 311-317页

作者： Satoshi konishi Shuhei Shimomura Shuhei Tajima yasuhiko Tabata Department of Mechanical Engineering Ritsumeikan University1-1-1 Noji-higashKusatsuShiga 525-8577Japan Graduate School of Science and Engineering Ritsumeikan University1-1-1 Noji-higashKusatsuShiga 525-8577Japan Institute for Frontier Medical Sciences Kyoto UniversityYoshida-shimoadachiSakyo-kuKyoto 606-8501Japan

This paper describes a pneumatic balloon actuator(PBA)composed of polydimethylsiloxane(PDMS)for cellular aggregate *** evaluated the ability of the microdevice to manipulate a tiny and sensitive cellular aggregate without causing serious *** used human mesenchymal stem cells(hMSCs)for the cellular *** describe the design,fabrication,characterization and operation of the soft microfingers to pinch and release a spherical hMSC aggregate(φ200μm),and we employed a PBA to serve as an artificial muscle to drive the microfingers.A design of the microfingers in terms of dimensions,generated force and contact conditions was *** designed dimensions of a single finger were 560μm×900μ*** summary,we demonstrate the utility of the surface modification of a fingertip for pinching and releasing a cellular aggregate and describe a manipulation system that was constructed to drive and control the *** implemented manipulation system,which is composed of microfingers and a positioning mechanism,was tested and verified in a series of operations.

关键词： cellular aggregate manipulation pinching releasing positioning pneumatic balloon actuator soft MEMS surface modification

Data-driven derivation of partial differential equations using neural network model

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International Journal of Modeling, Simulation, and Scientific Computing 2021年第2期12卷 1-19页

作者： Koji Koyamada yu Long Graduate Takuma Kawamura Katsumi konishi Academic Center for Computing and Media Studies Kyoto University Yoshida-honnmachi Sakyo-kuKyoto 606-8501Japan School of Engineering Kyoto University Yoshida-honnmachi Sakyo-kuKyoto 606-8501Japan Center for Computational Science and e-Systems Japan Atomic Energy Research Institute 148-4 Kashiwanoha Campus 178-4 WakashibaKashiwa-CityChiba 277-0871Japan Faculty of Computer and Information Sciences Hosei University 3-7-2Tajino-cho Koganei-shiTokyo 184-8584Japan

It has become critical to develop explanatory models using partial differential equations(PDEs)for big data from interesting scientific phenomena,e.g.,fluids,atmosphere,and cosmic *** data are often measured at discrete spatiotemporal *** this paper,we assume a PDE and consider a set of the PDE solution data at multiple discrete points as pseudo-measurement *** a data-driven PDE derivation,it is assumed that the PDE is a linear regression model comprising partial temporal and spatial differential terms,where the coefficients are estimated using regression analysis techniques,and the PDE derivation accuracy is defined as the difference(i.e.,error)between the exact and estimated coefficients.A spatiotemporal model is required to calculate the partial temporal and spatial differential terms;thus,we employ a spatiotemporal model based on a neural network(NN)obtained from big *** develop the data-driven PDE derivation technique,we employ PDEs with exact solutions such that we can calculate the differential terms by differentiating them analytically at multiple discrete *** we assume an activation function in the NN model,the partial differential term can be derived using a chain *** NN model accuracy is measured by the loss function and error between the exact and estimated partial differential *** addition,we clarify a requirement for an NN structure that can maximize the PDE derivation and NN model accuracy by varying the NN meta-parameters,i.e.,the numbers of NN layers and neurons.

关键词： Neural network partial differential equation regression analysis