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journal of Magnesium and Alloys 2023年第9期11卷 3323-3337页

作者： hyun ji Kim Sumi jo Sung Hyuk Park Department of Materials Science and Metallurgical Engineering Kyungpook National UniversityDaegu 41566the Republic of Korea

This study investigates the effect of{10-12}deformation twins on the continuous precipitation behavior of an extruded Mg-8.0Al-0.5Zn-0.2Mn(AZ80)alloy during *** extruded AZ80 alloy is compressed along the transverse direction to introduce{10-12}twins,followed by an aging treatment at 300℃.The extruded material exhibits a twin-free microstructure with low internal strain energy,whereas the pre-twinned material possesses abundant{10-12}twins and has high internal strain *** aging results reveal that the peak-aging time of the pre-twinned material(1 h)is one-eighth of that of the extruded material(8 h).Although Mg_(17)Al_(12)continuous precipitates(CPs)are observed in both the peak-aged materials,these CPs are much smaller and more densely distributed in the pre-twinned material despite the significantly shorter aging *** CPs size in the peak-aged materials increases in the following order:twinned region in the pre-twinned material(0.47μm)y in the twinned region of the pre-twinned material is approximately 11 times higher than that in the matrix region of the extruded *** peak-aged pre-twinned material exhibits significantly higher tensile strength and ductility than the peak-aged extruded *** results demonstrate that the formation of{10-12}twins in the extruded AZ80 alloy substantially accelerates the static precipitation of CPs during aging at 300℃and improves the tensile properties of the peak-aged material.

关键词： AZ80 alloy {10-12}twin Aging Continuous precipitation Tensile properties

Formation Mechanism of MgO·Al_(2)O_(3) Spinel Inclusions in Stainless Steelmaking Processes

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journal of Iron and Steel Research International 2011年第S2期18卷 320-330页

作者： PARK joo hyun TODOROKI Hidekazu School of Materials Science and Engineering University of UlsanUlsan 680-749Korea Technical Research Center Nippon Yakin Kogyo Co.Ltd.KawasakishiKanagawa 210-8558Japan

The latest publications regarding the development of technology to control inclusion compositions focusing on MgO?Al2O3 spinel inclusions were summarized in this review article. The problems caused by spinel inclusions, which affect practice as well as products were shown. The formation mechanism of MgO?Al2O3 spinel inclusions is secondly explained thermodynamically from the view points of chemistries of molten steels and slag compositions. Furthermore, crystallization behaviour of spinel was introduced. Countermeasures conducted in practices and laboratories were shown along with some problems still left that should be solved in the future.

关键词： inclusion MgO?Al2O3 spinel thermodynamics crystallization stability deoxidation slag basicity

Unraveling the role of METTL14 in metabolic dysfunction-associated fatty liver disease:insights and therapeutic implications

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1781-1783页

作者： So jung Kim jeongeun hyun Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonanRepublic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonanRepublic of Korea Mechanobiology Dental Medicine Research Center College of DentistryDankook UniversityCheonanRepublic of Korea

The recent article published in Signal Transduction and Targeted Therapy sheds light on the significance of N6-methyladenosine(m6A)methyltransferase-like protein METTL14 in mitigating the progression of metabolic dysfunction-associated fatty liver disease(MAFLD).1 In this study,Wang et *** the downregulation of METTL14 in hepatocytes from both MAFLD patients and high-fat diet(HFD)-induced MAFLD mouse models,underscoring its pivotal role in maintaining hepatic lipid and redox homeostasis in normal livers.

关键词： liver homeostasis al.

The secondary metabolite bioinformatics portal: Computational tools to facilitate synthetic biology of secondary metabolite production

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Synthetic and Systems Biotechnology 2016年第2期1卷 69-79页

作者： Tilmann Weber hyun Uk Kim The Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKogle Alle 62970 HosholmDenmark BioInformatics Research Center Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

Natural products are among the most important sources of lead molecules for drug *** the development of affordable whole-genome sequencing technologies and other‘omics tools,the field of natural products research is currently undergoing a shift in ***,for decades,mainly analytical and chemical methods gave access to this group of compounds,nowadays genomics-based methods offer complementary approaches to find,identify and characterize such *** paradigm shift also resulted in a high demand for computational tools to assist researchers in their daily *** this context,this review gives a summary of tools and databases that currently are available to mine,identify and characterize natural product biosynthesis pathways and their producers based on‘omics data.A web portal called Secondary Metabolite Bioinformatics Portal(SMBP at http://***)is introduced to provide a one-stop catalog and links to these bioinformatics *** addition,an outlook is presented how the existing tools and those to be developed will influence synthetic biology approaches in the natural products field.

关键词： Antibiotics Biosynthesis Bioinformatics NRPS PKS Natural product

Spatial Ecology of Translocated and Resident Amur Ratsnakes(Elaphe schrenckii) in Two Mountain Valleys of South Korea

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Asian Herpetological Research 2011年第4期2卷 223-229页

作者： jung-hyun LEE Daesik PARK Department of Biology Kangwon National UniversityChuncheonKangwon 200-701South Korea Department of Environmental Resources Research National Institute of Environmental ResearchSeo-GuIncheon 404-708South Korea Division of Science Education Kangwon National UniversityChuncheonKangwon 200-701South Korea

The translocation of snakes has been viewed as a useful tool to augment declining populations and to mitigate human-wildlife conflicts, even though released snakes often exhibit relatively high mortality. We radio-tracked 13 Amur Ratsnakes （Elaphe schrenckii） in the Woraksan National Park in South Korea from july 2008 to May 2009. Two of these snakes were residents, and 11 had been illegally captured in areas remote from the study site and were donated by the park office. During the study period, six of the translocated snakes were lost： two were killed by predators, one died of unknown causes, and the radio signals of three of the snakes were lost. In the field, the ratsnakes laid eggs in early August, moved into hibemacula in late November, and moved away from the hibemacula in mid-April. Compared to the resident snakes, five of the translocated snakes traveled approximately 1.3 times farther per week, and the home ranges of the translocated snakes were three to six times larger than those of the resident snakes. In addition, the translocated snakes were found underground more frequently than the resident snakes. The management recommendations resulting from this study will guide biologists and land use managers in making appropriate decisions regarding release sites and the use of gravid females in the translocation of this endangered ratsnake.

关键词： Amur Ratsnake conservation Elaphe schrenckii radiotelemetry translocation

3D cellular-resolution imaging in arteries using few-mode interferometry

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Light(Science & Applications) 2019年第1期8卷 183-191页

作者： Biwei yin Zhonglie Piao Kensuke Nishimiya Chulho hyun joseph A.Gardecki Adam Mauskapf Farouc A.jaffer Guillermo j.Tearney Wellman Center for Photomedicine Harvard Medical School and Massachusetts General HospitalBostonMA 02114USA Cardiovascular Research Center and Cardiology Division Harvard Medical School and Massachusetts General HospitalBostonMA 02114USA Department of Pathology Harvard Medical School and Massachusetts General HospitalBostonMA 02114USA Harvard-MIT Division of Health Sciences and Technology CambridgeMA 02139USA

Cross-sectional visualisation of the cellular and subcellular structures of human atherosclerosis in vivo is significant,as this disease is fundamentally caused by abnormal processes that occur at this scale in a depth-dependent ***,due to the inherent resolution-depth of focus tradeoff of conventional focusing optics,today’s highestresolution intravascular imaging technique,namely,optical coherence tomography(OCT),is unable to provide crosssectional images at this resolution through a coronary ***,we introduce an intravascular imaging system and catheter based on few-mode interferometry,which overcomes the depth of focus limitation of conventional highnumerical-aperture objectives and enables three-dimensional cellular-resolution intravascular imaging in vivo by a submillimetre diameter,flexible *** of diseased cadaver human coronary arteries and living rabbit arteries were acquired with this device,showing clearly resolved cellular and subcellular structures within the artery wall,such as individual crystals,smooth muscle cells,and inflammatory *** capability of this technology to enable cellularresolution,cross-sectional intravascular imaging will make it possible to study and diagnose human coronary disease with much greater precision in the future.

关键词： arteries rabbit resolution

Laparoscopic surgery for gastric cancer:Current status and future direction

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Chinese journal of Cancer Research 2021年第2期33卷 133-141页

作者： So hyun Kang hyung-Ho Kim Department of Surgery Seoul National University Bundang HospitalSeongnam 13620Republic of Korea Department of Surgery Seoul National University College of MedicineSeoul 03080Republic of Korea

Gastric cancer is still a major cause of death *** laparoscopic gastrectomy(LG)has gained evidence as a standard treatment for early gastric cancer in the distal stomach,there are still concerns regarding its application for gastric cancer in the upper stomach and advanced gastric ***,LG has shown to have faster recovery,shorter hospital stay,less pain,and less blood loss in many retrospective and prospective *** application of LG has now extended from conventional radical gastrectomy to novel approaches such as function-preserving gastrectomy and sentinel-node navigated *** on the use of laparoscopy in treatment for stage IV gastric cancer are rare,but show that there may be some roles of LG in selected *** the development of new laparoscopic tools that augment human ability,the future of LG should move on from proving non-inferiority to demonstrating superiority compared to the traditional open gastrectomy.

关键词： Laparoscopy stomach neoplasm minimally invasive surgical procedures

Transport of chemical signals in systemic acquired resistance

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journal of Integrative Plant Biology 2017年第5期59卷 336-344页

作者： Archana Singh Gah-hyun Lim Pradeep Kachroo Department of Plant Pathology University of Kentucky Lexington Kentucky USA

Systemic acquired resistance （SAR） is a form of broad-spectrum resistance induced in response to local infections that protects uninfected parts against subsequent secondary infections by related or unrelated pathogens. SAR signaling requires two parallel branches, one regulated by salicylic acid （SA）. and theother by azelaic acid （AzA） and glycerol-3-phosphate （G3P）. AzA and G3P function downstream of the free radicals nitric oxide （NO） and reactive oxygen species （ROS）. During SAR, SA, AzA and G3P accumulate in the infected leaves, but only a small portion of these is transported to distal uninfected leaves. SA is preferen- tially transported via the apoplast, whereas phloem loading of AzA and G3P occurs via the symplast. The symplastic transport of AzA and G3P is regulated by gating of the plasmodesmata （PD）. The PD localizing proteins, PDLP1 and PDLP5, regulate SAR by regulating PD gating as well as the subcellular partitioning of a SAR-associated protein.

关键词： William j. Lucas University of California Davis USA

UBP12/UBP13-mediated deubiquitination of salicylic acid receptor NPR3 suppresses plant immunity

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Molecular Plant 2023年第1期16卷 232-244页

作者： yu Zhou Su-hyun Park Nam-Hai Chua Temasek Life Sciences Laboratory National University of Singapore1 Research LinkSingapore 117604Singapore Disruptive&Sustainable Technologies for Agricultural Precision Singapore-MIT Alliance for Research and Technology1 CREATE WaySingapore 138602Singapore

Salicylic acid(SA),a defense hormone produced after pathogen challenge,is critical for plant *** NONEXPRESSER OF PR GENES 1(NPR1)and its paralogs NPR3 and NPR4 can bind SA and mediate SA signal ***1 functions as a transcriptional co-activator to promote defense gene expression,whereas NPR3 and NPR4 have been shown to function as negative regulators in the SA signaling *** the mechanism about NPR1 regulation has been well studied,how NPR3/NPR4 proteins are regulated in immune responses remains largely ***,we show that the stability of NPR3/NPR4 is enhanced by *** the absence of pathogen challenge,NPR3/NPR4 are unstable and degraded by the 26S proteasome,whereas the increase in cellular SA levels upon pathogen infection suppresses NPR3/NPR4 *** found that UBP12 and UBP13,two homologous deubiquitinases from a ubiquitin-specific protease subfamily,negatively regulate plant immunity by promoting NPR3/NPR4 *** genetic results further showed that UBP12/UBP13-mediated immunity suppression is partially dependent on NPR3/NPR4 *** interacting with NPR3 in the nucleus in an SA-dependent manner,UBP12 and UBP13 remove ubiquitin from polyubiquitinated NPR3 to protect it from being *** stabilization of NPR3/NPR4 promoted by UBP12/UBP13 is essential for negative regulation of basal and SA-induced immunity.

关键词： plant immunity salicylic acid NPR3 UBP12/UBP13

Microstructure and Mechanical Properties of Hyper-eutectic Al-Si Alloys Fabricated by Spray Casting

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journal of Materials Science & Technology 2008年第1期24卷 48-50页

作者： Min Ryou Chul-hyun Kim Myung-Ho Kim School of Materials Science and Engineering Inha University 253 Yonghyun-DongNam-GuIncheon 402-751Korea Dong yang Piston Co. LTD 1050Singil-DongDonwon-GuAnsanKyungki-DoKorea

Microstructure and mechanical properties of hyper-eutectic Al-Si alloy fabricated by spray casting were in- vestigated and then these results were compared with those by squeeze *** spray-cast specimen was found to have finer Si particles （～5μm） compared to the squeeze-cast specimen （10-25μm）.The tensile strength and elongation of the spray-cast specimen are also higher than those of the squeeze cast *** was considered that the increased mechanical properties of the spray-cast specimen were mainly due to finer size of the Si particles distributed in Al matrix.

关键词： Hyper-eutectic Al-Si alloy Squeeze casting Spray casting