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Response Evaluation Using Contrast-Enhanced Ultrasound for Unresectable Advanced hepatocellular Carcinoma Treated With Tyrosine Kinase Inhibitors Plus Anti-PD-1 Antibody Therapy

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Ultrasound in Medicine and Biology 2024年第1期50卷 142-149页

作者： Zhao C.-K. Guan X. Pu y.-y. Zhou B.-y. Wang L.-F. sun y.-K. yin h.-h. Xia h.-S. Wang X. han h. Xu h.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Shanghai Institute of Medical Imaging Shanghai China Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objective: The aim of the work described here was to evaluate the role of contrast-enhanced ultrasound (CEUS) in response evaluation for unresectable advanced hepatocellular carcinoma (hCC) treated with tyrosine kinase inhibitors (TKIs) plus anti-programmed cell death protein-1 (PD-1) antibody therapy. Methods: A prospective cohort of consecutive patients with hCC who received combined TKI/anti-PD-1 antibody treatment for unresectable hCC between January 2022 and October 2022 was included in this study. The patients underwent unenhanced ultrasound (US) and CEUS examinations before treatment and at follow-up. Changes in the largest diameters of the target tumor on unenhanced US and the largest diameters of the enhancing target tumors on CEUS were evaluated. Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with unenhanced US and magnetic resonance imaging/computed tomography (MRI/CT) and modified RECIST (mRECIST) with CEUS and CEMRI/CT were used to assess treatment response. Results: A total of 24 hCC patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y; Barcelona Clinic Liver Cancer stage C, 62.5%; 29 intrahepatic target tumors) were studied. Calculations of degree of necrosis in the target tumors revealed no significant differences between CEUS and CEMRI/CT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for the differentiation of responders from non-responders, the agreement between RECIST version 1.1 of unenhanced US and mRECIST-CEUS was poor (κ coefficient = 0.233). Meanwhile, there was a high degree of concordance between mRECIST-CEUS and mRECIST-CEMRI/CT (κ coefficient = 0.812). Conclusion: CEUS proved to be superior to baseline US and is comparable to CEMRI/CT in defining treatment outcome for combined TKI/anti-PD-1 antibody therapy. © 2023 World Federation for Ultrasound in Medicine & Biology

关键词： Anti-angiogenic therapy Anti-PD-1 antibody Contrast-enhanced ultrasound hepatocellular carcinoma

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Microstructure change in Fe-based metallic glass and nanocrystalline alloy induced by liquid nitrogen treatment

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Journal of Materials Science & Technology 2021年第10期69卷 1-6页

作者： M.C.Ri D.W.Ding y.h.sun W.h.Wang Institute of Physics Chinese Academy of SciencesBeijing100190China Songshan Lake Materials Laboratory Dongguan523808China

The effects of acyclic liquid nitrogen(LN)treatment in a temperature range of-196℃to 50℃on the thermal and magnetic stability of Fe78Si9B13 and Fe73.5Si13.5B9Nb3Cu1 glassy ribbons have been studied.The intrinsic heterogeneities of the metallic glasses can be activated through cryogenic thermal cycling,making irreversible structural changes after the treatment and inducing rejuvenation to the materials.The microstructural changes of both Fe-based metallic glass(MG)and nanocrystalline alloy induced by LN treatment were investigated.The experimental results show that the LN treatment could effectively rejuvenate the Fe-Si-B MGs and change their thermomechanical and magnetic properties.Based on the partially-crystallinity and well-known magnetic constants,the increase of the energy at the order of 10m J/g and magnetic domain wall movement and rotation at the order of 5-6μm and 0.5°-0.8°are found for FINEMET-type amorphous alloy after LN treatment.It is also found that LN treatment can contribute a little stored energy to the magnetic domain wall movement and magnetic domain rotation.

关键词： Metallic glasses Cryogenic thermal treatment Soft magnetic materials Rejuvenation Stored energy Domain wall

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Composition and size dependent torsion fracture of metallic glasses

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Journal of Materials Science & Technology 2021年第23期82卷 153-160页

作者： J.Dong J.Shen y.h.sun h.B.Ke B.A.sun W.h.Wang h.y.Bai Institute of Physics Chinese Academy of SciencesBeijing100190PR China College of Materials Science and Opto Electronic Technology University of Chinese Academy of SciencesBeijing100049PR China Songshan Lake Materials Laboratory DongguanGuangdong523808PR China

The fracture of metallic glasses(MGs)of different compositions and sizes down to micrometers under torsion loading were systematically investigated.Contrary to the flat shear fracture along the circumferential plane as commonly supposed under torsion,we find that the torsion fracture of metallic glasses can deviate from flat shear plane,and the fracture angle is closely dependent on the composition and the size of MG samples.With a conversion method,we show that the torsion fracture of both millimeterand micrometer-sized MGs can be described by the ellipse fracture criterion as originally proposed for the tension fracture.The deviation from the circumferential shear plane under torsion is further shown to intrinsically relate to the fracture toughness of MGs.The tougher MG tends to have a smaller fracture angle with respect to the maximum shear plane,and vice versa,indicating a correlation between the fracture toughness and pressure/normal stress sensitivity in MGs.Our results provide new insights on the fracture mechanism and are helpful to design and control the deformation and fracture behavior of MGs under torsion loading.

关键词： Metallic glasses Torsion fracture Pressure sensitivity Fracture toughness

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Rotational and translational domains of beta precipitate in aged binary Mg-Ce alloys

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Journal of Magnesium and Alloys 2021年第3期9卷 1039-1056页

作者： B.Z.sun h.X.Zhang y.Dong J.X.Ren y.Tian G.M.Xie J.Tan y.h.sun Na Xiao School of Materials Science and Engineering Northeastern UniversityShenyang 110819China State Key Lab Rolling&Automat Northeastern UniversityShenyang 110819China Key Laboratory for Anisotropy and Texture of Materials Ministry of EducationNortheastern UniversityShenyang 110819China Analytical and Testing Center Northeastern UniversityShenyang 110819China

The structural evolution fromβ_(1)(Mg_(3)Ce)toβ(Mg_(12)Ce)precipitates,which takes place at the over-aged stage of binary Mg-Ce alloys,are investigated by high-angle annular dark-field scanning transmission electron microscopy.The structural transformation mainly occurs in the{111}_(β1)crystallographic planes,where the newly formedβlattices exhibit two categories of domain structures,namely rotational and translational domains.The rotational domain is composed of threeβdomains(β_(RA),β_(RB)andβ_(RC)),which are related by a 120°rotation with respect to each other around the 111_(β1)axis of theirβ_(1)parent phase.The{111}_(β1)crystallographic planes can provide four sets of sublattices with the same orientation for an initial nucleation ofβlattice.It leads to the formation of four translationalβdomains(β_(TA),β_(TB),β_(TC)andβ_(TD)),among which any two differ by a vector of 1/6112_(β1).We deduce theoretically that there exist twenty-fourβdomains during this transition.however,considering the interfacial misfit,only one-third of domains can grow up and eventually formsβribbon.Furthermore,a majority ofβribbons overlap partiallyβ_(1)plate,which is beneficial to relax interfacial strain amongβ,β_(1)andα-Mg matrix(α/β/β_(1)).The configuration of multipleβdomains can effectively regulate interfacial misfit ofα/βandβ/β_(1),which are responsible for enhancing the hardness and strength of Mg-Ce alloy.Additionally,this study aims to provide some clues to improve the over-aged performance of magnesium alloys by constructingβdomains and optimizing theα/β/β_(1)interface.

关键词： Magnesium alloys hAADF-STEM Rotational domain Translational domain Phase transition Interfacial misfit

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Impact of effective stress on permeability for carbonate fractured-vuggy rocks

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 942-960页

作者： Ke sun huiqing Liu Juliana y.Leung Jing Wang yabin Feng Renjie Liu Zhijiang Kang yun Zhang State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China School of Mining&Petroleum Engineering University of AlbertaEdmontonT6G 1H9Canada SINOPEC Petroleum Exploration and Production Research Institute Beijing100083China

To gain insight into the flow mechanisms and stress sensitivity for fractured-vuggy reservoirs,several core models with different structural characteristics were designed and fabricated to investigate the impact of effective stress on permeability for carbonate fractured-vuggy rocks(CFVR).It shows that the permeability performance curves under different pore and confining pressures(i.***.altered stress conditions)for the fractured core models and the vuggy core models have similar change patterns.The ranges of permeability variation are significantly wider at high pore pressures,indicating that permeability reduction is the most significant during the early stage of development for fractured-vuggy reservoirs.Since each obtained effective stress coefficient for permeability(ESCP)varies with the changes in confining pressure and pore pressure,the effective stresses for permeability of four representative CFVR show obvious nonlinear characteristics,and the variation ranges of ESCP are all between 0 and 1.Meanwhile,a comprehensive ESCP mathematical model considering triple media,including matrix pores,fractures,and dissolved vugs,was proposed.It is proved theoretically that the ESCP of CFVR generally varies between 0 and 1.Additionally,the regression results showed that the power model ranked highest among the four empirical models mainly applied in stress sensitivity characterization,followed by the logarithmic model,exponential model,and binomial model.The concept of“permeability decline rate”was introduced to better evaluate the stress sensitivity performance for CFVR,in which the one-fracture rock is the strongest,followed by the fracture-vug rock and two-horizontalfracture rock;the through-hole rock is the weakest.In general,this study provides a theoretical basis to guide the design of development and adjustment programs for carbonate fractured-vuggy reservoirs.

关键词： Effective stress Permeability Carbonate fractured-vuggy rocks Structure characteristics Stress sensitivity

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Evaluation of water management on arsenic methylation and volatilization in arsenic-contaminated soils strengthened by bioaugmentation and biostimulation

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Journal of Environmental Sciences 2024年第3期137卷 515-526页

作者： Peng Chen yi Liu Guo-Xin sun State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China

Arsenic(As) fate in paddy fields has been one of the most significant current issues due to the strong As accumulation potential of rice plants under fooded conditions. however,no attempt was done to explore As methylation and volatilization under non-fooded conditions. herein, we investigated the effects of water management on As methylation and volatilization in three arsenic-contaminated soils enhanced by biostimulation with strawderived organic matter and bioaugmentation with genetic engineered Pseudomonas putida KT2440(GE P. putida). Under fooded conditions, the application of biochar(BC), rice straw(RS)and their combination(BC+RS) increased total As in porewater. however, these effects were greatly attenuated under non-fooded conditions. Compared with RS amendment alone, the combination of GE P. putida and RS further promoted the As methylation and volatilization,and the promotion percentage under non-fooded conditions were significantly higher than that under fooded conditions. The combined GE P. putida and RS showed the highest efficiency in As methylation(88 μg/L) and volatilization(415.4 μg/(kg·year)) in the non-fooded soil with moderate As contamination. Finally, stepwise multiple linear regression analysis presented that methylated As, DOC and p h in porewater were the most important factors contributing to As volatilization. Overall, our findings suggest that combination of bioaugmentation with GE P. putida and biostimulation with RS/BC+RS is a potential strategy for bioremediation of arsenic-contaminated soils by enhancing As methylation and volatilization under non-fooded conditions.

关键词： Arsenic methylation Arsenic volatilization Water management Straw incorporation Bioaugmentation

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In situ biosynthesis of bacterial cellulose hydrogel spheroids with tunable dimensions

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Journal of Bioresources and Bioproducts 2024年第1期9卷 90-101页

作者： Bianjing sun Ping Wang Jingang Zhang Jianbin Lin Lingling sun Xiaokun Wang Chuntao Chen Dongping sun Institute of Chemicobiology and Functional Materials School of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing 210094China Zhonghao Chenguang Chemical Research Institute Co. Ltd.Zigong 643201China

Bacterial cellulose(BC)hydrogel spheroid plays a significant role in diverse fields due to its spatial 3D structure and properties.In the present work,a series of BC spheroids with controllable size and shape was obtained via an in situ biosynthesis.Crucial factors for fabricating BC spheroid in-cluding inoculum concentration of 1.35×10^(3)CFU/mL,shaking speeds at 100 r/min,and 48-96 h incubation time during the biosynthetic process,were comprehensively established.An operable mechanism model for tuning the size of BC spheroids from 0.4 to 5.0 mm was proposed with a fresh feeding medium strategy of dynamic culture.The resulting BC spheroids exhibit an inter-active 3D network of nanofibers,a crystallinity index of 72.3%,a specific surface area of 91.2 m^(2)/g,and good cytocompatibility.This study reinforces the understanding of BC spheroid forma-tion and explores new horizons for the design of BC spheroids-derived functional matrix materials for medical care.

关键词： In situ biosynthesis Bacterial cellulose hydrogel Spheroid Tunable dimension

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NiO-Doped Fe_(2)O_(3)/MgO Properties for the Chemical Looping Oxidative Dehydrogenation of Ethane

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 27-33页

作者： Liang hao Chen Junjie sun Jie sun hui Shenyang Ligong University Shenyang 110159China Fushun Ecology Environment Bureau Qingyuan County Branch Fushun 113399China

Ethane chemical looping oxidative dehydrogenation(CL-ODh)to ethylene is a new technology for ethylene preparation.Fe_(2)O_(3)/MgO oxygen carrier was prepared using the co-precipitation method.The influence of added NiO and its different loadings on Fe_(2)O_(3)/MgO were investigated.Then,a series of oxygen carriers were applied in the CL-ODh of the ethane cycle system.Brunauer-Emmett-Teller(BET),X-ray diffractometry(XRD),X-ray photoelection spectroscopy(XPS),and h2-temperature programmed reduction(TPR)were used to characterize the physicochemical properties of these oxygen carriers.It was confirmed that an interaction between NiO and Fe_(2)O_(3) occurred based on the XPS and h2-TPR results.Based on the CL-ODh activity performance tests conducted in a fixed-bed reactor,it was revealed that ethylene selectivity was significantly improved after NiO addition.Fe_(2)O_(3)-10%NiO/MgO showed the best activity performance with 93%ethane conversion and 50%ethylene selectivity at a reaction temperature of 650℃,atmospheric pressure,and space velocity of 7500 mL/(g·h).

关键词： chemical looping oxidative dehydrogenation oxygen carrier Fe_(2)O_(3)/MgO NiO

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Catalyst design and structure control for photocatalytic refineries of cellulosic biomass to fuels and chemicals

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Journal of Energy Chemistry 2024年第7期94卷 102-127页

作者： Lulu sun Nengchao Luo State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Lignocellulosic biomass is the largest renewable hydrocarbon resource on earth.Converting cellulose,one of the major components of lignocellulose,powered by solar energy is a promising way of providing lowcarbon-footprint energy chemicals such as h_(2),hCOOh,CO,and transportation fuels.State-of-the-art biorefineries target the full use of biomass feedstocks as they have a maximum collection radius of 75-100 km,requesting efficient and selective photocatalysts that significantly influence the outcome of photocatalytic biorefineries.Well-performed photocatalysts can harvest a broad solar spectrum and are active in breaking the chemical bonds of cellulose,decreasing the capital investments of biorefineries.Besides,photocatalysts should control the selectivity of cellulose conversion,originating target products to level down separation costs.Charge separation in photocatalysts and interfacial charge transfer between photocatalysts and cellulose affect the activity and selectivity of cellulose refineries to h2 and carbonaceous chemicals.To account for the challenges above,this review summarizes photocatalysts for the refineries of cellulose and downstream platform molecules based on the types of products,with the structure features of different types of photocatalysts discussed in relation to the targets of either improving the activity or product selectivity.In addition,this review also sheds light on the methods for designing and regulating photocatalyst structures to facilitate photocatalytic refineries of cellulose and platform molecules,meanwhile summarizing proposed future research challenges and opportunities for designing efficient photocatalysts.

关键词： Photocatalysts Biorefineries Cellulose Fuels hydrogen

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Blindness-free beam scanning antenna with array of array architecture: principle,design,and experiment

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Science China(Information Sciences) 2024年第3期67卷 209-224页

作者： Jianxu sun yujian ChENG School of Electronic Science and Engineering University of Electronic Science and Technology of China

This paper presents a 66–76-Ghz sparsely-excited phased array antenna with the array of array(Ao A) architecture for eliminating the blindness and suppressing the grating lobe when scanning. For the array antennas printed on the thick dielectric layers with high relative permittivity, scanning blindness appears and seriously impacts the radiation performance. To address this issue, the Ao A topology is developed first. It finds that the scanning blindness appears due to the coupling of the radiating Floquet modes to the non-radiating surface wave(SW) modes. Therefore, the array is divided into two types of domino subarrays.The inner-phase distributions are introduced into the domino subarrays to break the one-to-one relationship between the Floquet mode and the SW mode. Then, the blindness inside ±60° scanning volume is eliminated by the aperiodic subarrays. Meanwhile, the aperiodic inner-phase distributions enhance the aperiodicity of the array and contribute to suppressing the grating lobe when scanning. Next, the meta-surface-based dipole with the shorted post is chosen as the unit cell for the proposed aperiodic array. Based on these methods,the array achieves the wide-scanning performance of ±60° in the E-plane and ±30° in the h-plane, without the blindness and the grating lobe. Finally, the 16×16 array is built and simulated with the dimension of32 mm × 32 mm. At the highest operating frequency, the simulated gains are 28.42, 25.17, and 24.01 d Bi when scanning to the broadside, 50° in the E-plane, and 30° in the h-plane, respectively. Compared to the ideal gain, it shows that the simulated radiation efficiency is about 84.13%, 62.08%, and 35.23% when scanning to the broadside, 50° in the E-plane, and 30° in the h-plane, respectively. The worst transmission coefficient, i.e., the worst isolation, is-11.97 d B between the central element and its two adjacent elements in the E-plane. The array prototypes are fabricated, and the experiments are carried out to verify the correctness of the principle and design.

关键词： 6G communication systems phased array AoA aperiodic subarray wideband wide-scanning surface-wave scanning blindness grating lobe

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