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Chinese Physics C 2020年第4期44卷 I0001-I0004,1-102页

作者： M.Ablikim M.N.Achasov P.Adlarson S.Ahmed M.Albrecht M.Alekseev A.Amoroso f.f.An Q.An y.Bai O.Bakina R.Baldini ferroli y.Ban K.Begzsuren J.V.Bennett N.Berger M.Bertani D.Bettoni f.Bianchi J Biernat J.Bloms I.Boyko R.A.Briere L.Calibbi H.Cai X.Cai A.Calcaterra G.f.Cao N.Cao S.A.Cetin J.Chai J.f.Chang W.L.Chang J.Charles G.Chelkov Chen G.Chen H.S.Chen J.C.Chen M.L.Chen S.J.Chen y.B.Chen H.y.Cheng W.Cheng G.Cibinetto f.Cossio X.f.Cui H.L.Dai J.P.Dai X.C.Dai A.Dbeyssi D.Dedovich Z.y.Deng A.Denig Denysenko M.Destefanis S.Descotes-Genon f.De Mori y.Ding C.Dong J.Dong L.y.Dong M.y.Dong Z.L.Dou S.X.Du S.I.Eidelman J.Z.fan J.fang S.S.fang y.fang R.farinelli L.fava f.feldbauer G.felici C.Q.feng M.fritsch C.D.fu y.fu Q.Gao X.L.Gao y.Gao y.Gao y.G.Gao Z.Gao B.Garillon I.Garzia E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco L.M.Gu M.H.Gu y.T.Gu A.Q.Guo f.K.Guo L.B.Guo R.P.Guo y.P.Guo A.Guskov S.Han X.Q.Hao f.A.Harris K.L.He f.H.Heinsius T.Held y.K.Heng y.R.Hou Z.L.Hou H.M.Hu J.f.Hu T.Hu y.Hu G.S.Huang J.S.Huang X.T.Huang X.Z.Huang Z.L.Huang N.Huesken T.Hussain W.Ikegami Andersson W.Imoehl M.Irshad Q.Ji Q.P.Ji X.B.Ji X.L.Ji H.L.Jiang X.S.Jiang X.y.Jiang J.B.Jiao Z.Jiao D.P.Jin S.Jin y.Jin T.Johansson N.Kalantar-Nayestanaki X.S.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk T.Khan A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc M.Kurth M.G.Kurth W.Kuhn J.S.Lange P.Larin L.Lavezzi H.Leithoff T.Lenz C.Li Cheng Li D.M.Li f.Li f.y.Li G.Li H.B.Li H.J.Li J.C.Li J.W.Li Ke Li L.K.Li Lei Li P.L.Li P.R.Li Q.y.Li W.D.Li W.G.Li X.H.Li X.L.Li X.N.Li X.Q.Li Z.B.Li H.Liang H.Liang y.f.Liang y.T.Liang G.R.Liao L.Z.Liao J.Libby C.X.Lin D.X.Lin y.J.Lin B.Liu B.J.Liu C.X.Liu D.Liu D.y.Liu f.H.Liu fang Liu feng Liu H.B.Liu H.M.Liu Huanhuan Liu Huihui Liu J.B.Liu J.y.Liu K.y.Liu Ke Liu Q.Liu S.B.Liu T.Liu X.Liu X.y.Liu y.B.Liu Z.A.Liu Zhiqing Liu y.f.long X.C.Lou H.J.Lu J.D.Lu J.G.Lu y.Lu y.P.Lu C.L.Luo M.X.Luo P.W.Luo T.Luo X.L.Luo S.Lusso X.R.Lyu f.C.Ma H.L.Ma L.L.Ma M.M.Ma Q.M.Ma X.N.Ma X.X. Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced Science and Technology Beijing 100190China COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan fudan University Shanghai 200443China G.I.Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INfN Laboratori Nazionali di frascati I-00044FrascatiItaly INfN Sezione di ferrara I-44122FerraraItaly Institute of Physics and Technology Peace Ave.54BUlaanbaatar 13330Mongolia Johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16D-35392 GiessenGermany KVI-CART University of GroningenNL-9747 AA GroningenThe Netherlands Lanzhou University Lanzhou 730000China Liaoning University Shenyang 110036China Nanjing Normal University Nanjing 210023China Nanjing University Nanjing 210093China Nankai University Tianjin 300071China Peking University Beijing 100871China Shandong University Jinan 250100China Shanghai

There has recently been a dramatic renewal of interest in hadron spectroscopy and charm physics. This renaissance has been driven in part by the discovery of a plethora of charmonium-like XyZ states at BESⅢ and B factories, and the observation of an intriguing proton-antiproton threshold enhancement and the possibly related X(1835) meson state at BESⅢ, as well as the threshold measurements of charm mesons and charm baryons. We present a detailed survey of the important topics in tau-charm physics and hadron physics that can be further explored at BESⅢ during the remaining operation period of BEPCⅡ. This survey will help in the optimization of the data-taking plan over the coming years, and provides physics motivation for the possible upgrade of BEPCⅡ to higher luminosity.

关键词： meson hadron optimization

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Evidence for the decays of ∧_c^+→∑^+η and ∑^+η’

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Chinese Physics C 2019年第8期43卷 15-23页

作者： M.Ablikim f.f.An Q.An y.Bai y.Ban H.Cai X.Cai G.f.Cao J.f.Chang G.Chen H.S.Chen J.C.Chen M.L.Chen P.L.Chen S.J.Chen y.B.Chen W.Cheng H.LDai J.P.Dai Z.y.Deng y.Ding C.Dong J.Dong L.y.Dong M.y.Dong Z.L.Dou S.X.Du P.f.Duan J.Z.fan J.fang S.S.fang y.fang C.Q.feng C.D.fu y.fu Q.Gao X.L.Gao y.Gao y.G.Gao Z.Gao L.Gong W.X.Gong L.M.Gu M.H.Gu y.T.Gu A.Q.Guo L.B.Guo R.P.Guo y.P.Guo S.Han X.Q.Hao K.L.He y.K.Heng Z.L.Hou H.M.Hu J.f.Hu T.Hu y.Hu G.S.Huang J.S.Huang X.T.Huang X.Z.Huang Z.L.Huang Q.Ji Q.P.Ji X.B.Ji X.L.Ji X.S.Jiang X.y.Jiang J.B.Jiao Z.Jiao D.P.Jin S.Jin y.Jin X.S.Kang B.C.Ke C.Li Cheng Li D.M.Li f.Li f.y.Li G.Li H.B.Li H.J.Li J.C.Li J.W.Li Ke Li Lei Li P.L.Li P.R.Li Q.y.Li T.Li W.D.Li W.G.Li X.L.Li X.N. Li X.Q.Li Z.B.Li H.Liang y.f.Liang y.T.Liang G.R.Liao L.Z.Liao C.X.Lin D.X.Lin B.Liu B.J.Liu C.X.Liu D.Liu D.y.Liu f.H.Liu fang Liu feng Liu H.B.Liu H.L.Liu H.M.Liu Huanhuan Liu Huihui Liu J.B.Liu J.y.Liu K.Liu K.y.Liu Ke Liu Q.Liu S.B.Liu X.Liu y.B.Liu Z.A.Liu Zhiqing Liu y.f.long X.C.Lou H.J.Lu J.D.Lu J.G.Lu y.Lu y.P.Lu C.L.Luo M.X.Luo T.Luo X.L.Luo X.R.Lyu f.C.Ma H.L.Ma L.L.Ma M.M.Ma Q.M.Ma X.N.Ma X.X.Ma X.y.Ma y.M.Ma y.J.Mao Z.P.Mao Z.X.Meng J.Min T.J.Min X.H.Mo y.J.Mo Z.Ning S.L.Niu S.L.Olsen Q.Ouyang y.Pan H.P.Peng J.L.Ping R.G.Ping H.R.Qi M.Qi T.y.Qi S.Qian C.f.Qiao N.Qin Z.H.Qin J.f.Qiu S.Q.Qu G.Rong W.Shan X.y.Shan M.Shao C.P. Shen P.X.Shen X.y.Shen H.y.Sheng X.Shi J.J.Song X.y.Song G.X.Sun J.f.Sun L.Sun S.S.Sun X.H.Sun y.J.Sun y.K.Sun y.Z.Sun Z.J.Sun Z.T.Sun y.T.Tan C.J.Tang G.y.Tang X.Tang B.Wang B.L.Wang C.W.Wang D.y.Wang Dan Wang K.Wang L.L.Wang L.S.Wang M.Wang Meng Wang P.Wang P.L.Wang W.P.Wang X.f.Wang y.Wang y.f.Wang Z.Wang Z.G.Wang Z.y.Wang Zongyuan Wang D.H.Wei S.P.Wen L.H.Wu L.J.Wu Z.Wu L.Xia y.Xia D.Xiao y.J.Xiao Z.J.Xiao y.G.Xie y.H.Xie X.A.Xiong Q.L.Xiu G.f.Xu J.J.Xu L.Xu Q.J.Xu Q.N.Xu X.P.Xu f.yan L.yan w.B.yan W.C.yan y.H.yan H.J.yang H.X.yang L.yang S.L.yang y.H.yang y.X.yang yifan yang Z.Q.yang M.ye M.H.ye J.H.yin Z.y.you B.X.yu C.X.yu J.S.yu C.Z.yuan y.yuan y.Zeng B.X.Zhang B.y.Zhang Institute of High Energy Physics G.I.Budker Institute of Nuclear Physics SB RAS(BINP) the Novosibirsk State University Helmholtz Institute Mainz Bochum Ruhr-University University of Turin INfN State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Southeast University Joint Institute for Nuclear Research INfN Laboratori Nazionali di frascati Peking University Institute of Physics and Technology Indiana University Bloomington Carnegie Mellon University Johannes Gutenberg University of Mainz INfN Sezione di ferrara Wuhan University Ankara University University of Chinese Academy of Sciences Istanbul Bilgi University the Moscow Institute of Physics and Technology the functional Electronics Laboratory Tomsk State University University of South China Nanjing University Shanghai Jiao Tong University Key Laboratory for Particle Physics Astrophysics and CosmologyMinistry of EducationShanghai Key Laboratory for Particle Physics and CosmologyInstitute of Nuclear and Particle Physics Liaoning University Nankai University Zhengzhou University Tsinghua University University of ferrara University of Eastern Piedmont Central China Normal University University of Minnesota Minneapolis GSI Helmholtzcentre for Heavy Ion Research GmbH Guangxi University Nanjing Normal University KVI-CART University of Groningen Henan Normal University University of Hawaii Honolulu Shandong University University of the Punjab University of Muenster Uppsala University Huangshan College University of Jinan Justus-Liebig-Universitaet Giessen II.Physikalisches Institut Istanbul Arel University Soochow University Beijing Institute of Petrochemical Technology China Center of Advanced Science and Technology Sun yat-Sen University Sichuan University Guangxi Normal University Indian Institute of Technology Madras Shanxi University Henan University of Science and Technology Lanzhou University Zhejiang University fudan University Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of

We study the hadronic decays of ∧c+ to the final states ∑+η and ∑+η’,using an e+e-annihilation data sample of 567 pb-1 taken at a center-of-mass energy of 4.6 GeV with the BESIII detector at the BEPCⅡ *** find evidence for the decays ∧c+→∑+η and ∑+η’ with statistical significance of 2.5σ and 3.2σ,*** to the reference decays ∧c+→∑+π0 and ∑+ω,we obtain the ratios of the branching fractions■and ■to be 0.35±0.16±0.02 and 0.86±0.34±0.04,*** upper limits at the 90% confidence level are set to be■and■.Using BESIII measurements of the branching fractions of the reference decays,we determine B（∧c+→∑+η）=（0.41±0.19±0.05）%（first uncertainties are statistical and the second *** obtained branching fraction of ∧c+→∑+η is consistent with the previous measurement,and the branching fraction of ∧c+→∑+η’ is measured for the first time.

关键词： charmed baryon ∧c^+ decays branching fractions

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Observation of e^+e^-→D_s^+■^((*)0)K^- and study of the P-wave D_s mesons

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Chinese Physics C 2019年第3期43卷 5-16页

作者： M.Ablikim M.N.Achasov S.Ahmed M.Albrecht M.Alekseev A.Amoroso f.f.An Q.An y.Bai O.Bakina R.Baldini ferroli y.Ban K.Begzsuren D.W.Bennett J.V.Bennett N.Berger M.Bertani D.Bettoni f.Bianchi I.Boyko R.A.Briere H.Cai X.Cai A.Calcaterra G.f.Cao S.A.Cetin J.Chai J.f.Chang W.L.Chang G.Chelkov G.Chen H.S.Chen J.C.Chen M.L.Chen S.J.Chen y.B.Chen W.S.Cheng G.Cibinetto f.Cossio H.L.Dai J.P.Dai A.Dbeyssi D.Dedovich Z.y.Deng A.Denig I.Denysenko M.Destefanis f.De Mori y.Ding C.Dong J.Dong L.y.Dong M.y.Dong Z.L.Dou S.X.Du J.Z.fan J.fang S.S.fang y.fang R.farinelli L.fava f.feldbauer G.felici C.Q.feng M.fritsch C.D.fu y.fu Q.Gao X.L.Gao y.N.Gao y.G.Gao Z.Gao B.Garillon I.Garzia A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco L.M.Gu M.H.Gu S.Gu y.T.Gu A.Q.Guo L.B.Guo R.P.Guo y.P.Guo A.Guskov Z.Haddadi S.Han X.Q.Hao f.A.Harris K.L.He f.H.Heinsius T.Held y.K.Heng Z.L.Hou H.M.Hu J.f.Hu T.Hu y.Hu G.S.Huang J.S.Huang X.T.Huang X.Z.Huang Z.L.Huang N.Huesken T.Hussain W.Ikegami Andersson W.Imoehl M.Irshad Q.Ji Q.P.Ji X.B.Ji X.L.Ji H.L.Jiang X.S.Jiang X.y.Jiang J.B.Jiao Z.Jiao D.P.Jin S.Jin y.Jin T.Johansson N.Kalantar-Nayestanaki X.S.Kang M.Kavatsyuk B.C.Ke I.K.Keshk T.Khan A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc M.Kurth W.Kühn J.S.Lange P.Larin L.Lavezzi H.Leithoff C.Li Cheng Li D.M.Li f.Li f.y.Li G.Li H.B.Li H.J.Li J.C.Li J.W.Li Ke Li L.K.Li Lei Li P.L.Li P.R.Li Q.y.Li W.D.Li W.G.Li X.L.Li X.N.Li X.Q.Li Z.B.Li H.Liang y.f.Liang y.T.Liang G.R.Liao L.Z.Liao J.Libby C.X.Lin D.X.Lin B.Liu B.J.Liu C.X.Liu D.Liu D.y.Liu f.H.Liu fang Liu feng Liu H.B.Liu H.L Liu H.M.Liu Huanhuan Liu Huihui Liu J.B.Liu J.y.Liu K.y.Liu Kai Liu Ke Liu Q.Liu S.B.Liu X.Liu y.B.Liu Z.A.Liu Zhiqing Liu y.f.long X.C.Lou H.J.Lu J.D.Lu J.G.Lu y.Lu y.P.Lu C.L.Luo M.X.Luo P.W.Luo T.Luo X.L.Luo S.Lusso X.R.Lyu f.C.Ma H.L.Ma L.L.Ma M.M.Ma Q.M.Ma X.N.Ma X.X.Ma X.y.Ma y.M.Ma f.E.Maas M.Maggiora S.Maldaner Q.A.Malik A.Mangoni y.J.Mao Z.P.Mao S.Marcello Z.X.Meng J.G.Messchendorp G.Mezzadri J.Min T.J.Min R.E.Mitchell X.H.Mo y Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced Science and Technology Beijing 100190China COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan fudan University Shanghai 200443China G.I.Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INfN Laboratori Nazionali di frascati I-00044FrascatiItaly INfN Sezione di ferrara I-44122FerraraItaly Institute of Physics and Technology Peace Ave.54BUlaanbaatar 13330Mongolia Johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16D-35392 GiessenGermany KVI-CART University of GroningenNL-9747 AA GroningenThe Netherlands Lanzhou University Lanzhou 730000China Liaoning University Shenyang 110036China Nanjing Normal University Nanjing 210023China Nanjing University Nanjing 210093China Nankai University Tianjin 300071China Peking University Beijing 100871China Shandong University Jinan 250100China Shanghai

Studies of e^+e~→D_s^+■^((*)0)K^-and the P-wave charmed-strange mesons are performed based on an e^+e^-collision data sample corresponding to an integrated luminosity of 567 pb^(-1) collected with the BESIII detector at s^(1/2)=4.600 GeV. The processes of e^+e^-→D_s^+■^(*0)K^- and D_s^+■~0K^- are observed for the first time and are found to be dominated by the modes D_s^+D_(s1)(2536)^-and D_s^+D_(s2)~*(2573)^-, respectively. The Born cross sections are measured to be σ~B(e^+e^-→D_s^+■^(*0)K^-) =(10.1±2.3±0.8) pb and σ~B(e^+e^-→D_s^+■~0K^-) =(19.4±2.3± 1.6) pb, and the products of Born cross section and the decay branching fraction are measured to be σ~B(e^+e^-→D_s^+D_(s1)(2536)^-+c.c.)·B(D_(s1)(2536)^-→■^(*0)K^-)=(7.5±1.8±0.7) pb and σ~B(e^+e^-→D_s^+D_(s2)~*(2573)^-+ c.c.)·B(D_(s2)~*(2573)^-→■~0 K^-)=(19.7 ± 2.9 ±2.0) pb. for the D_(s1)(2536)^-and D_(s2)~*(2573)^-mesons, the masses and widths are measured to be M(D_(s1)(2536)^-)=(2537.7±0.5 ±3.1) MeV/c2, Γ(D_(s1)(2536)^-) =(1.7 ±1.2 ±0.6)MeV, and M(D_(s2)~*(2573)^-)=(2570.7±2.0 ±1.7) MeV/c^2, Γ(D_(s2)~*(2573)^-)=(17.2 ±3.6 ±1.1) MeV. The spin-parity of the D_(s2)~*(2573)^-meson is determined to be J^p= 2^+. In addition, the processes e^+e^-→D_s^+■^((*)0)K^-are searched for using the data samples taken at four(two) center-of-mass energies between 4.416(4.527) and 4.575 GeV, and upper limits at the 90% confidence level on the cross sections are determined.

关键词： cross section P-wave D_s mesons resonance parameters spin-parity BESIII

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Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 62-72页

作者： Zhi-Da long Xiao yu Zhi-Xiang Xing Rui Wang Department of Hepatobiliary and Pancreaticosplenic Surgery Jingzhou Hospital Affiliated to Yangtze UniversityJingzhou 434100Hubei ProvinceChina

BACKGROUND The liver,as the main target organ for hematogenous metastasis of colorectal cancer,early and accurate prediction of liver metastasis is crucial for the diagnosis and treatment of ***,this study aims to investigate the application value of a combined machine learning(ML)based model based on the multiparameter magnetic resonance imaging for prediction of rectal metachronous liver metastasis(MLM).AIM To investigate the efficacy of radiomics based on multiparametric magnetic resonance imaging images of preoperative first diagnosed rectal cancer in predicting MLM from rectal *** We retrospectively analyzed 301 patients with rectal cancer confirmed by surgical pathology at Jingzhou Central Hospital from January 2017 to December *** participants were randomly assigned to the training or validation queue in a 7:3 *** first apply generalized linear regression model(GLRM)and random forest model(RfM)algorithm to construct an MLM prediction model in the training queue,and evaluate the discriminative power of the MLM prediction model using area under curve(AUC)and decision curve analysis(DCA).Then,the robustness and generalizability of the MLM prediction model were evaluated based on the internal validation set between the validation queue *** Among the 301 patients included in the study,16.28%were ultimately diagnosed with MLM through pathological *** analysis showed that carcinoembryonic antigen,and magnetic resonance imaging radiomics were independent predictors of ***,the GLRM prediction model was developed with a comprehensive nomogram to achieve satisfactory *** prediction performance of GLRM in the training and validation queue was 0.765[95%confidence interval(CI):0.710-0.820]and 0.767(95%CI:0.712-0.822),*** with GLRM,RfM achieved superior performance with AUC of 0.919(95%CI:0.868-0.970)and 0.901(95%CI:0.850-0.952)in the training and validation queue,respect

关键词： Rectal cancer Metachronous liver metastases Magnetic resonance imaging Radiomics Machine learning

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Bowel preparation before colonoscopy: Consequences, mechanisms, and treatment of intestinal dysbiosis

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World Journal of Gastroenterology 2025年第2期31卷 13-26页

作者： Ze-long Zheng Qing-fan Zheng Li-Qiang Wang yi Liu Department of Gastroenterology(Endoscopy Center) China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

The term“gut microbiota”primarily refers to the ecological community of various microorganisms in the gut,which constitutes the largest microbial community in the human *** adequate bowel preparation can improve the results of colonoscopy,it may interfere with the gut *** preparation for colonoscopy can lead to transient changes in the gut microbiota,potentially affecting an individual’s health,especially in vulnerable populations,such as patients with inflammatory bowel ***,measures such as oral pro-biotics may ameliorate these adverse *** focused on the bowel prepa-ration-induced changes in the gut microbiota and host health status,hypothesized the factors influencing these changes,and attempted to identify measures that may reduce dysbiosis,thereby providing more information for individualized bowel preparation for colonoscopy in the future.

关键词： Bowel preparation Colonoscopy Microbiota Inflammatory bowel disease Probiotics

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The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： yunfan long Jiajia Liu yu Wang Haidong Guo Guohong Cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a Nf-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAf6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

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Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma:A case report

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 239-251页

作者： yun-Chuan yang Zhi-Tao Chen Da-long Wan Hui Tang Mu-Lin Liu Department of Medical College Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Pathology The First Affiliated Hospital of Medical School of Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Gallbladder neuroendocrine carcinoma(NEC)represents a subtype of gallbladder malignancies characterized by a low incidence,aggressive nature,and poor *** its clinical severity,the genetic alterations,mechanisms,and signaling pathways underlying gallbladder NEC remain *** SUMMARy This case study presents a rare instance of primary gallbladder NEC in a 73-year-old female patient,who underwent a radical cholecystectomy with hepatic hilar lymphadenectomy and resection of liver segments IV-B and *** gene sequencing and bioinformatics analysis tools,including STRING,GeneMANIA,Metascape,TRRUST,Sangerbox,cBioPortal and GSCA,were used to analyze the biological functions and features of mutated genes in gallbladder *** mutations(APC,ARID2,IfNA6,KEAP1,RB1,SMAD4,TP53,BTK,GATA1,GNAS,and PRDM3)were identified,and the tumor mutation burden was determined to be 9.52 muts/Mb via targeted gene sequencing.A protein-protein interaction network showed significant interactions among the twelve mutated *** Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were used to assess mutation functions and *** results revealed 40 tumor-related pathways.A key regulatory factor for gallbladder NEC-related genes was identified,and its biological functions and features were compared with those of gallbladder *** Gallbladder NEC requires standardized *** with other gallbladder carcinomas revealed clinical phenotypes,molecular alterations,functional characteristics,and enriched pathways.

关键词： Gallbladder neuroendocrine carcinoma Targeted-gene sequencing Bioinformatics analysis case report Immunocytochemistry Case report

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MoS_(2)Lubricate‑Toughened MXene/ANf Composites for Multifunctional Electromagnetic Interference Shielding

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Nano-Micro Letters 2025年第2期17卷 358-371页

作者： Jiaen Wang Wei Ming longfu Chen Tianliang Song Moxi yele Hao Zhang long yang Gegen Sarula Benliang Liang Luting yan Guangsheng Wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EMI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** MXene/ANf(aramid nanofibers)–MoS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of MoS_(2)into binary MXene/ANf composite *** introduction of MoS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of MoS_(2)into binary MXene/ANf(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 MPa and to 25.8±0.7%and 167.3±9.1 MPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 MJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of MXene/ANf(mass ratio of 50:50)decreases~10.8%.EMI shielding effectiveness(EMI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of MoS_(2)into binary MXene/ANf(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EMI SE is 43.9 *** MoS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,MXene/ANf–MoS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high MXene content,electric heating performance,and photothermal conversion performance,EMI shielding ternary MXene/ANf–MoS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： MXene-MoS_(2) Lubrication toughening EMI shielding Photothermal conversion Electric heating performance

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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin long Chuanhua Ge yueyang Zhao yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

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Pretreatment red blood cell distribution width as a predictive marker for postoperative complications after laparoscopic pancreatoduodenectomy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 143-157页

作者： Xian-Rang Cao yin-long Xu Jia-Wei Chai Kai Zheng Jun-Jie Kong Jun Liu Shun-Zhen Zheng Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Breast and Thyroid Surgery Shandong Provincial Maternal and Child Health Care HospitalJinan 250014Shandong ProvinceChina

BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various *** To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively *** between pretreatment RDW and clinicopathological characteristics and short-term outcomes were *** Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal *** pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,Pf grade IIIa or higher(hazard ratio=3.138,95%confidence interval:2.042-4.824,Pfication *** analysis showed that high pretreatment RDW was an independent risk factor for Clavien-Dino classi-fication grade IIIb or higher POCs,a comprehensive complication index score≥26.2,severe postoperative pancreatic fistula,severe bile leakage and severe *** pretreatment RDW was positively associated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and was negatively associated with albumin and the prognostic nutritional *** Pretreatment RDW was a special parameter for patients who underwent *** was associated with malnutrition,severe inflammatory status and poorer short-term *** could be a surrogate marker for nutritional and inflammatory status in identifying patients who were at high risk of developing POCs after LPD.

关键词： Biomarker Laparoscopic pancreatoduodenectomy Postoperative complication Red blood cell distribution width Short-term outcomes

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