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Heterojunction between bimetallic metal-organic framework and TiO_(2):Band-structure engineering for effective photoelectrochemical water splitting

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Nano Research 2022年第9期15卷 8502-8509页

作者： Ji Won yoon Jae-Hyeok Kim young-Moo Jo jong-Heun Lee department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea

Bimetallic Fe/Ni-based metal-organic frameworks(MOFs)with different Fe/Ni ratios were coated on TiO_(2)nanorods(NRs),and the performances of the heterojunction photoanodes in photoelectrochemical water splitting were *** bandgaps and band positions of the MOFs could be modulated by changing the ratio of the Fe and Ni *** ideal band alignment was achieved between the TiO_(2)NRs and bimetallic MOFs with an optimum ratio of[Fe]/[Ni]=0.25/0.75,which allowed efficient light absorption and charge *** coating of NH_(2)-MIL(Fe)-88 layer on the TiO_(2)NRs decreased the photocurrent density by 33%.In comparison,TiO_(2)/NH_(2)-MIL(Ni)-88 showed a modest improvement in photocurrent density(0.85 mA·cm^(−2)at 1.23 V vs.a reversible hydrogen electrode(RHE)).When bimetallic NH_(2)-MIL(Fe_(0.25)Ni_(0.75))-88 was coated on the TiO_(2)NRs,the photocurrent density reached 1.56 mA·cm^(−2),which was an efficiency enhancement of 3.2 *** mechanism underlying high photoelectrochemical performance was investigated.

关键词： band-structure engineering bimetallic metal-organic frameworks(MOFs) solar water splitting TiO_(2)nanorods NH_(2)-MIL-88

Cell Cycle Arrest Mediates Global DNA Methylation Patterns in Normal Human Keratinocytes, Epidermoid Carcinoma Cells and Murine Embryonic Fibroblasts

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Journal of Cancer Therapy 2013年第1期4卷 199-207页

作者： John J. Wille jong y. Park Bioderm Technologies Inc Trenton USA Division of Cancer Prevention and Control Moffitt Cancer Center Tampa USA

The 5-methylationcytosine (5-MC) DNA content of murine embryonic fibroblasts arrested in G1 by four growth conditions (Gc, Gn, Gd, and Gs) were hypermethylated relative to rapidly growing (RG) fibroblasts. Normal human keratinocytes (NHK) arrested in G1 by suspension were hypermethylated relative to RG cultures. Four RG cultures of epidermoid carcinoma cells (ECC) were hypomethylated relative to RG NHK cultures, and two cultures (SCC25 and A431) were further hypomethylated by SUS-induced arrest. Linear regression analyses established a positive linear correlation between growth rate and 5-MC content for three murine fibroblasts lines, and a negative correlation for both NHK and ECC lines.

关键词： Anoikis Epitheliod Carcinoma Cells Cell Cycle DNA Methylation G1 Phase Restriction Points

Retinoid and Ethanol-Sensitive Benzo(<i>α</i>)Pyrene Induction of Cytochrome P450 in Human Keratinocytes

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Journal of Cancer Therapy 2012年第6期3卷 1080-1085页

作者： John J. Wille jong y. Park Bioderm Technologies Inc. Chesterfield USA Division of Cancer Prevention and Control Moffitt Cancer Center Tampa USA.

Polycyclic aromatic hydrocarbons (PAHs) induce cytochrome P-450 monoxygenase enzymes that catalyze the formation of DNA adducts. We investigated the effects benzo(α)pyrene (B[α]P) alone or in combination with ethanol on normal human keratinocyte (NHK) growth, induction of cytochrome P-4501A1 (CyP1A1), and modulation of these treatments by retinoic acid (RA) in a serum-free culture medium. Growth-arrested confluent NHK serum-free cultures were treated with B[α]P alone or in combination with ethanol and RA. The effects on CyP1A1 enzyme activity were investigated. B[α]P treatment alone was not toxic to post-confluent cells;sub-toxic ethanol stimulated cell growth regardless B[α]P treatment. No CyP1A1 activity was detected in control or ethanol-treated NHK cell cultures. B[α]P alone induced CyP1A1 activity, and B[α]P plus ethanol treatment further enhanced B[α]P-induced CyP1A1 activity. Pretreatment with all-trans-RA (t-RA) abolished ethanol enhancement of CyP1A1 activity. There is a synergistic action of ethanol in combination with PAH on induction of P-450 cytochrome enzymes. By contrast, RA reverses ethanol enhancement implying a role for retinoid therapy in counteracting the risk posed by combined alcohol and PAH exposure on epidermal cell carcinogenesis.

关键词： CyP1A1 Aryl Hydrocarbon Hydroxylase Benzo(α)Pyrene Ethanol Keratinocytes Retinoids

Effects of Okadaic Acid, Retinoic Acid, and Phorbol Myristate Acetate Tumor Promoter on Oncogene Expression

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Journal of Cancer Therapy 2014年第6期5卷 591-604页

作者： John J. Wille jong y. Park Bioderm Technologies Inc. Trenton USA department of Cancer Epidemiology Moffitt Cancer Center Tampa USA

The effect of okadaic acid (OA) on proto-oncogene protein expression of c-neu, c-myc, v-rasH, EGFR, and phosphotyrosine-containing phosphoproteins (P-Tyr) was investigated in rapidly growing (RG) normal human keratinocytes (NHK) and in SV-40 virally-transformed keratinocytes (SVK) cultured in a growth factor supplemented serum-free medium as assessed by indirect immunofluorescence microscopy. P-Tyr positively stains cell surface antigens (cytoplasm) diffusely at monopolar sites in RG NHK cultures. OA-treatment intensifies cytoplasmic P-Tyr staining at localized monopolar intercellular focal adhesion (IFA) sites with reduced cytoplasmic staining. P-Tyr expression was predominate at IFA sites with little cytoplasmic staining in RG SVK cultures. OA-treatment increased monopolar P-Tyr staining and cytoplasmic staining. OA-treatment in RG NHK cultures intensified cytoplasmic staining of c-myc and EGFR (epidermal growth factor receptor) expression. OA-treatment in RG NHK and SVK cultures intensified c-neu staining at monopolar IFA sites and intensified c-neu staining at both cytoplasmic and bipolar IFA sites in RG SVK cells. OA was especially cytotoxic for SVK cells. RA treatment decreased c-neu expression in RG NHK cultures while TPA treatment has a lesser effect on both cytoplasmic and IFA sites. RA treatment also decreased P-Tyr staining in both NHK and SVK cells. Again, TPA had a lesser inhibitory effect on P-Tyr staining pattern. RA-treatment had a similar effect on P-Tyr staining of RG cultures of a mouse fibroblast cell line. These results confirm the generality of OA, RA and TPA on the regulation of oncogene expression in both normal and malignantly transformed keratinocytes.

关键词： Epidermal Keratinocytes Indirect Immunofluorescence Microscopy Oncogene Protein Antibodies Okadaic Acid Phosphotyrosine Antibody Retinoic Acid SV-40 Transformed Keratinocytes TPA Tumor Promoter

Cancer Chemopreventive Retinoids: Validation and Analysis of in Vivo and in Vitro Bioassay Results

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Journal of Cancer Therapy 2016年第13期7卷 1008-1033页

作者： John J. Wille jong y. Park y. Fulmer Shealy department of Biochemistry Southern Research Institute Birmingham AL USA department of Cell Biology Bioplast Medical LLC Chesterfield NJ USA department of Cancer Epidemiology Moffitt Cancer Center Tampa FL USA

Several natural and synthetic retinoids (vitamin-A derived analogies) were examined for their potential anti-cancer activity in both in vivo animal models and a novel in vitro human keratinocyte clonal growth bioassay system. The natural retinoids included all-trans-retinoic (RA), 13-cis-retinoic acid, 4-oxoretinoic acid, and retinol. Among the synthetic retinoids tested were all trans N-(4-hydroxy(phenyl)retinamide, 3-substituted oxoretinoic acids, and 13 cis-N-ethylretinamide. The animal models employed were: 1) vitamin A-deficient hamster tracheal organ assay (HTOC);2) the benzo(α)pyrene-induced squamous metaplasia in a hamster tracheal organ system (BP-HTOC);3) the mouse skin tumor promoter (TPA)-induced ornithine decarboxylase enzyme assay(ODC);4) the mouse skin papilloma (MPA) assay;and 5) a novel retinoid bioassay in which retinoids display IC50 values to inhibit clonal growth of NHK. All-trans-RA, 4-oxoretinoic acid and retinol were consistently more active than any of the synthetic derivatives in all bioassays tested. A statistical model was developed and significant positive correlations were found between: 1) ED50 values in the HTOC system and reduction in TPA-induced ODC enzyme activity;2) tumors per animal in the MPA bioassay and suppression of TPA-induced ODC activity;and 3) a positive correlation between suppression of tumors per animal in the MPA assay, and retinoid inhibition of keratinocyte clonal growth. Test retinoids, were tested for their capacity to inhibit the clonal growth of a squamous carcinoma cell line (SCC-25), which were found to be 2 - 3 logs less sensitive for each tested retinoid than the corresponding activity against NHK cells. Antineoplastic retinoid drugs were reviewed.

关键词： Cancer Chemoprevention in Vivo Bioassays in Vitro Bioassays Retinoids

Experience with postmortem computed tomography in the forensic analysis of the November 2015 Paris attacks

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Forensic Sciences Research 2020年第3期5卷 242-247页

作者： Laura W.de jong Laurence Legrand Tania delabarde Ghazi Hmeydia Myriam Edjlali Lilia Hamza Joseph Benzakoun Catherine Oppenheim Bertrand Ludes Jean-Francois Meder department of Neuroradiology GHU Paris Psychiatrie et Neurosciences-Sainte-Anne HospitalUniversite de ParisParisFrance Inserm U1266 IMA-BrainInstitut de Psychiatrie et Neurosciences de ParisParisFrance Pole Universitaire d’Imagerie Post-Mortem Universite de ParisParisFrance Institut Medico-Legal de Paris ParisFrance Service d’Accueil des Urgences Hopital AvicenneBobignyFrance Universite de Paris BABELCNRSParisFrance

Several reports discuss the added value of postmortem computed tomography(PMCT)in the forensic analysis of mass fatality incidents(MFIs),such as the 2009 Victorian bushfires,the Grenfell tower disaster and the MH17 plane crash[1–5].In France,the first deployment of PMCT in an MFI took place during the forensic analysis of the November 2015 Paris terrorist attacks.

关键词： postmortem analysis disaster

Influence of dehydrating agents on the oxidative carbonylation of methanol for dimethyl carbonate synthesis over a Cu/y-zeolite catalyst

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Chinese Journal of Chemical Engineering 2018年第5期26卷 1059-1063页

作者： Dong-Ho Lee Jiin you Je-Min Woo Jung yoon Seo young Cheol Park jong-Seop Lee Hyunuk Kim jong-Ho Moon Seung Bin Park Greenhouse Gas Laboratory Korea Institute of Energy Research department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology Energy Material Laboratory Korea Institute of Energy Research

The influence of the dehydration by metal oxides on the synthesis of dimethyl carbonate （DMC） via oxidative carbonylation of methanol was studied. A Cu/y-zeolite catalyst was prepared by the ion exchange method from CuCl2.2H2O and the commercial NH4-form of the y type zeolite, The catalyst was characterized by X-ray fluorescence （XRF）, N2 adsorption （BET method）, X-ray diffraction （XRD）, and temperature-programmed de- sorption of ammonia （NH3-TPD） to evaluate its Cu and Cl content, surface area, structure, and acidity. Reaction tests were carried out using an autoclave （batch reactor） for 18 h at 403 K and 5.5 MPa （2CH3OH ＋ 1/2O2 ＋ CO （CH3O）2CO ＋ H2O）. The influence of various dehydrating agents （ZnO, MgO, and CaO） was examined with the aim of increasing the methanol conversion （XMeOH, MeOH conversion）. The MeOH conversion increased upon addition of metal oxides in the order CaO 〉〉 MgO 〉 ZnO, with the DMC selectivity （SDMC） following the order MgO 〉 CaO 〉 ZnO. The catalysts and dehydrating agents were characterized before and after the oxidative carbonylation of methanol by thermogravimetric and differential thermogravimetric （TG/DTG）, and XRD to con- firm that the dehydration reaction occurred via the metal oxide （MO ＋ H2O →M（OH）2）. The MeOH conversion increased from 8.7% to 14.6% and DMC selectivity increased from 39.0% to 53.1%, when using the dehydrating azent CaO.

关键词： Carbon monoxide Zeolite Catalyst Dimethyl carbonate Oxidative carbonylation dehydrating agent

An annotated checklist of mammals of Kenya

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Zoological Research 2019年第1期40卷 3-52页

作者： Simon Musila Ara Monadjem Paul W.Webala Bruce D.Patterson Rainer Hutterer yvonne A.de jong Thomas M.Butynski Geoffrey Mwangi Zhong-Zheng Chen Xue-Long Jiang Mammalogy Section Department of Zoology National Museums of Kenya department of Biological Sciences University of Swaziland Mammal Research Institute Department of Zoology & Entomology University of Pretoria department of Forestry and Wildlife Management Maasai Mara University Integrative Research Center Field Museum of Natural History Zoologisches Forschungsmuseum Alexander Koenig Leibniz-Institut für Biodiversit?t der Tiere Eastern Africa Primate Diversity and Conservation Program School of Natural Resources and Environmental Studies Karatina University Sino-African Joint Research Center Chinese Academy of Sciences Kunming Institute of Zoology Chinese Academy of Sciences

Kenya has a rich mammalian fauna. We reviewed recently published books and papers including the six volumes of Mammals of Africa to develop an up-to-date annotated checklist of all mammals recorded from Kenya. A total of 390 species have been identified in the country, including 106 species of rodents,104 species of bats, 63 species of even-toed ungulates(including whales and dolphins), 36 species of insectivores and carnivores, 19 species of primates,five species of elephant shrews, four species of hyraxes and odd-toed ungulates, three species of afrosoricids, pangolins, and hares, and one species of aardvark, elephant, sirenian and hedgehog. The number of species in this checklist is expected to increase with additional surveys and as the taxonomic status of small mammals(e.g., bats, shrews and rodents) becomes better understood.

关键词： Checklist Rodents Bats Ungulate Carnivores Shrews Kenya

Photo-Activated Ferroptosis for Cancer Therapy: Advances, Challenges, and Prospects

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CCS Chemistry 2023年第8期5卷 1718-1736页

作者： Le yu yunjie Xu jong Seung Kim department of Chemistry Korea UniversitySeoul 02841

Ferroptosis, a recently identified form of non-apoptotic programmed cell death, has attracted significant attention in the field of cancer therapy due to its unique mechanism of cell death. To meet the demands of ferroptosis-mediated cancer treatment, several small molecule-based drugs have been reported for the implementation of ferroptosis. However, some cancer cells are inherently resistant to these drugs, and the lack of selectivity of these drugs against cancer cells can limit their clinical application. Recent advancements in light-mediated biomedical techniques offer a promising alternative for the development of ferroptotic therapy, that is photo-controlled activation of ferroptosis. In this review, we systematically summarize the current strategies for photo-controlled ferroptosis activation and detail analysis of the underlying mechanisms of those photo-controlled ferroptotic therapies. Finally, we discuss the challenges associated with photo-activated ferroptosis and provide an outlook on the future developments in ferroptotic cancer therapy.

关键词： photo-activated ferroptosis ferroptoticcancer therapy photosensitizer photothermal agent photocatalyst