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Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance

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cellular & Molecular Immunology 2024年第4期21卷 393-408页

作者： Sujin Lee yeunjung Ko Hyun woo Lee Won Joon Oh Hun Gi Hong Dinuka Ariyaratne Se Jin Im Tae Jin Kim Department of Immunology Graduate School of Basic Medical ScienceSungkyunkwan University School of MedicineSuwon16419Republic of Korea Department of Immunology and Molecular Medicine Faculty of Medical SciencesUniversity of Sri JayewardenepuraNugegodaSri Lanka Present address:Immunology and Microbiology Graduate Program Baylor College of MedicineHoustonTX77030USA

Marginal zone(MZ)B cells,which are splenic innate-like B cells that rapidly secrete antibodies(Abs)against blood-borne pathogens,are composed of heterogeneous ***,we showed that MZ B cells can be divided into two distinct subpopulations according to their cD80 expression ***80^(high)MZ B cells exhibited greater Ab-producing,proliferative,and IL-10-secreting capacities than did cD80^(low)MZ B ***,cD80^(high)MZ B cells survived 2-Gy whole-body irradiation,whereas cD80^(low)MZ B cells were depleted by irradiation and then repleted with one month after *** of cD80^(low)MZ B cells led to accelerated development of type II collagen(cII)-induced arthritis upon immunization with bovine ***80^(high)MZ B cells exhibited higher expression of genes involved in proliferation,plasma cell differentiation,and the antioxidant ***80^(high)MZ B cells expressed more autoreactive B cell receptors(BcRs)that recognized double-stranded DNA or cII,expressed more immunoglobulin heavy chain sequences with shorter complementarity-determining region 3 sequences,and included more clonotypes with no N-nucleotides or with B-1a BcR sequences than cD80^(low)MZ B *** transfer experiments showed that cD21^(+)cD23^(+)transitional 2 MZ precursors preferentially generated cD80^(low)MZ B cells and that a proportion of cD80^(low)MZ B cells were converted into cD80^(high)MZ B cells;in contrast,cD80^(high)MZ B cells stably remained cD80^(high)MZ B *** summary,MZ B cells can be divided into two subpopulations according to their cD80 expression levels,Ab-producing capacity,radioresistance,and autoreactivity,and these findings may suggest a hierarchical composition of MZ B cells with differential stability and BcR specificity.

关键词： Marginal Zone B cell cD80 Autoreactivity Radioresistance

Depolarization mitigated in ferroelectric Hf_(0.5)Zr_(0.5)O_(2)ultrathin films(<5 nm)on Si substrate by interface engineering

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Journal of Advanced ceramics 2024年第3期13卷 282-292页

作者： Se Hyun Kim younghwan Lee Dong Hyun Lee Geun Hyeong Park Hyun woo Jeong Kun yang yong Hyeon cho young yong Kim Min Hyuk Park Department of Materials Science and Engineering College of EngineeringSeoul National UniversitySeoul 08826Republic of Korea Research Institute of Advanced Materials College of EngineeringSeoul National UniversitySeoul 08826Republic of Korea Inter-university Semiconductor Research center College of EngineeringSeoul National UniversitySeoul 08826Republic of Korea Pohang Accelerator Laboratory Pohang University of Science&TechnologyPohang 790784Republic of Korea

(Hf,Zr)O_(2)offers considerable potential for next-generation semiconductor devices owing to its nonvolatile spontaneous polarization at the ***,scaling this material to sub-5 nm thickness poses several challenges,including the formation of an interfacial layer and high trap *** particular,a low-k SiO_(2)interfacial layer is naturally formed when(Hf,Zr)O_(2)films are directly grown on a Si substrate,leading to high depolarization fields and rapid reduction of the remanent *** address these issues,we conducted a study to significantly improve ferroelectricity and switching endurance of(Hf,Zr)O_(2)films with sub-5 nm thicknesses by inserting a TiO_(2)interfacial *** deposition of a Ti film prior to Hf_(0.5)Zr_(0.5)O_(2)film deposition resulted in a high-k TiO_(2)interfacial layer and prevented the direct contact of Hf_(0.5)Zr_(0.5)O_(2)with *** findings show that the high-k TiO_(2)interfacial layer can reduce the SiO_(2)/Si interface trap density and the depolarization field,resulting in a switchable polarization of 60.2μc/cm^(2)for a 5 nm thick Hf_(0.5)Zr_(0.5)O_(2)***,we propose that inserting a high-k TiO_(2)interfacial layer between the Hf_(0.5)Zr_(0.5)O_(2)film and the Si substrate may offer a promising solution to enhancing the ferroelectricity and reliability of(Hf,Zr)O_(2)grown on the Si substrate and can pave the way for next-generation semiconductor devices with improved performance.

关键词： ferroelectric charge trapping hafnia depolarization

Structural insights on anti-biofilm mechanism of heated slightly acidic electrolyzed water technology against multi-resistant Staphylococcus aureus biofilm on food contact surface

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Food Science and Human Wellness 2024年第3期13卷 1556-1566页

作者： Pianpian yan Ramachandran chelliah Kyoung Hee Jo Xiuqin chen Akanksha Tyagi Hyeon yeong Jo Fazle Elahi Nam chan woo Min Seung wook Deog Hwan Oh Department of Food Science and Biotechnology College of Agriculture and Life SciencesKangwon National UniversityChuncheon 24341South Korea Kangwon Institute ofInclusive Technology(KIIT) Kangwon National UniversityChuncheon 24341South Korea Saveetha School of Engineering (SIMATS)UniversitySriperumbudur 600124India Seoulin Bioscience company Seongnam-si 13488South Korea

Slightly acidic electrolyzed water(SAEW)has proven to be an efficient and novel sanitizer in food and agriculture *** study assessed the efficacy of SAEW(30 mg/L)at 40℃on the inactivation of foodbome pathogens and detachment of multi-resistant Staphylococcus aureus(MRSA)*** underlying mechanism of MRS A biofilm under heated SAEW at 40℃treatment on metabolic profiles was *** results showed that the heated SAEW at 40℃significantly effectively against foodbome pathogens of 1.96-7.56(lg(cFU/g))reduction in pork,chicken,spinach,and *** heated SAEW at 40℃treatment significantly reduced MRS A biofilm cells by 2.41(lg(cFU/cm^(2))).The synergistic effect of SAEW treatment showed intense anti-biofilm activity in decreasing cell density and impairing biofilm cell *** metabolic response of MRSA biofilms,treated by SAEW at 40℃,revealed the alterations of intracellular metabolites,including amino acids,organic acid,fatty acid,and ***,signaling pathways involved in amino acid metabolism,energy metabolism,nucleotide synthesis,carbohydrate metabolites,and lipid biosynthesis were functionally disrupted by the SAEW at 40℃*** per our knowledge,this is the first research to uncover the potential mechanism of heated SAEW treatment against MRSA biofilm on food contact surface.

关键词： Multi-resistant Staphylococcus aureus Metabolic profile SAEW Biofilm Hurdle technology Electrode material

Surface-modified Ag@Ru-P25 for photocatalytic cO_(2) conversion with high selectivity over cH_(4) formation at the solid–gas interface

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carbon Energy 2024年第1期6卷 182-196页

作者： chaitanya B.Hiragond Sohag Biswas Niket SPowar Junho Lee Eunhee Gong Hwapyong Kim Hong Soo Kim Jin-woo Jung chang-Hee cho Bryan M.Wong Su-Il In Department of Energy Science&Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of chemical&Environmental Engineering Materials Science&Engineering ProgramDepartment of ChemistryDepartment of Physics&AstronomyUniversity of California-RiversideRiversideCaliforniaUSA Department of Physics and chemistry Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea NiceScience corporation DaeguRepublic of Korea

Systematic optimization of the photocatalyst and investigation of the role of each component is important to maximizing catalytic activity and comprehending the photocatalytic conversion of cO_(2) reduction to solar fuels.A surface-modified Ag@Ru-P25 photocatalyst with H_(2)O_(2) treatment was designed in this study to convert cO_(2) and H_(2)O vapor into highly selective *** doping followed by Ag nanoparticles(NPs)cocatalyst deposition on P25(TiO_(2))enhances visible light absorption and charge separation,whereas H_(2)O_(2) treatment modifies the surface of the photocatalyst with hydroxyl(–OH)groups and promotes cO_(2) ***-resonance transmission electron microscopy,X-ray photoelectron spectroscopy,X-ray absorption near-edge structure,and extended X-ray absorption fine structure techniques were used to analyze the surface and chemical composition of the photocatalyst,while thermogravimetric analysis,cO_(2) adsorption isotherm,and temperature programmed desorption study were performed to examine the significance of H_(2)O_(2) treatment in increasing cO_(2) reduction *** optimized Ag1.0@Ru1.0-P25 photocatalyst performed excellent cO_(2) reduction activity into cO,cH4,and c2H6 with a~95%selectivity of cH4,where the activity was~135 times higher than that of pristine TiO_(2)(P25).For the first time,this work explored the effect of H_(2)O_(2) treatment on the photocatalyst that dramatically increases cO_(2) reduction activity.

关键词： gas-phase cO_(2) reduction H_(2)O_(2) treatment plasmonic nanoparticles solar fuel photocatalyst surface modification

Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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cancer communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-young Park chulhwan Kwak yoonji Lee Dae-Geun Song Jae woo Jung Haesong Lee Eun-Ae Shin yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik Kim Soyeon Kim chang-Duck Jun Jeanho yun Sun choi Hyun-woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of chemistry Seoul National UniversitySeoulRepublic of Korea college of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLcSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLcSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLcSs,leading to mitochondrial fis-sion and ***4SF5 bound NPc intracellular cholesterol transporter 1(NPc1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TcA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLcSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

Efficacy of chemotherapy containing bevacizumab in patients with metastatic colorectal cancer according to programmed cell death ligand 1

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3521-3528页

作者： Shin woo Kang Sung Hee Lim Min-Ji Kim Jeeyun Lee young Suk Park Ho yeong Lim Won Ki Kang Seung Tae Kim Division of Hematology Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Samsung Biomedical Research Institute Samsung Medical CenterSeoul 06351South Korea

BAcKGROUND Bevacizumab,an anti-vascular endothelial growth factor(VEGF)monoclonal antibody,inhibits angiogenesis and reduces tumor *** VEGF-c,lactate dehydrogenase,and inflammatory markers have been reported as predictive markers related to bevacizumab *** cell death ligand 1(PD-L1)could act upon VEGF receptor 2 to induce cancer cell angiogenesis and *** To investigate the efficacy of bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer(cRc)according to the expression of *** This analysis included cRc patients who received bevacizumab plus FOLFOX or FOLFIRI as first-line therapy between June 24,2014 and February 28,2022,at Samsung Medical center(Seoul,South Korea).Analysis of patient data included evaluation of PD-L1 expression by the combined positive score(cPS).We analyzed the efficacy of bevacizumab according to PD-L1 expression status in patients with *** A total of 124 patients was included in this *** all patients were treated with bevacizumab plus FOLFIRI or FOLFOX as the first-line *** 77%of patients received FOLFOX,23%received FOLFIRI as backbone first-line *** numbers of patients with a PD-L1 cPS of 1 or more,5 or more,or 10 or more were 105(85%),64(52%),and 32(26%),*** results showed no significant difference in progression-free survival(PFS)and overall survival(OS)with bevacizumab treatment between patients with PDL1 cPS less than 1 and those with PD-L1 cPS of 1 or more(PD-L1cPS less than 5 and of 5 or more(PD-L1cPS less than 10 and of 10 or more(PD-L1cONcLUSION chemotherapy containing bevacizumab can be considered as first-line therapy in metastatic cRc irrespective of PD-L1 expression.

关键词： Bevacizumab colorectal cancer Programmed cell death ligand 1 expression First-line chemotherapy Metastatic colorectal cancer

Microwave-accelerated direct regeneration of LicoO_(2)cathodes for Li-ion batteries

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Science china chemistry 2024年第7期67卷 2181-2189页

作者： Xueshan Hu yun-chao yin chao Li Lihui Zhou Lin yang yitian Feng Daxian Zuo chenhui Ning Das Soham Sheng Dai Longbin Qiu Lin Zeng Haw Jiunn woo Jiayu Wan Future Battery Research center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China centre for Ionics University of Malaya Department of PhysicsFaculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research center School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Natural and Applied Sciences Duke Kunshan UniversityKunshan 215316China

Recycling spent lithium-ion batteries is integral to today's low-carbon environmental protection *** concept of direct regeneration,acknowledged for its environmental sustainability,economic viability,and consistent performance of recycled materials,is gaining *** study presents an efficient and nondestructive approach by utilizing an ultrafast microwave technology to directly regenerate spent lithium cobaltate(LcO)cathode *** contrast to conventional furnacebased processes,this method significantly reduces the regeneration *** subjecting the spent LcO mixed with lithium sources to three microwave heating cycles(at approximately 1,350 K),LcO regeneration is achieved,yielding a specific capacity of 140.8 mAh g^(-1)(0.2 c)with a robust cycle *** further environmental and economic benefits,the ultrafast microwave technology holds scientific promise for directly regenerating cathode materials,while establishing competitiveness for industrial applications.

关键词： battery recycling spent lithium cobaltate microwave directly regeneration cathode materials

Over 18.2% efficiency of layer-by-layer all-polymer solar cells enabled by homoleptic iridium(III) carbene complex as solid additive

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ScIENcE BULLETIN 2024年第18期69卷 2862-2869页

作者： Zhou, Hang Sun, yingjie Zhang, Miao Ni, yuheng Zhang, Fenghua Jeong, Sang young Huang, Tianhuan Li, Xiong woo, Han young Zhang, Jian Wong, Wai-yeung Ma, Xiaoling Zhang, Fujun Beijing Jiaotong Univ Key Lab Luminescence & Opt Informat Minist Educ Beijing 100044 Peoples R China Beijing Jiaotong Univ Tangshan Res Inst Tangshan 063000 Peoples R China Hong Kong Polytech Univ Res Inst Smart Energy Dept Appl Biol & Chem Technol Hong Kong 999077 Peoples R China Beijing Technol & Business Univ Dept Phys Beijing 100048 Peoples R China Korea Univ Coll Sci Dept Chem Organ Optoelect Mat Lab Seoul 02841 South Korea Guilin Univ Elect Technol Engn Res Ctr Elect Informat Mat & Devices Sch Mat Sci & Engn Minist EducGuangxi Key Lab Informat Mat Guilin 541004 Peoples R China

The vertical phase distribution of active layers plays a vital role in balancing exciton dissociation and charge transport for achieving efficient polymer solar cells (PScs). The layer-by-layer (LbL) PScs are commonly prepared by using sequential spin-coating method from donor and acceptor solutions with distinct solvents and solvent additives. The enhanced exciton dissociation is expected in the LbL PScs with efficient charge transport in the relatively neat donor or acceptor layers. In this work, a series of LbL all-polymer solar cells (APScs) were fabricated with PM6 as donor and Py-DT as acceptor, and triplet material m-Ir(cPmPB)3 is deliberately incorporated into Py-DT layer to prolong exciton lifetimes of active layers. The power conversion efficiency (PcE) of LbL APScs is improved to 18.24% from 17.32% by incorporating 0.3 wt% m-Ir(cPmPB)3 in Py-DT layer, benefiting from the simultaneously enhanced short-circuit current density (JSc) of 25.17 mA cm-2 and fill factor (FF) of 74.70%. The enhancement of PcE is attributed to the efficient energy transfer of m-Ir(cPmPB)3 to PM6 and Py-DT, resulting in the prolonged exciton lifetime in the active layer and the increased exciton diffusion distance. The efficient energy transfer from m-Ir(cPmPB)3 to PM6 and Py-DT layer can be confirmed by the increased photoluminescence (PL) intensity and the prolonged PL lifetime of PM6 and Py-DT in PM6 + m-Ir(cPmPB)3 and Py-DT + m-Ir(cPmPB)3 films. This study indicates that the triplet material as solid additive has great potential in fabricating efficient LbL APScs by prolonging exciton lifetimes in active layers. (c) 2024 Science china Press. Published by Elsevier B.V. and Science china Press. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

关键词： Layer-by-layer All-polymer solar cells Additive strategy Triplet material Energy transfer

Light-Material Interactions Using Laser and Flash Sources for Energy conversion and Storage Applications

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Nano-Micro Letters 2024年第12期16卷 468-514页

作者： Jung Hwan Park Srinivas Pattipaka Geon-Tae Hwang Minok Park yu Mi woo young Bin Kim Han Eol Lee chang Kyu Jeong Tiandong Zhang yuho Min Kwi-Il Park Keon Jae Lee Jungho Ryu Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering)Kumoh National Institute of Technology61Daehak-RoGumiGyeongbuk 39177Republic of Korea Department of Materials Science and Engineering Pukyong National University45Yongso-RoNam-GuBusan 48513Republic of Korea Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea Division of Advanced Materials Engineering Jeonbuk National UniversityJeonju 54896JeonbukRepublic of Korea School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbin 150080People’s Republic of China Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbin 150080People’s Republic of China Department of Materials Science and Metallurgical Engineering Kyungpook National University80 Daehak-RoBuk-GuDaegu 41566Republic of Korea School of Materials Science and Engineering Yeungnam UniversityDaehak-RoGyeongsan-Si 38541Gyeongsangbuk-doRepublic of Korea

This review provides a comprehensive overview of the progress in light-material interactions(LMIs),focusing on lasers and flash lights for energy conversion and storage *** discuss intricate LMI parameters such as light sources,interaction time,and fluence to elucidate their importance in material *** addition,this study covers various light-induced photothermal and photochemical processes ranging from melting,crystallization,and ablation to doping and synthesis,which are essential for developing energy materials and ***,we present extensive energy conversion and storage applications demonstrated by LMI technologies,including energy harvesters,sensors,capacitors,and *** the several challenges associated with LMIs,such as complex mechanisms,and high-degrees of freedom,we believe that substantial contributions and potential for the commercialization of future energy systems can be achieved by advancing optical technologies through comprehensive academic research and multidisciplinary collaborations.

关键词： Light Light-material interaction Nanomaterials Energy conversion and storage devices