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Actinidia chinensis polysaccharide interferes with the epithelial-mesenchymal transition of gastric cancer by regulating the nuclear transcription factor-κb pathway to inhibit invasion and metastasis

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Journal of Traditional Chinese Medicine 2024年第5期44卷 896-905页

作者： ZHANG Guangshun xu Xiaonan xu Chuyun LIAO Guanghui xu Hao LOU Zhaohuan ZHANG Guangji School of Pharmaceutical Sciences Zhejiang Chinese Medical University Key Labortary of blood-stasis-toxin Syndrome of Zhejiang Province School of basic Medical Sciences Zhejiang Chinese Medical University Traditional Chinese Medicine "Preventing Disease" Wisdom Health Project Research Center of Zhejiang the First Affiliated Hospital of Zhejiang Chinese Medical University

ObJECTIVE: To investigate the mechanisms of the effect of Actinidia chinensis polysaccharide(ACPS) on the invasion and metastasis of gastric cancer ***: bGC-823-Luc gastric cancer cells stably transfected with a luciferase gene were used to establish an insitutransplanted tumor mouse model. A live mouse imaging system was used to observe tumor growth, and hematoxylin and eosin staining was applied to analyze tissue histopathology. Transwell and scratch wound assays were performed to examine the invasive and migratory ability of bGC-823 cells. Immunofluorescence,confocal microscopy, immunohistochemistry, and Western blot assays were used to analyze the expressions of the nuclear transcription factor-κb(NF-κb)signaling pathway and epithelial-mesenchymal transition(EMT)-related ***: ACPS significantly inhibited the growth of subcutaneously transplanted bGC-823-Luc gastric cancer tumors in nude mice and reduced inflammatory cell infiltration in tumor tissues. ACPS inhibited Epidermal Growth Factor-induced invasion, migration, and morphological changes in the cytoskeleton of bGC-823cells. ACPS inhibited gastric cancer EMT and decreased the expression of matrix metallopeptidase 9, N-cadherin and p-NF-κb p65 in transplanted tumor tissues. ACPS inhibited the expression of matrix metalloproteinases and vascular adhesion factors in bGC-823 cells, promoted p65-NF-κb nuclear translocation, and regulated proteins associated with the NF-κb p65 ***: ACPS inhibited gastric cancer invasion and metastasis both in vivo and in vitro, which evidenced the inhibition of gastric cancer EMT via regulating the NF-κb inflammatory pathway.

关键词： Actinidia chinensis polysaccharide NF-kappa b epithelial-mesenchymal transition invasion neoplasm metastasis signal transduction stomach neoplasms

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Modulating low-frequency tribocatalytic performance through defects in uni-doped and bi-doped SrTiO_(3)

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Journal of Advanced Ceramics 2024年第8期13卷 1153-1163页

作者： yjing xu yingzhi Meng xu Xiang Qing Tang Hongfang Zhang Lajun Liu Ju Gao bo xu Renhong Liang Longlong Shu yanmin Jia Wanping Chen School of Physical Science and Technology Suzhou University of Science and TechnologySuzhou 215009China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004China Key Laboratory of Advanced Electrode Materials for Novel Solar Cells for Petroleum and Chemical Industry of China Suzhou University of Science and TechnologySuzhou 215009China School of Science and Key Laboratory of biomedical Functional Materials China Pharmaceutical UniversityNanjing 211198China School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China School of Physics and Materials Science Nanchang UniversityNanchang 330031China School of Physics and Information Technology Shaanxi Normal UniversityXi'an 710062China School of Physics and Technology Wuhan UniversityWuhan 430072China

Triboelectrification,a process that transforms mechanical energy into electrical energy through friction,holds promise for eco-friendly wastewater *** study delves into the enhancement of tribocatalytic dye degradation using SrTiO_(3),a material notable for its non-piezoelectric and centrosymmetric *** synthesis of uni-and bi-doped SrTiOs particles,achieved through a solid-state reaction at 100℃,results in a high-purity cubic perovskite *** with rhodium(Rh)and carbon(C)causes crystal lattice contraction,internal stress,and significant oxygen *** changes notably improve tribocatalytic efficiency under solar irradiation,with Rh-doped SrTiO_(3) demonstrating an impressive degradation rate of approximately 88% for Rhodamine b(Rhb),along with reaction rate constants near 0.9 h^(-1) at 554 nm and a noticeable *** study highlights that defects introduced by doping are integral to this process,boosting catalytic activity through energy state modification and enhancing surface redox radical ***,these defects are instrumental in generating a flexoelectric field,which markedly influences the separation of electron-hole pairs under solar *** findings illuminate the complex interplay between material composition,defect states,and environmental conditions,paving the way for advanced strategies in environmental remediation through optimized tribocatalytic activity.

关键词： tribocatalysis SrTiO_(3)(STO) doping-induced defects blueshift flexoelectric field

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Comprehension-driven design of advanced multi-block single-ion conducting polymer electrolytes for high-performance lithium-metal batteries

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Journal of Energy Chemistry 2024年第7期94卷 357-359页

作者： xu Dong Dominic bresser Helmholtz Institute Ulm(HIU) Helmholtzstrasse 1189081 UlmGermany Karlsruhe Institute of Technology(KIT) P.O.Box 364076021 KarlsruheGermany

The continuously growing importance of batteries for powering(hybrid)electric vehicles and storing renewable energy has prompted a renewed focus on lithium-metal batteries(LMbs)in recent years,as its high theoretical specific capacity of about 3860 mA h g^(-1) and very low redox potential(-3.04 V *** standard hydrogen electrode)promise substantially higher energy densities compared to current lithium-ion batteries(LIbs)[1].However,lithium metal electrodes face severe challenges associated with the risk of dendritic lithium deposition and the high reactivity with traditional organic liquid electrolytes,resulting in a continuous loss of electrochemically active lithium and a relatively low Coulombic efficiency[2].To address these challenges,solid inorganic and polymer electrolytes have emerged as a potentially saferalternative.

关键词： lithium polymer prompt

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.bai y.bai O.bakina A.barnyakov V.blinov V.bobrovnikov D.bodrov A.bogomyagkov A.bondar I.boyko Z.H.bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.Q.Chen H.y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.y.Dong W.H.Dong V.Druzhinin D.S.Du y.J.Du Z.G.Du L.M.Duan D.Epifanov y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng y.T.Feng J.L.Fu J.Gao y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong b.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.b.He S.Q.He X.G.He y.L.He Z.b.He Z.X.Heng b.L.Hou T.J.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.y.Huang W.Q.Huang X.T.Huang X.J.Huang y.b.Huang y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.b.Jiang J.Jiang S.Z.Jiang J.b.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang b.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.Lei E.Levichev C.H.Li C.Li D.y.Li F.Li G.Li G.Li H.b.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li y.Li y.y.Li Z.J.Li H.Liang J.H.Liang y.T.Liang G.R.Liao L.Z.Liao y.Liao C.X.Lin D.X.Lin X.S.Lin b.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.b.Liu J.Liu J.J.Liu J.b.Liu K.Liu K.y.Liu K.Liu L.Liu Q.Liu S.b.Liu T.Liu X.Liu y.W.Liu y.Liu y.L.Liu Z.Q.Liu Z.y.Liu Z.W.Liu I.Logashenko y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü y.Lu y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma y.Ma y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan y.Pan E.Passemar y.P.Pei H.P.Peng L.Peng X.y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata b.b.Qi y.Q.Qi W.b.Qian y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.y.Sang Anhui University Hefei 230039China beihang University Beijing 100191China budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the bEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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Single-cell transcriptomics reveals tumor landscape in ovarian carcinosarcoma

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Journal of Zhejiang University-Science b(biomedicine & biotechnology) 2024年第8期25卷 686-699页

作者： Junfen xu Mengyan TU Department of Gynecologic Oncology Women’s HospitalZhejiang University School of MedicineHangzhou 310006China Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology Hangzhou 310006China

Objective:The present study used single-cell RNA sequencing(scRNA-seq)to characterize the cellular composition of ovarian carcinosarcoma(OCS)and identify its molecular ***:scRNA-seq was performed in resected primary OCS for an in-depth analysis of tumor cells and the tumor *** staining was used for *** scRNA-seq data of OCS were compared with those of high-grade serous ovarian carcinoma(HGSOC)tumors and other OCS ***:both malignant epithelial and malignant mesenchymal cells were observed in the OCS patient of this *** identified four epithelial cell subclusters with different biological *** them,epithelial subcluster 4 presented high levels of breast cancer type 1 susceptibility protein homolog(bRCA1)and DNA topoisomerase 2-α(TOP2A)expression and was related to drug resistance and cell *** analyzed the interaction between epithelial and mesenchymal cells and found that fibroblast growth factor(FGF)and pleiotrophin(PTN)signalings were the main pathways contributing to communication between these ***,we compared the malignant epithelial and mesenchymal cells of this OCS tumor with our previous published HGSOC scRNA-seq data and OCS *** the epithelial subclusters in the OCS tumor could be found in the HGSOC ***,the mesenchymal subcluster C14 exhibited specific expression patterns in the OCS tumor,characterized by elevated expression of cytochrome P450 family 24 subfamily A member 1(CyP24A1),collagen type XXIIIα1 chain(COL23A1),cholecystokinin(CCK),bone morphogenetic protein 7(bMP7),PTN,Wnt inhibitory factor 1(WIF1),and insulin-like growth factor 2(IGF2).Moreover,this subcluster showed distinct characteristics when compared with both another previously published OCS tumor and normal ovarian ***:This study provides the single-cell transcriptomics signature of human OCS,which constitutes a new resource for elucidating OCS diversity.

关键词： Ovarian carcinosarcoma Single-cell RNA sequencing(scRNA-seq) Tumor heterogeneity

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A DERIVATIVE-HILbERT OPERATOR ACTING FROM LOGARITHMIC bLOCH SPACES TO bERGMAN SPACES

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Acta Mathematica Scientia 2024年第5期44卷 1916-1930页

作者： Shanli yE yun xu School of Science Zhejiang University of Science and TechnologyHangzhou310023China

Letμbe a positive borel measure on the interval[0,1).The Hankel matrix■with entriesμn,k=μn+k,whereμn=⨜[0,1)tndμ(t),induces,formally,the operator■where■is an analytic function *** characterize the measuresμfor which■is bounded(resp.,compact)operator from the logarithmic bloch space■into the bergman space■,where 0≤αbounded(resp.,compact)operator from the logarithmic bloch space■into the classical bloch space■.

关键词： derivative-Hilbert operator logarithmic bloch space Carleson measure

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The high-energy particle package onboard CSES

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Radiation Detection Technology and Methods 2019年第3期3卷 45-55页

作者： X.Q.Li y.b.xu Z.H.An X.H.Liang P.Wang X.y.Zhao H.y.Wang H.Lu y.Q.Ma X.H.Shen X.y.Wen H.Wang D.L.Zhang F.Shi W.X.Peng M.Gao X.X.yu J.Z.Wang y.J.Zhang J.L.Zhang J.Zhang H.X.Li J.R.Zeng y.F.Nan Institute of High Energy Physics CASBeijing 100049China Institute of Crustal Dynamics CEABeijing 100085China Nanchang Hangkong University Nanchang 330063China Northwest University Xi’an 710127China

Introduction The China Seismo-Electromagnetic Satellite(CSES)aims to monitor space electromagnetic fields,ionospheric plasma,high-energy charged particles and other features of the global space *** high-energy particle package(HEPP),which can effectively detect the energy spectrum,flux and pitch angle distribution of space electrons and protons,and soft X-ray emission from solar flares,is one of the main payloads of *** and methods In this study,we designed,developed and calibrated the high-energy particle package and launched it into orbit with *** consists of the high-energy detector(HEPP-H),the low-energy detector(HEPP-L),and the solar X-ray monitor(HEPP-X).The three sub-detectors mainly use silicon detector and crystal calorimeter detection *** launching,we calibrated the three sub-detectors in detail by using radiation source and accelerator *** All the three sub-detectors have good energy *** launching into orbit,the space energetic particles and X-ray distribution detected by HEPP are consistent with *** performance indices of the detector reach the advanced level of the same kind of detector in the *** HEPP has a wide energy detection range,good energy resolution and high angular resolution ability for electrons and *** will play an important role in the study of space particle response and space physics of seismic activity.

关键词： ZH-1 CSES HEPP High-energy particle Radiation belt

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Adversarial data splitting for domain generalization

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Science China(Information Sciences) 2024年第5期67卷 28-42页

作者： Xiang GU Jian SUN Zongben xu School of Mathematics and Statistics Xi'an Jiaotong University

Domain generalization aims to learn a model that is generalizable to an unseen target domain,which is a fundamental and challenging task in machine learning for out-of-distribution generalization. This paper proposes a novel domain generalization approach that enforces the learned model to be able to generalize well over the train/val subset splitting of the training dataset. This idea is modeled herein as an adversarial data splitting framework, formulated as a min-max optimization problem inspired by the metalearning approach. The min-max optimization problem is solved by iteratively splitting the training dataset into the training and val subsets to maximize the domain shift measured by the objective function and updating the model parameters to enable the model to generalize well from the training subset to the val subset by minimizing the objective function. This adversarial training approach does not assume the known domain labels of the training data; instead, it automatically investigates the “hard” splitting of the train/val subsets to learn the generalizable model. Extensive experimental results using three benchmark datasets demonstrate the superiority of this approach. In addition, we derive a generalization error bound for the theoretical understanding of our proposed approach.

关键词： domain generalization adversarial learning data splitting meta-learning out of distribution

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Revealing the role of honokiol in human glioma cells by RNA-seq analysis

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bIOCELL 2024年第6期48卷 945-958页

作者： yUNbAO GUO xu LIU QI xu XIAOTONG ZHOU JIAWEI LIU yANyAN xu yAN LU HAIyAN LIU The Department of Neurosurgery First Hospital of Jilin UniversityChangchun130021China The Department of Anatomy College of Basic Medical SciencesJilin UniversityChangchun130021China The Third College of Clinical Medicine Jilin UniversityChangchun130021China

background:Glioma is a kind of tumor that easily deteriorates and originates from glial cells in nerve *** is a bisphenol compound that is an essential monomeric compound extracted from the roots and bark of Magnoliaceae *** also has anti-infection,antitumor,and immunomodulatory *** this study,we found that honokiol induces cell apoptosis in the human glioma cell lines U87-MG and ***,the mechanism through which honokiol regulates glioma cell apoptosis is still ***:We performed RNA-seq analysis of U251-MG cells treated with honokiol and control ***-protein interaction(PPI)network analysis was performed,and the 10 top hub unigenes were examined via real-time quantitative ***,MAPK signaling and ferroptosis were detected via western ***:332 differentially expressed genes(DEGs)were found,comprising 163 increased and 169 decreased *** of the DEGs revealed that various biological processes were enriched,including‘response to hypoxia’,‘cerebellum development cellular response to hypoxia,’‘iron ion binding,’‘oxygen transporter activity,’‘oxygen binding,’‘ferric iron binding,’and‘structural constituent of cytoskeleton.’Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed that the DEGs were enriched in the following pathways:‘mitogen-activated protein kinases(MAPK)’,‘Hypoxia-inducible factor 1(HIF-1)’,‘ferroptosis,’‘Peroxisome proliferator-activated receptor(PPAR),’‘Phosphatidylinositol-4,5-bisphosphate 3-kinase(PI3K)-protein kinase b(Akt),’and‘phagosome.’Among these pathways,the MAPK signaling pathway and ferroptosis were veriﬁ***:This study revealed the potential mechanism by which honokiol induces apoptosis and provided a comprehensive analysis of DEGs in honokiol-treated U251-MG cells and the associated signaling *** data could lead to new ideas for future research and therapy for patients with glioma.

关键词： Human glioma Honokiol RNA-seq Apoptosis Ferroptosis MAPK

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Design and experimental study of the end-effector for broccoli harvesting

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International Journal of Agricultural and biological Engineering 2024年第1期17卷 137-144页

作者： Xiong Zhao Gangji xu Pengfei Zhang Gaohong yu yadan xu Faculty of Mechanical Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China Key Laboratory of Transplanting Equipment and Technology of Zhejiang Province Hangzhou 310018China Hangzhou vocational&Technical College Hangzhou 310018China

The end-effector is an important part of the broccoli harvesting *** at the physical characteristics of a large broccoli head and thick stem,a spherical cutting tool broccoli harvesting end-effector was designed in this ***,the physical characteristics of broccoli were tested,and physical parameters such as the broccoli head diameter and stem diameter of broccoli were *** maximum cutting force of broccoli stems under different cutting angles was ***,according to the physical characteristics and harvesting process of broccoli,the end-effector was designed,and the mathematical model of kinematics and dynamics was *** on the results of dynamic analysis,the end-effector rod was optimized,and the unilateral width of the slider was 40 mm,the length of the connecting rod was 120 mm,and the length of the crank was 42 *** mechanism needed an external driving force of 140.54 N to cut the broccoli ***,a 32 mm cylinder with a load rate of 50%was selected as the power ***,the feasibility of the broccoli harvesting end-effector was verified by the harvesting *** showed that the overall harvesting success rate of the end-effector is 93.3%,and the smoothness rate of the stem section is 83.3%.The harvesting performance of the broccoli end-effector was *** lays a foundation for agricultural robots to harvest broccoli.

关键词： harvesting robot broccoli end-effector dynamic analysis mechanism optimization

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