检索结果-南通市图书馆

眼软脑膜型淀粉样变性的神经影像学和临床病理学特征

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(神经病学分册) 2006年第2期 51-52页

作者： Nakamura M. yamashita T. Ueda M. y.ando 方伯言 Department of Diagnostic Medicine Graduate School of Medical Sciences Kumamoto University 1-1-1 Honjo Kumamoto 860-0811 Japan.Dr

Objective: To clarify the pathogenesis of leptomeningeal amyloidosis in familial amyloidotic polyneuropathy amyloidogenic transthyretin y114C (FAP ATTR y114C). Methods: The authors analyzed eight FAP ATTR y114C patients. Six patients showed CNS symptoms associated with leptomeningeal amyloidosis. To examine the function of the blood-CSF barrier and blood-brain barrier (BBB), the authors performed CSFand MRI studies. The authors also performed a histopathologic study of autopsy specimens to examine the distribution of amyloid deposition in the CNS. Results: CSF study showed high total protein concentrations and increased albumin CSF/serum concentration quotients (Qalb; an indication of blood-CSF barrier function). MRI with gadolinium (Gd) revealed enhancement from brainstem to spinal ord. Serial brain MRI studies with FLAIR images after Gd administration showed Gd leakage into the subarachnoid space (two patients). These findings suggested the blood-CSF barrier and BBB dysfunctions. Constructive interference in steady state (CISS) three-dimensional Fourier transformation (CISS-3DFT) sequence ana lysis demonstrated amyloid-induced funiculus structures joining the spinal cord and dura mater (one patient). Histopathologic study revealed intense amyloid de position in leptomeninges, vessel walls, and parenchyma in spinal cord and the b rain. These distributions of amyloid deposition are unique compared to other TTR related leptomeningeal amyloidosis. Conclusions: Patients with familial amyloid otic polyneuropathy amyloidogenic transthyretin y114C had CNS disorders related to amyloid deposition in leptomeninges, vessel walls, and parenchyma in spinal c ord and the brain. The pathogenesis of CNS disorders may reflect disruption of t he blood-CSF barrier and blood-brain barrier by amyloid deposition.

关键词：软脑膜淀粉样变性淀粉样变代谢病淀粉样沉积

绿脓假单胞菌肺炎和巨细胞病毒肺炎的HRCT表现对比

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2015年第1期 100-101页

作者： A.K.Omeri F.Okada S.Takata A.Ono T.Nakayama y.ando Department of Radiology Oita University Faculty of Medicine

目的比较绿脓假单胞菌肺炎和巨细胞病毒肺炎病人肺部的HRCT表现。方法 124例绿脓假单胞菌肺炎病人（男77例,女47例;年龄20;9岁,平均65.4岁）和44例

关键词：巨细胞病毒肺炎绿脓假单胞菌肺部病人 HRCT 铺路石征

Refinement of Adaptive Dynamical Simulation of Quantum Mechanical Double Slit Interference Phenomenon

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Physics 2024年第3期15卷 239-249页

作者： Tadashi ando Andrei Khrennikov Ichiro yamato Department of Applied Electronics Tokyo University of Science Tokyo Japan International Center for Mathematical Modelling in Physics and Cognitive Sciences Linnaeus University V&aumlxj&oum Sweden Department of Biological Science and Technology Tokyo University of Science Tokyo Japan

We applied adaptive dynamics to double slit interference phenomenon using particle model and obtained partial successful results in our previous report. The patterns qualitatively corresponded well with experiments. Several properties such as concave single slit pattern and large influence of slight displacement of the emission position were different from the experimental results. In this study we tried other slit conditions and obtained consistent patterns with experiments. We do not claim that the adaptive dynamics is the principle of quantum mechanics, but the present results support the probability of adaptive dynamics as the candidate of the basis of quantum mechanics. We discuss the advantages of the adaptive dynamical view for foundations of quantum mechanics.

关键词： Double Slit Interference Adaptive Dynamics Quantum Mechanics Particle Model Simulation

The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2024年第1期16卷 154-162页

作者： yutaro ando Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi Okamura Akira yamaguchi Kazuyuki Ishihara Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral Health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction

维普期刊数据库

Genomic medicine in clinical practice:national genomic medicine program in Japan

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2024年第1期21卷 4-9页

作者： Teruhiko yoshida yasushi yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

急性克雷伯菌肺炎的临床与肺部薄层CT表现

国际医学放射学杂志 2009年第3期 304-304页

作者： F.Okada y.ando K.Honda T.Nakayama M.Kiyonaga A.Ono 文露 Department of Diagnostic and Interventional Radiology Oita University Faculty of MedicineOitaJapan

本研究目的是评估急性克雷伯菌肺炎的临床与肺部薄层CT表现。回顾性分析了在1991年1月和2007年12月之间行肺部薄层CT扫描的962例急性克雷伯菌肺炎。其中,764例合并有其他传染病被排除。因此,本研究组包括198例(男118例,女80例,年龄18～9... 详细信息

本研究目的是评估急性克雷伯菌肺炎的临床与肺部薄层CT表现。回顾性分析了在1991年1月和2007年12月之间行肺部薄层CT扫描的962例急性克雷伯菌肺炎。其中,764例合并有其他传染病被排除。因此,本研究组包括198例(男118例,女80例,年龄18～97岁,平均年龄61.5岁)。对基础疾病及临床表现进行了评估。

关键词：克雷伯菌肺炎肺炎 CT

Morphology and gene expression of sex‐determining region y‐box 9 and runt‐related transcription factor 2 in centrifugally compressed cell collagen‐combined constructs (C^(6))

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Biosurface and Biotribology 2023年第3期9卷 78-83页

作者： Xu ye Masashi yamazaki Wataru ando Norimasa Nakamura Hiromichi Fujie Faculty of System Design Tokyo Metropolitan UniversityTokyoJapan Research Center for Medicine‐Engineering Collaboration TokyoJapan Department of Orthopaedic Surgery Kansai Rosai HospitalAmagasakiJapan Department of Orthopaedic Surgery Osaka University Graduate School of MedicineSuitaJapan Institute for Medical Science in Sports Osaka Health Science UniversityOsakaJapan Center for Advanced Medical Engineering and Informatics Osaka UniversitySuitaJapan

The authors previously developed a scaffold‐free tissue‐engineered construct(TEC)from mesenchymal stem cells(MSCs).Although the TEC exhibited even cell distribution and was successfully applied for cartilage repair in animal models,it is unsuitable for relatively large‐scale cartilage defects due to its small *** solve the problem,the authors recently developed a novel biomaterial,a centrifugally compressed cell‐collagen combined construct(C^(6))from a mixture of MSCs and atelocollagen,both of which are subjected to *** results of the previous study indicated that C^(6) exhibited high cell viability(70%)and sufficient cell distribution similar to that of the *** the present study,the morphology and gene expression of C^(6) were *** ex-amination indicated that C6 is six times thicker(approximately 1 mm)than the TEC after a 7‐day *** C^(6) remained unchanged in scale with increased cell density after a 21‐day *** electron microscopic observation indicated that C^(6) exhibited interconnected and porous microstructures,while the TEC had close‐knit *** transcriptase‐polymerase chain reaction analysis indicated that the expression of sex‐determining region y‐box 9 and runt‐related transcription factor 2 was significantly higher in C^(6) than that in TEC.

关键词： biomaterials cartilage microstructures

Ultrasound-guided rectus sheath block for anterior cutaneous nerve entrapment syndrome after laparoscopic surgery:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第7期10卷 2357-2362页

作者： Ryuji Sawada Kunitaro Watanabe Joho Tokumine Alan Kawarai Lefor Tadao ando Tomoko yorozu Department of Pain Clinic NTT Medical Center TokyoHigashigotanda 141-8625TokyoJapan Department of Anesthesiology Hino Municipal HospitalTamadaira 191-0062TokyoJapan Department of Anesthesiology Kyorin University School of MedicineMitaka 181-8611TokyoJapan Department of Surgery Jichi Medical UniversityShimotsuke 329-0498TochigiJapan

BACKGROUND Anterior cutaneous nerve entrapment syndrome is defined as abdominal pain due to entrapped intercostal *** is the first report of a patient successfully treated for anterior cutaneous nerve entrapment syndrome after laparoscopic surgery with an ultrasound-guided rectus sheath *** rectus sheath block physically lysed adhesions and relieved pain from anterior cutaneous nerve entrapment *** SUMMARy The patient is a 44-year-old man who presented with severe left upper abdominal pain at an operative scar one month after laparoscopic ulcer *** and treatment were performed using an ultrasound-guided rectus sheath block with 0.1%lidocaine 20 *** pain was relieved after the *** diagnosis was anterior cutaneous nerve entrapment *** sheath block may be effective for patients with anterior cutaneous nerve entrapment *** Ultrasound-guided rectus sheath block is a promising treatment modality for patients with postoperative anterior cutaneous nerve entrapment syndrome due to adhesions.

关键词： Anterior cutaneous nerve entrapment syndrome Rectus sheath block Hydrodissection Laparoscopic surgery Case report

Aggregation-enhanced direct S_(0)-T_(n) transitions and room-temperature phosphorescence in gold(I)-complex single crystals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aggregate

Aggregate 2022年第1期3卷 159-167页

作者： Akihiro ando Kazuhisa Ozaki Urara Shiina Eikichi Nagao Kyohei Hisano Kenji Kamada Osamu Tsutsumi Department of Applied Chemistry Ritsumeikan UniversityKusatsuJapan Nanomaterials Research Institute(NMRI) National Institute of Advanced Industrial Science and Technology(AIST)IkedaJapan

The design of efficient aggregation-induced emission materials requires an improved understanding of photophysical processes in aggregated ***,the photophysical behavior of an Au(I)complex(R6)that exhibits intense roomtemperature phosphorescence(RTP)in crystals is *** addition,the photophysical processes related to RTP are discussed based on the structure of the molecular aggregates and the primary structure of the *** extremely efficient S_(0)-T_(n) direct transition is found to occur in the R6 ***,intermolecular Au-Au interactions and the internal/external heavy-atom effects of Au atoms are demonstrated to enhance the electronic transitions involving intersystem crossing,namely,direct S_(0)-T_(n) excitation,radiative T_(1)-S_(0) transition(phosphorescence),and S_(1)-T_(n) intersystem *** of the dense molecular packing,both Au-Au interactions and heavy-atom effects play important roles in the *** a result,R6 shows more efficient RTP in crystals than in *** insights into the mechanism of highly efficient RTP in Au(I)-complex crystals are expected to advance the development of new luminogens for a variety of sensing and imaging applications.

关键词： aggregation-induced emission aurophilic interaction gold(I)complex phosphorescence spin-forbidden transition