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Acta Mechanica Solida Sinica 2020年第1期33卷 98-120页

作者： z.wan y.P.yao z.W.Gao Research Institute of Base and Foundation China Academy of Building ResearchBeijing 100013China School of Transportation Science and Engineering Beihang UniversityBeijing 100091China School of Engineering University of GlasgowGlasgow G128QQUK

Widely distributed in natural deposits,the overconsolidated(OC)clays have attracted extensive experimental investigations on their mechanical behaviors,especially in the 1960s and *** on these results,numerous constitutive models have also been *** models generally fall into two categories:one based on the classical plasticity theory and the other the bounding surface(BS)plasticity theory,with the latter being more popular and *** BS concept and the subloading surface(SS)concept are the two major BS plasticity *** features of these two concepts and the representative models based on them are introduced,*** unified hardening(UH)model for OC clays is also based on the BS plasticity theory but distinguishes itself from other models by the integration of the reference yield surface,unified hardening parameter,potential failure stress ratio,arid transformed stress *** is made to the Hvorslev envelop employed in the UH model to improve its capability of describing the behaviors of clays with extremely high overconsolidation ratio in this *** comparison among the BS model,SS model,and UH model is *** shows that all these three models can characterize the fundamental behaviors of OC clays,such as the stress dilatancy,strain softening and attainment of the critical *** UH model with the revised Hvorslev envelop has the fewest parameters which are identical to those of the modified Cam-Clay model.

关键词： Clay Overconsolidation Critical state Bounding surface Subloading surface Unified hardening model

A method for analyzing on-line video images of crystallization at high-solid concentrations

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Particuology 2008年第1期6卷 9-15页

作者： Jian wan Cai y. Ma Xue z. wang Institute of Particle Science and Engineering School of Process Environmental and Materials Engineering University of Leeds Leeds LS2 9JT UK

Recent research has demonstrated that on-line video imaging is a very promising technique for monitoring crystallization processes. The bottleneck in applying the technique for real-time closed-loop control is considered as image analysis that needs to be robust, fast and able to handle varied image qualities due to temporal variations of operating conditions such as mixing and solid concentrations. Image analysis at highsolid concentrations turns out to be extremely challenging because crystals tend to overlap or attach to each other and the boundaries between the crystals are usually ambiguous. This paper presents an image segmentation algorithm that can effectively deal with images taken at high-solid concentrations. The method segments crystals attached to each other along the mostly related concave points on the contours of crystal blocks. The detailed procedure is introduced with application to crystallization of L-glutamic acid in a hot-stage reactor.

关键词： Crystallization High-solid concentrations Image processing Multi-scale segmentation Watershed segmentation Crystal size distribution

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Flavones in pomelo peel resist fibril formation of human islet amyloid polypeptide

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Chinese Herbal Medicines 2025年第1期17卷 166-177页

作者： Cuiyun Gao zhiruo wan yan Liu yuting Meng Xu Chen Xiaohan Tang Lingyu Hang Hailong yuan Department of Pharmacy Air Force Medical Center Air Force Medical University

Objective:Exploring the formation and aggregation of human islet amyloid polypeptide(hIAPP)(amylin)fibers is significant for promoting the prevention and treatment of type II diabetes mellitus(T2DM).Flavones in pomelo peel have visible biological activity in the anti-diabetes *** present study aimed to investigate the effects of five flavones [naringin(NRG),narirutin(NRR),nobiletin(NOB),sinensetin(SIN),and neohesperidin(NHP)] in pomelo peel on peptide aggregation and explore its possible *** cell viability of flavones against peptide aggregation was also ***:The thioflavin T(ThT) assay and transmission electron microscopy(TEM) were used for evaluating the inhibition and disaggregation of flavones on peptide *** interaction mechanism was analyzed by endogenous fluorescence,molecular dynamics(MD) simulations,ultraviolet spectroscopy(UV) and isothermal titration calorimetry(ITC) *** 3-[4,5-dimethylthiazol-2-y l]-2,5-diphenyl tetrazolium bromide(MTT) and immune assays were performed to characterize the cell viability of flavones against peptide ***:The five flavones showed a decrease in fluorescence intensity,fiber number and size under incubation with different molar ratios of *** compounds can bind to the aromatic tyrosine(Tyr)residueTyr 37,resulting in the intrinsic fluorescence quenching of the *** flavones can form hydrogen bonds with hIAPP,which is likely to be based on their phenolic hydroxyl *** showed strong binding affinity with *** reaction system of NRG and NRR observed an exothermic reaction,and the others were endothermic *** absorption peaks of the compounds with hIAPP changed and showed hypochromic effects,indicating that there may be π-π stacking *** noticeably increased the cell viability in the presence of amyloid peptides and reduced the absorption intensity induced by peptide ***:A total of five flav

关键词： flavones human islet amyloid polypeptide inhibition interaction pomelo peel peptide aggregation

The MON1–CCz1 complex plays dual roles in autophagic degradation and vacuolar protein transport in rice

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Journal of Integrative Plant Biology 2025年第1期67卷 35-54页

作者： Binglei zhang yihua wang yun zhu Tian Pan Haigang yan Xin wang Ruonan Jing Hongming Wu Fan wang yu zhang Xiuhao Bao yongfei wang Pengcheng zhang yu Chen Erchao Duan Xiaohang Han Gexing wan Mengyuan yan Xiejun Sun Cailin Lei zhijun Cheng zhichao zhao Ling Jiang yiqun Bao yulong Ren Jianmin wan State Key Laboratory of Crop Gene Resources and Breeding National Key Facility for Crop Gene Resources and Genetic ImprovementInstitute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China College of Life Sciences Nanjing Agricultural UniversityNanjing 210095China State Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization Nanjing Agricultural UniversityNanjing 210095China zhongshan Biological Breeding Laboratory Nanjing 210095China

Autophagy is a highly conserved cellular program in eukaryotic cells which mediates the degradation of cytoplasmic components through the lysosome,also named the vacuole in ***,the molecular mechanisms underlying the fusion of autophagosomes with the vacuole remain ***,we report the functional characterization of a rice(Oryza sativa)mutant with defects in storage protein transport in endosperm cells and accumulation of numerous autophagosomes in root *** and immunocytochemical experiments showed that this mutant exhibits a defect in the fusion between autophagosomes and *** mutant harbors a loss-of-function mutation in the rice homolog of Arabidopsis thaliana MONENSIN SENSITIVITy1(MON1).Biochemical and genetic evidence revealed a synergistic interaction between rice MON1 and AUTOPHAGy-RELATED 8a in maintaining normal growth and *** addition,the rice mon1 mutant disrupted storage protein sorting to protein storage ***,quantitative proteomics verified that the loss of MON1 function influenced diverse biological pathways including autophagy and vacuolar transport,thus decreasing the transport of autophagic and vacuolar cargoes to ***,our findings establish a molecular link between autophagy and vacuolar protein transport,and offer insights into the dual functions of the MON1–CCz1(CAFFEINE zINC SENSITIVITy1)complex in plants.

关键词： autophagic degradation MON1–CCz1 Rab7 rice vacuolar trafficking

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Deep view of composite SNR CTA1 with LHAASO in γ-rays up to 300 TeV

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： zhen Cao F.Aharonian Axikegu y.X.Bai y.W.Bao D.Bastieri X.J.Bi y.J.Bi W.Bian A.V.Bukevich Q.Cao W.y.Cao zhe Cao J.Chang J.F.Chang A.M.Chen E.S.Chen H.X.Chen Liang Chen Lin Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen S.Chen S.H.Chen S.z.Chen T.L.Chen y.Chen N.Cheng y.D.Cheng M.C.Chu M.y.Cui S.W.Cui X.H.Cui y.D.Cui B.z.Dai H.L.Dai z.G.Dai Danzengluobu X.Q.Dong K.K.Duan J.H.Fan y.z.Fan J.Fang J.H.Fang K.Fang C.F.Feng H.Feng L.Feng S.H.Feng X.T.Feng y.Feng y.L.Feng S.Gabici B.Gao C.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge T.T.Ge L.S.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo J.Guo X.L.Guo y.Q.Guo y.y.Guo y.A.Han O.A.Hannuksela M.Hasan H.H.He H.N.He J.y.He y.He y.K.Hor B.W.Hou C.Hou X.Hou H.B.Hu Q.Hu S.C.Hu C.Huang D.H.Huang T.Q.Huang W.J.Huang X.T.Huang X.y.Huang y.Huang y.y.Huang X.L.Ji H.y.Jia K.Jia H.B.Jiang K.Jiang X.W.Jiang z.J.Jiang M.Jin M.M.Kang I.Karpikov D.Khangulyan D.Kuleshov K.Kurinov B.B.Li C.M.Li Cheng Li Cong Li D.Li F.Li H.B.Li H.C.Li Jian Li Jie Li K.Li S.D.Li W.L.Li W.L.Li X.R.Li Xin Li y.z.Li zhe Li zhuo Li E.W.Liang y.F.Liang S.J.Lin B.Liu C.Liu D.Liu D.B.Liu H.Liu H.D.Liu J.Liu J.L.Liu M.y.Liu R.y.Liu S.M.Liu W.Liu y.Liu y.N.Liu Q.Luo y.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao z.Min W.Mitthumsiri H.J.Mu y.C.Nan A.Neronov K.C.y.Ng L.J.Ou P.Pattarakijwanich z.y.Pei J.C.Qi M.y.Qi B.Q.Qiao J.J.Qin A.Raza D.Ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.W.Shu H.C.Song yu.V.Stenkin V.Stepanov y.Su D.X.Sun Q.N.Sun X.N.Sun z.B.Sun J.Takata P.H.T.Tam Q.W.Tang R.Tang z.B.Tang W.W.Tian L.H.wan C.wang C.B.wang G.W.wang H.G.wang H.H.wang J.C.wang Kai wang Kai wang L.P.wang L.y.wang P.H.wang R.wang W.wang X.G.wang X.y.wang y.wang y.D.wang y.J.wang z.H.wang z.X.wang zhen wang zheng wang D.M.Wei J.J.Wei y.J.Wei T.Wen C.y.Wu H.R.Wu Q.W.Wu S.Wu X.F.Wu y.S.Wu S.Q.Xi J.Xia G.M.Xiang D.X.Xiao G.Xiao y.L.Xin y.Xing D.R.Xiong z.Xiong D.L.Xu R.F.Xu R.X.Xu W.L.Xu L.Xue D.H.yan J.z.yan T.yan C.W.yang C.y.yang F.yang F.F.yang L.L.yang M.J.yang R.z.yang W.X.yang y.H.yao z.G.yao L.Q.yin N.yin X.H.you z.y.you y.H Southwest Jiaotong University School of Astronomy and Space Science Nanjing University Center for Astrophysics Guangzhou University Tsung-Dao Lee Institute & School of Physics and Astronomy Shanghai Jiao Tong University Institute for Nuclear Research of Russian Academy of Sciences Hebei Normal University University of Science and Technology of China LHAASO Collaboration State Key Laboratory of Particle Detection and Electronics Key Laboratory of Dark Matter and Space Astronomy & Key Laboratory of Radio Astronomy Purple Mountain Observatory Chinese Academy of Sciences Research Center for Astronomical Computing zhejiang Laboratory Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Key Laboratory of Particle Astrophysics & Experimental Physics Division & Computing Center yunnan University Key Laboratory of Cosmic Rays (Tibet University) Ministry of Education Department of Physics The Chinese University of Hong Kong Key Laboratory of Radio Astronomy and Technology National Astronomical Observatories Chinese Academy of Sciences School of Physics and Astronomy (zhuhai) & School of Physics (Guangzhou) & Sino-French Institute of Nuclear Engineering and Technology (zhuhai) Sun yat-sen University Institute of High Energy Physics Institute of Frontier and Interdisciplinary Science Shandong University APC Université Paris Cité CNRS/IN2P3 CEA/IRFU Observatoire de Paris Department of Engineering Physics & Department of Astronomy Tsinghua University School of Physics and Microelectronics Chinese Academy of Sciences zhengzhou University yunnan Observatories Chinese Academy of Sciences China Center of Advanced Science and Technology College of Physics Sichuan University School of Physics Peking University Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and Technology University of Chinese Academy of Sciences Guangxi University Department of Physics Faculty of Science Mahidol University Moscow Institute

The ultra-high-energy（UHE） gamma-ray source 1LHAASO J0007+7303u is positionally associated with the composite SNR CTA1 that is located at high Galactic Latitude b ≈ 10.5°. This provides a rare opportunity to spatially resolve the component of the pulsar wind nebula（PWN） and supernova remnant（SNR） at UHE. This paper conducted a dedicated data analysis of 1LHAASO J0007+7303u using the data collected from December 2019 to July 2023. This source is well detected with significances of 21σ and 17σ at 8-100 TeV and >100 TeV, respectively. The corresponding extensions are determined to be 0.23°±0.03°and 0.17°±0.03°. The emission is proposed to originate from the relativistic electrons accelerated within the PWN of PSR J0007+7303. The energy spectrum is well described by a power-law with an exponential cutoff function dN/dE =（42.4 ± 4.1）(E/（20 TeV）)-2.31±0.11exp(-E/（110±25 TeV）) TeV-1cm-2s-1in the energy range from 8 to 300 TeV, implying a steady-state parent electron spectrum dNe/dEe∝(Ee/（100 TeV）)-3.13±0.16exp[(-Ee/（373±70 TeV）)2] at energies above ≈ 50 TeV. The cutoff energy of the electron spectrum is roughly equal to the expected current maximum energy of particles accelerated at the PWN terminal shock. Combining the X-ray and gamma-ray emission, the current space-averaged magnetic field can be limited to≈ 4.5 μG. To satisfy the multi-wavelength spectrum and the γ-ray extensions, the transport of relativistic particles within the PWN is likely dominated by the advection process under the free-expansion phase assumption.

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LHAASO detection of very-high-energy γ-ray emission surrounding PSR J0248+6021

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Science China(Physics,Mechanics & Astronomy) 2025年

We report the detection of an extended very-high-energy(VHE) γ-ray source coincident with the location of middle-aged(62.4 kyr) pulsar PSR J0248+6021, by using the LHAASO-WCDA data of live 796 d and LHAASO-KM2A data of live 1216d. A significant excess of γ-ray induced showers is observed both by WCDA in energy bands of 1-25 Te V and KM2A in energy bands of >25 TeV with 7.3σ and 13.5σ, respectively. The best-fit position derived through WCDA data is R.A. = 42.06°± 0.12°and Dec. = 60.24°± 0.13°with an extension of 0.69°±0.15°and that of the KM2A data is R.A.= 42.29°± 0.13°and Dec. =60.38°± 0.07°with an extension of 0.37°±0.07°. No clear extended multiwavelength counterpart of this LHAASO source has been found from the radio band to the GeV band. The most plausible explanation of the VHE γ-ray emission is the inverse Compton process of highly relativistic electrons and positrons injected by the pulsar. These electrons/positrons are hypothesized to be either confined within the pulsar wind nebula or to have already escaped into the interstellar medium, forming a pulsar halo.

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Observation of the γ-ray emission from W43 with LHAASO

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Science China(Physics,Mechanics & Astronomy) 2025年

In this paper, we report the detection of the very-high-energy (VHE, 100 Ge V100 TeV) γ-ray emissions from the direction of the young star-forming region W43, observed by the Large High Altitude Air Shower Observation (LHAASO). The extended γ-ray source was detected with a significance of～16σby KM2A and～17σby WCDA, respectively. The angular extension of this γ-ray source is about 0.5 degrees, corresponding to a physical size of about 50pc. We discuss the origin of the γ-ray emission and possible cosmic ray acceleration in the W43 region using multi-wavelength data. Our findings suggest that W43 is likely another young star cluster capable of accelerating cosmic rays (CRs) to at least several hundred TeV.

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Regulatory T cells: immune suppression and beyond

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Cellular & Molecular Immunology 2010年第3期7卷 204-210页

作者： yisong y wan Lineberger Comprehensive Cancer Center Department of Microbiology and ImmunologyThe University of North Carolina at Chapel HillSchool of MedicineNorth CarolinaNCUSA

Foxp3-expressing regulatory T cells(Tregs)were originally identified as critical in maintaining self-tolerance and immune *** immunosuppressive functions of Tregs are widely acknowledged and have been extensively *** studies have revealed many diverse roles of Tregs in shaping the immune system and the inflammatory *** review will discuss our efforts as well as the efforts of others towards understanding the multifaceted function of Tregs in immune regulation.

关键词： Foxp3 Treg immunosuppression and plasticity

Loading-unloading judgement for advanced plastic UH model

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Acta Mechanica Sinica 2020年第4期36卷 827-839页

作者： X.Feng y.P.yao R.N.Li z.wan X.Dai College of Airport Civil Aviation University of ChinaTianjin 300300China School of Transportation Science and Engineering Beihang UniversityBeijing 100191China School of Automobile and Transportation Tianjin University of Technology and EducationTianjin 300222China Research Institute of Base and Foundation China Academy of Building ResearchBeijing 100013China

The unified hardening(UH)model proposed by yao et al.(Geotechnique 2009)is the constitutive model which can consider the influence of the complex stress path and stress history on the deformation and strength of clays ***,the loading-unloading criterion of material model is defined as the change law of the intersection of current yield surface and the p axis,which makes the loading-unloading in the process of hardening and softening can be unified considered in UH ***,the Newton-Raphson method is adopted to attain the nonlinear problems solution in the finite element method of UH model,and the semi-implicit return mapping method is adopted to update *** application of the UH model in the finite element is *** then,the analyses of triaxial test are performed using the unit prediction and finite element *** results of the unit prediction method are compared with the experimental results to illustrate the rationality of the UH *** the results with the unit prediction method and the finite element method,the correctness of the finite element program of the UH model is ***,Ae three-dimensional firdte element andysis of embankment on soft soil is performed by the *** comparison between the results calculated by the UH model and the modified Cam-clay(MCC)model and the experimental data shows that the UH model is rational in analyzing the actual embankment engineering on soft soil.

关键词： Over-consolidated clay Unified hardening model Loading-unloading judgement Finite element method Stress-strain