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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei weng Guijun Bi youxiang Chew Shang Sui Chaolin Tan Zhenglin Du Jinlong Su Fern Lan Ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

Assembly of Highly Ordered 2D Arrays of Silver-PNIPAM Hybrid Microgels

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Chinese Journal of Polymer Science 2017年第10期35卷 1212-1221页

作者： Jun-ying weng Zhuo Tang 关英 x.x.Zhu 张拥军 Key Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal Chemical Biology The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300071 China Department of Chemistry Universite de Montreal C. P. 6128 Succursale Centre-ville Montreal QC H3C 3J7 Canada

A strategy was developed for the synthesis of highly ordered 2D arrays of Ag-PNIPAM hybrid microgel. The highly ordered 2D arrays of PNIPAM microgel were prepared by dispersing PNIPAM microgel on a charge-reversible substrate. The microgel spheres self-assembled into a 3D colloidal crystal, and the first 111 plane was fixed in situ onto the substrate as a result of spontaneous charge reversal of the substrate, leaving a high-quality 2D array of PNIPAM microgel. Ag nanoparticles were then synthesized in situ inside the microgel spheres by introduction of Ag＋ ions into the microgel spheres and reduction with sodium borohydride. The resulting 2D arrays are highly ordered. The inter-particle distance in the array can be tuned. In addition, the method allows the synthesis of large size arrays and the use of nonplanar substrate.

关键词： bonding conductive triazine intermolecular Hydrogen PEDOT responsive glycol polyethylene compressive

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao weng Adam M.R.Groh Moein yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

THE SyNTHESIS OF STEROID-OLIGOPEPTIDE

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Chinese Chemical Letters 1995年第8期6卷 663-666页

作者： Zhang, x weng, LL Zheng, H Guangdong Med Coll Dept Biochem Zhanjiang 524023 Peoples R China W China Univ Med Sci Sch Pharm Chengdu 610041 Peoples R China

Six new compounds-steroid-oligopeptide were designed and synthesized with active ester method,their structures (CA-G(1), DCA-G(1), CA-G(2), DCA-G(2), CA-G(3), DCA-G(3)) were confirmed by spectra and elemental analysis. Preliminary study on their bioactivities showed that the DCA-G(3) his the ability of acid-inhibition and the others have the ability of promoting acid-secretion. The metabolic time of six title compounds are longer than the positive control(Boc-G(2)).

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Glass-forming Ability and Corrosion Resistance of Zr—Cu—Al—Co Bulk Metallic Glass

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Journal of Materials Science & Technology 2016年第4期32卷 349-354页

作者： W.Zhou W.P.weng J.x.Hou Shagang School of Iron and Steel Soochow University

Investigations were carried out to examine the effects of Co addition on the glass-forming ability （GFA） and corrosion resistance of Zr46Cu46AI8 bulk metallic glass in chloride-containing solution. It is found that the GFA of （Zr46Cu46Al8）100-xCox （x = 0, 1, 2, and 4 at.%） alloys reduces with the increase in Co content and correlates well with the parameters, such as the supercooled liquid region width ATx, the reduced glass transition temperature Trg and γ. The corrosion resistance is however found to be enhanced with the in- crease in Co concentration. The addition of Co causes the enrichment of Zr and Al, but depletes Cu in the surface films, which effectively enhances the corrosion potential and lowers the corrosion current density.

关键词： Bulk metallic glassCo-additionGlass-forming abilityCorrosion resistance

III-Nitride-Based Quantum Dots and Their Optoelectronic Applications

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Nano-Micro Letters 2011年第3期3卷 200-207页

作者： G.E.weng A.K.Ling x.Q.Lv J.y.Zhang B.P.Zhang Department of Physics Laboratory of Micro-Nano Optoelectronics Xiamen University MEMS Research Center Xiamen University

During the last two decades, III-nitride-based quantum dots(QDs) have attracted great attentions for optoelectronic applications due to their unique electronic properties. In this paper, we first present an overview on the techniques of fabrication for III-nitride-based QDs. Then various optoelectronic devices such as QD lasers, QD light-emitting diodes(LEDs), QD infrared photodetectors(QDIPs) and QD intermediate band(QDIB) solar cells(SCs) are discussed. Finally, we focus on the future research directions and how the challenges can be overcome.

关键词： III-nitride-based quantum dots Lasers Light-emitting diods Infrared photodetectors Solar cells

有机肥氮替代化肥氮对青稞生长特性、叶片碳氮平衡和氮代谢酶活性的影响

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麦类作物学报 2025年第1期45卷 121-129页

作者：闫佳会翁华何涛青海大学/省部共建三江源生态与高原农牧业国家重点实验室青海西宁810016

为探讨青藏高原有机肥氮替代化肥氮对青稞生长及碳氮代谢的影响,在氮磷钾施用量相同条件下,通过盆栽试验,比较分析了不同比例有机肥氮替代化肥氮(0%、40%和100%,分别记为ORF0、ORF40、ORF100)处理下青稞品种昆仑14号生长特性、叶片碳氮... 详细信息

为探讨青藏高原有机肥氮替代化肥氮对青稞生长及碳氮代谢的影响,在氮磷钾施用量相同条件下,通过盆栽试验,比较分析了不同比例有机肥氮替代化肥氮(0%、40%和100%,分别记为ORF0、ORF40、ORF100)处理下青稞品种昆仑14号生长特性、叶片碳氮平衡和氮代谢酶活性的差异。结果表明,与ORF0处理相比,ORF40处理下青稞的根系长度、老叶碳氮比均显著增加(P<0.05),株高及地上部和根系生物量变化不显著;ORF100处理下株高和地上部生物量均显著降低,根系长度和生物量均显著增加,新叶的碳氮比显著提高。与ORF0处理相比,ORF40处理的老叶中谷氨酸合成酶(GOGAT)和谷氨酸脱氢酶(GDH)活性在苗期至扬花期分别增加1.18%~2.53%和17.39%~39.40%(P<0.05);ORF100处理的新叶和老叶GOGAT活性无明显变化规律,GDH活性显著降低。ORF40处理的新叶谷氨酰胺合成酶(GS)活性在抽穗期和扬花期均高于ORF0处理,新叶中谷草转氨酶(GOT)活性在苗期至扬花期显著增加,增幅22.22%~35.29%;ORF100处理的新叶和老叶GS活性均显著下降。综合来看,与ORF0处理相比,ORF40处理下青稞根长和株高变化较小,叶片拥有更稳定的碳氮比,且老叶中谷氨酸合成酶和谷氨酸脱氢酶活性增加,新叶中GS活性和GOT增加,ORF40处理的新叶与老叶都保持了一定的氮代谢能力,其中老叶的氮代谢能力更为稳定,说明适宜比例的有机肥替代化肥有助于青稞植株稳健生长和碳氮代谢。

关键词：青稞有机肥替代生长特性碳氮比氮代谢酶

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Supposition of graphene stacks to estimate the contact resistance and conductivity of nanocomposites

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 663-676页

作者： y.ZARE M.T.MUNIR G.J.weng K.y.RHEE Biomaterials and Tissue Engineering Research Group Department of Interdisciplinary TechnologiesBreast Cancer Research CenterMotamed Cancer InstituteTehran ***Iran College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait Department of Mechanical and Aerospace Engineering Rutgers UniversityNew BrunswickNJ 08903U.S.A. Department of Mechanical Engineering(BK21 Four) College of EngineeringKyung Hee UniversityYongin 446701Republic of Korea

In this study,the effects of stacked nanosheets and the surrounding interphase zone on the resistance of the contact region between nanosheets and the tunneling conductivity of samples are evaluated with developed equations superior to those previously *** contact resistance and nanocomposite conductivity are modeled by several influencing factors,including stack properties,interphase depth,tunneling size,and contact *** developed model's accuracy is verified through numerous experimental *** further validate the models and establish correlations between parameters,the effects of all the variables on contact resistance and nanocomposite conductivity are ***,the contact resistance is primarily dependent on the polymer tunnel resistivity,contact area,and tunneling *** dimensions of the graphene nanosheets significantly influence the conductivity,which ranges from 0 S/m to90 S/*** increased number of nanosheets in stacks and a larger gap between them enhance the nanocomposite's ***,the thicker interphase and smaller tunneling size can lead to higher sample conductivity due to their optimistic effects on the percolation threshold and network efficacy.

关键词： graphene polymer composite stacked nanosheet tunneling conductivity contact resistance interphase

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外泌体miRNA参与肿瘤化疗耐药的机制

中国组织工程研究 2025年第7期29卷 1504-1511页

作者：翁宗琴赵海龙遵义医科大学病理生理学教研室贵州省遵义市563000

背景:化疗作为癌症治疗的常见手段,前期具有一定的治疗效果,但随着化疗次数增加,肿瘤细胞对药物的抵抗性也逐渐增加,即化疗耐药性。目前化疗耐药性产生的主要机制包括化疗药物未能达到肿瘤部位,药物活性丧失导致药效下降,肿瘤细胞通过... 详细信息

背景:化疗作为癌症治疗的常见手段,前期具有一定的治疗效果,但随着化疗次数增加,肿瘤细胞对药物的抵抗性也逐渐增加,即化疗耐药性。目前化疗耐药性产生的主要机制包括化疗药物未能达到肿瘤部位,药物活性丧失导致药效下降,肿瘤细胞通过重塑代谢功能、基因表型和微环境逃避药物攻击等,但具体机制还有待深入探讨。目的:归纳并总结不同肿瘤中外泌体miRNA参与耐药的机制,提出潜在靶点。方法:以“hematological malignancies,liver cancer,lung cancer,breast cancer,melanoma,colorectal cancer,drug resistance,exosomal miRNAs”为英文检索词,检索PubMed数据库。检索时间范围为2013年1月至2023年8月。通过阅读文题和摘要进行初步筛选,排除与此次研究内容相关性差或内容重复的文献,最后纳入60篇文献进行综述。结果与结论:(1)外泌体miRNA进入细胞间质和循环,通过发挥局部旁分泌或远端效应,参与不同肿瘤生物进程的形成和发展,包括肿瘤微环境重塑、血管生成和耐药性产生;(2)外泌体miRNA可以透过细胞膜进入另一个细胞的胞浆内,通过传递miRNA启动或抑制受体细胞中的信号通路,在化疗过程中维持细胞存活、增殖和转移能力,从而导致耐药产生;(3)目前已经鉴定出许多与化疗耐药有关的外泌体miRNA,并将其作为常见肿瘤治疗靶点来开展研究;(4)虽然外泌体miRNA作为潜在的生物标志物和治疗靶点具有很大的前景,但仍有一些研究缺陷需要解决:一是缺乏用于外泌体分离和表征的标准化方案,导致不同研究中使用的方法存在差异;二是虽然外泌体中miRNA的存在和丰度已被广泛研究,但其功能作用和作用机制尚不完全清楚,阐明外泌体miRNA调控的特定靶点和途径可以为它们的生物学意义和潜在的治疗应用提供有价值的见解。解决这些研究缺陷将有助于更全面了解外泌体miRNA及其在各个领域的潜在应用,包括诊断、治疗和个性化医疗。

关键词：肿瘤化疗耐药外泌体 miRNA 病理生理学机制转移增殖肿瘤微环境