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国际医学放射学杂志 2024年第3期 377-377页

作者： s.yoon y.s.shim s.H.Park J.sung M.D.Nickel y.J.Kim 余翔玲

摘要目的旨在比较肝硬化病人用压缩感知（Cs）和同时应用超快速并行采集技术（CAPIRINHA）的肝胆期（HBP）成像的影像质量和局灶病变检测能力。方法回顾性纳入

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Tetramic acid-motif natural products from a marine fungus Tolypocladium cylindrosporum FB06 and their anti-Parkinson activities

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Marine Life science & Technology 2024年第1期6卷 84-92页

作者： yuna Jung Chaesun Kwon Taeyeon Kim Jin Woo Lee Min-Kyoo shin sang Hee shim Natural Products Research Institute College of PharmacySeoul National UniversitySeoul 08826Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical sciences Seoul National UniversitySeoul 08826Republic of Korea College of Pharmacy Duksung Women’s UniversitySeoul 01369Republic of Korea

Tetramic acid-containing natural products are attracting significantly increasing attention from biologists and chemists due to their intriguing structures and biological *** the present study,two new tetramic acid alkaloids tolypyridone I(1)and tolypyridone J(2),together with five known ones(3–7),were isolated from cultures of a marine fungus Tolypocladium cylindrosporum FB06 isolate obtained from a marine sediment in Beaufort sea of North *** structures were elucidated using 1D,2D NMR,and *** configurations were established on the basis of 1H coupling constants,ROEsy correlations and DP4 *** 2 was isolated as mixtures of rotational isomers with C-3 to C-7 axis between 4-hydroxy-2-pyridone and 1-ethyl-3,5-dimethylcyclohexane,hindering *** our unbiased screening to discover neuroprotective compounds in an in vitro Parkinson’s disease(PD)model,sH-sy5y dopaminergic cells were treated with isolated compounds followed by treatment with 1-methyl-4-phenylpyridinium(MPP^(+)),a parkinsonian *** tested compounds,F-14329(7)significantly protected cells from MPP^(+)-induced ***^(+)-mediated cell death is known to be related to the regulation of Bcl-2 family proteins,specifically the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax *** with 2 mmol/L of MPP^(+)for 24 h significantly reduced Bcl-2 levels compared to control treated with ***,treatment with F-14329(7)attenuated such *** study demonstrates that tetramic acid-motif compounds could be potential lead compounds for treating PD.

关键词： Tolypocladium cylindrosporum Tetramic acid Tolypyridone Parkinson’s disease

New insights into ATR inhibition in muscle invasive bladder cancer:The role of apolipoprotein B mRNA editing catalytic subunit 3B

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Oncology Research 2024年第6期32卷 1021-1030页

作者： HyUNHO KIM UIJU CHO sOOK HEE HONG HyUNG sOON PARK IN-HO KIM HO JUNG AN ByOUNG yONG shim JIN HyOUNG KANG Division of Medical Oncology Department of Internal MedicineSt.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwonKorea Department of Pathology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwonKorea Division of Medical Oncology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulKorea

Background:Apolipoprotein B mRNA editing catalytic polypeptide(APOBEC),an endogenous mutator,induces DNA damage and activates the ataxia telangiectasia and Rad3-related(ATR)-checkpoint kinase 1(Chk1)*** cisplatin-based therapy is the mainstay for muscle-invasive bladder cancer(MIBC),it has a poor survival ***,this study aimed to evaluate the efficacy of an ATR inhibitor combined with cisplatin in the treatment of APOBEC catalytic subunit 3B(APOBEC3B)expressing ***:Immunohistochemical staining was performed to analyze an association between APOBEC3B and ATR in patients with *** APOBEC3B expression in MIBC cell lines was assessed using real-time polymerase chain reaction and western blot *** blot analysis was performed to confirm differences in phosphorylated Chk1(pChk1)expression according to the APOBEC3B *** viability and apoptosis analyses were performed to examine the anti-tumor activity of ATR inhibitors combined with ***:There was a significant association between APOBEC3B and ATR expression in the tumor tissues obtained from patients with *** with higher APOBEC3B expression showed higher pChk1 expression than cells expressing low APOBEC3B *** treatment of ATR inhibitor and cisplatin inhibited cell growth in MIBC cells with a higher APOBEC3B *** to cisplatin single treatment,combination treatment induced more apoptotic cell death in the cells with higher APOBEC3B ***:Our study shows that APOBEC3B’s higher expression status can enhance the sensitivity of MIBC to cisplatin upon ATR *** result provides new insight into appropriate patient selection for the effective application of ATR inhibitors in MIBC.

关键词： Apolipoprotein B mRNA editing catalytic polypeptide(APOBEC) Ataxia telangiectasia and Rad3-related(ATR) Bladder cancer DNA damage response DNA replication stress

简化MRI联合选择性多期CT作为全序列MRI的替代方法：HCC筛查队列的LI-RADs验证

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国际医学放射学杂志 2020年第3期 378-378页

作者： s.H.Park B.Kim s.y.Kim y.s.shim J.H.Kim J.Huh 柴一桐 Department of Radiology Gil Medical Center Gachon University College of Medicine

摘要目的为了比较联合多期CT (mCT)的简化MRI(AMRI)和全序列钆塞酸增强MRI(EOB-MRI)在肝细胞癌(HCC)筛查队列中的诊断价值。方法从3个中心回顾性招

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RUFy4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

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Bone Research 2024年第2期12卷 407-420页

作者： Minhee Kim Jin Hee Park Miyeon Go Nawon Lee Jeongin seo Hana Lee Doyong Kim Hyunil Ha Taesoo Kim Myeong seon Jeong suree Kim Taesoo Kim Han sung Kim Dongmin Kang Hyunbo shim soo young Lee Department of Life science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FyVE domain-containing protein 4(RUFy4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFy4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFy4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

Key Considerations on the Industrial Application of Lignocellulosic Biomass Pyrolysis Toward Carbon Neutrality

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Engineering 2023年第10期29卷 35-38页

作者： shu Zhang Kan Zou Bin Li Hojae shim yong Huang Joint International Research Laboratory of Biomass Energy and Materials Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesCollege of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China school of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013China Department of Civil and Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacao 999078China

*** importance of biomass in carbon neutrality With the increasing urgency to mitigate climate change,over 100 countries have committed to net-zero carbon emissions by the mid-21st century[1].For example,China has announced that it will reach a carbon peak and carbon neutrality,with the rapid development of renewable energy undoubtedly playing a key role in achieving these *** with other renewable energy sources,such as wind energy,solar energy.

关键词： doubt Biomass neutral

Bimetallic Ni-Co MOF@PAN modified electrospun separator enhances high-performance lithium-sulfur batteries

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Journal of Energy Chemistry 2023年第7期82卷 484-496,I0010页

作者： Xiaolong Leng Jie Zeng Mingdai yang Changping Li s.V.Prabhakar Vattikuti Jielin Chen shuang Li Jaesool shim Tong Guo Tae Jo Ko school of Mechanical Engineering Yeungnam UniversityGyeongsangbuk-do 38541Republic of Korea College of Mechanical and Electrical Engineering Hunan University of Science and TechnologyXiangtan 411201HunanChina Key Laboratory for soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and TechnologyNanjing 210094JiangsuChina

Lithium-sulfur(Li-s)batteries with high energy density are considered promising energy storage devices for the next ***,the shuttle effect and the passive layer between the separator and the electrodes still seriously affect the cycle stability and ***,a bimetallic Ni-Co metal-organic framework(MOF)with adsorption and catalytic synergism for polysulfides was successfully synthesized as an electrospinning separator sandwich for Li-s *** porous Ni-Co MOF coatings into the separator provides more adsorption catalytic sites for polysulfides,prevents their diffusion to the anode,and enhances sulfur ***,the improved Li-s batteries with a Ni-Co MOF@PAN(NCMP)electrospun separator delivered excellent rate performance and outstanding cycle stability,yielding an ultra-high initial capacity of 1560 mA h g^(-1)at 0.1 ***,remarkable Li-s battery performance with a discharge capacity of 794 mA h g^(-1)(84.1%capacity retention)was obtained after500 cycles,while delivering a low capacity decay rate of 0.032%during long-term cycling(up to 500cycles)at 1 ***,even at the current density of 2 C,the capacity attenuation rate of 2000 cycles is only 0.034%per *** addition,compared with the Celgard separator,the NCMP separator also had high thermal stability(keeping the separator outline at 200℃)that ensured battery safety and excellent electrolyte wettability(73%porosity and 535%electrolyte absorption)and significantly enhanced the ionic conductivity and Li^(+) transfer number,and protected the surface integrity of the anode.

关键词： Li-s batteries Ni-Co MOF Adsorption catalysis synergistic effect

Boosting electrocatalytic activity with the formation of abundant heterointerfaces and N, s dual-doped carbon nanotube for rechargeable Zn-air battery

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Journal of Energy Chemistry 2023年第9期84卷 140-152页

作者： Rin Na Kyeongseok Min Hyejin Kim yujin son sang Eun shim sung-Hyeon Baeck Department of Chemistry and Chemical Engineering Education and Research Center for Smart Energy Materials and ProcessInha UniversityIncheon 22212Republic of Korea

Herein,a facile synthetic strategy is proposed to fabricate high-performance electrocatalysts for rechargeable Zn-air batteries(ZABs).Heterostructured NiCo/NiCo_(2)s_(4) nanoparticles encapsulated in N-,s-co-doped CNT(NiCo/NiCo_(2)s_(4)@NsCNT) are synthesized via co-precipitation,thermal carbonization,and partial sulfidation *** strongly coupled NiCo/NiCo_(2)s_(4) heterostructure can improve the redox property and charge transfer ***,the CNTs with abundant foreign dopants provide high electrical conductivity and abundant defect sites for both the oxygen evolution reaction(OER) and oxygen reduction reaction(ORR).The prepared NiCo/NiCo_(2)s_(4)@NsCNT electrocatalyst exhibits a low overpotential of 349 mV at a current density of 10 mA cm-2 and a half-wave potential of 0.865 V for the OER and ORR,***,the ZAB assembled using as-prepared NiCo/NiCo_(2)s_(4)@NsCNT can provide superior specific capacity(756.16 mA h g_(Zn)^(-1)],peak power density(155.82 mW cm^(-2)),and long-term cyclability compared to those of the precious metal-based electrocatalyst(Pt/C+RuO_(2)).

关键词： Bifunctional electrocatalyst NiCo alloy Bimetallic sulfide Heterojunction Zinc–air battery

Organic photodiode with dual functions of indoor photovoltaic and high-speed photodetector

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Frontiers of Optoelectronics 2022年第2期15卷 45-51页

作者： Tae Wook Kim sung Hyun Kim Jae Won shim Do Kyung Hwang Center of Opto-Electronic Materials and Devices Post-Silicon Semiconductor InstituteKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea school of Electrical Engineering Korea UniversitySeoul02841Republic of Korea Division of Nano&Information Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea

Energy harvesting and light detection are key technologies in various emerging optoelectronic *** high absorption capability and bandgap tunability of organic semiconductors make them promising candidates for such ***,a poly(3-hexylthiophene-2,5-diyl)(P3HT):indene-C60 bisadduct(ICBA)bulk heterojunction-based organic photodiode(OPD)was reported,demonstrating dual functionality as an indoor photovoltaic(PV)and as a high-speed *** OPD demonstrated decent indoor PV performance with a power conversion efficiency(PCE)of(11.6±0.5)%under a light emitting diode(LED)lamp with a luminance of 1000 *** a photodetector,this device exhibited a decent photoresponsivity of 0.15 A/W(green light)with an excellent linear dynamic range(LDR)of over 127 dB within the optical power range of 3.74×10^(−7) to 9.6×10^(−2) W/cm^(2).Furthermore,fast photoswitching behaviors could be observed with the rising/falling times of 14.5/10.4μs and a cutoff(3 dB)frequency of 37 *** results might pave the way for further development of organic optoelectronic applications.

关键词： Organic semiconductor Photodiode Indoor photovoltaics Photodetector

Boosting Pseudocapacitive Behavior of supercapattery Electrodes by Incorporating a schottky Junction for Ultrahigh Energy Density

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Nano-Micro Letters 2023年第5期15卷 15-35页

作者： selvaraj seenivasan Kyu In shim Chaesung Lim Thangavel Kavinkumar Amarnath T.sivagurunathan Jeong Woo Han Do-Heyoung Kim school of Chemical Engineering Chonnam National University77 Yongbong-RoGwangju 61186Republic of Korea Division of Environmental science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Pseudo-capacitive negative electrodes remain a major bottleneck in the development of supercapacitor devices with high energy density because the electric double-layer capacitance of the negative electrodes does not match the pseudocapacitance of the corresponding positive *** the present study,a strategically improved Ni-Co-Mo sulfide is demonstrated to be a promising candidate for high energy density supercapattery devices due to its sustained pseudocapacitive charge storage *** pseudocapacitive behavior is enhanced when operating under a high current through the addition of a classical schottky junction next to the electrode-electrolyte interface using atomic layer *** schottky junction accelerates and decelerates the diffusion of OH-/K+ions during the charging and discharging processes,respectively,to improve the pseudocapacitive *** resulting pseudocapacitive negative electrodes exhibits a specific capacity of 2,114 C g^(-1)at 2 A g^(-1)matches almost that of the positive electrode’s 2,795 C g^(-1)at 3 A g^(-1).As a result,with the equivalent contribution from the positive and negative electrodes,an energy density of 236.1 Wh kg^(-1)is achieved at a power density of 921.9 W kg^(-1)with a total active mass of 15 mg *** strategy demonstrates the possibility of producing supercapacitors that adapt well to the supercapattery zone of a Ragone plot and that are equal to batteries in terms of energy density,thus,offering a route for further advances in electrochemical energy storage and conversion processes.

关键词： Pseudo-capacitance Negative electrode supercapattery Atomic layer deposition Energy density