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Ultrafast laser processing of camouflaged metals by topography inherited multistep removal for information encryption

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Nano Research 2024年第8期17卷 7242-7249页

作者： Guangzhi He Jianfeng yan Jiawang Xie Ming qiao Ma Luo yuzhi Zhao Haoze Han State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China

Surfaces with micro-nanoscale structures show different optical responses,including infrared reflection,thermal radiation,and protective *** realization of structure camouflage is important for material ***,external cloaks or coatings are necessary in structure camouflage,which limits the surface ***,we propose a novel strategy for the direct structure camouflage through topography inherited removal(TIR)with ultrafast laser,featuring pristine topography preservation and scattering surface *** multistep TIR,pristine topographies are partially and uniformly removed to preserve the original designed *** response changes show the suppression of specular reflection by uniformizing reflected light intensity to a low level on the inherited *** produce various structure camouflages on large scaled substrates,and demonstrate applications of information encryption in code extraction and word recognition through structure *** proposed strategy opens opportunities for infrared camouflage and other technologies,such as thermal management,device security,and information encryption.

关键词： topography inherited removal ultrafast laser structure camouflage optical response information encryption

Rehabilitation care for pain in elderly knee replacement patients

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World Journal of Clinical Cases 2024年第4期12卷 721-728页

作者： Li Liu qiao-Zhen Guan Li-Fang Wang Wuhan Fourth Hospital Wuhan 430033Hubei ProvinceChina department of Orthopaedics Wuhan Third HospitalWuhan 430074Hubei ProvinceChina

BACKGROUND Total knee arthroplasty(TKA)is recognized as the most effective surgical intervention for relieving pain and improving joint mobility and deformity in patients with knee osteoarthritis and other synovial *** application of accelerated postoperative rehabilitation(enhanced recovery after surgery)has demonstrated its efficacy in improving patient outcomes,and early postoperative joint function exercise has become a key prognostic factor in knee *** unexpected appearance of limb pain and swelling hindered the patient’s tendency for early mobilization,leading in prolonged hospitalization,delayed functional recovery and negative psychological responses.A retrospective analysis was conducted on a cohort of 116 patients who under-went TKA at our hospital between July 2019 and July *** patients were divided into two groups:A control group(n=58)receiving programmatic nur-sing,and an observed group(n=58)receiving programmed nursing combined with a collaborative nursing model.A pain management team consisting of attending physicians,head nurses,and responsible nurses was *** measures included visual analogue scale(VAS)scores,activities of daily living(ADL)scale scores,and functional *** ADL scores of patients in both groups exhibited a continuous ***,there was no statistically significant difference in the ADL scores between the two groups at 48 h and the 7th d post-surgery(P>0.05).Upon reexamination at the 3rd mo,the observation group demonstrated higher ADL scores compared to the control group(67.48±14.69 vs 59.40±16.06,Py decreased,with no significant difference observed between the groups at each time point(P>0.05).The functional status of patients in both groups exhibited a gradual increase prior to intervention and at the 1st,2nd,and 3rd month following discharge(Py significant difference in knee joint function scores b

关键词： Programmed pain nursing Collaborative nursing Total knee arthroplasty

A polymyxin B loaded hypoxia-responsive liposome with improved biosafety for efficient eradication of bacterial biofilms

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Nano Research 2024年第9期17卷 8325-8336页

作者： Fang Liu Lingyun Zou yongcheng Chen Zuolong Liu yue Huang qiao Jin Jian Ji MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Transvascular Implantation Devices The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310009China

Biofilm-associated bacterial infection brings serious threats to global public health owing to serious antibiotic *** is urgently needed to develop innovative strategies to combat biofilm-associated bacterial *** stand out as the last line of defense against Gram-negative ***,serious nephrotoxicity of polymyxins severely limits their clinical ***,a hypoxia-responsive liposome is designed as the nanocarrier of polymyxin B(PMB)to combat biofilms developed by Gram-negative bacteria.A metronidazole modified lipid(hypoxia-responsive lipid(HRLipid))is synthesized to fabricate hypoxia-responsive liposomes(HRLip).PMB loaded hypoxia-responsive liposomes(HRL-PMB)is then prepared to mitigate the nephrotoxicity of PMB while preserving its excellent bactericidal ***-PMB shows very low hemolysis and cytotoxicity due to liposomal encapsulation of *** can be readily released from HRL-PMB in response to hypoxic biofilm microenvironment,exerting its bactericidal activity to realize biofilm *** excellent in vivo antibiofilm ability of HRL-PMB is confirmed by a Pseudomonas aeruginosa infected zebrafish model and a *** pneumonia infection ***,HRL-PMB can greatly reduce the nephrotoxicity of PMB after intravenous *** hypoxia-sensitive liposomes held great promise to improve the biosafety of highly toxic antibiotics while preserving their intrinsic bactericidal ability,which may provide an innovative strategy for combating biofilm-associated infections.

关键词： bacterial biofilm hypoxia liposome polymyxin B nephrotoxicity

CONTACT FRICTION ANALySIS AND STRESS OSCILLATION SUPPRESSION WITH A SIMPLE INTERFACE ELEMENT

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Acta Mechanica Solida Sinica 2000年第1期13卷 33-41页

作者： Lei Xiaoyan (department of civil engineering,East China Jiaotong university,Nanchang 330013,China) department of civil engineering East China Jiaotong University Nanchang 330013 China

A simple interface element for analyzing contact friction problems is developed. Taking nodal displacements and contact stresses as unknowns, this element can simulate frictional slippage, decoupling and re-bonding of two bodies initially mating or having gaps at a common interface. The method is based on the Finite Element Method and load incremental theory. The geometric and static constraint conditions on contact surfaces are treated as additional conditions and are included in stiffness equations. This simple element has the advantages of easy implementation into standard finite element programs and fast speed for convergence as well as high accuracy for stress distribution in interface. Undesirable stress oscillations are also investigated whenever large stress gradients exist over the contact surfaces. Exact integration or the conventional Gauss integration scheme used to evaluate the interpolation function matrix of the interface element is found to be the source of the oscillations. Eigenmode analysis demonstrates that the stress behavior of an interface element can be improved by using the Newton-Cotes integration scheme. Finally, the test example of a strip footing problem is presented.

关键词： contact friction interface element stress oscillation eigenmode analysis

Immune checkpoint inhibitor-associated gastritis:Patterns and management

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World Journal of Gastroenterology 2024年第14期30卷 1941-1948页

作者： Jing Lin Zhong-qiao Lin Shi-Cheng Zheng yu Chen department of Medical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350000Fujian ProvinceChina Phase I Clinical Trial Ward Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350000Fujian ProvinceChina School of Basic Medical Sciences Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina

Immune checkpoint inhibitors(ICIs)are widely used due to their effectiveness in treating various ***-related adverse events(irAEs)are defined as adverse effects resulting from ICI *** irAEs are a common type of irAEs characterized by intestinal side effects,such as diarrhea and colitis,which may lead to the cessation of *** irAE gastritis is rarely reported,it may lead to serious complications such as ***,irAE gastritis is often difficult to identify early due to its diverse *** steroid hormones and immunosuppressants are commonly used to reverse irAEs,the best regimen and dosage for irAE gastritis remains *** addition,the risk of recurrence of irAE gastritis after the reuse of ICIs should be *** this editorial,strategies such as early identification,pathological diagnosis,mana-gement interventions,and immunotherapy rechallenge are discussed to enable clinicians to better manage irAE gastritis and improve the prognosis of these patients.

关键词： Immunotherapy Immune checkpoint inhibitor Immune-related adverse events Immune checkpoint inhibitor-related gastritis

Regulation role of miR-204 on SIRT1/VEGF in metabolic memory induced by high glucose in human retinal pigment epithelial cells

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1232-1237页

作者： qiao-Ling Lai Ting Xie Wei-Dong Zheng yan Huang department of Ophthalmology Renmin Hospital of Wuhan UniversityWuhan 460060Hubei ProvinceChina department of Ophthalmology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina department of Ophthalmology&Optometry Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina

AIM:To examine the regulatory role of microRNA-204(miR-204)on silent information regulator 1(SIRT1)and vascular endothelial growth factor(VEGF)under highglucose-induced metabolic memory in human retinal pigment epithelial(hRPE)***:Cells were cultured with either normal(5 mmol/L)or high D-glucose(25 mmol/L)concentrations for 8d to establish control and high-glucose groups,*** induce metabolic memory,cells were cultured with 25 mmol/L D-glucose for 4d followed by culture with 5 mmol/L D-glucose for *** addition,exposed in 25 mmol/L D-glucose for 4d and then transfected with 100 nmol/L miR-204 control,miR-204 inhibitor or miR-204 mimic in 5 mmol/L D-glucose for *** reverse transcription-polymerase chain reaction(RT-qPCR)was used to detect miR-204 mRNA ***1 and VEGF protein levels were assessed by immunohistochemical and Western *** cytometry was used to investigate apoptosis ***:It was found that high glucose promoted miR-204 and VEGF expression,and inhibited SIRT1 activity,even after the return to normal glucose culture *** of miR-204 promoted apoptosis inhibiting SIRT1 and increasing VEGF ***,downregulation of miR-204 produced the opposite ***:The study identifies that miR-204 is the upstream target of SIRT1and VEGF,and that miR-204 can protect hRPE cells from the damage caused by metabolic memory through increasing SIRT1 and inhibiting VEGF expression.

关键词： human retinal pigment epithelial metabolic memory microRNA-204 silent information regulator 1 vascular endothelial growth factor high-glucose

Temporally consistent video colorization with deep feature propagation and self-regularization learning

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Computational Visual Media 2024年第2期10卷 375-395页

作者： yihao Liu Hengyuan Zhao Kelvin CKChan Xintao Wang Chen Change Loy yu qiao Chao Dong Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China university of Chinese Academy of Sciences Beijing 100049China department of Electrical&Computer engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798 Applied Research Center Tencent PCGShenzhenChina

Video colorization is a challenging and highly ill-posed *** recent years have witnessed remarkable progress in single image colorization,there is relatively less research effort on video colorization,and existing methods always suffer from severe flickering artifacts(temporal inconsistency)or unsatisfactory *** address this problem from a new perspective,by jointly considering colorization and temporal consistency in a unified ***,we propose a novel temporally consistent video colorization(TCVC)*** effectively propagates frame-level deep features in a bidirectional way to enhance the temporal consistency of ***,TCVC introduces a self-regularization learning(SRL)scheme to minimize the differences in predictions obtained using different time *** does not require any ground-truth color videos for training and can further improve temporal *** demonstrate that our method can not only provide visually pleasing colorized video,but also with clearly better temporal consistency than state-of-the-art methods.A video demo is provided at https://***/watch?v=c7dczMs-olE,while code is available at https://***/lyh-18/TCVC-Tem porally-Consistent-Video-Colorization.

关键词： video colorization temporal consistency feature propagation self-regularization

Study on multi-scheme analysis and evaluation method for concrete sequence placement of high arch dam

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Science China(Technological Sciences) 2011年第S1期54卷 47-53页

作者： ZHONG GuiLiang,REN Bingyu & TONG DaWei department of Hydraulic and Hydroelectric engineering,School of civil engineering,Tianjin university,Tianjin 300072,China department of Hydraulic and Hydroelectric engineering School of Civil Engineering Tianjin University Tianjin China

A complete scheme for solving the key scientific problems of how to make concrete sequence placement scheme of high arch dam reasonable and feasible and how to meet the need of construction process was ***,based on a coupling analysis of concrete sequence placement system of high arch dam,a mathematical model considering complex construction constraints was ***,a multi-scheme computational analysis method for concrete sequence placement of high arch dam was proposed based on dynamic ***,a multi-scheme evaluation method for concrete sequence placement was put forward based on analytic hierarchy ***,feedback guidance for progress control and management in the high arch dam construction process was ***,these methods were applied to a practical project to show that the methods can analyze and evaluate multi-scheme for concrete sequence placement of high arch dam effectively,optimize the process of dam concrete sequence placement,and recommend engineering *** methods provide new theoretical principles and technical measures for real-time progress control in the high arch dam construction.

关键词： sequence placement analysis multi-scheme evaluation dynamic simulation analytic hierarchy process high arch dam construction

Research on analysis method for temperature control information of high arch dam construction

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Science China(Technological Sciences) 2011年第S1期54卷 40-46页

作者： ZHONG DengHua,ZHAO ChenSheng & REN Bingyu department of Hydraulic and Hydroelectric engineering,School of civil engineering,Tianjin university,Tianjin 300072,China department of Hydraulic and Hydroelectric engineering School of Civil Engineering Tianjin University Tianjin China

Temperature control,which is directly responsible for the project quality and progress,plays an important role in high arch dam *** to discover the rules from a large amount of temperature control information collected in order to guide the adjustment of temperature control measures to prevent cracks on site is the key scientific *** this paper,a mathematic logical model was built firstly by means of a coupling analysis of temperature control system decomposition and coordination for high arch ***,an analysis method for temperature control information was presented based on data mining ***,the data warehouse of temperature control was designed,and the artificial neural network forecasting model for the highest temperature of concrete was also ***,these methods were applied to a practical project. The result showed that the efficiency and precision of temperature control was improved,and rationality and scientificity of management and decision-making were *** of these researches provided an advanced analysis method for temperature control in the high arch dam construction process.

关键词： high arch dam construction temperature control information data mining data warehouse neural network model