检索结果-南通市图书馆

ROS-responsive hydrogels with spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs for the repair of MRSA-infected wounds

在线全文

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2024年第1期3卷 119-131页

作者： Bowen qiao Jiaxin Wang Lipeng qiao Aziz Maleki yongping Liang Baolin Guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Zanjan Pharmaceutical Nanotechnology Research Center(ZPNRC) Zanjan 45139-56184Iran department of Orthopaedics The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061People’s Republic of China

For the treatment of MRSA-infected wounds,the spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs is a promising *** this study,ROS-responsive HA-PBA/PVA(HPA)hydrogel was prepared by phenylborate ester bond cross-linking between hyaluronic acid-grafted 3-amino phenylboronic acid(HA-PBA)and polyvinyl alcohol(PVA)to achieve spatiotemporally controlled release of two kinds of drug to treat MRSA-infected *** hydrophilic antibiotic moxifloxacin(M)was directly loaded in the *** hydrophobic curcumin(Cur)with anti-inflammatory function was first mixed with Pluronic F127(PF)to form Cur-encapsulated PF micelles(Cur-PF),and then loaded into the HPA *** to the different hydrophilic and hydrophobic nature of moxifloxacin and Cur and their different existing forms in the HPA hydrogel,the final HPA/M&Cur-PF hydrogel can achieve different spatiotemporally sequential delivery of the two *** addition,the swelling,degradation,self-healing,antibacterial,anti-inflammatory,antioxidant property,and biocompatibility of hydrogels were ***,in the MRSA-infected mouse skin wound,the hydrogel-treated group showed faster wound closure,less inflammation and more collagen *** experiments further confirmed that the hydrogel promoted better repair by reducing inflammation(TNF-a)and promoting vascular(VEGF)*** conclusion,this HPA/M&CurPF hydrogel that can spatiotemporally sequential deliver antibacterial and anti-inflammatory drugs showed great potential for the repair of MRSA-infected skin wounds.

关键词： MRSA-infected wounds spatiotemporally sequential delivery antibacterial anti-inflammatory

Supercoiled DNA Minicircles under Double-strand Breaks

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第9期42卷 1353-1359,I0007页

作者： ye-Peng qiao Chun-Lai Ren National Laboratory of Solid State Microstructures and department of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China

Understanding how supercoiled DNA releases intramolecular stress is essential for its functional ***,the molecular mechanism underlying the relaxation process remains insufficiently *** we employed MD simulations based on the oxDNA2 model to investigate the relaxation process of a 336-base pair supercoiled minicircular DNA under double-strand breaks with two fixed *** simulations show that the conformational changes in the DNA occur continuously,with intramolecular stress release happening abruptly only when the DNA chain traverses the breakage *** relaxation process is influenced not only by the separation distance between the fixed ends but also their ***,we observe an inhibitory effect on the relaxation characterized by small angles,where short terminal loops impede DNA conformational adjustments,preserving the supercoiled *** findings elucidate the intricate interplay between DNA conformational change,DNA motion and intramolecular stress release,shedding light on the mechanisms governing the relaxation of supercoiled DNA at the molecular level.

关键词： Supercoiled DNA DNA minicircle DNA relaxation oxDNA model MD simulation

Spin Resolved Zero-Line Modes in Minimally Twisted Bilayer Graphene from Exchange Field and Gate Voltage

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2024年第7期41卷 111-116页

作者： Sanyi you Jiaqi An Zhenhua qiao International Centre for Quantum Design of Functional Materials CAS Key Laboratory of Strongly Coupled Quantum Matter Physicsand Department of PhysicsUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

The reliance on spin-orbit coupling or strong magnetic fields has always posed significant challenges for the mass production and even laboratory realization of most topological materials. Valley-based topological zero-line modes have attracted widespread attention due to their substantial advantage of being initially realizable with just an external electric field. However, the uncontrollable nature of electrode alignment and precise fabrication has greatly hindered the advancement in this field. By utilizing minimally twisted bilayer graphene and introducing exchange fields from magnetic substrates, we successfully realize a spin-resolved, electrode-free topological zeroline mode. Further integration of electrodes that do not require alignment considerations significantly enhances the tunability of the system's band structure. Our approach offers a promising new support for the dazzling potential of topological zero-line mode in the realm of low-energy-consumption electronics.

关键词： structure field topological

Preface to the Special Issue in Celebration of Professor Shouwen yu’s 85th Birthday

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 2024年第3期37卷 361-362页

作者： Xi-qiao Feng Qunyang Li department of engineering Mechanics Tsinghua UniversityBeijing100084China

Shouwen yu,Emeritus Professor of Applied Mechanics at Tsinghua university,was born on May 4,1939 in Xianyou County,Fujian Province,*** pursued his undergraduate studies from 1955 to 1958 in the department of civil Str... 详细信息

关键词： Fujian Preface pursue

Potential role of hippocampal neurogenesis in spinal cord injury induced post-trauma depression

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第10期19卷 2144-2156页

作者： ying Ma yue qiao Xiang Gao Spinal Cord and Brain Injury Research Group Stark Neuroscience Research InstituteIndianapolisINUSA department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA department of Neurology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropathic pain, bladder/bowel dysfunction, and loss of sexual function, there are a variety of secondary complications, including memory loss, cognitive decline, depression, and Alzheimer's disease. The largescale longitudinal population-based studies indicate that post-trauma depression is highly prevalent in spinal cord injury patients. yet, few basic studies have been conducted to address the potential molecular mechanisms. One of possible factors underlying the depression is the reduction of adult hippocampal neurogenesis which may come from less physical activity, social isolation, chronic pain, and elevated neuroinflammation after spinal cord injury. However, there is no clear consensus yet. In this review, we will first summarize the alteration of hippocampal neurogenesis post-spinal cord injury. Then, we will discuss possible mechanisms underlie this important spinal cord injury consequence. Finally, we will outline the potential therapeutic options aimed at enhancing hippocampal neurogenesis to ameliorate depression.

关键词： antidepressants chronic pain depression exercise hippocampal neurogenesis inflammation inhibition neuroinflammation physical activity deficits social isolation spinal cord injury

Self-centering seismic retrofit scheme for reinforced concrete frame structures:SDOF system study

在线全文

学校读者我要写书评

暂无评论

Earthquake engineering and engineering Vibration 2010年第2期9卷 271-283页

作者： yunfeng Zhang and Xiaobin Hu department of civil and Environmental engineering,university of Maryland,College Park,MD 20742,usa department of civil and Environmental engineering University of Maryland College Park USA College Park USA

This paper presents the results of a parametric study of self-centering seismic retrofit schemes for reinforced concrete (RC) frame buildings. The self-centering retrofit system features flag-shaped hysteresis and minimal residual deformation. For comparison purpose,an alternate seismic retrofit scheme that uses a bilinear-hysteresis retrofit system such as buckling-restrained braces (BRB) is also considered in this paper. The parametric study was carried out in a single-degree-of-freedom (SDOF) system framework since a multi-story building structure may be idealized as an equivalent SDOF system and investigation of the performance of this equivalent SDOF system can provide insight into the seismic response of the multi-story building. A peak-oriented hysteresis model which can consider the strength and stiffness degradation is used to describe the hysteretic behavior of RC structures. The parametric study involves two key parameters -the strength ratio and elastic stiffness ratio between the seismic retrofit system and the original RC frame. An ensemble of 172 earthquake ground motion records scaled to the design basis earthquake in California with a probability of exceedance of 10% in 50 years was constructed for the simulation-based parametric study. The effectiveness of the two seismic retrofit schemes considered in this study is evaluated in terms of peak displacement ratio,peak acceleration ratio,energy dissipation demand ratio and residual displacement ratio between the SDOF systems with and without retrofit. It is found from this parametric study that RC structures retrofitted with the self-centering retrofit scheme (SCRS) can achieve a seismic performance level comparable to the bilinear-hysteresis retrofit scheme (BHRS) in terms of peak displacement and energy dissipation demand ratio while having negligible residual displacement after earthquake.

关键词： earthquake reinforced concrete frame structure nonlinear analysis SDOF system seismic retrofit self-centering

Adversarial attacks and defenses for digital communication signals identification

在线全文

学校读者我要写书评

暂无评论

Digital Communications and Networks 2024年第3期10卷 756-764页

作者： qiao Tian Sicheng Zhang Shiwen Mao yun Lin College of Computer Science and Technology Harbin Engineering UniversityHarbin150001China College of Information and Communication engineering Harbin Engineering UniversityHarbin150000China department of Electrical and Computer engineering Auburn UniversityAuburnAL36849USA

As modern communication technology advances apace,the digital communication signals identification plays an important role in cognitive radio networks,the communication monitoring and management *** has become a promising solution to this problem due to its powerful modeling capability,which has become a consensus in academia and ***,because of the data-dependence and inexplicability of AI models and the openness of electromagnetic space,the physical layer digital communication signals identification model is threatened by adversarial *** examples pose a common threat to AI models,where well-designed and slight perturbations added to input data can cause wrong ***,the security of AI models for the digital communication signals identification is the premise of its efficient and credible *** this paper,we first launch adversarial attacks on the end-to-end AI model for automatic modulation classifi-cation,and then we explain and present three defense mechanisms based on the adversarial *** we present more detailed adversarial indicators to evaluate attack and defense ***,a demonstration verification system is developed to show that the adversarial attack is a real threat to the digital communication signals identification model,which should be paid more attention in future research.

关键词： Digital communication signals identification AI model Adversarial attacks Adversarial defenses Adversarial indicators

Double stabilizations and convergence analysis of a second-order linear numerical scheme for the nonlocal Cahn-Hilliard equation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Mathematics 2024年第1期67卷 187-210页

作者： Xiao Li Zhonghua qiao Cheng Wang department of Applied Mathematics The Hong Kong Polytechnic UniversityHong KongChina department of Mathematics The University of MassachusettsNorth DartmouthMA 02747USA

In this paper,we study a second-order accurate and linear numerical scheme for the nonlocal CahnHilliard *** scheme is established by combining a modified Crank-Nicolson approximation and the Adams-Bashforth extrapolation for the temporal discretization,and by applying the Fourier spectral collocation to the spatial *** addition,two stabilization terms in different forms are added for the sake of the numerical *** conduct a complete convergence analysis by using the higher-order consistency estimate for the numerical scheme,combined with the rough error estimate and the refined *** regarding the numerical solution as a small perturbation of the exact solution,we are able to justify the discrete?^(∞)bound of the numerical solution,as a result of the rough error ***,the refined error estimate is derived to obtain the optimal rate of convergence,following the established?∞bound of the numerical ***,the energy stability is also rigorously proved with respect to a modified *** proposed scheme can be viewed as the generalization of the second-order scheme presented in an earlier work,and the energy stability estimate has greatly improved the corresponding result therein.

关键词： nonlocal Cahn-Hilliard equation second-order stabilized scheme higher-order consistency analysis rough and refined error estimate

Cervical cancer prevention in China: where are we now, and what's next?

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2024年第3期21卷 213-217页

作者： Huijiao yan Qiankun Wang youlin qiao School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100730China department of Cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100021China

Cervical cancer(CC) epidemiology CC, the fourth most frequently diagnosed malignancy in women worldwide, is a major global health challenge, particularly in low-resource regions. Approximately 88.1% of the 604,000 CC new cases occurred in low-and middle-income countries in 2020, and more than 90% of the 342,000 CC deaths occurred in low-and middle-income countries in 2020~1.

关键词： prevention Cervical epidemiology