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Fulminant hepatic failure caused by Salmonella paratyphi A infection

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World Journal of Gastroenterology 2006年第32期12卷 5253-5255页

作者： Fahmi yousef Khan Ahmed A Kamha Ibrahim y Alomary Department of Medicine Hamad General Hospital DohaQatar

We report a case of fulminant hepatic failure associated with Salmonella paratyphi A infection, in a 29-yearold patient who was admitted to the intensive care unit （ICU） with fever of two days, headache and vomiting followed by behavioural changes and disorientation. On examination, the patient appeared acutely ill, agitated, confused, and deeply jaundiced. Temperature 38.5℃, pulse 92/min, blood pressure 130/89 mmHg. Both samples of blood grew S. paratyphi A, which was sensitive to ceftriaxone and ciprofloxacin. Ceftriaxon was administered with high-dose dexamethasone. Two weeks after treatment with ceftriaxon, the patient was discharged in satisfactory condition.

关键词： Typhoid hepatitis Fulminant hepatic failure Salmonella paratyphi A

Remarks on Centers of Rings

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Algebra Colloquium 2021年第1期28卷 1-12页

作者： Juan Huang Hailan Jin Tai Keun Kwak yang lee Zhelin piao Department of Mathematics Yanbian UniversityYanjiJilin 133002China Department of Mathematics Daejin UniversityPocheon 11159Korea Institute of Basic Science Daejin UniversityPocheon 11159Korea

It is proved that for matrices A,B in the n by n upper triangular matrix ring T_(n)(R)over a domain R,if AB is nonzero and central in T_(n)(R)then AB=*** n by n full matrix rings over right Noetherian domains are also shown to have this *** this article we treat a ring property that is a generalization of this result,and a ring with such a property is said to be weakly *** class of weakly reversible-over-center rings contains both full matrix rings over right Noetherian domains and upper triangular matrix rings over *** structure of various sorts of weakly reversible-over-center rings is studied in relation to the questions raised in the process *** also consider the connection between the property of being weakly reversible-over-center and the related ring properties.

关键词： weakly reversible-over-center ring center commutative domain right Noetherian domain reduced ring full(upper)triangular matrix ring NI ring

Simultaneous analytical method of the bioactive marker compounds of a herbal drug,evodiaefructus

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Simultaneous analytical method of the bioactive marker compo...

1,2,3,4,6-penta-O-galloyl-β-D-glucose up-regulates heme oxygenase-1 expression by stimulating Nrf2 nuclear translocation in an extracellular signal-regulated kinase-dependent manner in HepG2 cells

30th International Symposium on Capillary Chromatography、4th GC×GC Symposium、16th National Symposium and Exhibition on Chromatography,i.e. 1st Dalian International Symposium and Exhibition on Chromatography

作者： Moon,D.C. Kim,N.H. Jeong,E.S. Cho,H.E. Ahn,S.y. Hwang,B.y. lee,y.M. lee,J.J. College of pharmacy CBITRC Chungbuk NationalUniversityCheongju 361-763Korea Korea Research Institute of Bioscience and Biotechnology Daejon 305-600 Korea

HpLC-pDA and LC-tandem MS methods have been developed and validated for the simultaneous analyses of indolequinazoline-(IQAs)and quinolone alkaloids(QAs)in a herbal drug,“Evodiae Fructus”.The bioactive marker compounds,evodiamine(1),rutaecarpine(2)and quinolone alkaloids were simultaneously determined in the 20 drug specimens that collected from Korea and China markets..HpLC analysis was performed on a reversed-phase phenyl-C6 column using solvent system of MeOH(A):20mM NH4OAc(B):AcCN(C)using gradient flow detecting at UV ***-ESI-MS/MS analysis was accomplished by multiple reaction monitoring(MRM)method after separation on a minibore phenyl-C6 column using 74% AcCN(5mM NHAc). Contents of evodiamine(1)and rutaecarpine(2)were in the range between 0.12-1.14% and 0.07-1.02%, respectively,which together with other compounds,showed variable profiles depending on specimens. Clustering analysis was performed as an evaluating mean of the herbal *** methods would be useful as a crucial quality control of the herbal drug or the related products.

关键词： Evodiae fructus Marker compounds HpLC-pDA LC-ESI-MS/MS

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World Journal of Gastroenterology 2006年第2期12卷 214-221页

作者： Hyun-Ock pae Gi-Su Oh Sun-On Jeong Gil-Saeng Jeong Bok-Soo lee Byung-Min Choi Ho-Sub lee Hun-Taeg Chung Medicinal Resources Research Institute Wonkwang UniversityIksan-ShiChunbug570-749Republic of Korea Department of Microbiology and Immunology Wonkwang University School of MedicineWonkwang UniversityIksan-ShiChunbug570-749Republic of Korea

AIM: To examine the potency of 1,2,3,4,6-penta-O-galloyl-β-D-glucose (pGG) as a hepatic heme oxygen-ase-1(HO-1) inducer and its regulation in HepG2 cells. METHODS: Expression of HO-1 and NF-E2-related factor 2 (Nrf2) and activation of mitogen-activated protein (MAp) kinases were analyzed by Western blot, immuno-fluorescence assay, and flow cytometry. Transfections of HO-1 gene, small interfering RNAs for HO-1 and Nrf2, and dominant-negative gene for MAp/extracellular signal-regulated kinase (ERK) were carried out to dissect the signaling pathways leading to HO-1 expression in HepG 2 cells. RESULTS: pGG up-regulated HO-1 expression and this expression conferred cytoprotection against oxidative injury induced by t-butyl hydroperoxide. Moreover, pGG induced Nrf2 nuclear translocation, which was found to be an upstream step of pGG-induced HO-1 expression, and ERK activation, of which pathway was involved in pGG-induced Nrf2 nuclear translocation, HO-1 expression and cytoprotection. CONCLUSION: pGG up-regulates HO-1 expression by stimulating Nrf2 nuclear translocation in an ERK-depen-dent manner, and HO-1 expression by pGG may serve as one of the important mechanisms for its hepatoprotective effects.

关键词： 1,2,3,4,6-penta-O-galloyl-β-D-glucose Heme oxygenase-1 Oxidative stress Hepatoprotection

DETERMINATION　OF　TRACEFLUORIDE　AND　MOLyBDENUM　IN　SERUM　SAMpLE　By　ELECTROCHEMICAL　ANALySIS

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Chinese Chemical Letters 1996年第2期7卷 161-164页

作者： Wang, LZ Zhang, XL yu, y Ma, CS SHANDONG UNIV DEPT CHEMJINAN 250100PEOPLES R CHINA

In thia paper, the determination of both fluoride and bolybdenum can be carried out in the same serum sample as follows: the content of fluoride is determined by direct potentiometry in the solution containing (CH2)6N4 and HNO3(pH= 5. 4) while that of molybdenum is determined by adsorptive vol tammetry after the above-mentioned solution has been nitrified with mixed acid containing HNO3 and HC104.

关键词： ADSORpTIVE STRIppING VOLTAMMETRy

The Measurement of Thermal Conductivities of Silica and Carbon Black powders at Different pressures by Thermal Conductivity probe

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Journal of Thermal Science 1992年第2期1卷 75-79页

作者： X.G.Liang X.S.Ge y.p.Chang G.Liu D.p.Wu Department of Engineering Thermophysics,University of Science and Technology of China,Hefei,Anhui 230026,China Department of Engineering Thermophysics University of Science and Technology of China Hefei China

This investigation was done to study the gas filled powder insulation and thermal conductivity probe for the measurement of thermal conductivity of *** mathematical analysis showed that the heat capacity of the probe itself and the thermal resistance between the probe and powder must be *** authors developed a slender probe and measured the effective thermal conductivity of silica and carbon black powders under a variety of conditions.

关键词： thermal conductivity powders conductivity probe

Tissue inhibitors of metalloproteases strike a nerve

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Neural Regeneration Research 2018年第11期13卷 1890-1892页

作者： veronica i.shubayev alex y.strongin department of anesthesiology university of californiasan diego va san diego healthcare system la jollacausa sanford burnham prebys medical discovery institute la jollacausa

Signals of touch,pressure,pain,temperature,position,and vibration are transmitted from the peripheral nervous system（pNS）to the dorsal horn of the segmental spinal cord via pseudounipolar dorsal root ganglia（DRG）*** information gathering relies on functional integrity of DRG neurons and can be interrupted by pNS injury due to trauma,disease or exposure to drugs, toxins or viral pathogens. Despite the high regenerative capacity of DRG neurons, sensory recovery after pNS injury is often incomplete and severe neuropathic pain may last for years. Although numerous mechanisms of pNS injury have been established, neuropathic pain is refractory to therapy, contributing to the physical and emotional suffering of patients and the enormous economic burden to society.

关键词： TIMps pNS In Tissue inhibitors of metalloproteases strike a nerve

Formation potential and analysis of 32 regulated and unregulated disinfection by-products: Two new simplified methods

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Journal of Environmental Sciences 2022年第7期34卷 209-221页

作者： Jillian N.Murakami Xu Zhang Joanne ye Amy M.MacDonald Jorge perez David W.Kinniburgh Susana y.Kimura Department of Chemistry University of CalgaryCalgaryAlbertaT2N 1N4Canada Alberta Centre for Toxicology University of CalgaryCalgaryAlbertaT2N 4N1Canada

Water disinfection is an essential process that provides safe water by inactivating pathogens that cause waterborne diseases. However, disinfectants react with organic matter naturally present in water, leading to the formation of disinfection by-products(DBps). Multi-analyte methods based on mass spectrometry(MS) are preferred to quantify multiple DBp classes at once however, most require extensive sample pre-treatment and significant resources. In this study, two analytical methods were developed for the quantification of 32 regulated and unregulated DBps. A purge and trap(p&T) coupled with gas chromatography mass spectrometry(GC-MS) method was optimized that automated sample pre-treatment and analyzed volatile and semi-volatile compounds, including trihalomethanes(THMs), iodinated trihalomethanes(I-THMs), haloacetonitriles(HANs), haloketones(HKTs) and halonitromethanes(HNMs). LOQs were between 0.02-0.4 μg/L for most DBps except for 8 analytes that were in the low μg/L range. A second method with liquid chromatography(LC) tandem mass spectrometry(MS/MS) was developed for the quantification of 10 haloacetic acids(HAAs) with a simple clean-up and direct injection. The LC-MS/MS direct injection method has the lowest detection limits reported(0.2-0.5 μg/L). Both methods have a simple sample pre-treatment, which make it possible for routine analysis. Hyperchlorination and uniform formation conditions(UFC) formation potential tests with chlorine were evaluated with water samples containing high and low TOC. Hyperchlorination formation potential test maximized THMs and HAAs while UFC maximized HANs. Ascorbic acid was found to be an appropriate quencher for both analytical methods. Disinfected drinking water from four water utilities in Alberta, Canada were also evaluated.

关键词： Disinfection byproducts purge and trap LC-MS/MS Drinking water DBp formation potential HAAs HANs

EXpERIMENTAL STUDy ON BED RESISTANCE CHARACTERISTICS OF NONUNIFORM SEDIMENT

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Journal of Hydrodynamics 2000年第4期12卷 66-74页

作者： Zhou, G.D. Liu, Q.y. Wang, G.X. Hui, y.J. pang, D.M. Tsinghua Univ. Beijing 100084 China

Under natural circumstances, the bed of fluvial river is composed of nonuniform sediment, and its nonuniform property influences very much the bed resistance and flow characteristics. By using a one-dimensional laser velocimeter, flume experiments are carried out to analyze the resistance characteristics of open channel flow with the bed sediment composed of different representative particles and having different nonuniform properties. By means of separating factors, the factors affecting the bed resistance, including particle diameter, nonuniform property and flow conditions, are studied. A great number of laboratory test results and field data from other investigators have been analyzed.

关键词： Sediments