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Multi-layer perceptron-based data-driven multiscale modelling of granular materials with a novel Frobenius norm-based internal variable

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2198-2218页

作者： Mengqi Wang y.T.Feng Shaoheng Guan Tongming Qu Zienkiewicz Centre for Computational Engineering Faculty of Science and EngineeringSwansea UniversitySwanseaWalesSA18EPUK Institute of Theoretical and Computational Physics Graz University of TechnologyGraz8010Austria Department of Civil and Environmental Engineering Hong Kong University of Science and TechnologyClearwater BayKowloonHong KongChina

One objective of developing machine learning(ML)-based material models is to integrate them with well-established numerical methods to solve boundary value problems(BVPs).In the family of ML models,recurrent neural networks(RNNs)have been extensively applied to capture history-dependent constitutive responses of granular materials,but these multiple-step-based neural networks are neither sufficiently efficient nor aligned with the standard finite element method(FEM).Single-step-based neural networks like the multi-layer perceptron(MLP)are an alternative to bypass the above issues but have to introduce some internal variables to encode complex loading *** this work,one novel Frobenius norm-based internal variable,together with the Fourier layer and residual architectureenhanced MLP model,is crafted to replicate the history-dependent constitutive features of representative volume element(RVE)for granular *** obtained ML models are then seamlessly embedded into the FEM to solve the BVP of a biaxial compression case and a rigid strip footing *** obtained solutions are comparable to results from the FEM-DEM multiscale modelling but achieve significantly improved *** results demonstrate the applicability of the proposed internal variable in enabling MLP to capture highly nonlinear constitutive responses of granular materials.

关键词： Granular materials History-dependence Multi-layer perceptron(MLP) Discrete element method FEM-DEM Machine learning

Dysregulated microRNAs in type 2 diabetes and breast cancer:Potential associated molecular mechanisms

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World Journal of Diabetes 2024年第6期15卷 1187-1198页

作者： Alex Cleber Improta-Caria Filipe Ferrari João lucas Penteado Gomes Paloma Brasilio Villalta Úrsula Paula RenóSoci Ricardo Stein Edilamar M Oliveira Laboratory of Biochemistry and Molecular Biology of the Exercise Physical Education and Sport SchoolUniversity of São PauloSão Paulo 05508-030Brazil Graduate Program in Cardiology and Cardiovascular Sciences Federal University of Rio Grande do SulHospital de Clínicas de Porto AlegrePorto Alegre 90035003Brazil Laboratory of Metabolic Disorders(Labdime) School of Applied SciencesUniversity of Campinas-UNICAMPCampinas 13484-350Brazil Departments of Internal Medicine Molecular Pharmacology and PhysiologyCenter for Regenerative MedicineUSF Health Heart InstituteMorsani College of MedicineUniversity of South FloridaTampaFL 33602United States

Type 2 diabetes(T2D)is a multifaceted and heterogeneous syndrome associated with complications such as hypertension,coronary artery disease,and notably,breast cancer(BC).The connection between T2D and BC is established through processes that involve insulin resistance,inflammation and other *** this comprehension the specific cellular and molecular mechanisms linking T2D to BC,especially through microRNAs(miRNAs),remain *** are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological ***,the signaling pathways and biological processes regulated by miRNAs that are associated with T2D and BC have not yet been *** review aims to identify dysregulated miRNAs in both T2D and BC,exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.

关键词： Type 2 diabetes Breast cancer MicroRNAs Molecular mechanisms

Multi-population particle swarm optimization algorithm for automatic design of steel frames

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Frontiers of Structural and Civil Engineering 2024年第1期18卷 89-103页

作者： Wenchen SHAN Jiepeng LIU yao DING y.Frank CHEN Junwen ZHOU Institute of Smart City and Intelligent Transportation Southwest Jiaotong UniversityChengdu 610000China School of Civil Engineering Chongqing UniversityChongqing 400045China Department of Civil Engineering the Pennsylvania State UniversityMiddletownPA 17057USA

Steel structures are widely used;however,their traditional design method is a trial-and-error procedure which is neither efficient nor cost ***,a multi-population particle swarm optimization(MPPSO)algorithm is developed to optimize the weight of steel frames according to standard design *** are made to improve the algorithm performances including the constraint-based strategy,piecewise mean learning strategy and multi-population cooperative *** proposed method is tested against the representative frame taken from American standards and against other steel frames matching Chinese design *** related parameter influences on optimization results are *** the representative frame,MPPSO can achieve greater efficiency through reduction of the number of analyses by more than 65% and can obtain frame with the weight for at least 2.4%lighter.A similar trend can also be observed in cases subjected to Chinese design *** addition,a migration interval of 1 and the number of populations as 5 are recommended to obtain better MPPSO *** purpose of the study is to propose a method with high efficiency and robustness that is not confined to structural scales and design *** aims to provide a reference for automatic structural optimization design problems even with dimensional *** proposed method can be easily generalized to the optimization problem of other structural systems.

关键词： steel frame multi-population particle swarm optimization automatic structural optimization design

Enabling low-cost decentralized power reserves adopting carbon dioxide for green methane exchange in stabilized clathrate adsorbent

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Journal of Energy Chemistry 2024年第10期97卷 438-443页

作者： lucas Hanssens Maarten Houlleberghs C.Vinod Chandran Geert Watson Sambhu Radhakrishnan Pascal Van Der Voort Joeri F.M.Denayer Christine E.A.Kirschhock Johan A.Martens Eric Breynaert Centre for Surface Chemistry and Catalysis-Characterization and Application Team (COK-KAT) NMR/X-Ray Platform for Convergence Research (NMRCoRe) Centre for Ordered Materials Organometallics and Catalysis (COMOC) Department of Chemistry Ghent University Department of Chemical Engineering Vrije Universiteit Brussel

*** circular methane energy systems In recent decades,methane-based energy systems have rapidly gained traction across the globe because of the increasing availability of low-cost methane production ***,fossil methane... 详细信息

关键词： Long duration energy storage Green methane Carbon neutrality Confined clathrate hydrates CH4 /CO2 exchange Direct gas exchange ENERGy-STORAGE CONFINED NANOSPACE TO-METHANE GAS MECHANISMS ADSORPTION HyDROGEN

Artemisia vulgaris Induces Tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) Signaling

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Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： lucas dos Santos Zamarioli Michele Rosana Maia Santos Adolfo Garcia Erustes Vanessa Marques Meccatti Thais Cristine Pereira Soraya S Smaili Maria Cristina Marcucci Carlos Rocha Oliveira Gustavo JS Pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and SKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,SKBR-3 and K562 cells(Py of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(Py by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(Py of K562 cells treated with HEAV relative to cells exposed to HEAV alone(Py from lysosomes in K562 cells(Pytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

中新世气候适宜期构造运动加速全球海洋碳循环

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Science Bulletin 2024年第6期69卷 823-832页

作者：刘丰豪杜金龙黄恩清马文涛马小林 lucas J.Lourens 田军 State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Department of Earth Sciences Faculty of GeosciencesUtrecht UniversityUtrecht CB 3584Netherlands

Global warming during the Miocene Climate Optimum(MCO,~17-14 million years ago)is associated with massive carbon emissions sourced from the flood basalt volcanism and ocean crustal ***,the perturbation of tectonic carbon degassing on the interaction between climate change and carbon cycle remains ***,through time-evolutive phase analysis of new and published high-resolution benthic foraminiferal oxygen(δ^(18)O)and carbon(δ^(13)C)isotope records from the global ocean,we find that variations in the marine carbon cycle lead the climate-cryosphere system(δ^(13)Clead-δ^(18)O)on 405,000-year eccentricity timescales during the *** is in contrast to the previously reported climate-lead-carbon(δ^(18)O-lead-δ^(13)C)scenario during most of the Oligo-Miocene(~34-6 million years ago).Further sensitivity analysis and model simulations suggest that the elevated atmospheric CO_(2) concentrations and the resulting greenhouse effect strengthened the low-latitude hydrological cycle during the MCO,accelerating the response of marine carbon cycle to eccentricity *** climate processes played a more important role in regulating carbon-cycle variations when Earth's climate was in a warm regime,as opposed to the dominant influence of polar ice-sheet dynamics during the PlioPleistocene(after~6 million years ago).

关键词： Global warming Eccentricity cycle Carbon cycle Low-latitude hydrological cycle

Macrocyclic trichothecenes from Myrothecium verrucaria PA 57 and their cytotoxic activity

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Chinese Journal of Natural Medicines 2024年第9期22卷 854-863页

作者： MO J. TAN y. AI W. LI y. yUAN y. JIANG y. XU K. TAN G. WANG W. LI J. LIU S. Department of Pharmacy National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha 410008 China Xiangya School of Pharmaceutical Sciences Central South University Changsha 410008 China

Four novel macrocyclic trichothecenes, termed mytoxins D−G (1−4), along with four known analogs (5−8), were isolated from the ethyl acetate extract of fermented rice inoculated with the fungus Myrothecium verrucaria PA57. Each compound features a tricyclic 12,13-epoxytrichothec-9-ene (EPT) core. Notably, mytoxin G (4) represents the first instance of a macrocyclic trichothecene incorporating a glucosyl unit within the trichothecene structure. The structures of the newly identified compounds were elucidated through comprehensive spectroscopic analysis combined with quantum chemical calculations. All isolated compounds demonstrated cytotoxic activity against the CAL27 and HCT116 cell lines, which are models for human oral squamous cell carcinoma and colorectal cancer, respectively. Specifically, mytoxin D (1) and mytoxin F (3) exhibited pronounced cytotoxic effects against both cancer cell lines, with IC50 values ranging from 3 to 6 nmol·L−1. Moreover, compounds 1 and 3 were found to induce apoptosis in HCT116 cells by activating caspase-3. © 2024 China Pharmaceutical University

关键词： Cytotoxicity Macrocyclic trichothecenes Myrothecium verrucaria Secondary metabolite Soil fungi

Molecular insights of exercise therapy in disease prevention and treatment

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2564-2597页

作者： David Walzik Tiffany y.Wences Chirino Philipp Zimmer Niklas Joisten Division of Performance and Health(Sports Medicine) Institute for Sport and Sport ScienceTU Dortmund University44227 DortmundNorth Rhine-WestphaliaGermany Division of Exercise and Movement Science Institute for Sport ScienceUniversity of Göttingen37075 GöttingenLower SaxonyGermany

Despite substantial evidence emphasizing the pleiotropic benefits of exercise for the prevention and treatment of various diseases,the underlying biological mechanisms have not been fully *** exercise benefits have been attributed to signaling molecules that are released in response to exercise by different tissues such as skeletal muscle,cardiac muscle,adipose,and liver *** signaling molecules,which are collectively termed exerkines,form a heterogenous group of bioactive substances,mediating inter-organ crosstalk as well as structural and functional tissue *** scientific endeavors have focused on identifying and characterizing new biological mediators with such ***,some investigations have focused on the molecular targets of exerkines and the cellular signaling cascades that trigger adaption processes.A detailed understanding of the tissue-specific downstream effects of exerkines is crucial to harness the health-related benefits mediated by exercise and improve targeted exercise programs in health and ***,we review the current in vivo evidence on exerkine-induced signal transduction across multiple target tissues and highlight the preventive and therapeutic value of exerkine signaling in various *** emphasizing different aspects of exerkine research,we provide a comprehensive overview of(i)the molecular underpinnings of exerkine secretion,(ii)the receptor-dependent and receptor-independent signaling cascades mediating tissue adaption,and(iii)the clinical implications of these mechanisms in disease prevention and treatment.

关键词： prevention treatment collective

Rational design of AgGaS/ZnS/ZnS quantum dots with a near-unity photoluminescence quantum yield via double shelling scheme

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Journal of Materials Science & Technology 2024年第2期169卷 235-242页

作者： H.X.Lu H.Liu Z.Z.Fu y.y.Chen H.Q.Dai Z.Hu W.L.Zhang R.Q.Guo Institute for Electric Light Sources School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Future Lighting Academy for Engineering and TechnologyFudan UniversityShanghai 200433China yiwu Research Institute of Fudan University YiwuZhejiang 322000China Zhongshan-Fudan Joint Innovation Center Zhongshan 528437China

In this study,a two-step method was used to synthesize highly luminescent AgGaS/ZnS/ZnS quantum dots(QDs).In the first step,an inner ZnS shell was formed via a one-pot method,which resulted in a smaller lattice mismatch between the AgGaS core and the outer ZnS shell,thereby facilitating the formation of a thick outer *** the two-step shelling process,the synthesized AgGaS/ZnS/ZnS QDs showed an excellent photoluminescence quantum yield(PLQy)of 96.4%with a peak wavelength of 508 nm,repre-senting the highest PLQy reported thus far for AgGaS ***,the effect of halogen ions in Zn precursors on the shelling process was *** was proposed that the capacity of halogen ions to coordinate with the QDs influenced the balance between Zn cation diffusion and ZnS shelling ***,the ZnS shelling reaction was dominant when ZnCl_(2)was employed,while Zn cation diffusion was the dominant process under the I^(−)-rich *** work provides insights into the interfacial restructuring during the ZnS shelling and offers a clear map for the tailored synthesis of core/shell QDs.

关键词： AgGaS Quantum dots Photoluminescence Core/shell Alloyed core/shell interface