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Pan-TRk positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee yu-Ra Jeon Changmin shin Sun-young kwon Sojin shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACkGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRk)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRk immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRk-fusion *** SUMMARy We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRk IHC-positive but lacked NTRk gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRk sarcoma with positive immunochemical pan-TRk ***,subsequent next generation sequencing revealed no NTRk gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRk gene fusion lies in potential treatment with TRk inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

Dual-Donor-Induced Crystallinity Modulation Enables 19.23% Efficiency Organic Solar Cells

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NANO-MICRO LETTERS 2025年第1期17卷 1-13页

作者： Liang, Anhai Sun, yuqing Chung, Sein shin, Jiyeong Sun, kangbo Zhu, Chaofeng Zhao, Jingjing Zhao, Zhenmin Zhong, yufei Zhang, Guangye Cho, kilwon kan, Zhipeng Guangxi Univ Inst Sci & Technol Carbon Peak & Neutral Ctr Nanoenergy Res Sch Phys Sci & Technol Nanning 530004 Peoples R China Pohang Univ Sci & Technol Dept Chem Engn Pohang 37673 South Korea Shenzhen Technol Univ Coll New Mat & New Energies Shenzhen 518118 Peoples R China NingboTech Univ Zhejiang Engn Res Ctr Fabricat & Applicat Adv Phot Sch Mat Sci & Engn Ningbo 315100 Peoples R China State key Lab Featured Met Mat & Life Cycle Safety Nanning 530004 Peoples R China

By modulating the crystalline properties of the active layer with dual donors, the efficiency of organic solar cells reaches 19.23%.The introduction of PTzBI-dF suppresses the accumulation of traps and charge recombination, allowing ternary devices to maintain 82% of their initial power conversion efficiency (PCE) after illumination for 800 *** dual-donor strategy for modulating the crystallinity of the active layer is applicable to a variety of y6 derivatives, and the increase in PCE exceeds 1%. Trap-assisted charge recombination is one of the primary limitations of restricting the performance of organic solar cells. However, effectively reducing the presence of traps in the photoactive layer remains challenging. Herein, wide bandgap polymer donor PTzBI-dF is demonstrated as an effective modulator for enhancing the crystallinity of the bulk heterojunction active layers composed of D18 derivatives blended with y6, leading to dense and ordered molecular packings, and thus, improves photoluminescence quenching properties. As a result, the photovoltaic devices exhibit reduced trap-assisted charge recombination losses, achieving an optimized power conversion efficiency of over 19%. Besides the efficiency enhancement, the devices comprised of PTzBI-dF as a third component simultaneously attain decreased current leakage, improved charge carrier mobilities, and suppressed bimolecular charge recombination, leading to reduced energy losses. The advanced crystalline structures induced by PTzBI-dF and its characteristics, such as well-aligned energy level, and complementary absorption spectra, are ascribed to the promising performance improvements. Our findings suggest that donor phase engineering is a feasible approach to tuning the molecular packings in the active layer, providing guidelines for designing effective morphology modulators for high-performance organic solar cells.

关键词： Trap-assisted charge recombination Photoluminescence Miscibility Current leakage Power conversion efficiency

Combating an invisible enemy: The American military response to global pandemics

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Military Medical Research 2021年第3期8卷 326-335页

作者： Lauren k.Dutton Peter C.Rhee Alexander y.shin Richard J.Ehrlichman Richard J.Shemin Department of Orthopedic Surgery Mayo Clinic2001st Street SWRochesterMN 55905USA Navy Medicine Professional Development Center BethesdaMD 20889USA United States Air Force Reserve the 60th Ops SquadronTravis AFBCA 94535USA Division of Plastic and Reconstructive Surgery Massachusetts General HospitalBostonMA 02114USA Massachusetts National Guard United States ArmyHanscom AFBMA 01731USA Division of Cardiac Surgery Department of SurgeryCardiovascular Center at UCLADavid Geffen School of Medicine at UCLALos AngelesCA 90095USA

The present moment is not the first time that America has found itself at war with a pathogen during a time of international conflict. Between crowded barracks at home and trenches abroad, wartime conditions helped enable the spread of influenza in the fall of 1918 during World War I such that an estimated 20%–40% of U.S. military members were infected. While the coronavirus disease 2019(COVID-19) pandemic is unparalleled for most of today's population, it is essential to not view it as unprecedented lest the lessons of past pandemics and their effect on the American military be forgotten. This article provides a historical perspective on the effect of the most notable antecedent pandemic, the Spanish Influenza epidemic, on American forces with the goal of understanding the interrelationship of global pandemics and the military, highlighting the unique challenges of the current pandemic, and examining how the American military has fought back against pandemics both at home and abroad, both 100 years ago and today.

关键词： Pandemic Spanish influenza COVID-19 Military Influenza

Low cycle fatigue properties and cyclic deformation behavior of as-extruded AZ31 magnesium alloy

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Transactions of Nonferrous Metals Society of China 2010年第B07期20卷 533-539页

作者： S.kWON k.SONG k.S.shin S.I.kWUN Department of Materials Science and Engineering Korea University School of Materials Science and Engineering Seoul National University

The low cycle fatigue(LCF)properties of as-extruded AZ31 Mg alloy were investigated under total strain amplitudes in the range of 0.4%-1.2%with strain rate of 1×10- 2s -*** to the twinning effect in compression during loading and the detwinning effect during unloading,the alloy showed an asymmetric hysteresis *** cyclic stress response exhibited cyclic hardening at high total strain *** cyclic deformation behaviors were discussed using the Coffin-Manson plot,which divided the plastic strain amplitudes into the tension side and the compression *** the LCF tests that were started from either tension or compression under a total strain amplitude of 1.0%,the interaction between the twinning effect and dislocation was *** twinning effect during the LCF test and the variation of the dislocation density were investigated using optical microscopy and transmission electron microscopy,respectively.

关键词： AZ31 magnesium alloy low cycle fatigue twinning dislocation

Clawed Miniature Inchworm Robot Driven by Electromagnetic Oscillatory Actuator

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Journal of Bionic Engineering 2015年第4期12卷 519-526页

作者： kyung-min Lee youngshik kim Jamie k. Paik Buhyun shin korean Intellectual Property Office Gov. Complex-Daejeon Bldg. 4 189 Cheongsa-ro Se-gu Daejeon 302-701 Korea Department of Mechanical Engineering Hanbat National University 125 Dongseodaero Yuseong-gu Daejeon 305-719 Korea The Institute of Mechanical Engineering EPFL STIlGM UPPAIK BM 4118 (B~timent BM) Station 17 Switzerland

In this research we propose a novel inchworm robot, which is composed of an Electromagnetic Oscillatory Actuator （EOA） and claws. The EOA consists of a yoke, a magnet, and a coil. The overall robot size is 12.2 mm x 11 mm x 9 mm （length x height ~ width）. The locomotion of the robot is achieved by different amounts of slips when the robot stretches and contracts its front leg. To realize locomotion, the working conditions were calculated theoretically and the calculated input signal was applied to the robot. The performance of the inchworm robot was evaluated experimentally with varying input voltages and frequencies. A simple op-amps based driving circuit was used to provide a square-wave input. Travel speed, average distance per step of the robot, and moving distance of the leg and body at each step were measured. The maximum travel speed was 36 mm-s-1 at 30 Hz, which validates our simple locomotion strategy experimentally.

关键词： electromagnetic actuator micro mobile robot inchworm crawler locomotion

Effect of texture and twinning on mechanical properties and corrosion behavior of an extruded biodegradable Mg-4Zn alloy

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Journal of Magnesium and Alloys 2019年第4期7卷 707-716页

作者： M.Sabbaghian R.Mahmudi k.S.shin School of Metallurgical and Materials Engineering College of EngineeringUniversity of TehranTehran 14395-515Iran Magnesium Technology Innovation Center School of Materials Science and EngineeringSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Kore

Microstructure,texture,mechanical properties and corrosion behavior of the extruded Mg-4Zn alloy,as a biodegradable material,were investigated.A refined microstructure caused by dynamic recrystallization(DRX),and a general fiber texture were achieved after *** properties along different directions of the extruded samples were investigated using shear punch test(SPT).The shear yield stress(SyS)of 113.8 MPa obtained in the transverse direction(TD)was higher than the 106 MPa achieved for the extruded direction(ED)and 45˚*** was attributed to the higher amounts of twins and also lower Schmid factor(SF)in the *** the other hand,encouraged activation of the basal slip system in the 45˚samples resulted in improved room temperature formability,as indicated by the normalized displacement in the SPT *** back scattered diffraction(EBSD)analysis of the surfaces corroded in the phosphate buffered saline(PBS)solution,showed that despite having similar grain sizes and second phase particles shape and volume fractions,surfaces containing grains near(0001)orientations and extension twins(TD and 45˚samples)have lower corrosion rates,as compared to the ED specimens.

关键词： Mg-Zn alloy Corrosion rate Dynamic recrystallization Texture Twinning

Retrieval of the Single Scattering Albedo of Asian Dust Mixed with Pollutants Using Lidar Observations

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Advances in Atmospheric Sciences 2014年第6期31卷 1417-1426页

作者： Sungkyun shin young Min NOH kwonho LEE Hanlim LEE Detlef MLLER y.J.kIM kwanchul kIM Dongho shin School of Environmental Science and Engineering Gwangju Institute of Science and TechnologyKorea Department of Geoinformatics Engineering Kyungil UniversityKorea Department of Spatial Information Engineering Pukyong National UniversityKorea Science System and Applications Inc. NASA Langley Research CenterUSA University of Hertfordshire United kingdom

The vertical distribution of single scattering albedos （SSAs） of Asian dust mixed with pollutants was derived using the multi-wavelength Raman lidar observation system at Gwangju （35.10°N,126.53°E）.Vertical profiles of both backscatter and extinction coefficients for dust and non-dust aerosols were extracted from a mixed Asian dust plume using the depolarization ratio from lidar *** profiles of backscatter and extinction coefficients of non-dust particles were input into an inversion algorithm to retrieve the SSAs of non-dust *** aerosol layers at different heights had different light-absorbing *** SSAs of non-dust particles at each height varied with aerosol type,which was either urban/industrial pollutants from China transported over long distances at high altitude,or regional/local pollutants from the korean *** advantage of independent profiles of SSAs of non-dust particles,vertical profiles of SSAs of Asian dust mixed with pollutants were estimated for the first time,with a new approach suggested in this study using an empirical determination of the SSA of pure *** SSAs of the Asian dust-pollutants mixture within the planetary boundary layer （PBL） were in the range 0.88-0.91,while the values above the PBL were in the range 0.76-0.87,with a very low mean value of 0.76 ± *** total mixed dust plume SSAs in each aerosol layer were integrated over height for comparison with results from the Aerosol Robotics Network （AERONET） *** of SSA retrieved from lidar observations of 0.92 ± 0.01 were in good agreement with the results from AERONET measurements.

关键词： lidar Asian dust depolarization ratio microphysical properties single scattering albedo

Development of an Anthropomorphic Robotic Arm and Hand for Interactive Humanoids

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Journal of Bionic Engineering 2012年第2期9卷 133-142页

作者： Jamie k. Paik Bu Hyun shin young-bong Bang young-Bo Shim The Institute of Mechanical Engineering EPFL STI I G M UPPAIK BM 4118 （Bdtiment BM） Station 17 Switzerland Department of Mechanical Engineering Hanbat University Daejeon 305-719 South Korea Advanced Institutes of Convergence Technology Seoul National University Suwon-si Gyeonggi-do 443-270 South Korea Mechatronics and Manufacturing Technology Center Samsung Electronics Co Suwon-si Gyeonggi-do 443-742 South Korea

Humanoid robots are designed and built to mimic human form and movement. Ultimately, they are meant to resemble the size and physical abilities of a human in order to function in human-oriented environments and to work autonomously but to pose no physical threat to humans. Here, a humanoid robot that resembles a human in appearance and movement is built using powerful actuators paired with gear trains, joint mechanisms, and motor drivers that are all encased in a package no larger than that of the human physique. In this paper, we propose the construction of a humanoid-applicable anthropomorphic 7-DoF arm complete with an 8-DoF hand. The novel mechanical design of this humanoid ann makes it sufficiently compact to be compatible with currently available narrating-model humanoids, and to be sufficiently powerful and flexible to be functional; the number of degrees of freedom endowed in this robotic arm is sufficient for executing a wide range of tasks, including dexterous hand movements. The developed humanoid arm and hand are capable of sensing and interpreting incoming external force using the motor in each joint current without conventional torque sensors. The humanoid ann adopts an algorithm to avoid obstacles and the dexterous hand is capable of grasping objects. The developed robotic ann is suitable for use in an interactive humanoid robot.

关键词： humanoid arm humanoid hand human robot interaction safe robot arm and torque sensing

Effect of Reactivity of Quick Lime on the Properties of Hydrated Lime Sorbent for SO_2 Removal

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Journal of Materials Science & Technology 2009年第3期25卷 329-332页

作者： H.G. shin H. kim y.N. kim H.S. Lee Department of Materials Science and Engineering Seoul National University Material Analysis Team Korea Testing Laboratory School of Materials Science and Engineering Pusan National University

The hydration of quick lime and the sulfation of hydrated lime were carried out for verification of relationship between the reactivity of quick lime and the properties of hydrated lime as a sorbent. The effect of reactivity of quick lime was investigated with the change of calcination temperature and time. Results obtained showed that the temperature rise during the hydration of quick limes varied from 31 to 69℃ with the variation of calcination temperature and time. The specific surface area and the sulfation ability of hydrated lime prepared by hydration of quick lime showed a proportional relationship with the reactivity of quick lime. The hydrated lime which was prepared by hydration of quick lime calcined at 1100℃ had the highest reactivity and showed 41.53 m^2/g of the specific surface area, 0.16 cm^3/g of the pore volume and 87% of the removal efficiency for SO2 removal,

关键词： Reactivity Quick lime Hydrated lime Calcination Hydration Sorbent