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Microsystems & Nanoengineering 2024年第1期10卷 217-230页

作者： Muhammad Soban Khan Mushtaq Ali Song Ha Lee Keun young jang Seong jae Lee jinsoo Park Department of Mechanical Engineering Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea Department of Polymer Engineering The University of Suwon17 Wauan-gilBongdam-eupHwaseongGyeonggi 18323Republic of Korea

Most microfluidic separation techniques rely largely on object size as a separation *** ability to separate micro-objects based on their shape is crucial in various biomedical and chemical ***,we develop an ondemand,label-free acoustofluidic method to separate prolate ellipsoids from spherical microparticles based on traveling surface acoustic wave-induced acoustic radiation force and *** freely rotating non-spherical microobjects were aligned under the progressive acoustic field by the counterrotating radiation torque,and the major axis of the prolate ellipsoids was parallel to the progressive wave *** specific alignment of the ellipsoidal particles resulted in a reduction in the cross-sectional area perpendicular to the wave *** a consequence,the acoustic backscattering decreased,resulting in a decreased magnitude of the radiation *** the variation in radiation force,which depended on the micro-object morphology enabled the acoustofluidic shape-based *** conducted numerical simulations for the wave scattering of spherical and prolate objects to elucidate the working mechanism underlying the proposed method.A series of experiments with polystyrene microspheres,prolate ellipsoids,and peanut-shaped microparticles were performed for *** quantitative analysis of the separation efficiency,we confirmed the high purity and high recovery rate of the proposed acoustofluidic shapebased separation of *** a bioparticle,we utilize Thalassiosira eccentrica to perform shape-based separation,as the species has a variety of potential applications in drug delivery,biosensing,nanofabrication,bioencapsulation and immunoisolation.

关键词： separation spherical rotating

Lipid nanoparticles deliver mRNA to the blood-brain barrier

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Nano Research 2024年第10期17卷 9126-9134页

作者： yanina Kuzminich Avraham Shakked Randi Calkins Sebastian Rudden Camille jones jessie Doan Bora jang Elisa Schrader Echeverri Ryan Zenhausern Liming Lian David Loughrey Hannah E.Peck Rachelle Wiese Dorothy Koveal Philip j.Santangelo james E.Dahlman George C.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

Lipid nanoparticles(LNPs)have delivered RNA to hepatocytes in patients after intravenous *** clinical data support efforts to design LNPs that transfect cells in the central nervous system(CNS).However,delivery to the CNS has been difficult,in large part because quantifying on-target delivery alongside common off-target cell types in adult mice remains *** we report methods to isolate different cell types from the CNS,and subsequently present mRNA delivery readouts using a liver-detargeted *** data suggest that LNPs without targeting ligands can transfect cerebral endothelial cells in mice after intravenous *** the difficulty of crossing the blood-brain barrier,they also underscore the value of quantifying delivery in the CNS with cell-type resolution instead of whole-tissue resolution.

关键词： lipid nanoparticle mRNA nanomedicine central nervous system blood-brain barrier

Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第6期16卷 1-13页

作者： jeong‑Woong Shin Dong‑je Kim Tae‑Min jang Won Bae Han joong Hoon Lee Gwan‑jin Ko Seung Min yang Kaveti Rajaram Sungkeun Han Heeseok Kang jun Hyeon Lim Chan‑Hwi Eom Amay j.Bandodkar Hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(ymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics

超声导引下经皮胆囊胆管成像对早期排除胆道闭锁和类型判定的有效性

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国际医学放射学杂志 2012年第1期 87-87页

作者： S.y.Lee G.C.Kim B.H.Choe H.K.Ryeom y.j.jang H.j.Kim 管宇 Department of Radiology Kyungpook National University School of Medicine101 Dongin dong 2 GaJung guDaegu 700-422Republic of Korea

目的评估超声引导下经皮胆囊胆管成像对胆汁淤积性肝病婴儿胆道闭锁的早期诊断及其特征的有效性。材料与方法本研究获得当地伦理委员会批准。受试者父母签

关键词：胆道闭锁早期诊断胆囊 PCC 胆道经皮超声引导下有效性

可能行活体肝脏捐献者的胆道显示:同一个体3.0和1.5T MR胆道成像的比较

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国际医学放射学杂志 2010年第2期 182-182页

作者： S.y.Kim j.H.Byun S.S.Lee S.H.Park y.j.jang M.G.Lee 王智 Department of Radiology and Research Institute of Radiology University of Ulsan College of MedicineAsan Medical Center388-1Pungnap2-dongSongpa-kuSeoul 138-736Korea

目的以术中胆道造影作为参考标准,比较同一个体在3.0T和1.5T两种不同场强下MR胆道成像时胆道解剖显示的准确性和胆道显示的质量。材料与方法得到审查委员会批准及

关键词： MR 胆道活体肝脏

Experimental and finite element analysis for fracture of coating layer of galvannealed steel sheet

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 111-116页

作者： S.I.KIM j.U.HER y.C.jang y.LEE Sheet Products and Process Research Group POSCO Techology Research Laboratory Department of Mechanical Engineering Chung-Ang University

Mechanical properties of galvannealed (GA) steel sheet used for automotive exposed panel and predicted failure phenomenon of its coating layer were evaluated using finite element method. V-bending test was performed to understand better the fracture of coating layer of GA steel sheet during plastic deformation. yield strength of the coating layer was calculated by using a relative difference between hardness of coating layer measured from the nano-indentation test and that of substrate. To measure shearing strength at the interface between substrate and coating layer, shearing test with two specimens attached by an adhesive was carried out. Using the mechanical properties measured, a series of finite element analyses coupled with a failure model was performed. Results reveal that the fracture of coating layer occurs in an irregular manner at the region where compressive deformation is dominant. Meanwhile, a series of vertical cracks perpendicular to material surface are observed at the tensile stressed-region. It is found that 0.26-0.28 of local equivalent plastic strain exists at the coating and substrate at the beginning of failure. The fracture of coating layer depends on ductility of the coating layer considerably as well.

关键词： galvannealed steel sheet fracture simulation coating layer finite element analysis, failure model

Degradation of Synthetic Dyeing Wastewater by Underwater Electrical Discharge Processes

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Plasma Science and Technology 2013年第7期15卷 659-665页

作者： S.D.KIM D.I.jang B.j.LIM S.B.LEE y.S.MOK yeongsan River Environment Research Center National Institute of Environmental ResearchGwangju 500-480 Korea Department of Chemical and Biological Engineering Jeju National UniversityJeju 690-756 Korea

Electrical discharge treatments of synthetic dyeing wastewater were carried out with two different systems： underwater pulsed electrical discharge （UPED） and underwater dielectric barrier discharge （UDBD）. Reactive Blue 4 （RB4） and Acid Red 4 （AR4） were used as model contaminants for the synthetic wastewater. The performance of the aforementioned systems was compared with respect to the chromaticity removal and the energy requirement. The results showed that the present electrical discharge systems were very effective for degradation of the dyes. The dependences of the dye degradation rate on treatment time, initial dye concentration, electrical energy, and the type of working gas including air, 02, and N2 were examined. The change in the initial dye concentration did not largely affect the degradation of either RB4 or AR4. The energy delivered to the UPED system was only partially utilized for generating reactive species capable of degrading the dyes, leading to higher energy requirement than the UDBD system. Among the working gases, the best performance was observed with O2. As the degradation proceeded, the concentration of total dissolved solids and the solution conductivity kept increasing while pH showed a decreasing trend, revealing that the dyes were effectively mineralized.

关键词： degradation dyeing wastewater pulsed electrical discharge dielectric barrierdischarge

Fabrication of ultrafine Nd-Fe-B powder by a modified reduction-diffusion process

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Rare Metals 2006年第Z2期25卷 223-226页

作者： jang T.S. LEE D.H. CHOI C.j. SEO W.S. LEE y.H. Department of Electronic Materials Engineering Sunmoon University Korea Powder Materials Research Center Korea Institute of Machinery and Materials Korea Advanced Materials Analysis & Evaluation Center Korea Institute of Ceramic Engineering and Technology Korea

In order to obtain ultrafine Nd-Fe-B powder, a spray-dried precursor was treated by reduction-diffusion (R/D) process. And, unlike the conventional R/D process, calcium reduction that is a crucial step for the formation of Nd2Fe14B was performed without conglomerating the precursor with Ca powder. By adopting this modified process, it is possible to synthesize the hard magnetic Nd2Fe14B at the reaction temperature as low as 850 ℃. The average size of Nd2Fe14B particles that are uniformly distributed in the optimally treated powder was yers of Nd-rich phase. Typical magnetic properties of such powder without eliminating impurity CaO were iHc=～5.9 kOe, Br=～5.5 kG, and (BH)max=～6 MGOe.

关键词： NdFeB powder spray drying reduction-diffusion process Nd2Fe14B magnetic powder

Asymptotic dynamics of a modified discrete Leslie-Gower competition system

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International journal of Biomathematics 2017年第6期10卷 1-23页

作者： yunshyong Chow Sophia R.-j. jang Institute of Mathematics Academia Sinica Taipei 10617 Taiwan Department of Mathematics and StatisticsTexas Tech University Lubbock TX 79409-1042 USA

We propose a modified discrete-time Leslie-Gower competition system of two popula- tions to study competition outcomes. Depending on the magnitude of a particular model parameter that measures intraspecific competition between individuals within the same population, either one or both populations may be subject to Allee effects. The resulting system can have up to four coexisting steady states. Using the theory of planar compet- itive maps, it is shown that the model has only equilibrium dynamics. The competition outcomes then depend not only on the parameter regimes but may also depend on the initial population distributions.

关键词： Competition saddle points Allee effects.