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特发性REM睡眠行为障碍3.0 T MR成像中黑质高信号丢失:与123I-FP-CIT SPECT的对照研究

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国际医学放射学杂志 2018年第3期 357-357页

作者： y.j.bae j.M.Kim K.j.Kim E.Kim H.S.Park S.y.Kang 孙鹤 Department of Neurology Seoul National University Bundang Hospital Seoul National University College of Medicine

摘要目的研究3.0 T MR磁敏感(SW)加权成像上的黑质高信号(NH)的丢失对识别特发性快速动眼睡眠障碍(i RBD)病人罹患突触核蛋白病高风险的价值。材料与方法

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

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journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee yong Nam Ahn Seongjoon So Chanwoo Park jong-Seong bae Taehyun Park Il Tae Kim jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Perovskite

Spin-correlation function of the fully frustrated Ising model and ±j Ising spin glass on a square lattice

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Chinese Physics B 2013年第6期22卷 549-552页

作者： M y Ali j Poulter Department of Mathematics Faculty of ScienceMahidol University

In this work we study the correlation function of the ground state of a two-dimensional fully frustrated Ising model as well as spin glass. The Pfaffian method is used to calculate free energy and entropy as well as the correlation function. We estimate the exponent of spin correlation function for the fully frustrated model and spin glass. In this paper an overview of the latest results on the spin correlation function is presented.

关键词： spin glass correlation function exponent square lattice

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New york Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Effect of Solute Contents of Al-Ni-Sr Alloy on Glass Forming Ability and Thermal Stability

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journal of Rare Earths 2004年第Z2期22卷 73-77页

作者： Taek Soo Kim j K Lee H j Kim j C bae Advanced Materials R&D Center Korea Institute of Industrial Technology994-32 Dongchun-dongYeonsu-kuIncheon 406-130Korea Advanced Materials R&D CenterKorea Institute of Industrial Technology994-32 Dongchun-dongYeonsu-kuIncheon 406-130Korea Advanced Materials R&D CenterKorea Institute of Industrial Technology994-32 Dongchun-dongYeonsu-kuIncheon 406-130Korea Advanced Materials R&D CenterKorea Institute of Industrial Technology994-32 Dongchun-dongYeonsu-kuIncheon 406-130Korea

Glass forming ability (GFA) and structural characterization of a new amorphous Al-Ni-Sr alloy melt spun were investigated on the theory of the factors for the glass formation. The GFA was varied with the ratio of Ni to Sr in detail and successful amorphous phase dispersed with 2 ～ 5 nm precipitates was prepared from Al-Ni5-Sr3. Thermal stability and crystallization behavior of the amorphous phase were determined by continuous and isothermal heating technique on DCS, resulting that the crystallization occurs by the growth of fcc Al nanocrystals on the preexistent nuclei.

关键词： glass formation crystallization Al base amorphous alloys rapid solidification

DESIGN AND IMPLEMENTATION OF REAL-TIME PHySICS SIMULATION ENGINE FOR e-ENTERTAINMENT

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International journal of Modeling, Simulation, and Scientific Computing 2013年第S1期4卷 20-39页

作者： MyUNGSOO bae yOUNG j.KIM Computer Science and Engineering Ewha Womans University SeoulKorea

We present our recent research results regarding the designing and implementation of real-time physics simulation engines,which aim at developing physics-inspired e-entertainment such as computer games,mobile applications,interactive TV and other smart media in *** real-time physics engine consists of three functional components:rigid body dynamics simulation,deformable body simulation,and data-driven physics *** core simulation techniques to realize these simulation components include real-time collision detection and response,large-scale model simulation,and character model *** this paper,we highlight these features and demonstrate their *** also showcase some of the gaming applications that we have integrated our physics engine into.

关键词： Real-time physics simulation engine rigid body dynamics simulation deformable body simulation data-driven simulation.