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GC-MS analysis of Cocus nucifera flower extract and its effects on heterogeneous symptoms of polycystic ovarian disease in female Wistar rats

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Chinese Journal of Natural Medicines 2014年第9期12卷 677-684页

作者： V.Soumya y.indira muzib P.Venkatesh K.Hariprasath Department of Pharmaceutical Technology Sri Padmavathi Mahila Viswavidyalayam Tirupathi- 517502 Andhra Pradesh India Department of Pharmaceutical Chemistry Sir C.R.Reddy College of Pharmaceutical Sciences

AIM: To evaluate the effect of Cocus nucifera L. flowers in reducing the major multiple symptoms of letrozole-induced polycystic ovarian disease(PCOD) in female rats. METHOD: Female, virgin Wistar rats were treated with letrozole(1 mg/kg body wt) to induce PCOD, and after 21 days of induction rats were administered orally with 100 and 200 mg·kg-1 of Cocus nucifera flower aqueous extract, respectively. Estrus cycle and blood sugar were monitored once a week throughout the study. After scarification, various biochemical parameters, such as antioxidant status(superoxide dismutase(SOD) and glutathione reductase(GSH)) of the uterus homogenate, lipid profile(total cholesterol(TC), high density lipoprotein(HDL), low density lipoprotein(LDL), and triglycerides(TG)) of the serum were determined. Weights of the uterus and ovaries were separately monitored. The characteristics of changes in the ovary were evaluated by histopathological studies. RESULTS: GC-MS analysis of the aqueous extract showed the presence of volatile and pharmacologically active phytoconstituents. C. nucifera flower extract-treated groups showed estrus cyclicity and increased uterus weight which indicates the estrogenic effect. The improved blood sugar level, ideal lipid profile, good antioxidant status, and histopathology results revealed the recovery from poly cystic ovaries. CONCLUSION: The results indicate that C. nucifera flower is a potential medicine for the treatment of PCOD and this study supports the traditional uses of C. nucifera flower.

关键词： PCOD Cocus nucifera Poly cystic ovarian disease Estrus cyclicity Lipid profile Antioxidant Histopathology of ovary

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