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World Journal of Gastroenterology 2015年第7期21卷 2159-2168页

作者： Ryo inada Shigeki Sekine Hirokazu Taniguchi Hitoshi Tsuda Hitoshi Katai Toshiyoshi Fujiwara Ryoji Kushima Pathology and Clinical Laboratory Division National Cancer Center Hospital Department of Gastroenterological Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Molecular Pathology Division National Cancer Center Research Institute Gastric Surgery Division National Cancer Center Hospital

AIM:To analyze the mismatch repair(MMR)status and the ARID1A expression as well as their clinicopathological significance in gastric ***:We examined the expressions of MMR proteins and ARID1A by immunohistochemistry in consecutive 489 primary gastric *** results were further correlated with clinicopathological ***:The loss of any MMR protein expression,indicative of MMR deficiency,was observed in 38cases(7.8%)and was significantly associated with an older age(68.6±9.2 vs 60.4±11.7,Py(57.9%vs 39.7%,P=0.023).Abnormal ARID1A expression,including reduced or loss of ARID1A expression,was observed in 109 cases(22.3%)and was significantly correlated with lymphatic invasion(80.7%vs 69.5%,P=0.022)and lymph node metastasis(83.5%vs 73.7%,P=0.042).The tumors with abnormal ARID1A expression more frequently indicated MMR deficiency(47.4%vs 20.2%,Pysis identified abnormal ARID1A expression as an independent poor prognostic factor(HR=1.36,95%CI:1.01-1.84;P=0.040).CONCLUSION:Our observations suggest that the AIRD1A inactivation is associated with lymphatic invasion,lymph node metastasis,poor prognosis,and MMR deficiency in gastric adenocarcinomas.

关键词： Adenocarcinoma ARID1A Mismatch Repair Stomach Immu

Usefulness of Monitoring Stroke Volume Variations for Fluid Management During Pediatric Living-Donor Liver Transplantation

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Open Journal of Anesthesiology 2012年第4期2卷 146-149页

作者： yoshihiro Kasagi Manabu Hashimoto Shugo Kasuya Seisuke Sakamoto Mureo Kasahara yasuyuki Suzuki Eiichi inada Department of Anesthesia and Intensive Care National Center for Child Health and Development Okura Setagaya-ku Tokyo Japan Department of Anesthesiology and Pain Medicine Juntendo University School of Medicine Hongo Bunkyo-ku Tokyo Japan Transplantation Surgery National Center for Child Health and Development Okura Setagaya-ku Tokyo Japan

Purpose: Central venous pressure (CVP) is considered to be unsuitable as preload parameter. Stroke volume variation (SVV) has recently been reported to be effective as a preload and fluid responsiveness parameter, and its usefulness for fluid management during living-donor liver transplantation (LDLT). However, use of SVV has not been reported in children. Our aim is to evaluate the use of SVV as a target parameter of circulating blood volume during pediatric LDLT. Methods: This retrospective study was conducted in 40 consecutive patients aged between 5 and 109 months who underwent elective LDLT. Twenty patients underwent LDLT without FloTrac? (C group) and the rest patients underwent LDLT with the FloTrac? monitoring (F group). As a fluid management target, CVP was maintained at 10 mmHg in the C group and SVV at 10% in the F group. We compared MAP and CVP at the times of the greatest decrease within 5 minutes after reperfusion. Results: MAP after reperfusion was significantly decreased in both groups (P y greater in the C group compared with the F group (P = 0.02). MAP before and after reperfusion did not significantly differ between the groups. After reperfusion, CVP was nearly the same in both groups, with that in the C group slightly decreased and nearly no change in the F group. SVV after reperfusion was significantly increased (P ynamic changes was less when SVV was used as the parameter of circulating blood volume.

关键词： Pediatric Living-Donor Liver Transplantation Fluid Management Stroke Volume Variation Reperfusion

Antimicrobial Efficacy of Curcumin Formulations byPhotodynamic Therapy

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Journal of Pharmacy and Pharmacology 2017年第8期5卷 506-511页

作者： Kate C. Blanco Natalia M. inada Fernanda M. Carbinatto Vanderlei S. Bagnato University of S6o Paulo Sao Carlos Institute of Physics Sao Paulo 13566-590 Brazil

URTI （upper respiratory tract infections） are caused by acute, chronic or recurrent infections including pharyngitis andtonsillitis. The etiologic agents involved are bacteria, virus, and fungi. The standard treatment for bacterial infections is the use ofantibiotics. The antibiotic resistance, side effects of drugs and URTI complications indicate the importance of new therapies. PDT（photodynamic therapy） is a treatment option with a fast onset of action, low side effects, and easy administration of PS（photosensitizer） based on this study. The main aim of this study was to develop a new modality for the treatment of infectiouspharyngotonsillitis by photodynamic therapy. In addition, this study aims to evaluate components of the therapy as the PS, curcumin,in two formulations and irradiation conditions in the effectiveness of treatment. The procedure consists of two steps： oraladministration of CFs （curcumin formulations） containing a PS and illumination （450 nm and 0-60 J/cm2）. Bacterial isolates wereobtained from patients in a routine clinical pratice. The new methodology has been developed from the principle ofPI （photodynamicinactivation）. The strain identification number of colony forming units determined the efficacy of PI using each component, lightingand PS. The use of curcumin formulations in PI presented microbial reduction of 5 log.

关键词： Upper respiratory tract infections, pharyngitis, tonsillitis, curcumin, photodynamic therapy, clinical isolates, syrup, gum.

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高炉内型对炉内状态的影响

鞍钢技术 2004年第3期 49-55页

作者： Takanobu inada 孙永芳

调查了高炉内型对操作的影响。采用数学模拟模型进行了研究。该模型能够分析如下操作条件 :压差、燃料比和炉况稳定性 (防止管道行程 )。在高炉内容积、有效高度和炉缸直径等数据的基础上 ,评价了大量的高炉内型数据。在这次调查过程中 ... 详细信息

调查了高炉内型对操作的影响。采用数学模拟模型进行了研究。该模型能够分析如下操作条件 :压差、燃料比和炉况稳定性 (防止管道行程 )。在高炉内容积、有效高度和炉缸直径等数据的基础上 ,评价了大量的高炉内型数据。在这次调查过程中 ,弄清了炉型几何参数对高炉状态的影响。

关键词：高炉内型燃料比炉缸炉况炉型状态操作条件数学模拟有效高度

布南色林治疗精神分裂症的临床应用中日专家建议

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中国心理卫生杂志 2021年第9期35卷 751-757页

作者：于欣司天梅陆峥石川 IyO Masaomi IWATA Nakao UENO Takefumi inada Ken HORI Hikaru 北京大学第六医院北京大学精神卫生研究所国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院)北京100083 同济大学附属同济医院上海200065 上海市精神卫生中心上海200030 Chiba University Graduate School of Medicine Chiba 260-0856Japan Fujta Health Universi-ty Aichi 470-1192Japan National Hospital Organization Hizen Psychiatric CenterSaga 842-0192Japan Tokyo Women's Medical University Hospital Tokyo 162-8666Japan Fukuoka University Faculty of MedicineFukuoka City 814-0180Japan

第二代(非典型)抗精神病药布南色林对多巴胺D_(2)、D_(3)受体和5-HT_(2A)受体均有较高亲和力,而对肾上腺素α_(1)、5-HT_(2c)、组胺H_(1)、毒蕈碱M_(1)和M_(3)等受体亲和力较低。多项短期和长期临床研究显示:该药对精神分裂症的阳性症... 详细信息

第二代(非典型)抗精神病药布南色林对多巴胺D_(2)、D_(3)受体和5-HT_(2A)受体均有较高亲和力,而对肾上腺素α_(1)、5-HT_(2c)、组胺H_(1)、毒蕈碱M_(1)和M_(3)等受体亲和力较低。多项短期和长期临床研究显示:该药对精神分裂症的阳性症状、阴性症状均有较好疗效,并改善患者的部分认知症状和社会功能。本文在循证证据和多位中日专家临床用药经验基础上撰写,希望为临床精神科医生提供用药参考,帮助精神分裂症患者早日康复,回归社会。

关键词：精神分裂症布南色林临床应用

Efficacy of Photogem（Hematoporphyrin Derivative） as a Photoactivatable Larvicide against Aedes aegypti （Diptera： Culicidae） Larvae

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Journal of Life Sciences 2017年第2期11卷 74-81页

作者： Larissa Marila de Souza Natalia Mayumi inada Sebastiao Pratavieira Juliano Jose Corbi Cristina Kurachi Vanderlei Salvador Bagnato Federal University of S6o Carlos PPG Biotec S6o Carlos 13565-905 Sao Paulo Brazil Sao Carlos Institute of Physics University of Sao Paulo Sao Carlos 13560-970 Sao Paulo Brazil Sao Carlos School of Engineering University of Sao Paulo Sao Carlos 13560-970 Sao Paulo Brazil

Dengue vector is responsible for millions of deaths every year and has caused disastrous impacts on health systems. The continuous use of chemical insecticides, such as carbamates, pyrethroids and organophosphates generates resistant populations of the mosquito, therefore, new control methods must be investigated. The joint action of the population and guidelines for preventing the reproduction of the mosquito associated with the use of photoactivatable insecticides can be the alternative for the control of epidemiological outbreaks in affected regions. In this study, the photo-larvicidal activity of Photogem^（PG）, a derivative of hematoporphyrin, was investigated against 2nd-early 3rd instar of Aedes aegypti larvae （Diptera： Culicidae） under different lighting conditions （artificial lighting system and sunlight）. The dynamics of PG accumulation was characterized by CLSM （confocal laser scanning microscopy） and total time PG eliminationin solution was investigated by ultraviolet-visible spectrophotometry. The maximum photo-activity of PG was observed in 0.5 h under sunlight exposure which achieved 100% larval mortality. Fluorescence images showed a uniform distribution of PG along the digestive tract. PG remained stable in the sunlight for 48 h and in an artificial lighting system for longer periods, therefore, it can be used for the control ofAedes aegypti larvae as a new alternative to chemical insecticides. The method is considered environmentally friendly due to its rapid degradation in the presence of light. Further studies are required, so that the potential of the technique can be explored in real breeding places.

关键词： Photoactivatable larvicide PG hematoporphyrin derivative Aedes aegypti natural lighting artificial lighting.

A Promising Strategy for the Treatment of Onychomycosis with Curcumin and Photodynamic Therapy

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Journal of Pharmacy and Pharmacology 2015年第9期3卷 434-437页

作者： Ana Paula da Silva Fernanda M. Carbinatto Vanderlei S. Bagnato Natalia M. inada University of Sao Paulo Physics Institute of Sao Carlos 13566-590 Sao Carlos SP Brazil

Onychomycosis is a disease of high incidence in the nail plate and responsible for approximately half of the cases of nail infections. Conventionally, dermatologists prescribe antibiotics and antifungals for long periods for its treatment. The high incidence of this type of infection and the increase of microbial strains resistant to the available drugs have justified the importance of the development of new technologies and treatments. This paper presents the photodynamic therapy as an alternative treatment of onychomycosis. New strategies for the use of curcumin as a photosensitizer and its therapeutic response were investigated in different formulations （gel and emulsion）. Photodynamic therapy is a promising technique by which microorganisms are eliminated by a photosensitizing compound, light and oxygen. It was evaluated in two patients who had developed lesions in the fmgernails caused by onychomycosis for approximately 10 years. The lesions were treated by photodynamic therapy with curcumin. The therapeutic efficacy was observed after a maximum of six photodynamic therapy sessions without any other adjuvant therapy. Curcumin has become more promising than the therapeutic standard as it is a natural and versatible drug for incorporation in different formulations, at low cost and low probability of side effects.

关键词： Onychomycosis photodynamic therapy curcumin formulations.

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高炉炉缸数模技术的开发与应用

梅山科技 1999年第4期 60-64页

作者： Takanobu inada 王文娟

1 前言延长高炉寿命是降低炼铁生产成本最重要措施之一。为此在工艺操作、炉型设计、高炉维修方面已做了许多努力,然而炉缸在役维修困难,因此控制炉缸侵蚀是延长高炉寿命的主要措施之一。

关键词：炼铁高炉炉缸数模技术

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抗静电预涂钢板的开发

中国冶金 2008年第10期18卷 24-27页

作者： Hiroyasu Furukawa Hiroshi Kanai Kenji inada 金旭芳新日钢君津技术研究所新日钢钢铁研究所新日钢君津钢厂

PCM(预涂金属)的涂膜主要由有机树脂(绝缘体)组成,涂膜表面与其它材料(如模具、皮带输送机)摩擦时产生静电,灰尘会粘附在PCM表面。在面涂中加入适当的树脂和添加剂,能抑制与其它材料摩擦所产生的表面静电压,从而防止灰尘的粘附。基于这... 详细信息

PCM(预涂金属)的涂膜主要由有机树脂(绝缘体)组成,涂膜表面与其它材料(如模具、皮带输送机)摩擦时产生静电,灰尘会粘附在PCM表面。在面涂中加入适当的树脂和添加剂,能抑制与其它材料摩擦所产生的表面静电压,从而防止灰尘的粘附。基于这种想法,开发了抗静电预涂钢板,抑制静电所导致的灰尘粘附。当静电压产生和灰尘粘附时,PCM显示了显著效果。通过选择底涂和预处理,也得到了一种不含铬酸盐型的PCM。希望这种抗静电的PCM将来能广泛应用于各个领域。

关键词：抗静电预涂钢板灰尘附着力表面静电压

西南日本秋吉带石炭系高山(Ko-yama)灰岩群的褶皱构造(英文)

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西南日本秋吉带石炭系高山(Ko-yama)灰岩群的褶皱构造(英文)