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Integrated bound-state-in-the-continuum photon-pair source

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Photonics Research 2024年第6期12卷 1322-1327页

作者： FAN yE yUE QIN CHENFEI CUI XIANKAI SUN hon KI TSANG Department of Electronic Engineering The Chinese University of Hong KongHong KongChina

Integrated photon-pair sources based on spontaneous parametric down conversion(SPDC)in novel high-χ^((2))materials are used in quantum photonic systems for quantum information processing,quantum metrology,and quantum ***,the need for extensive fabrication process development and optimization of dry-etching processes significantly impedes the rapid exploration of different material platforms for low-loss quantum photonic ***,bound states in the continuum(BICs)have emerged as a promising approach for realizing ultralow-loss integrated photonic circuits without requiring an etching *** realizations of BIC photonic circuits have,however,been limited primarily to the classical ***,we explore the BIC phenomena in the quantum regime and show that the etchless BIC platform is suitable for use in integrated entangled photon-pair sources based on the SPDC process in high-χ^((2))*** lithium niobate as an example,we demonstrate photon-pair generation at telecommunication wavelengths,attaining a maximum internal generation rate of 3.46 MHz,a coincidence-to-accidental ratio of 5773,and an experimental two‐photon interference visibility of 94%.Our results demonstrate that the BIC platform can be used for quantum photonic circuits,and this will enable the rapid exploration of different emergingχ^((2))materials for possible use in integrated quantum photonics in the future.

关键词： process quantum continuum

Outcomes of combined mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

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World Journal of Stem Cells 2024年第6期16卷 690-707页

作者： Kun-Chen Lin Wen-Feng Fang Jui-Ning yeh John y Chiang Hsin-Ju Chiang Pei-Lin Shao Pei-Hsun Sung hon-Kan yip Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and Critical Care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BACKGROUND The treatment of acute respiratory distress syndrome(ARDS)complicated by sepsis syndrome(SS)remains *** To investigate whether combined adipose-derived mesenchymal-stem-cells(ADMSCs)-derived exosome(EXAD)and exogenous mitochondria(mitoEx)protect the lung from ARDS complicated by *** In vitro study,including L2 cells treated with lipopolysaccharide(LPS)and in vivo study including male-adult-SD rats categorized into groups 1(sham-operated-control),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were included in the present *** In vitro study showed an abundance of mitoEx found in recipient-L2 cells,resulting in significantly higher mitochondrial-cytochrome-C,adenosine triphosphate and relative mitochondrial DNA levels(Py(ADP-ribose)polymerase)]were significantly attenuated in lipopolysaccharide(LPS)-treated L2 cells with EXAD treatment than without EXAD treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhibited an opposite pattern of inflam-mation(all Py 72 h post-48 h-ARDS induction,and lung tissues were *** 72 h,flow cytometric analysis of bronchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(Ly6G+/CD14+/CD68+/CD11b/c+/myeloperoxidase+)and albumin were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all Pygen-saturation(SaO2%)displayed an opposite pattern of albumin among the *** findings of lung injury/fibrosis area and inflammatory/DNA-damaged markers(CD68+/γ-H2AX)displayed an identical pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation

Quantum Realities and Observer-Dependent Universes: An Advanced Observer Model

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Journal of Quantum Information Science 2024年第3期14卷 69-121页

作者： Joseph hon Cheung Wong Department of Computing The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong China

This paper presents a novel observer model that integrates quantum mechanics, relativity, idealism, and the simulation hypothesis to explain the quantum nature of the universe. The model posits a central server transmitting multi-media frames to create observer-dependent realities. Key aspects include deriving frame rates, defining quantum reality, and establishing hierarchical observer structures. The model’s impact on quantum information theory and philosophical interpretations of reality are examined, with detailed discussions on information loss and recursive frame transmission in the appendices.

关键词： Quantum Mechanics Observer Model Frame Rates Quantum Reality Hierarchical Observers Information Theory Simulation Hypothesis Recursive Frame Transmission Information Loss

Achieving High CO_(2)Photoreduction Activity by Conductive Crosslinks of Metal–Organic Framework

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CCS Chemistry 2024年第5期6卷 1211-1221页

作者： Ning Li Gui-Qi Lai Lai-hon Chung Fei yu Jun He ya-Qian Lan Department School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhouGuangdong 510006 School of Chemistry South China Normal UniversityGuangzhou 510006 School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023

Fast photogenerated charge migration is crucial for the improvement of photocatalytic performance,but its deliberate modulation is *** work presents two Zr-based metal–organic framework catalysts,GDUT-8 and GDUT-8-Ox,for photocatalytic CO_(2)***,thiophene pendants in GDUT-8 were coupled covalently via Scholl reaction to give GDUT-8-Ox,a catalyst with at least two orders of magnitude(up to 6.1×10^(−3)S cm^(−1))enhanced conductivity and faster transport of photogenerated carriers during ***,from GDUT-8 to GDUT-8-Ox,stronger ligand-to-cluster charge transfer with pronounced light absorption extension was *** a result,GDUT-8-Ox exhibited the highest photocatalytic CO_(2)-to-HCOO−conversion rate(1725μmol g^(−1)h^(−1))to date,in the absence of photosensitizer,as well as turnover number,turnover frequency,and quantum efficiency much higher than *** work presents an unprecedented strategy to accelerate the photogenerated carrier transport of photocatalysts.

关键词： metal-organic framework Scholl reaction covalent crosslinks high conductivity CO_(2)photoreduction CO_(2)-to-HCOO−conversion

Adaptive Fourier Decomposition of the First Three SARS-CoV-2 Infection Waves with Epidemic Intervention—London,UK,2020-2022

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China CDC weekly 2024年第21期6卷 478-486,I0006-I0008页

作者： Zige Liu Guibin Lu Cheokieng Vong Zhiqi Zeng Wei He Zhijie Lin Cuiyun Lin Kaichin Hsieh Zifeng yang Arlindo L.Oliveira Chitin hon Department of Engineering Science Faculty of Innovation EngineeringMacao University of Science and TechnologyMacao SARChina Queen Ethelburga’s Collegiate Thorpe Underwood EstateYorkUK State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Respiratory Disease AI Laboratory on Epidemic and Medical Big Data Instrument Applications Department of Engineering ScienceFaculty of Innovation EngineeringMacao University of Science and TechnologyMacao SARChina Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases KingMed School of Laboratory MedicineGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Faculty of Innovation Engineering School of Computer Science and EngineeringMacao University of Science and TechnologyMacao SARChina University College London UCL Faculty of Engineering SciencesLondonUK Guangzhou Laboratory Guangzhou CityGuangdong ProvinceChina Instituto de Engenharia de Sistemas e Computadores:Investigação e Desenvolvimento em Lisboa LisboaPortugal Instituto Superior Técnico Universidade de LisboaLisboaPortugal

Background:This study provides a detailed analysis of the daily fluctuations in coronavirus disease 2019(COVID-19)case numbers in London from January 31,2020 to February 24,*** primary objective was to enhance understanding of the interactions among government pandemic responses,viral mutations,and the subsequent changes in COVID-19 case ***:We employed the adaptive Fourier decomposition(AFD)method to analyze diurnal changes and further segmented the AFD into novel multi-component groups consisting of one to three *** restructured components were rigorously evaluated using Pearson correlation,and their effectiveness was compared with other signal analysis *** study introduced a novel approach to differentiate individual components across various time-frequency scales using basis decomposition ***:Analysis of London’s daily COVID-19 data using AFD revealed a strong correlation between the“stay at home”directive and high-frequency components during the first epidemic *** indicates the need for sustained implementation of vaccination policies to maintain their ***:The AFD component method provides a comprehensive analysis of the immediate and prolonged impact of governmental policies on the spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).This robust tool has proven invaluable for analyzing COVID-19 pandemic data,offering critical insights that guide the formulation of future preventive and public health strategies.

关键词： offering sustained London

Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin Lam Zonglin Dai Eric Ho yin Lau Carrie yuen Ting Ip Ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew Sik hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

The Impact of Medical Resources and Oral Antiviral Drugs on SARS-CoV-2 Mortality.hon. Kong SAR,China,2022

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China CDC weekly 2024年第21期6卷 469-477,I0001-I0005页

作者： Zhiqi Zeng Jingyi Liang Zhijie Lin Wenda Guan Wei He Qianying Li Lixi Liang Weiqi Pan Zige Liu Guibin Lu Xiaoyan Deng Eric Hy Lau Chitin hon Zifeng yang Guangzhou key laboratory for clinical rapid diagnosis and early warning of infectious diseases KingMed School of Laboratory MedicineGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Macao Institute of Systems Engineering Macao University of Science and TechnologyMacao SARChina Respiratory Disease AI Laboratory on Epidemic Intelligence and Medical Big Data Instrument Applications Faculty of Innovative EngineeringMacao University of Science and TechnologyMacao SARChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina School of Public Health The University of Hong KongHong Kong SARChina Laboratory of Data Discovery for Health Hong Kong SARChina Guangzhou Laboratory Guangzhou CityGuangdong ProvinceChina

Introduction:The Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)demonstrates increased transmissibility compared to earlier strains,contributing to a significant number of fatalities in hong Kong Special Administrative Region(HKSAR),*** medical resources and medications are essential in mitigating these *** study evaluates the effects of supplementary resources from the Chinese mainland during the fifth wave of the pandemic in ***:Vector autoregression(VAR)was employed to analyze data from the Oxford coronavirus disease 2019(COVID-19)Government Response Tracker to assess the effectiveness of control measures during five waves of the pandemic in ***,a transmission dynamics model was created to investigate the influence of supplementary medical resources from the Chinese mainland and oral medications on ***:In the initial four waves,workplace closures,restrictions on public events,international travel bans,and shielding the elderly significantly influenced pandemic ***,during the fifth wave,these measures showed no notable *** comparing a situation without extra medical resources or COVID-19 oral medication,there was a 17.7%decrease in COVID-19 fatalities with mainland medical resources and an additional 10.2%reduction with oral ***,they contributed to a 26.6%decline in ***:With the rapid spread of the virus,regional reallocation of medical resources may reduce mortality even when the local healthcare system is overstretched.

关键词： mainland Impact travel

Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-yu Kan Ben Chung-Lap Chan Grace Gar-Lee yue LI Pei-ting Sharon Sze-Man hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum yip yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(Pypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(Pynergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

Precision medicine in acute lymphoblastic leukemia

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Frontiers of Medicine 2020年第6期14卷 689-700页

作者： Ching-hon Pui Departments of Oncology and Pathology St.Jude Children’s Research HospitalMemphisTN 38105USA

The cure rate of childhood acute lymphoblastic leukemia(ALL)has exceeded 90%in some contemporary clinical ***,the dose intensity of conventional chemotherapy has been pushed to its *** improvement in outcome will need to rely more heavily on molecular therapeutic as well as immuno-and cellular-therapy approaches together with precise risk *** with ETV6-RUNX1 or hyperdiploid>50 ALL who achieve negative minimal residual disease during early remission induction are suitable candidates for reduction in *** with Philadelphia chromosome(Ph)-positive or Ph-like ALL with ABL-class fusion should be treated with ***3 profiling and other preclinical methods have identified several high-risk subtypes,such as hypodiplod,early T-cell precursor,immature T-cell,KMT2A-rearranged,Ph-positive and TCF-HLF-positive ALL,that may respond to BCL-2 inhibitor *** are other fusions or mutations that may serve as putative targets,but effective targeted therapy has yet to be *** other high-risk patients or poor early treatment responders who do not have targetable genetic lesions,current approaches that offer hope include blinatumomab,inotuzumab and CAR-T cell therapy for B-ALL,and daratumumab and nelarabine for *** the expanding therapeutic armamentarium,we should start focus on rational combinations of targeted therapy with non-overlapping toxicities.

关键词： acute lymphoblastic leukemia molecular therapeutics targeted therapy tyrosine kinase inhibitors immunotherapy CAR T-cell therapy