检索结果-南通市图书馆

Association between Subjective Evaluation of Skin Toxicities and Quality of Life in Patients with Lung Cancer Undergoing Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Treatment: A Pilot Study for Developing Skin Toxicity Assessment

引用

Open Journal of Nursing 2019年第12期9卷 1226-1239页

作者： Kengo hirayama ya Su yasuyuki Ikezawa Megumi Chiba Kenichiro Ito Michiko yuki Faculty of Health Sciences Hokkaido UniversitySapporoJapan Graduate School of Health Sciences Hokkaido UniversitySapporoJapan Department of Respiratory Medicine Oji General HospitalTomakomaiJapan KKR Sapporo Medical Center SapporoJapan

Purposes: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) exert satisfactory therapeutic effects in lung cancer patients. However, the resultant skin toxicity can deteriorate patients’ quality of life (QoL). Differences exist in skin toxicity evaluation between patients and clinicians. We aimed to clarify the association between the subjective evaluation of skin toxicities and QoL in lung cancer patients and to establish a document of scale development in the subjective evaluation of skin toxicity. Methods: We used self-administered questionnaires to evaluate 12 lung cancer patients receiving EGFR-TKI treatment. Indices of QoL were generated using the Functional Assessment of Cancer Therapy-Lung and Hospital Anxiety and Depression Scale, and a subjective evaluation questionnaire concerning skin toxicity was completed. The data were collected immediately before treatment initiation and at 4 weeks post treatment. Results: In the subjective evaluation of skin toxicity, four patients (33.3%) were classified as ≥Grade 2 (painful group), experiencing painful pruritus at the emergence site of the skin rash or xerosis. In this group, the QoL scores of physical and emotional aspects declined after treatment. Conversely, patients in the painless group (Grade 0 - 1) demonstrated an improved emotional QoL following treatment (p = 0.028). Conclusions: Lung cancer patients suffering from painful skin toxicity tended to show a decline in the physical and emotional aspects of QoL following EGFR-TKI treatment. The skin toxicity questionnaire was useful from the point of view of a subjective evaluation and could be a powerful assessment tool in future clinical settings with further modification.

关键词： Lung Cancer EGFR-Tyrosine Kinase Inhibitors Skin Toxicity Quality of Life

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

日本の寒地,北海道におけるもち米良質育種(日语原文)

引用

粮油食品科技 2022年第5期30卷 13-25页

作者：丹野久吉村徹平山裕治日本水稲品質・食味研究会日本東京都中央区104-0033 北海道立総合研究機構中央農業試験場遺伝資源部日本北海道滝川073-0013 北海道立総合研究機構上川農業試験場日本北海道比布078-0397

北海道のもち米は,従来,硬化性が低く硬くなりにくいため,おこわや和菓子などに向く。しかし,東北以南の銘柄もち米に比べ,精米蛋白含有率(蛋白質)が高く,精米白度や搗き餅の食味が劣っていた。さらに,近年には需要を広げるため,切り餅... 详细信息

北海道のもち米は,従来,硬化性が低く硬くなりにくいため,おこわや和菓子などに向く。しかし,東北以南の銘柄もち米に比べ,精米蛋白含有率(蛋白質)が高く,精米白度や搗き餅の食味が劣っていた。さらに,近年には需要を広げるため,切り餅·成型餅および米菓に向く搗き餅の硬化性が高い品種の育成も要望された。そこで,新品種の早期開発のために世代促進栽培や葯培養を行い,選抜効率を高めるため初期世代から玄米と精米の白度,蛋白質および硬化性と関係がある糊化特性の機器による分析を,また少量もち米による硬化性を実測し,さらに中期世代からのおこわや搗き餅の食味試験などを行い,農業形質とともに品質改良を進めた。その結果,近年の育成品種では粒大が大きく,穂ばらみ期と開花期の両障害型耐冷性も強く生産の安定性が向上した。さらに,育成年次が新しい品種ほど蛋白質が低く,蛋白質と負の相関関係がある精米白度が高くなった。また,おこわや搗き餅の食味も向上した。一方,搗き餅の硬化性については,従来の低い品種だけで無く,粳品種を母本として硬化性が高い品種も育成された。しかし,東北以南の銘柄もち米には搗き餅の食味や硬化性の高さがまだ及ばず,さらに改良を進める必要がある。

关键词：搗き餅の硬化性精米白度精米蛋白質含有率食味もち米育種寒地

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of Manipulating Hypoxia in Solid Tumors on Radiation Dose-Rate Effect in Vivo,with Reference to That in Quiescent Tumor Cell Population

Influence of Manipulating Hypoxia in Solid Tumors on Radiati...

引用

作者： S.Masunaga R.hirayama A.Uzawa G.Kashino y.Sakurai H.Tanaka M.Suzuki y.Kinashi y.Liu S.Koike K.Ando K.Ono National Institute of Radiological Sciences Heavy Ion Medical Center Gunma University

BACKGROUNDS AND PURPOSES:Intensity modulated radiotherapy(IMRT) and stereotactic irradiation have become common as a new radiotherapy technique for treatment of *** modalities generally use multiple arc or fixed-portal radiation beams,and radiation beams are exposed *** techniques often require 30 rain or a longer time in one treatment session for precise positioning of *** of irradiation time may reduce a radiation effect,and evokes a major concern for the dose rate ***,it is needed to clarify the

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Clinical relevance of fluorodeoxyglucose positron emission tomography/computed tomography and magnifying endoscopy with narrow band imaging in decision-making regarding the treatment strategy for esophageal squamous cell carcinoma

引用

World Journal of Gastroenterology 2019年第46期25卷 6767-6780页

作者： Kazuhiro Toriyama Masahiro Tajika Tsutomu Tanaka Makoto Ishihara yutaka hirayama Sachiyo Onishi Nobumasa Mizuno Takamichi Kuwahara Nozomi Okuno Shinpei Matsumoto Eiichi Sasaki Tetsuya Abe yasushi yatabe Kazuo Hara Keitaro Matsuo Tsuneo Tamaki yasumasa Niwa Department of Gastroenterology Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Endoscopy Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Gastroenterology Anjo Kosei HospitalAnjo 446-8602Japan Department of Pathology and Molecular Diagnostics Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Gastroenterological Surgery Aichi Cancer Center HospitalNagoya 464-8681Japan Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research InstituteNagoya 464-8681Japan East Nagoya Imaging Diagnosis Center Nagoya 464-0044Japan

BACKGROUND Recent advances in endoscopic technology,especially magnifying endoscopy with narrow band imaging(ME-NBI)enable us to detect superficial esophageal squamous cell carcinoma(ESCC),but determining the appropriate method of resection,endoscopic resection(ER)vs surgical resection,is often ***,several studies have reported that 18F-fluorodeoxyglucose positron emission tomography(FDG-PET)is a useful indicator for decision-making regarding treatment for superficial ***,there are not enough reports on association between FDG-PET uptake and clinicopathological characteristics of superficial ***,there are not enough reports on evaluating the usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial *** study evaluated clinical relevance of FDG-PET and ME-NBI in decision-making regarding the treatment strategy for *** To investigate the association between FDG uptake and the clinicopathological characteristics of superficial ESCC and its usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial *** A database of all patients with superficial ESCC who had undergone both MENBI and FDG-PET for pre-treatment staging at Aichi Cancer Center Hospital between January 2008 and November 2018 was retrospectively *** uptake was defined positive or negative whether the primary lesion was visualized or could be distinguished from the background,or *** invasion depth of ESCC was classified according to the Japan Esophageal *** endpoint is to evaluate the association between FDG uptake and clinicopathological characteristics of superficial *** endpoint is to investigate the efficacy of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial *** A total of 82 lesions in 82 patients were ***-PET showed positive uptake in 29(35.4%)*** analysis sh

关键词： ^18F-fluorodeoxyglucose positron emission tomography Magnifying endoscopy Narrow band imaging Superficial esophageal cancer Squamous cell carcinoma Treatment strategy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高输出功率太赫兹量子级联激光器与温度特性（英文）

引用

红外与毫米波学报 2018年第5期37卷 513-517,522页

作者：林宗澤王科王利平山秀樹日本国立研究開発法人理化学研究所光量子工程研究领域太赫兹量子器件研究室

半导体太赫兹量子级联激光器(THz QCL)是一种相干性好线宽窄的太赫兹辐射源,有潜力获得高的输出功率.采用基于非平衡格林函数(NEGF)方法的计算工具设计、生长、制备了基于砷化镓系材料的THz QCL.在10 K温度下,峰值功率达到270 mW,平均... 详细信息

半导体太赫兹量子级联激光器(THz QCL)是一种相干性好线宽窄的太赫兹辐射源,有潜力获得高的输出功率.采用基于非平衡格林函数(NEGF)方法的计算工具设计、生长、制备了基于砷化镓系材料的THz QCL.在10 K温度下,峰值功率达到270 mW,平均功率为2. 4 mW,单位面积的输出功率与已报道的最高值相当.采用NEGF方法对器件的温度变化特性做了详细的分析.

关键词：太赫兹量子级联激光器砷化镓

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In Vivo Development of Fetal Pig Kidneys in Mature Monkeys under Clinically Approved Immunosuppressant Drugs

引用

Engineering 2022年第3期8卷 65-73页

作者： Tsuyoshi Takamura Kenji Matsui Naoto Matsumoto yatsumu Saito Toshinari Fujimoto Susumu Tajiri Shuichiro yamanaka Kei Matsumoto Akimitsu Kobayashi Izumi yamamoto Hiroshi Sasaki Haruyuki hirayama Hitomi Matsunari Kazuaki Nakano Hiroshi Nagashima Akihiko Kiyoshi Takao Kuroda Makoto Inoue Takeshi Miyawaki Takashi yokoo Eiji Kobayashi Division of Nephrology and Hypertension Department of Internal MedicineThe Jikei University School of MedicineTokyo 105-8461Japan Department of Urology The Jikei University School of MedicineTokyo 105-8461Japan Department of Plastic and Reconstructive Surgery The Jikei University School of MedicineTokyo 105-8461Japan Meiji University International Institute for Bio-Resource Research Kanagawa 214-8571Japan Sumitomo Dainippon Pharma Co. Ltd.Osaka-fu 564-0053Japan Department of Kidney Regenerative Medicine The Jikei University School of MedicineTokyo 105-8461Japan

Controlling the immune response with only clinically approved immunosuppressant drugs is difficult in renal heterotra ns plantation from pigs to nonhuman ***,to the best of our knowledge,no reports exist on the use of fetal pigs as kidney *** study aimed to compare the degree of transplant rejection between neonatal and fetal kidneys,with genetically unmodified pigs as donors and cynomolgus monkeys as *** left kidneys of the recipient monkeys were removed,followed by transplantation of neonatal as well as fetal pig kidneys,which had undergone vascular anastomosis at the same site,into the *** was performed with only US Food and Drug Administration-approved *** fetal kidneys were transplanted into the omentum and paraaortic regions of cynomolgus ***,the engraftment and development of the transplanted tissues were pathologically examined by sampling over time(twice in each experiment).An acute rejection was observed after a few weeks in neonatal renal grafts with vascular ***,fetal pig kidneys were spared from rejection despite the administration of the same immunosuppressive protocol to the monkeys and the recipient blood vessels flowing into the fetal *** immunogenicity of fetal kidneys in pig-monkey renal heterotransplantation was lower than that of neonatal kidneys.

关键词： Cynomolgus monkey Pig Kidney Fetal kidney Immunosuppression

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dispersal Ability and Environmental Adaptability of Deep-Sea Mussels <i>Bathymodiolus</i>(Mytilidae: Bathymodiolinae)

引用

Open Journal of Marine Science 2013年第1期3卷 31-39页

作者： Jun-Ichi Miyazaki Saori Beppu Satoshi Kajio Aya Dobashi Masaru Kawato yoshihiro Fujiwara Hisako hirayama Faculty of Education and Human Sciences University of Yamanashi Kofu Japan Institute of Biogeosciences Japan Agency for Marine-Earth Science and Technology Yokosuka Japan

Dispersal ability and environmental adaptability are profoundly associated with colonization and habitat segregation of deep-sea animals in chemosynthesis-based communities, because deep-sea seeps and vents are patchily distributed and ephemeral. Since these environments are seemingly highly different, it is likely that vent and seep populations must be genetically differentiated by adapting to their respective environments. In order to elucidate dispersal ability and environmental adaptability of deep-sea mussels, we determined mitochondrial ND4 sequences of Bathymodiolus platifrons and B. japonicus obtained from seeps in the SagamiBayand vents in the Okinawa Trough. Among more than 20 species of deep-sea mussels, only three species in the Japanese waters including the above species can inhabit both vents and seeps. We examined phylogenetic relationships, genetic divergences (Fst), gene flow (Nm), and genetic population structures to compare the seep and vent populations. Our results showed no genetic differentiation and extensive gene flow between the seep and vent populations, indicating high dispersal ability of the two species, which favors colonization in patchy and ephemeral habitats. Our results also indicate that the environmental type (vent or seep) is not the primary factor responsible for habitat segregation in the two species.

关键词： Chemosynthesis-Based Community Vent Seep Mitochondrial DNA Stepping Stone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High concentrations of human β-defensin 2 in gastric juice of patients with Helicobacter pylori infection

引用

World Journal of Gastroenterology 2005年第31期11卷 4782-4787页

作者： Hajime Isomoto Hiroshi Mukae Hiroshi Ishimoto yoshito Nishi Chun-yang Wen Akihiro Wad Ken Ohnita Toshiya hirayama Masamitsu Nakazato Shigeru Kohno Second Department of Internal Medicine Nagasaki University School of Medicine Sakamoto 1-7-1Nagasaki Japan Department of Molecular Pathology Atomic Bomb Disease Institute Nagasaki University School of MedicineSakamoto 12-4 Nagasaki Japan Department of Bacteriology Institute of Tropical Medicine Nagasaki University School of Medicine Sakamoto 12-4 Nagasaki Japan Third Department of Internal Medicine Miyazaki Medical College Kiyotake Miyazaki Japan

MIA： Human β-defensin （HBD）-1 and HBD-2 are endogenous antimicrobial peptides. Unlike HBD-1, the HBD-2 expression is augmented by Helicobacter pylori （H pylon）. We sought to determine HBD-1 and HBD-2 concentrations in gastric juice during Hpylori infection. METHODS： HBD-1 and HBD-2 concentrations were measured by radioimmunoassay in plasma and gastric juice of 49 Hpylori-infected and 33 uninfected subjects and before and after anti-H pyloritreatment in,13 patients with Hpylori-associated gastritis. Interleukin （IL）-1β and IL-8 concentrations in gastric juice were measured by enzyme-linked immunosorbent assay （ELISA）. Histological grades of gastritis were determined using two biopsy specimens taken from the antrum and corpus. Reverse phase high performance liquid chromatography （RP-HPLC） was used to identify HBD-2. RESULTS： HBD-2 concentrations in gastric juice, but not in plasma, were significantly higher in Hpylori-positive than -negative subjects, albeit the post-treatment levels were unchanged. Immunoreactivity for HBD-2 was exclusively identified in Hpylori-infected mucosa by RPHPLC. HBD-2 concentrations in gastric juice correlated with histological degree of neutrophil and mononuclear cell infiltration in the corpus. IL-1β levels correlated with those of IL-8, but not HBD-2. Plasma and gastric juice HBD-1 concentrations were similar in H pylori-infected and uninfected subjects. CONCLUSION： Our results place the β-defensins, especiallyHBD-2, in the front line of innate immune defence. Moreover, HBD-2 may be involved in the pathogenesis of Hpylori-associated gastritis, possibly through its function as immune and inflammatory mediator.

关键词： β-defensin 1 β-defensin 2 Helicobacterpylori

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of preferable insertion routes for esophagogastroduodenoscopy using ultrathin endoscopes

引用

World Journal of Gastroenterology 2014年第17期20卷 5045-5050页

作者： Satoshi Ono Keiko Niimi Mitsuhiro Fujishiro yu Takahashi yoshiki Sakaguchi Chiemi Nakayama Chihiro Minatsuki Rie Matsuda Itsuko hirayama-Asada yosuke Tsuji Satoshi Mochizuki Shinya Kodashima Nobutake yamamichi Atsuko Ozeki Lumine Matsumoto yumiko Ohike Tsutomu yamazaki Kazuhiko Koike Center for Epidemiology and Preventive Medicine Graduate School of MedicineUniversity of TokyoTokyo 113-8655Japan Department of Gastroenterology Graduate School of MedicineUniversity of TokyoTokyo 113-8655Japan Department of Endoscopy and Endoscopic Surgery Graduate School of MedicineUniversity of TokyoTokyo 113-8655Japan

AIM: To evaluate the discomfort associated with esophagogastroduodenoscopy (EGD) using an ultrathin endoscope through different insertion routes.

关键词： Esophagogastroduodenoscopy Ultrathin endoscope Visual analog scale

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

萧红作品的魅力--一个外国读者看萧红

引用

学习与探索 2011年第3期 209-213页

作者： [日]平石淑子日本大正大学文学部东京170-8470

在中国现代文学史上,萧红的出现是中国现代文学发展中的标志性事件,其貌似通俗的文字在诸多方面拥有着无法复制的历史意义与永恒的艺术价值。她之所以能够进入文学史,是以其永远变换的文学创新的姿态参与到中国现代文学史的建构之中,从... 详细信息

在中国现代文学史上,萧红的出现是中国现代文学发展中的标志性事件,其貌似通俗的文字在诸多方面拥有着无法复制的历史意义与永恒的艺术价值。她之所以能够进入文学史,是以其永远变换的文学创新的姿态参与到中国现代文学史的建构之中,从而给中国现代文学史带来的崭新素质与历史性超越。2011年是萧红诞辰100周年,为此我们特邀请国内外萧红研究方面的专家学者,就萧红在中国现代文学史上的价值和意义各抒己见,以纪念这位中国20世纪30年代的"文学洛神"、从荒原走向世界的中国现代女作家。

关键词：外国读者萧红作品学者

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：