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Favipiravir and its potentials in COVID-19 pandemic:An update

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Asian Pacific Journal of Tropical Medicine 2021年第10期14卷 433-455页

作者： Dao Ngoc Hien Tam Ahmad T Qarawi Mai Ngoc Luu Morgan Turnage Linh Tran Gehad Mohamed Tawfik Le Huu Nhat Minh Nguyen Tien Huy Tatsuo Iiyama Kyoshi Kita Kenji hirayama Online Research Club School of Tropical Medicine and Global HealthNagasaki UniversityNagasaki 852-8523Japan Asia Shine Trading&Service CO.LTD. Ho Chi Minh City 700000Vietnam Essen Healthcare BronxNew York 10461 USA Department of Internal Medicine University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh City 700000Vietnam American University of the Caribbean CupecoySint Maarten Institute of Fundamental and Applied Sciences Duy Tan UniversityHo Chi Minh City 700000Vietnam Faculty of Natural Sciences Duy Tan UniversityDa Nang City 550000Vietnam Department of Otorhinolaryngology Faculty of MedicineAin Shams UniversityCairoEgypt Methodist Hospital MerrillvilleIndianaUnited States School of Tropical Medicine and Global Health Nagasaki University1-12-4 SakamotoNagasaki 852-8523Japan Department of International Trials Center of Clinical SciencesNational Center for Global Health and Medicine(NCGM)TokyoJapan

The COVID-19 pandemic has caused millions of deaths and hundreds of millions of confirmed infections *** pandemic has prompted researchers to produce medications or vaccines to reduce or stop the progression and spread of this disease.A variety of previously licensed and marketed medications are being tested for the treatment and recurrence of SARS-CoV2,including favipiravir(Avigan).Favipiravir was recognized as an influenza antiviral drug in Japan in 2014,and has been known to have a potential in vitro activity against SARS-CoV-2,in addition to its broad therapeutic safety *** was recently approved and officially used in many countries *** review provides insights and up-to-date knowledge of the current role of favipiravir in the treatment of COVID-19 infection,focusing on preclinical and ongoing clinical trials,evidence of its efficacy against SARS-CoV-2 in COVID-19,side effects,anti-viral mechanism,and the pharmacokinetic properties of the drug in the treatment of *** to its teratogenic effects,favipiravir cannot be offered to expectant or pregnant *** practical efficacy of such an intervention regimen will depend on its dose,treatment duration,and cost as well as difficulties in application.

关键词： Favipiravir Avigan COVID-19 SARS-CoV-2 Antiviral Review Efficacy

单克隆抗体生物素-亲和素系统诊断日本血吸虫病的研究

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中华预防医学杂志 2006年第4期40卷 244-247页

作者：陈红根曾小军葛军姜唯声 Mihoko Kikuchi Kenji hirayama 江西省寄生虫病防治研究所诊断研究室南昌330046 Department of Molecular Immunogentics Institute of Tropical Medicine Nagasaki UniversityJapan

目的探讨TM5．28单克隆抗体-生物素-亲和素系统检测日本血吸虫循环抗原及其诊断效果。方法制备TM5．28抗日本血吸虫肠相关抗原单克隆抗体,建立单抗-生物素-链霉亲和素检测系统,对各类血清(50份急性血吸虫病人、224份慢性血吸虫病人、49... 详细信息

目的探讨TM5．28单克隆抗体-生物素-亲和素系统检测日本血吸虫循环抗原及其诊断效果。方法制备TM5．28抗日本血吸虫肠相关抗原单克隆抗体,建立单抗-生物素-链霉亲和素检测系统,对各类血清(50份急性血吸虫病人、224份慢性血吸虫病人、49份晚期血吸虫病人;46份血吸虫病治疗前、治疗后6个月和治疗后1年的连续追踪病人;19份华支睾吸虫病人;31份肺吸虫病人; 23份乙型肝炎病人;100份正常人)进行检测。结果检测系统对慢性血吸虫病人和正常人检测的敏感性和特异性分别为83．1％和94．0％,youden指数为0．771;对急性血吸虫病人的检出率94．0％;对肺吸虫、华支睾吸虫和肝炎病人的交叉反应为12．9、15．8和13．0％。血吸虫病人治疗后6个月和1年的阴转率分别为43．9％和62．1％,其OD值几何均数从治疗前的0．172下降到治疗后6个月的0．081和1年的0．068,下降了60．30％。轻、中感染度慢性血吸虫病人的检出率相近,分别为83．9％和82．1％,重感染度病人的检出率最高达90．00%。结论该系统对血吸虫病人检测显示了较高的诊断效能和化疗后阴转率,对人群感染状况的判定和个体诊断有一定的应用价值,为日本血吸虫病的免疫诊断和疗效考核提供了一种可行方法。

关键词：抗体,单克隆血吸虫病,日本免疫学试验

敦煌《毛诗音》反切中的“开合一致原则”及其在韵母拟音上的应用

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中国语文 2010年第3期 256-269页

作者：平山久雄日本东京大学文学部

本文作为平山久雄(2009)的续篇,介绍敦煌《毛诗音》残卷反切结构中的"开合一致原则"的统计基础,并说明应用这条结构原则对阐释一些韵母如鱼韵、东韵、覃韵、江韵等拟音问题的功用。"开合一致"表示反切上字和被切字开合一致。带"唇性韵尾... 详细信息

本文作为平山久雄(2009)的续篇,介绍敦煌《毛诗音》残卷反切结构中的"开合一致原则"的统计基础,并说明应用这条结构原则对阐释一些韵母如鱼韵、东韵、覃韵、江韵等拟音问题的功用。"开合一致"表示反切上字和被切字开合一致。带"唇性韵尾"/u/、/m/、/w/等的韵母不属开口或合口,而构成另一范畴"唇尾"。唇尾诸韵对"开合一致原则"表现出的性质因韵而有所不同,作者根据统计数据拟定每一唇尾韵的"合口度"。

关键词：敦煌残卷《毛诗音》开合反切结构《切韵》音系

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论“他的年纪比我大”类“比”字句

汉语学习 2014年第3期 51-57页

作者：平山邦彦拓殖大学外国语学部

本文探讨"X的N比yW"格式类"比"字句,如"他的年纪比我大"。本文着眼于比较项X/y和比较点N的语义关系,对这类"比"字句成立的条件进行了探讨。经探讨发现:对于这类"比"字句,从X/y的词汇意义或借助于"X比yNW"的结构意义,可以看出N在X/y的支... 详细信息

本文探讨"X的N比yW"格式类"比"字句,如"他的年纪比我大"。本文着眼于比较项X/y和比较点N的语义关系,对这类"比"字句成立的条件进行了探讨。经探讨发现:对于这类"比"字句,从X/y的词汇意义或借助于"X比yNW"的结构意义,可以看出N在X/y的支配域中具有显著性,同时X/y和N之间存在"整体—部分"的关系,而这种显著性和"整体—部分"关系是这类"比"字句能够成立的一个必要条件。

关键词： X的N比yW 支配域显著性整体—部分

Manipulating Hypoxia in Solid Tumors Has the Potential to Influence Lung Metastases in vivo

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Manipulating Hypoxia in Solid Tumors Has the Potential to In...

Cardiogenic Shock Caused by a Large Sub-Epicardial Hematoma Complicating Percutaneous Coronary Intervention

作者： S.Masunaga y.Matsumoto R.hirayama G.Kashino y.Sakurai H.Tanaka M.Suzuki y.Kinashi y.Liu K.Ando K.Ono National Institute of Radiological Sciences Heavy Ion Medical Center Gunma University

BACKGROUNDS AND PURPOSES:Many cells in solid tumors are quiescent in situ but are still clonogenic .Quiescent(Q) tumor cells are more resistant to low-LET radiation because of their larger hypoxic fraction and greater capacity to recover from radiation -induced DNA damage than proliferating(P) tumor *** original method for selectively detecting the response of intratumor Q cells has made it possible to evaluate the usefulness of various modalities for cancer therapy in terms of effectiveness against intratumor Q

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Case Reports in Clinical Medicine 2015年第6期4卷 233-236页

作者： yoshiharu Higuchi Daisuke Fukamachi Nobuyuki Fujii Toshihiko Nishida Atsushi hirayama Division of Cardiology Department of Medicine Nihon University School of Medicine Tokyo Japan

A 56-year-old man with a history of old myocardial infarction and coronary artery bypass grafting was performed percutaneous coronary intervention to the totally occluded lesion of native left anterior descending artery. He developed a coronary arterial perforation that led to a large dissecting sub-epicardial hematoma. Emergent surgery was performed, and a large hematoma was removed from the sub-epicardial space. Continuous drainage of blood was observed after surgery, and the patient died due to the development of multiorgan dysfunction. An autopsy revealed an extensive sub-epicardial hematoma on the lateral wall of the left ventricle and broad necrosis of the myocardium in the lateral wall.

关键词： Sub-Epicardial Hematoma Cardiac Tamponade Percutaneous Coronary Intervention Coronary Artery Bypass Grafting

A case of Bickerstaff brainstem encephalitis successfully treated with intravenous immunoglobulin and methylprednisolone after unsuccessful immunoadsorption plasmapheresis

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Open Journal of Clinical Diagnostics 2013年第1期3卷 1-4页

作者： Takeshi Imai Takahiro Shimizu yuta Hagiwara Toshikazu hirayama yasuhiro Hasegawa Department of Internal Medicine Division of Neurology St. Marianna University School of Medicine Kawasaki Japan

Bickerstaff brainstem encephalitis (BBE) is a rare post-infectious neurological syndrome for which an effective treatment strategy has not been established. Here, we report a case of a 71-year-old male who suffered from an upper respiratory tract infection, and 7 days later, developed numbness of the bilateral upper and lower limbs, unsteady gait and dysarthria. Brain magnetic resonance imaging was normal, nerve conduction study and cerebral spinal fluid analysis were nonspecific. Based on the clinical features, we tentatively diagnosed Guillain-Barré syndrome and started immunoadsorption plasmapheresis. However, consciousness progressively declined to coma level within 10 days. Electroencephalogram showed diffuse slowing, and auditory evoked brainstem response (ABR) demonstrated absence of waves II, III and V. Serum anti-GQ1b IgG autoantibody and anti-GM1b IgG autoantibody were negative. Subsequently, we diagnosed BBE, and clinical symptoms resolved after treatment with intravenous immunoglobulin and methyllprednisolone. On day 62, neurological symptoms were remarkably alleviated with an improvement in ABR. Our observations suggest that immunoadsorption plasmapheresis should be used only when anti-ganglioside antibodies are detected. Combination therapy with intravenous immunoglobulin and methylprednisolone or plasma exchange?is recommended as initial therapy.

关键词： Bickerstaff Brainstem Encephalitis Intravenous Immunoglobulin Methylprednisolone Immunoadsorption Plasmapheresis

试谈汉语介词短语状语的语序规则——从语义结合力的角度谈起

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汉语学习 2018年第3期 25-32页

作者：平山邦彦拓殖大学外国语学部日本东京1930985

现代汉语中介词短语为一种代表性的状语格式,其所处位置可在主语前后。介词短语从语序分布看有三种情况:介词短语(Ⅰ)只能采用后者语序;介词短语(Ⅱ)前后两种语序都可以采用;介词短语(Ⅲ)只能采用前者语序。文章对形成这一现象的核心因... 详细信息

现代汉语中介词短语为一种代表性的状语格式,其所处位置可在主语前后。介词短语从语序分布看有三种情况:介词短语(Ⅰ)只能采用后者语序;介词短语(Ⅱ)前后两种语序都可以采用;介词短语(Ⅲ)只能采用前者语序。文章对形成这一现象的核心因素从语义结合力角度进行探讨发现:介词短语(Ⅰ)(Ⅱ)(Ⅲ)在语义结合力以及谓语对介词宾语的施事性或受事性的凸显程度上存在差异,其对介词短语状语呈三种不同的语序倾向起关键作用。这是语义靠近原理共性语序规则在汉语中作为语言个性的充分体现。

关键词：介词短语语义结合力施事性受事性凸显

Plasma-Electrolysis of Dinitrophenol in Gas-Liquid Boundary and Interpretation Using Molecular Orbital Theory

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World Journal of Engineering and Technology 2019年第1期7卷 141-157页

作者： Hiroshi Okawa Hiroki Kuroda Keiko hirayama-Katayama Shin-Ichiro Kojima Tetsuya Akitsu Happy Science University Chosei-Chiba Japan University of yamanashi Kofu Japan Kyushu University Fukuoka Japan

The advanced oxidation of 2,4-dinitrophenol (DNP), 2,5-DNP, and 3,4-DNP in aqueous solution has been investigated using a multi-gas, dielectric barrier discharge. Dielectric barrier discharge was operated in the aqueous solution and gas boundary. The degradation was measured by high performance liquid chromatography (HPLC). The acceleration of the advanced-oxidation has been investigated by the combination of the anion exchange polymer membrane. The result indicated that the degradation pathways involve a rapid detachment of the nitro group and a slow opening of the aromatic-ring. The hydroxyl radical and the excited hydroxyl anion are responsible for the primary attack of the DNP with the production of dihydroxy-nitrobenzenes. The attack of hydroxyl radical occurs at the benzene ring carbon activated by the presence of a phenolic OH group and a nitro group. The result suggested that the reaction is dominated by a pseudo-first order kinetic reaction. The degradation process is interpreted using Molecular Orbital Theory.

关键词： Dielectric Barrier Discharge Dinitrophenol Advanced Oxidation Molecular Orbital Theory