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作者： Toshitaka futagawa Sashi Kesavapany Melitta Schachner Gavin S.Dawe Department of Clinical Research Singapore General HospitalSingapore Department of Biochemistry Yong Loo Lin School of MedicineNational University of SingaporeSingapore Department of Pharmacology and Department of Anatomy Yong Loo Lin School of MedicineNational University of SingaporeSingapore

＜正＞APP,commonly associated with Alzheimer’s disease,marks axonal *** physiological distribution and function along myelinated axons remain *** report that APP null and APP overexpressing transgenic（APPtg） mice show minor hypo- and hyper-myelination,*** axoglial interactions, APP aggregates at nodes of Ranvier（NORs） in the ***,coexpression of APP or its intracellular domains containing a VTPEER motif with Navl.6 sodium channels in Xenopus oocytes resulted in an increase in peak sodium currents,which was enhanced by APPT668E mutation and blocked by APPT668A mutation and inhibitors of CDK5 and *** cell surface expression of Navl.6 sodium channels in the white matter of spinal cord is decreased in APP,p35 and JNK3 null ***,APP,p35 and JNK3 deficiency significantly reduce spinal conduction ***,APP acts as a novel component at CNS NORs,modulating Navl.6 sodium channels in an APPThr668 phosphorylation-dependent manner.

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应用亲水涂层导管经桡动脉心导管术时桡动脉痉挛的发生率低

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 32-32页

作者： Koga S. Ikeda S. futagawa K. y. Miyahara 任付先 The Second Dept. of Int. Med icine Nagasaki Univ. School of Medicine 1-7-1 Sakamoto 852-8501 Nagasaki Japan

Background: Radial artery spasm (RAS) is a common complication of trans radial approach (TRA) to percutaneous coronary angiography (CAG) and coronary intervent ion. Lower friction resistance between catheter and RA wall may reduce RAS upon insertion, manipulation, and withdrawal of the catheter. The aim of this study w as to investigate whether the use of a hydrophilic-coated (HC) catheter, which has lower friction coefficient, could reduce the incidence of RAS compared with a non-hydrophilic-coated (NHC) catheter. Methods: A total 250 patients attempt ed diagnostic CAG using 5-French catheters via the TRA between September 2000 a nd April 2002. Two hundred thirty-four (93.6%) patients who achieved successfu l coronary cannulation were selected for the study. NHC catheters were used in 1 49 patients (63.7%), and HC catheters were used in 85 patients (36.3%). We com pared the incidence of RAS between NHC and HC catheters. Results: RAS occurred i n 17 (7%) patients totally. RAS was less likely to occur in HC group (one patie nt, 1%) than in the NHC group (16 patients, 11%, P=0.007). Conclusions: We con clude that the use of HC catheters can reduce RAS upon insertion, manipulation, and withdrawal of the catheter compared with NHC catheters.

关键词：桡动脉痉挛心导管亲水冠状动脉介入术

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