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Neural Regeneration Research 2020年第9期15卷 1590-1600页

作者： Koji Kamagata Christina Andica Taku Hatano Takashi Ogawa Haruka Takeshige-Amano Kotaro Ogaki Toshiaki Akashi Akifumi Hagiwara Shohei fujita Shigeki Aoki Department of Radiology Juntendo University Graduate School of MedicineTokyoJapan Department of Neurology Juntendo University School of MedicineTokyoJapan

The prevalence of neurodegenerative diseases is increasing as human longevity increases. The objective biomarkers that enable the staging and early diagnosis of neurodegenerative diseases are eagerly anticipated. It has recently become possible to determine pathological changes in the brain without autopsy with the advancement of diffusion magnetic resonance imaging techniques. Diffusion magnetic resonance imaging is a robust tool used to evaluate brain microstructural complexity and integrity, axonal order, density, and myelination via the micron-scale displacement of water molecules diffusing in tissues. Diffusion tensor imaging, a type of diffusion magnetic resonance imaging technique is widely utilized in clinical and research settings;however, it has several limitations. To overcome these limitations, cutting-edge diffusion magnetic resonance imaging techniques, such as diffusional kurtosis imaging, neurite orientation dispersion and density imaging, and free water imaging, have been recently proposed and applied to evaluate the pathology of neurodegenerative diseases. This review focused on the main applications, findings, and future directions of advanced diffusion magnetic resonance imaging techniques in patients with Alzheimer's and Parkinson's diseases, the first and second most common neurodegenerative diseases, respectively.

关键词： Alzheimer's disease biomarkers diffusional kurtosis imaging disease progression early diagnosis free-water imaging neurites neurite orientation dispersion and density imaging Parkinson's disease

New Technology for the Evaluation of Clinical Manifestations of Osteoporosis——Objective Pain Assessment by Electroalgometry and Sway Analysis by Computerized Posturography

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New Technology for the Evaluation of Clinical Manifestations...

Factor Structure and Measurement Invariance of the Prenatal Attachment Inventory: A Study among Japanese Pregnant Women

第五届国际骨质疏松研讨会暨第三届国际骨矿研究会议

作者： Takuo fujita Professor Emeritus Kobe University and Honorary DirectorKatsuragi Hospital

＜正＞Osteoporosis sometimes called a silent disease is usually painless until fracture and skeletal deformity appears,when backache especially on physical strain persistently interferes with daily *** is also associated with muscle weakness and postural instability precipitating falls and further *** order to prevent such downhill "Osteoporosis Spiral" leading to complete helplessness and bed—ridden state,new technology was introduced for objective assessment of pain by measurement of skin impedance by electeoalgometry（EAM ） and for detailed sway analysis by computed posturography to evaluate the risk for falls and fracture.

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Open Journal of Nursing 2021年第4期11卷 230-240页

作者： Kayoko fujita Eliko Otsuki Faculty of Nursing Mejiro University Saitama Japan Graduate School of Health Care and Nursing Juntendo University Chiba Japan

Background: Maternal emotional tie towards a foetus is a predictor of later maternal and child’s mental health. Methods: A questionnaire survey was conducted among 539 first trimester women. It included the Prenatal Attachment Inventory (PAI), Relationship Questionnaire (RQ), and Edinburgh Postnatal Depression Scale (EPDS). The factor structure models derived from exploratory factor analyses were compared by confirmatory factor analyses. Results: A three-factor bifactor model of the PAI was bet fit to the data. The omega coefficients and explained common variance suggested that the influences of three group factors were not negligible. The scores of the three subscales (derived from the three factors) were differently associated with age, gestation week, and adult attachment styles (derived from RQ). They were, however, not correlated with the EPDS scores. Conclusion: The PAI has a model of three groups and one general factor with an excellent fit to the data. The three subscales have construct validity too.

关键词： Prenatal Attachment Inventory Maternal Emotional Ties Factor Structure Measurement Invariance

Synthesis, crystal structure, magnetic properties and second harmonic generation of a new noncentrosymmetric coordination compound：Triaqua(4-amino-6-methoxypyrimidine) cuprate(Ⅱ)sulfate

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Chinese Chemical Letters 2016年第6期27卷 896-900页

作者： Mahjouba Ben Nasr Kamel Kaabi Matthias Zeller Wataru fujita Pedro Sidónio Pereira da Silva Cherif Ben Nasr Laboratoire de Chimie des Materiaux Universite de Carthage Facultedes Sciences de Bizerte 7021 Zarzouna Tunisia Department of Chemistry Youngstown State University One University Plaza Youngstown OH 44555-3663 USA Graduate School of Natural Science Nagoya City University Yamanohata Mizuho-cho Mizuho-ku Nagoya 467-8501 Japan CFisUC Department of Physics University of Coimbra 3004-516 Coimbra Portugal

The chemical preparation, crystal structure and infrared spectroscopic characterization of the triaqua（4-amino-6-methoxypyrimidine） cuprate（II） sulfate, [Cu（C5H7N3）（H2O）3]SO4, is reported. The compound crystallizes in the noncentrosymmetric orthorhombic space group P212121 with lattice parameters a = 7.9025（3）, b = 11.1189（4）, c = 12.9720（4） , V = 1139.81（7） ~3 and Z = 4. The Cu（II） cation is fivecoordinated, in an early half-way between square pyramidal and trigonal bipyramidal fashion, by two nitrogen atoms of the 4-amino-6-methoxypyrimidine ligand and three water oxygen atoms. In the atomic arrangement, the organic ligands and the 5-connected Cu centers are linked with each other to give a 1-D corrugated hybrid chain running along the b-axis direction. The chains are interconnected by the SO4^（2-） anions via O–H...O, O–H...S, C–H...O and N–H...O hydrogen bonds to form layers spreading parallel to the（011） plane. The vibrational absorption bands were identified by infrared spectroscopy. Quantitative measurements of the second harmonic generation（SHG） of a powdered sample at 1064 nm were performed and a relative efficiency of 5.2 times the KDP standard was observed. Magnetic properties were also defined to characterize the complex. Magnetic measurements revealed that this material had a onedimensional antiferromagnetic character. The magnetic parameters were g = 2.11 and 2J/k B = -36 K.

关键词： Square pyramid Cu(II) complex X-ray diffraction Magnetic properties Second harmonic generation

Targeting Glycinebetaine for Abiotic Stress Tolerance in Crop Plants:Physiological Mechanism,Molecular Interaction and Signaling

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Phyton-International Journal of Experimental Botany 2019年第3期88卷 185-221页

作者： Mirza Hasanuzzaman Aditya Banerjee M.H.M.Borhannuddin Bhuyan Aryadeep Roychoudhury Jubayer Al Mahmud Masayuki fujita Department of Agronomy Faculty of AgricultureSher-e-Bangla Agricultural UniversityDhakaBangladesh Post Graduate Department of Biotechnology St.Xavier’s College(Autonomous)30Mother Teresa SaraniKolkataWest BengalIndia Laboratory of Plant Stress Responses Department of Applied Biological ScienceFaculty of AgricultureKagawa University2393 IkenobeMiki-choKita-gunKagawaJapan Bangladesh Agricultural Research Institute JoydebpurGazipurBangladesh Department of Agroforestry and Environmental Science Faculty of AgricultureSher-e-Bangla Agricultural UniversityDhakaBangladesh

In the era of climate change,abiotic stresses(e.g.,salinity,drought,extreme temperature,flooding,metal/metalloid(s),UV radiation,ozone,etc.)are considered as one of the most complex environmental constraints that restricts crop production *** of stress-tolerant crop cultivars is the most auspicious way of surviving this constraint,and to produce these types of tolerant *** bioengineering mechanisms involved in stress signaling are being adopted in this *** example of this kind of manipulation is the osmotic *** quarternary ammonium compound glycinebetaine(GB),also originally referred to as betaine is a methylated glycine *** the betaines,GB is the most abundant one in plants,which is mostly produced in response to dehydration caused by different abiotic stresses like drought,salinity,and extreme *** helps in decreased accumulation and detoxification of ROS,thereby restoring photosynthesis and reducing oxidative *** takes part in stabilizing membranes and *** is also involved in the stabilization and protection of photosynthetic components,such as ribulose-1,5-bisphosphate carboxylase/oxygenase,photosystem II and quarternary enzyme and protein complex structures under environmental *** was found to perform in chaperone-induced protein *** addition,GB can confer stress tolerance in very low concentrations,and it acts in activating defense responsive genes with stress ***,field application of GB has also shown protective effects against environmental adversities increasing crop yield and *** this review,we will focus on the role of GB in conferring abiotic stress tolerance and the possible ways to engineer GB biosynthesis in plants.

关键词： Osmolytes compatible solutes biostimulants proline amino acids stress signaling

Diagnostic ability of multi-detector spiral computed tomography for pathological lymph node metastasis of advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2020年第4期12卷 435-446页

作者： Zhi-yong Jiang Shinichi Kinami Naohiko Nakamura Takashi Miyata Hideto fujita Hiroyuki Takamura Nobuhiko Ueda Takeo Kosaka Department of Surgical Oncology Kanazawa Medical University1-1 DaigakuUchinada-machiKahoku-gunIshikawa 920-0293Japan

BACKGROUND The reliability of preoperative nodal diagnosis of advanced gastric cancer by multi-detector spiral computed tomography(MDCT)is still *** To examine the diagnostic ability of MDCT more precisely by using data on intranodal pathological metastatic *** A total of 108 patients with advanced gastric cancer who underwent MDCT and curative gastrectomy at Kanazawa Medical University Hospital were enrolled in this *** nodal sizes measured on computed tomography(CT)images were compared with the pathology results.A receiver-operating characteristic curve was constructed,from which the critical value(CV)was calculated by using the data of the first 69 patients *** using the CV,sensitivity and specificity were calculated with prospectively collected data from 39 consecutive *** enabled a more precise one-to-one correspondence of lymph nodes between CT and pathological examination by using the size data of lymph node *** intranodal pathological metastatic patterns were classified into the following four types:Small nodular,peripheral,large nodular,and *** Although all the cases were clinically suspected as having metastasis,81 had lymph node metastasis and 27 had no *** number of dissected,detected on CT,and metastatic nodes were,4241,897,and 801,*** CV obtained from the receiver-operating characteristic was 7.6 mm for the long *** sensitivity was 91.4%and the specificity was 47.3%in the prospective *** large nodular and diffuse metastases were easy to diagnose becausemetastatic nodes with a large axis often exhibit these *** The ability of MDCT to contribute to a nodal diagnosis of advanced gastric cancer was examined prospectively with precise size data from node mapping,using a CV of 7.6 mm for the long axis that was calculated from the retrospectively collected *** sensitivity was as high as 91%,and would be improved when referring to the en

关键词： Advanced gastric cancer Lymph node metastasis Multi-detector spiral computed tomography Pathological diagnosis

Preparation Procedure of Liposome-Absorbed Substrate and Tip Shape Correction of Diameters of Liposome Measured by AFM

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Microscopy Research 2013年第3期1卷 24-28页

作者： yuichi Muraji Takaya fujita Hiroshi Itoh Daisuke fujita Advanced Key Technologies Division National Institute for Materials Science (NIMS) Tsukuba Japan Research Institute of Instrumentation Frontier National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Japan Surface Analysis Laboratories Toray Research Center Inc. (TRC) Otsu Japan

The procedure to measure liposome in aqueous solution has been examined using atomic force microscope (AFM). We concluded a chemical modified silicon wafer (substrate for AFM observation of liposome) with 3-aminopropyltrieth-oxysilane (APTES) which enabled us to scan anionic liposome softly in water because they were keeping structures as vesicles and stably adsorbed on the substrate by electrostatic force. From captured AFM topographic images, we counted the amount of liposome and analyzed the distribution of mean diameters, which were corrected by an approximated curve of the tip shape. We discussed the method of effective evaluation as practical analysis and its problems for robust analysis.

关键词： Atomic Force Microscope (AFM) Dynamic Light Scattering (DLS) Anionic Liposome 3-Aminopropyltriethoxysilane (APTES)

Synthesis and Binding Properties of Novel Cyclodextrin Dimers Linked at C-6 by the Shortest Bridge-a Sulfur Atom

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Chinese Chemical Letters 1997年第6期8卷 475-476页

作者： De Qi yUAN Kahee fujita yuji OKABE (Faculty of Pharmaceutical Sciences, Nagasaki University, Bunkyo-machi 14-1, Nagasaki 852, Japan ) Faculty of Pharmaceutical Sciences Nagasaki University Bunkyo-machi 14-1 Nagasaki 852 Japan

Three cyclodextrin dimers bridged at C-6 by the shortest tether - a sulfur atom are synthesized by reacting cyclodextrin tosylates with Na2S and their binding properties are evaluated

关键词： ppm

Comparison of β-decay and Charge-exchange Reactions in Mirror T=2 Nuclei and Isospin Mixing

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原子核物理评论 2016年第2期33卷 225-229页

作者： B. Rubio S. E. A. Orrigo A. Algora B. Blank y. Fuiita H. fujita E. Ganioglu W. Gelletly A. Montaner-Piza A. Poves Instituto de Fisica Corpuscular(CSIC-Uni. Valencia) Valencia E-46071 Spain Centre d'Etudes Nucleaires de Bordeaux Gradignan CNRS/IN2P3- Univ. Bordeaux Gradignan Cedex 33175 France Department of Physics Osaka University Toyonaka-Osaka 560-0043 Japan Research Center for Nuclear Physics Osaka University Ibaraki Osaka 567-0047 Japan Department of Physics Istanbul University Istanbul 34134 Turkey Department of Physics University of Surrey Guildford Surrey GU2 7XH UK Departamento de Fisica teorica and IFT UAM-CSIC Universidad Autonoma de Madrid Madrid E-28049 Spain

We have carried out β decay studies of proton rich nuclei in the fp shell at different *** we present our recent results on the β decay of Tz =-2 nuclei performed at GANIL and compare them with the Charge Exchange reactions on their stable, mirror-partner targets, performed at *** one of the cases, the ^(56)Zn-^(56)Fe pair, a strong isospin mixing has been observed. The results are well reproduced in the framework of Shell Model calculations.

关键词： β-delayed proton γ decay isospin mixing Charge-Exchange reaction Shell Model