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Effects of Chinese Medicine Five-Element Music on the Quality of Life for Advanced Cancer Patients:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2013年第10期19卷 736-740页

作者：廖娟杨宇飞 Lorenzo cohen 赵元辰许云 Oncology Department of Xiyuan Hospital China Academy of Chinese Medical Sciences The University of Texas MD.Anderson Cancer Center Texas 77030USA

Objectives： To evaluate the effects of the Chinese medicine （CM） five-element music on quality of life for senior and non-senior advanced cancer patients. Methods： With a randomized controlled trial, 170 advanced cancer patients were randomly assigned to three groups： the CM five-element music group （68 patients）, the Western music therapy group （68 cases）, and the no music therapy group （34 cases）. All patients of 70 years old or older were considered seniors and the remaining patients younger than 70 years were considered non- seniors. Patients in the CM five-element music group listened to CM five-element music, the patients in the Western music group listened to Western music, and the patients in the no music group did not listen to music. A course of treatment was 3 weeks, with 30 rain each day, 5 days a week. The Hospice Quality of Life Index- Revised （HQOLI-R） and Karnofsky performance score （KPS） were measured in the three groups before and after treatment. The symptom diary score was measured in the three groups every 3 days, 7 times in total. Results： CM five-element music group showed a significant difference of HQOLI-R, KPS and symptom diary score with other groups （all P〈0.01）. There were significant differences of HQOLI-R, symptom diary score, and KPS after treatment in CM five-element music group and other groups in the non-senior subgroup （P〈0.05）. Additionally, there were significant differences in HQOLI-R and KPS after treatment among the three groups in the senior subgroup （P〈0.05）. Conclusions： CM five-element music therapy could improve the quality of life and KPS for senior and non senior advanced cancer patients, and it could improve subjective symptoms for non-senior advanced cancer patients.

关键词： five-element music advanced cancer quality of life randomized controlled trial music theragpy

Mixtures of tetrakis hydroxymethyl phosphonium chloride and ammonium influence plankton community structure in blackwater pond mesocosms

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Emerging Contaminants 2020年第1期6卷 62-71页

作者： Marina N.Osier Risa A.cohen Department of Biology Georgia Southern UniversityPO Box 8042-1StatesboroGA30460USA

Mixtures of chemicals from human sources are pervasive in aquatic systems,yet their effects on aquatic communities are relatively *** contaminants such as organophosphorus flameretardants(*** hydroxymethyl phosphonium chloride(THPC)),are toxic to planktonic species at environmentally relevant ***,inorganic ammonium from agriculture and industry is likely to enter surface waters simultaneously with flame retardant *** effects of ammonium on plankton are known,its presence has the potential to influence the toxicity of other *** study mixture effects on plankton communities,floating mesocosms were dosed with THPC(0.08 or 0.8 mg L^-1)with or without ammonium(0.3 mg L^-1).Weekly measurements of zooplankton community composition and phytoplankton abundance(as chlorophyll a)were *** factor alone had no effect on zooplankton abundance or species ***,the mixture decreased the proportion of calanoid copepods and increased rotifers during weeks *** a was unaffected by treatments,but concentrations were highly variable for the duration of the *** interaction between THPC and ammonium suggests that the contaminants together reduce abundance of large zooplankton,releasing smaller zooplankton from predation and competitive pressure while potentially limiting food availability to planktivorous fish.

关键词： Emerging contaminant Flame retardant Freshwater Nitrogen Phytoplankton Zooplankton Ecotoxicology

FATTy ACIDS PROFILE IN A HIGH CELL DENSITy CULTURE OF ARACHIDONIC ACID-RICH PARIETOCHLORIS INCISA (TREBOUXIOPHyCEAE,CHLOROPHyTA) EXPOSED TO HIGH PFD

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Chinese Journal of Oceanology and Limnology 2002年第2期20卷 149-156页

作者：刘建国 Zvi cohen 等 ResearchandDevelopmentCenterofMarineBIotechnolgy InstituteofOceanologyChineseAcademyofSciencesQingdao266071China MicroalgalBiotechnology TheJacobBlausteinInstituteforDesertResea

The changes in arachidonic acid (AA) and fatty acids profiles along the growth curve of Parietochloris incisa, a coccoid snow green alga, were studied in a 2.8 cm light-path flat photobioreactor, exposed to strong photon flux density [PFD, 2400 μEmol/(m 2·s)]. Sixteen fatty acids were identified by gas chromatography showing that AA was the dominant fatty acid (33%-41%) followed by linoleic acid (17%-21%). AA content was closely investigated with respect to total fatty acids (TFA), ash free dry weight (AFDW) of cell mass as well as total culture content. These parameters were influenced significantly in a similar manner by culture growth phase, i.e., slightly decreasing in the lag period, gradually increasing in the logarithmic phase, becoming maximal at the early stationary phase, starting to decrease at the late stationary phase, sharply dropping at the decline phase. The increase in AA per culture volume during the logarithmic phase was not only associated with the increase in AFDW but also connected with a corresponding increase in AA/TFA, TFA/AFDW as well as AA/AFDW. The sharp decrease in AA content of the culture during the decline phase was mainly due to the decrease in AA/TFA, TFA/AFDW and AA/AFDW, although AFDW declined only a small extent. Maximal AA concentration, obtained at the early stationary phase, was 900 mg/L culture volume, and the average daily net increase of AA during 9 days logarithmic growth was 1.7 g/(m 2·day). Therefore, harvesting prior to the decline phase in a batch culture, or at steady state in continuous culture mode seems best for high AA production. The latter possibility was also further confirmed by continuous culture with 5 gradients of harvesting rate.

关键词： arachidonic acid Parietochloris incisa growth high cell density culture

Delivery Outcomes in Non-Tertiary Referral Centers for Women with Congenital Heart Disease

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Congenital Heart Disease 2023年第3期18卷 315-323页

作者： Daniel Sweeney Scott cohen Salil Ginde Jennifer Gerardin Peter Bartz Matthew Buelow Medical College of Wisconsin MilwaukeeWIUSA Department of Pediatrics Medical College of WisconsinMilwaukeeWIUSA Department of Internal Medicine Medical College of WisconsinMilwaukeeWIUSA

Background:Women with congenital heart disease(CHD)have increased risk for adverse events during pregnancy and *** studies have assessed pregnancy and delivery outcomes at tertiary referral centers(TRC).The aim of our study was to assess pregnancy outcomes in women with CHD who deliver in a non-tertiary referral center(non-TRC).Methods:Clinical demographics were collected,including anatomic complexity,physiologic state and pre-pregnancy risk *** were stratified by delivery location,either TRC or *** and neonatal complications of pregnancy were ***:Women with CHD who delivered in a TRC had a higher pre-pregnancy risk when assessed by the Zahar and CARPREG-II scores,and had more patients fall into a higher WHO *** was no difference in rates of maternal cardiac complications between delivery locations(11%)and neonatal complications(20%)between deliveries at TRC and ***:There were not increased maternal cardiac or neonatal complications when delivery occurred at a *** complications remained high regardless of delivery *** study suggests that proper risk assessment may help identify women who are candidates for safe delivery at non-TRC in women with CHD,and that neonatal resources should be considered when planning delivery location.

关键词： Congenital heart disease pregnancy delivery outcome

Sequence-based Functional Metagenomics Reveals Novel Natural Diversity of Functional CopA in Environmental Microbiomes

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Genomics, Proteomics & Bioinformatics 2023年第6期21卷 1182-1194页

作者： Wenjun Li Likun Wang Xiaofang Li Xin Zheng Michael F.cohen yong-Xin Liu Hebei Key Laboratory of Soil Ecology Centre for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050022China University of Chinese Academy of Sciences Beijing 100049China Department of Biology Sonoma State UniversityRohnert ParkCA 94928USA State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Exploring the natural diversity of functional genes/proteins from environmental DNA in high throughput remains *** this study,we developed a sequence-based functional metagenomics procedure for mining the diversity of copper(Cu)resistance gene copA in global microbiomes,by combining the metagenomic assembly technology,local BLAST,evolutionary trace analysis(ETA),chemical synthesis,and conventional functional *** total,87 metagenomes were collected from a public database and subjected to copA detection,resulting in 93,899 *** curation of 1214 hits of high confidence led to the retrieval of 517 unique CopA candidates,which were further subjected to ***,175 novel copA sequences of high quality were *** analysis showed that almost all these putative CopA proteins were distantly related to known CopA proteins,with 55 sequences from totally unknown *** novel and three known copA genes were chemically synthesized for further functional genomic tests using the Cu-sensitive Escherichia coli(DcopA).The growth test and Cu uptake determination showed that five novel clones had positive effects on host Cu resistance and *** recombinant harboring copA-like 15(copAL15)successfully restored Cu resistance of the host with a substantially enhanced Cu *** novel copA genes were fused with the gfp gene and expressed in *** for microscopic *** results showed that they were successfully expressed and their proteins were localized to the *** results here greatly expand the diversity of known CopA proteins,and the sequence-based procedure developed overcomes biases in length,screening methods,and abundance of conventional functional metagenomics.

关键词： Functional metagenomics Natural diversity CopA Evolutionary trace analysis Cu resistance

Astrometric calibration and source characterisation of the latest generation neuromorphic event-based cameras for space imaging

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Astrodynamics 2023年第4期7卷 415-443页

作者： Nicholas Owen Ralph Alexandre Marcireau Saeed Afshar Nicholas Tothill Andre van Schaik Gregory.cohen International Centre for Neuromorphic Systems MARCS Institute for BrainBehaviour and DevelopmentWestern Sydney UniversityKingswood 2747NSWAustralia

As an emerging approach to space situational awareness and space imaging,the practical use of an event-based camera(EBC)in space imaging for precise source analysis is still in its *** nature of event-based space imaging and data collection needs to be further explored to develop more effective event-based space imaging systems and advance the capabilities of event-based tracking systems with improved target measurement ***,for event measurements to be meaningful,a framework must be investigated for EBC calibration to project events from pixel array coordinates in the image plane to coordinates in a target resident space object’s reference *** this paper,the traditional techniques of conventional astronomy are reconsidered to properly utilise the EBC for space imaging and space situational *** paper presents the techniques and systems used for calibrating an EBC for reliable and accurate measurement *** techniques are vital in building event-based space imaging systems capable of real-world space situational awareness *** calibrating sources detected using the EBC,the spatiotemporal characteristics of detected sources or“event sources”can be related to the photometric characteristics of the underlying astrophysical ***,these characteristics are analysed to establish a foundation for principled processing and observing techniques which appropriately exploit the capabilities of the EBC.

关键词： neuromorphic event-based camera(EBC) space imaging space situational awareness(SSA) astronomy

Le Corbusier, 1887-1965

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Le Corbusier, 1887-1965

Development of a short duration method to assess the envelope thermal performance of multi-family housings

作者： Jean-Louise cohen.

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Building Simulation 2023年第4期16卷 527-545页

作者： Lorena de Carvalho Araujo Simon Thébault Laurent Mora Thomas Recht Alain Sempey Patrick Schalbart Michae cohen CSTB 84 Av.Jean JauresChamps-sur-Marne77420France Bordeaux University 351 Cours de la LiberationTalence33405France MINES ParisTech Centre for Energy Efficiency of Systems5 rue Léon BlumPalaiseau91120France

Building energy efficiency is a key factor in reducing CO_(2) *** this reason,European Union(EU)member states have developed thermal regulations to ensure building thermal *** results are often based on results achieved with building simulation software during the design ***,the actual thermal performance can deviate significantly from the predicted one,and this difference is known as the energy performance *** indicators of the actual thermal performance are a valuable tool to guarantee building *** indicators,including the heat transfer coefficient(HTC)and the heat loss coefficient(HLC),can be estimated by the application of in situ *** multi-family housing and tertiary sector buildings are an important part of the building stock,mature methods to measure their thermal performance are *** paper presents a short-duration method for assessing the HTC in large building typologies using a sampling *** method was applied in a four-storey building model under different conditions to study the limits of the method and to improve indicator bias and *** quality was strongly influenced by the external weather conditions,the temperature variation during the protocol and the heat exchange with the adjacent *** winter conditions and with stable indoor temperatures,the method had a high accuracy when the protocol was applied for half a *** is recommended that the protocol be used over two days to improve indicator quality under less favorable test conditions.

关键词： building envelope thermal performance HTC estimation multi-family housing

Bacterial microcosms obey Taylor’s law:effects of abiotic and biotic stress and genetics on mean and variance of population density

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Ecological Processes 2012年第1期1卷 77-82页

作者： Oliver Kaltz Patricia Escobar-Páramo Michael E Hochberg Joel E cohen Institut des Sciences de l’Evolution UMR CNRS-UM2-IRD5554CC 065UniversitéMontpellier 2Place Eugène BataillonMontpellier Cedex 0534095France Centro Internacional de Física(CIF) Biotechnology GroupUniversidad Nacional de ColombiaCra 30 N°45-03BogotáDCColombia Laboratory of Populations Rockefeller and Columbia Universities1230 York AvenueBox 20New YorkNY10065-6399USA

Introduction:According to the empirical regularity called Taylor’s law,the variance of population density in samples of populations is a power of the mean population *** exponent is often between 1 and *** experiments investigated how genetics,evolution,and environment shape Taylor’s ***:Genetically different strains(wild type and hypermutator)of the bacterium Pseudomonas fluorescens evolved and were assayed under different environmental conditions(with and without antibiotic rifampicin and bacteriophage SBW252,separately and in combination).Results:Experimental treatments altered the exponent b,but not the power law form,of the relation between variance and mean population *** populations treated only with rifampicin had a narrow range of mean population densities and exponent b=*** exposed to rifampicin plus phage had b=*** ancestral,control,and phage-exposed populations,mean abundance varied widely and b was not significantly different from *** factors(mutation rate,selection)and ecological factors(abiotic,biotic)jointly influenced ***:Taylor’s power law relationship accurately and robustly described variance as a function of mean population density,with overall exponent b=*** and other experiments with different factors acting on bacterial population size support the relevance of models that predict‘universal’patterns of fluctuation scaling.

关键词： Taylor’s law Pseudomonas fluorescens rifampicin bacteriophage genetics