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Assessment of the dietary amino acid profiles and the relative biomarkers for amino acid balance in the low-protein diets for broiler chickens

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Journal of Animal Science and Biotechnology 2025年第1期16卷 238-266页

作者： Bin Wang Xiaodan Zhang yongfa liu Mingkun Gao Mi Wang yuan Wang Xinzhi Wang yuming Guo State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Shenyang Boeing Feed company Shenyang 110141China

Background Research on low-protein-level diets has indicated that even though the profiles of essential amino acids(EAAs)follow the recommendation for a normal-protein-level diet,broilers fed low-protein diets failed to achieve pro-ductive performance compared to those fed normal ***,it is imperative to reassess the optimum profile of EAAs in low-protein diets and establish a new ideal pattern for amino acid ***,identifying novel sensitive biomarkers for assessing amino acid balance will greatly facilitate the development of amino acid nutrition and application *** this study,12 dietary treatments[con(+),con(-),L&A(-),L&A(+),M&c(-),M&c(+),BcAA(-),BcAA(+),Thr(-),Thr(+),Trp(-)and Trp(+)]were established by.c.mbining different EAAs including lysine and argi-nine,methionine and cysteine,branched-chain amino acid(BcAA),threonine,and tryptophan to observe the growth and development of the broiler chickens fed with low-protein-level *** on the biochemical parameters and untargeted metabolomic analysis of animals subjected to different treatments,biomarkers associated with opti-mal and suboptimal amino acid balance were *** Growth performance,carcass characteristics,hepatic enzyme activity,serum biochemical parameters,and breast muscle mRNA expression differed significantly between male and female broilers under different dietary amino acid *** broilers exhibited higher sensitivity to the adjustment of amino acid patterns than female *** the low-protein diet,the dietary.c.ncentrations of lysine,arginine,and tryptophan,but not of methionine,cystine,or threonine,needed to be ***,further research on individual BcAA is *** untar-geted metabolomic analysis,con(+)was selected as a normal diet(NP)while con(-)represented a low-protein diet(LP).L&A(+)denotes a low-protein amino acid balanced diet(LPAB)and Thr(+)represents a low-protein amino acid imbalance diet(LPAI).The metaboli

关键词： Amino acid balance Biomarkers Essential amino acid Low-protein diet Metabolomics

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SyNTHESIZING KINETIcS AND MIcRO-cHARAcTERIZATION OF SPINEL LiMn_(2)O_(4) FOR LITHIUM-ION BATTERy.c.THODE MATERIAL

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Acta Metallurgica Sinica(English Letters) 2001年第5期14卷 323-329页

作者： cATHODE MATERIAL M.S. Zhao, y.c. Zhai and y.W. Tian School of Material & Metallurgy, Northeastern University, Shenyang 110004, china School of Material & Metallurgy Northeastern University

The reaction process during synthesis of LiMn2O4 with LiOH·H2O and MnO2 was studied by means of DTA in dynamical air atmosphere, and it could be applied as an important theoretical principle for preparing LiMn2O4. The active energies of four reaction processes were obtained with Doyle-Ozawa method and Kissinger method as follows: 66.299, 72.640, 128.11 and 113.876 kJ·mol-1, respectively. Reaction orders, frequency factors and kinetic equations of each reaction were determined by Kissinger method. XRD, SEM and TEM show that the synthesized LiMn2O4 is a pure phase, with regular appearance and higher ratio-surface.

关键词： cathodes Inorganic compounds Kinetic theory Synthesis (chemical)

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calcium bridges built by mitochondria-associated endoplasmic reticulum membranes:potential targets for neural repair in neurological diseases

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Neural Regeneration Research 2025年第12期20卷 3349-3369页

作者： y.c.en Peng Li Zhou yaju Jin Danli Wu Na chen chengcai Zhang Hongpeng liu chunlan Li Rong Ning Xichen yang Qiuyue Mao Jiaxin liu Pengyue Zhang yunnan Key Laboratory of Integrated Traditional chinese and Western Medicine for chronic Disease in Prevention and Treatment Key Laboratory of Acupuncture and Massage for Treatment of EncephalopathyCollege of AcupunctureTuina and RehabilitationYunnan University of Chinese MedicineKunmingYunnan ProvinceChina School of Medicine Kunming University of Science and TechnologyKunmingYunnan ProvinceChina

The exchange of information and materials between organelles plays a crucial role in regulating cellular physiological functions and metabolic ***-associated endoplasmic reticulum membranes serve as physical contact channels between the endoplasmic reticulum membrane and the mitochondrial outer membrane,formed by various proteins and protein *** microstructural domain mediates several specialized functions,including calcium(ca^(2+))signaling,autophagy,mitochondrial morphology,oxidative stress response,and ***,the dysregulation of ca^(2+)signaling mediated by mitochondria-associated endoplasmic reticulum membranes is a critical factor in the pathogenesis of neurological *** proteins or protein complexes within these membranes directly or indirectly regulate the distance between the endoplasmic reticulum and mitochondria,as well as the transduction of ca^(2+)***,ca^(2+)signaling mediated by mitochondria-associated endoplasmic reticulum membranes influences other mitochondria-associated endoplasmic reticulum membraneassociated *** functions can vary significantly across different neurological diseases—such as ischemic stroke,traumatic brain injury,Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,and Huntington's disease—and their respective stages of *** modulation of these disease-related pathways and functional proteins can enhance neurological function and promote the regeneration and repair of damaged ***,mitochondria-associated endoplasmic reticulum membranes-mediated ca^(2+)signaling plays a pivotal role in the pathological progression of neurological diseases and represents a significant potential therapeutic *** review focuses on the effects of protein complexes in mitochondria-associated endoplasmic reticulum membranes and the distinct roles of mitochondria-associated endoplasmic reticulum membranes-mediated ca^(2+)sign

关键词： Alzheimer’s disease amyotrophic lateral sclerosis ca^(2+)signaling conduction Huntington’s disease ischemic stroke mammals mitochondrial dynamics neural function repair oxidative stress Parkinson’s disease traumatic brain injury

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Facilitation of microbialite development by.c.ntinental weathering in the cambrian Zhangxia Formation,southern North china Block

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Journal of Palaeogeography 2025年第1期14卷 172-185页

作者： Wen-Tao yang Jia-Qi Zhu Min Wang chao liu yong-An Qi School of Resources and Environment Henan Polytechnic University Key Laboratory of Biogenic Traces and Sedimentary Minerals of Henan Province Henan Polytechnic University State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of Sciences

We report geochemical data for carbonate rocks from the cambrian Zhangxia Formation,southern North china Block,including trace-element contents and c,O,and Sr isotopic compositions,to determine the controls on the development of microbialites in this *** sedimentary environment of the Zhangxia Formation evolved from carbonate-slope through platform-margin-reef to ooid-shoal,and then to open-platform settings,corresponding to the development of micrites,microbialites,and oolitic *** data show that δ13c values decrease upwards through the Zhangxia Formation,from 0.99‰to-1.59‰,whereas δ18O values increase from-9.91‰to-7.10‰.Total rare earth element （REE）contents decrease upwards through the stratigraphy,and the contents of Th and Sc show a similar trend.87Sr/86Sr ratios reach a maximum of 0.710544 in the horizons of microbialite development,Member 2 of the Zhangxia Formation,above which the ratios are uniform,with a mean value of *** these geochemical data with the inferred sedimentary evolution,the Zhangxia Formation is interpreted to have formed in a depositional environment that changed from transgression to *** weathering played a crucial role in promoting the input of terrigenous materials,which in turn favored the development of microbialites during the early stage of deposition of the Zhangxia Formation.

关键词： carbonate rocks Trace elements c and Sr isotopes Microbialites cambrian

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Influence of heat treatment on microstructure of a newβ-solidifyingγ-TiAl alloy

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Journal of Iron and Steel Research International 2025年第1期32卷 239-248页

作者： Li Quan Xiao-bing Li Peng Xue Jun-jie Hao Kun Qian Bo chen Jian-zhong Li Kui liu School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina Department of Materials Science and Technology Ji Hua LaboratoryFoshan528200GuangdongChina

The high strength and stability of the full-lamellar structure guarantee the industrial application of theβ-solidifyingγ-TiAl ***,it is a huge challenge to design an alloy with good hot-deformability as well as the full-lamellar *** low-cost Ti-42.5Al-2Mn-0.4Mo-0.1B-0.1c(at.%)alloy was designed,which undergoes bothβandαsingle-phase region during the *** is found that the full-lamellar structure can be obtained by the solution heat treatment at 1230℃ for 20 min and then aging treatment at 800℃ for 3 ***,a new microstructure,namely,the pearlitic-like microstructure(PM)induced by theα_(2)/γ→βo+γcellular reaction was observed when the aging temperature is increased to above 800℃.The volume fraction of the PM is gradually increased from 0%to 25.5%,65%,and 94%according to elevated aging temperature from 800 to 900,1000,and 1050℃,*** mechanism of the reducedα_(2)/γlamellae and PM formation was discussed regarding the heterogeneous distribution ofβstabilizing elements and the interface energy stored inα_(2)/γlamellae.

关键词： β-γ-TiAl Alloy design Two-step heat treatment Full-lamellar structure cellular reaction

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Systematic review of amyloid-beta clearance proteins from the brain to the periphery:implications for Alzheimer's disease diagnosis and therapeutic targets

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Neural Regeneration Research 2025年第12期20卷 3574-3590页

作者： Letian Huang Mingyue liu Ze Li Bing Li Jiahe Wang Ke Zhang Department of Oncology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Developmental cell Biology Key Laboratory of Cell BiologyMinistry of Public HealthChina Medical UniversityShenyangLiaoning ProvinceChina Department of Family Medicine Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Amyloid-beta clearance plays a key role in the pathogenesis of Alzheimer's disease.H oweve r,the variation in functional proteins involved in amyloid-beta clearance and their correlation with amyloid-beta levels remain unclea *** this study,we conducted meta-analyses and a systematic review using studies from the PubMed,Embase,Web of Science,and cochrane Library databases,including journal articles published from inception to J une 30,*** inclusion criteria included studies comparing the levels of functional proteins associated with amyloid-beta clearance in the blood,cere b rospinal fluid,and brain of healthy.c.ntrols,patients with mild cognitive impairment,and patients with Alzheimer's ***,we analyzed the correlation between these functional proteins and amyloid-beta levels in patients with Alzheimer's *** methodological quality of the studies was assessed via the Newcastle-Ottawa *** to heterogeneity,we utilized either a fixed-effect or random-effect model to assess the 95%confidence interval(cI)of the standard mean difference(SMD)among healthy.c.ntrols,patients with mild cognitive impairment,and patients with Alzheimer's *** findings revealed significant alterations in the levels of insulin-degrading enzymes,neprilysin,matrix metalloproteinase-9,cathepsin D,receptor for advanced glycation end products,and P-glycoprotein in the brains of patients with Alzheimer's disease,patients with mild cognitive impairment,and healthy *** cerebrospinal fluid,the levels of triggering receptor expressed on myeloid cells 2 and ubiquitin c-terminal hydrolase L1 are altered,whereas the levels of TREM2,cD40,cD40L,cD14,cD22,cathepsin D,cystatin c,andα2 M in peripheral blood ***,TREM2 and cathepsin D showed changes in both brain(SMD=0.31,95%cI:0.16-0.47,PcI:0.01-2.48,P=0.048,I^(2)=90.1%)and peripheral blood(SMD=1.01,95%cI:0.35-1.66,P=0.003,I^(2)=96.5%;SMD=7.55,95%cI:3.92-11.18,P<0.001,I^(

关键词： Alzheimer’s disease amyloid-β blood‒brain barrier cerebrospinal fluid diagnostic biomarker meta-analysis mild cognitive impairment peripheral blood systematic review therapeutic targets

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china Liver Transplant Registry plays an important role in liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 14-17页

作者： Zhe yang Jian-Peng liu Jun-Li chen Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalHangzhou 310003China Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of combined Multi-organ Transplantation Ministry of Public Healththe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China National center for Healthcare Quality Management in Liver Transplant Hangzhou 310003China

In china, liver transplantation is an important discipline in the field of organ transplantation. china Liver Transplant Registry (cLTR) is a scientific project that has been set up to advance surgical techniques and procedures and to improve both short-and long-term post-transplant follow-up and outcome of the liver recipients. cLTR also serves as a robust data support platform for the National Liver Transplant Quality.c.ntrol center in the quest to upscale its quality.c.ntrol protocols. The mission of cLTR is to register all liver transplantation activities in the mainland of china and to conduct scientific analyses of the collected data. The huge number of compiled cases and the scientific research conducted over the past decade based on this database drastically revolutionized the clinical practice in the country. All cLTR activities and projects will be a guarantee to foster progresses of liver transplantation in china in a more scientific way, to standardize the systematic care in the field of liver transplantation.

关键词： Transplant registry china Liver Transplant Registry Liver transplantation Hepatocellular cancer

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Hierarchical hollow microspheres assembled from carbon nanosheets integrated with molybdenum carbide nanoparticles for boosting microwave absorption properties

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Nano Research 2025年第1期18卷 10-20页

作者： Zongsheng chen yahui Wang yi liu Zhigang Li Xiangyin Lv Liping liu yajing chang Jiaming Shi Xiao Zhang State Key Laboratory of Pulsed Power Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China Anhui Provincial Laboratory of Advanced Laser Technology School of Electronic EngineeringNational University of Defense TechnologyHefei 230037China centre for Environmental and Energy Nanomaterials Anhui Key Laboratory of Nanomaterials and NanotechnologyCAS Centre for Excellence in NanoscienceInstitute of Solid State PhysicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

Hierarchical hollow structure has demonstrated potential for enhancing electromagnetic(EM)attenuation and improving impedance matching,garnering significant attention for ***,we have successfully implemented compositional and structural engineering to fabricate hollow Mo2c/c microspheres with controllable composition by.c.upling interaction between dopamine hydrochloride and ammonium *** the synergistic effect of composition and hollow structure,the strongest reflection loss intensity and broadest effective absorption of the optimized sample reach-70.2 dB and 6.2 GHz,*** formation of hollow heterogeneous structures not only favors impedance matching feature,but also generates considerable contribution to EM attenuation ***,radar cross-section simulation data indicate that hollow Mo2c/c microspheres with compositional optimization and heterogeneous structures have broad prospects for practical applications.

关键词： electromagnetic absorption Mo2c/c microwave absorption hollow structure

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A machine learning method approach for designing novel high strength and plasticity metastable β titanium alloys

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Progress in Natural Science:Materials International 2025年第01期 156-165页

作者： Zhiduo liu Haoyu Zhang Shuai Zhang Jun cheng yixuan He Ge Zhou Jiawei liu Suping Song Lijia chen School of Materials Science and Engineering Shenyang University of Technology Shenyang Key Laboratory of Advanced Structural Materials and Applications Shenyang University of Technology Northwest Institute for Nonferrous Metal Research Shaanxi Key Laboratory of Biomedical Metal Materials State Key Laboratory of Solidification Processing Northwestern Polytechnical University Ansteel Group Automation co. Ltd

In order to improve efficiency and reduce costs, four machine learning models were established for the design of metastable β titanium alloys, including the Adaboost model, the LightGBM model, the Voting model, and the Stacking model. The accuracy of these models was evaluated, and all models exhibited excellent accuracy for tensile strength, yield strength, and elongation. The values of R-squared coefficients（R2） all greater than *** them, the LightGBM model showed the highest accuracy, with relatively smallest values of mean absolute error（MAE） and root mean square error（RMSE） and relatively largest value of R2. To further verify the accuracy of the model, a metastable β titanium alloy Ti-5.5cr-5Al-4Mo-3Nb-2Zr was designed by the LightGBM model. The predicted values of the alloy's tensile strength, yield strength, and elongation under three heat treatment processes were in high agreement with the experimental values. The alloy exhibited optimal strength-plasticity matching after undergoing a solution treatment at 850°c for 0.5 h, followed by aging at 650°c for 8 h, with a tensile strength of 1317 MPa, an elongation of 11.17 %, and a strength-plasticity product of 14.711 GPa·%.

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月球钛铁矿原位分选富集多物理场仿真与优化分析

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中国科学:地球科学 2025年第1期55卷 194-206页

作者：张鹏刘欣刘光辉代巍杨瀚哲郑海菠王之牛冉白一帆张阳刘成保杨格杨军伟张光中国科学院空间应用工程与技术中心北京100094 北京合工仿真技术有限公司北京100089

月球资源的探测与利用已成为未来月球探测任务的主要目标.月球矿物的分类采集与处理是月球资源原位探测与利用的基础前提.本文提出了一种基于干式磁选法的月壤磁性矿物原位分选富集方案,通过改变不同磁性特征月壤颗粒的运动轨迹实现磁... 详细信息

月球资源的探测与利用已成为未来月球探测任务的主要目标.月球矿物的分类采集与处理是月球资源原位探测与利用的基础前提.本文提出了一种基于干式磁选法的月壤磁性矿物原位分选富集方案,通过改变不同磁性特征月壤颗粒的运动轨迹实现磁性矿物从月壤中分离.我们对该干式磁选装置进行了详细建模,对磁性参数的三维分布特征进行了有限元计算和分析.基于嫦娥五号样品的表征与分析结果,进一步开展月壤颗粒形貌和物理特征的建模与仿真模拟.最后,对月壤颗粒多物理场作用下的运动过程进行了离散元仿真分析,研究了关键参数对月壤中钛铁矿富集性能的影响.结果表明,在特定的磁场强度和滚筒转速下,可有效实现月壤中钛铁矿的分选富集.此外,还研究了月球弱重力和月壤颗粒带电特性对富集过程的影响,结果表明弱重力作用和带电特性均能有效促进钛铁矿的富集过程.本研究验证了干式磁选法用于月壤钛铁矿富集的可行性,为月球矿物资源的开采、处理和利用等科学任务的实施提供了理论基础.

关键词：月壤原位资源利用磁选分选富集

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