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Quercetin Alleviates Lipopolysaccharide-Induced Cardiac Inflammation via Inhibiting Autophagy and Programmed Cell Death

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biomedical and Environmental Sciences 2024年第1期37卷 54-70页

作者： yU Jin Hai HU Guo Liang GUO xiao Quan CAO Hua bin xia Zhao Fei AMIN buhe Jiangxi Provincial Key Laboratory for Animal Health Institute of Animal Population HealthCollege of Animal Science and TechnologyJiangxi Agricultural UniversityNanchang 330045JiangxiChina Internal Medicine Laboratory Department of Veterinary Clinical MedicineCollege of Veterinary MedicineChina Agricultural UniversityBeijing 100091China Department of Cancer Surgery Beijing Shijitan Hospital Affiliated with Capital Medical UniversityBeijing 100038China

Objective The aim of this study is to explore the potential modulatory role of quercetin against Endotoxin or lipopolysaccharide(LPS)induced septic cardiac *** Specific pathogen-free chicken embryos(n=120)were allocated untreated control,phosphate buffer solution(PbS)vehicle,PbS with ethanol vehicle,LPS(500 ng/egg),LPS with quercetin treatment(10,20,or 40 nmol/egg,respectively),Quercetin groups(10,20,or 40 nmol/egg).Fifteenday-old embryonated eggs were inoculated with abovementioned solutions via the allantoic *** embryonic day 19,the hearts of the embryos were collected for histopathological examination,RNA extraction,real-time polymerase chain reaction,immunohistochemical investigations,and Western *** They demonstrated that the heart presented inflammatory responses after LPS *** LPS-induced higher mRNA expressions of inflammation-related factors(TLR4,TNFα,MyD88,NF-κb1,IFNγ,IL-1β,IL-8,IL-6,IL-10,p38,MMP3,and MMP9)were blocked by quercetin with three *** significantly decreased immunopositivity to TLR4 and MMP9 in the treatment group when compared with the LPS *** significantly decreased protein expressions of TLR4,IFNγ,MMP3,and MMP9 when compared with the LPS *** treatment prevented LPS-induced increase in the mRNA expression of Claudin 1 and ZO-1,and significantly decreased protein expression of claudin 1 when compared with the LPS *** significantly downregulated autophagyrelated gene expressions(PPARα,SGLT1,APOA4,AMPKα1,AMPKα2,ATG5,ATG7,beclin-1,and LC3b)and programmed cell death(Fas,bcl-2,CASP1,CASP12,CASP3,and RIPK1)after LPS *** significantly decreased immunopositivity to APOA4,AMPKα2,and LC3-II/LC3-I in the treatment group when compared with the LPS *** significantly decreased protein expressions of AMPKα1,LC3-I,and *** significantly decreased the protein expression to CASP1 and CASP3 by immunohistochemical investigation or

关键词： Quercetin Lipopolysaccharide Inflammation Autophagy Programmed cell death Myocardiocytes permeability

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An Assembly of Pyrano[3,2-b]indol-2-ones via NHC-Catalyzed[3+3]Annulation of Indolin-3-ones with ynals

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Chinese Journal of Chemistry 2024年第13期42卷 1487-1492页

作者： xia Wang Shulei Zhang Shao-Jie Wang Hao An xiaolan Xin Haonan Lin Zhifeng Tu Shenci Lu Frontiers Science Center for Flexible Electronics(FSCFE) Shaanxi Institute of Flexible Electronics(SIFE)&Shaanxi Instituteof Biomedical Materials and Engineering(SiBME)Northwestern Polytechnical University(NPU)127 West Youyi RoadXi'anShaanxi 710072China School of Chemistry and Chemical Engineering Northwestern Polytechnical University(NPU)127 West Youyi RoadXi'anShaanxi 710072China

We report herein an unprecedented N-heterocyclic carbene-catalyzed formal[3+3]annulation of ynals with N-Ts indolin-3-ones under the oxidation condition affording the functionalized pyrano[3,2-b]*** alkynyl acylazoliums via the combination of a carbene with ynals in the presence of oxidate proved to be the important intermediates for the success of this *** method features a broad substrate scope and mild conditions,including axially chiral skeletons with suitable substitutions.

关键词： N-Heterocyclic carbene Annulation Organocatalysis Atropisomerism Carbazole Aldehydes Heterocycles Asymmetric catalysis

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Dual-functional POM@IL complex modulate hole transport layer properties and interfacial charge dynamics for highly efficient and stable perovskite solar cells

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Chinese Chemical Letters 2024年第7期35卷 461-464页

作者： boyuan Hu Jian Zhang yulin yang yayu Dong Jiaqi Wang Wei Wang Kaifeng Lin Debin xia MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China

The severe interfacial charge recombination as well as the stability issues brought by the Li-TFSI still hinder the commercialization of high-performance perovskite solar cells(PSCs).Here,a polyoxometalates(POMs)-based complex,POM@ionic liquid(IL),is synthesized and applied as an effective additive that simultaneously enhances the performance and stability of *** interactions between POM@IL complex and Li-TFSI inhibit the aggregation of *** synergistic oxidation of POM@IL complex and Li-TFSI towards 2,2,7,7-tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9'-spirobifluorene(Spiro-OMeTAD)effectively enhances the electrical properties of hole transport layer film and the photovoltaic performances of *** champion device modified with the POM@IL complex yields an excellent power conversion efficiency(PCE)of 22.73%.Moreover,the incorporation of POM@IL improves the humidity stability of *** storing under high humidity conditions(25℃,60%RH)for 1200 h,the POM@IL modified device retained a remarkable 81.2%of its initial *** work provides new insight into constructing POMs-based materials for high-performance photovoltaic devices.

关键词： Polyoxometalates Ionic liquid Perovskite solar cells Energy alignment Humidity stability

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Influence of surface acidity and chemical valence on low temperature activity over Pt-HSiW/CeO_(2) for catalytic combustion of chlorobenzene

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Journal of Rare Earths 2024年第9期42卷 1693-1703,I0002页

作者： Zhongxian Song Zepeng Liu Xuejun Zhang yanli Mao Wei Liu Chunxiang Gao Haiyang Li xia Zhang Changrui Han Zhenzhen Huang Key Laboratory of Carbon Emission Reduction and Combined Air Pollution Control Technology Faculty of Environmental and Municipal EngineeringHenan University of Urban ConstructionPingdingshan467036China College of Environmental and Safety Engineering Shenyang University of Chemical TechnologyShenyang110142China

Pt-HSiW/CeO_(2) catalysts were prepared for chlorobenzene(Cb) catalytic combustion by hydrothermal method at different calcination temperatures,and the effects of the surface acidity and chemical valence on the catalytic activity were *** results show that the catalyst calcined at 450℃(Cat-b)exhibits the outstanding catalytic performance,and the Cat-b catalyst possesses 90% conversion of Cb at148℃.The excellent catalytic activity of Cat-b is attributed to more Ce^(3+)/(Ce^(3+)+Ce^(4+)),Pt~0/(Pt^(0)+Pt^(2+)),O_(ads)/(O_(latt)+O_(ads)) and Lewis acid *** degradation mechanism is proposed based on the analysis of the intermediates with the following reaction pathway:chlorobenzene→phenates/benzoquinone→acetate→maleate→CO_(2)+H_(2)O.

关键词： Pt-HSiW/CeO_(2) Catalytic combustion Chlorobenzene Acid sites Rare earths

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Personalized and continuous care intervention affects rehabilitation,living quality,and negative emotions of patients with breast cancer

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World Journal of Psychiatry 2024年第6期14卷 876-883页

作者： Ling-xia Kong yan-Hong Zhao Zhi-Lin Feng Ting-Ting Liu Department of breast Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Operating Room The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

bACKGROUND breast cancer is among the most common malignancies *** progress in treatment methods and levels,the overall survival period has been prolonged,and the demand for quality care has *** To investigate the effect of individualized and continuous care intervention in patients with breast *** Two hundred patients with breast cancer who received systemic therapy at The First Affiliated Hospital of Hebei North University(January 2021 to July 2023)were retrospectively selected as research *** them,134 received routine care intervention(routing group)and 66 received personalized and continuous care(intervention group).Self-rating anxiety scale(SAS),self-rating depression scale(SDS),and Functional Assessment of Cancer Therapy-breast(FACT-b)scores,including limb shoulder joint activity,complication rate,and care satisfaction,were compared between both groups after *** SAS and SDS scores were lower in the intervention group than in the routing group at one and three months after *** total FACT-b scores and five dimensions in the intervention group were higher than those in the routing group at three months of *** range of motion of shoulder anteflexion,posterior extension,abduction,internal rotation,and external rotation in the intervention group was higher than that in the routing group one month after *** incidence of postoperative complications was 18.18%lower in the intervention group than in the routing group(34.33%;Pbreast cancer,quicken rehabilitation of limb function,decrease the incidence of complications,and improve living quality and care satisfaction.

关键词： breast cancer Personalized care Continuous care Negative emotions Living quality Rehabilitation effect

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Orientation bias of Self-Assembled Alkanes and Their Derivatives Under Dynamic Lateral Nanoconfinement Conditions

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CCS Chemistry 2024年第4期6卷 1024-1033页

作者： Conditions Lihua yu yuanzhi xia Tianze Hu brent Daelemans Steven De Feyter Department of Chemistry Division of Molecular Imaging and PhotonicsKU LeuvenB-3001 Leuven

Self-assembled molecular networks(SAMNs)formed on crystalline solid substrates result from the spontaneous arrangement of individual molecules into structured *** interaction between molecules and the substrate leads to a nonrandom orientation of SAMNs with respect to the substrate’s *** the case of graphite,the sixfold rotational symmetry of the substrate results in an equivalent rotational degeneracy in the orientation of *** this study,we explored how nanoconfinement,that is,the restriction of SAMN formation to nanometersized areas,known as nanocorrals,could impact and potentially alleviate the orientational degeneracy of SAMNs,with emphasis on the influence of molecule symmetry,size,and intermolecular *** this end,we investigated the orientation distribution of n-alkanes and functionalized alkanes within nanocorrals,which were fabricated using scanning tunneling microscopy lithography(nanoshaving).We observed lifting of orientational degeneracy for long alkanes,contrary to shorter alkanes,which did not exhibit this orientation ***,functionalized alkanes with hydrogen bonding groups demonstrated preferential alignment regardless of length,highlighting the significance of stabilizing intermolecular interactions in the alignment *** study discussed the underlying principles of the molecular packing process and shed light on the complexity of molecular self-assembly in nanoconfined spaces.

关键词： self-assembly confinement condition nanocorral orientation bias scanning tunneling microscopy

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Assessing impact of intermittent window opening strategies on pathogen-laden droplet dispersion in a coach bus

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building Simulation 2024年第7期17卷 1183-1200页

作者： Qiqi Luo Xingdong Deng Jian Hang Cuiyun Ou Zhiwen Luo xiaodan Fan xia yang yifei Zhang Zhongli Gu Xuelin Zhang School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong LaboratoryZhuhai 519082China Key Laboratory of Urban Meteorology China Meteorological AdministrationBeijing 100089China China Meteorological Administration Xiong'an Atmospheric boundary Layer Key Laboratory Xiong'anChina Guangzhou Urban Planning&Design Survey Research Institute Guangzhou 510060China Guangzhou Collaborative Innovation Center of Natural Resources Planning and Marine Technology Guangzhou 510060China Guangdong Enterprise Key Laboratory for Urban Sensing Monitoring and Early WarningGuangzhou 510060China Welsh Schoolof Architecture Cardiff UniversityUK Guangdong Province Engineering Laboratory for Air Pollution Control South China Institute of Environmental Sciencesthe Ministry of Ecology and Environment of ChinaNo.7 West Street YuancunGuangzhou 510655China Guangdong Fans-tech Agro Co. LtdGuangdong ProvinceChina

Opening windows in coach buses is a practical approach to improving natural ventilation and mitigating infection risk(IR).Due to human behavior and weather conditions,the intermittent window opening strategy(IWOS)is a more common practice than keeping windows constantly *** its prevalence,there are no studies exploring IWOS specifically in *** employed indoor-outdoor coupled CFD simulations to assess the effects of various IWOS on pathogen-laden droplet(PLD)dispersion and IR in a coach bus that occurred a COVID-19 outbreak in Hunan,*** reveal that after ventilating through two skylights for 600–1800 s,opening front and rear windows(FW+RW)or FW with a wind catcher(FW+WCH)for just 40 s can reduce PLD concentration(Cave)to 5%of its initial level and the intake fraction of the infector’s neighbor(IFn)drops by 95%.Upon closing FW+RW or FW+WCH,Cave and IFn take over 580 s to return to the pre-opening ***,intermittent FW opening halves Cave and IFn within 7 min,but leads to rapid increases upon window ***,opening FW+RW and FW+WCH intermittently have pronounced impacts on indoor PLD concentration and are applicable approaches to control respiratory disease transmission in *** to the inhaled viral dose,it is recommended to open windows when driving time is over 12 minutes to reduce infection *** scenarios like epidemiological surveys and risk assessments,where assessing passenger infection risk is vital,some behaviors of opening windows cannot be overlooked and necessitate extra attention.

关键词： infection risk computational fluid dynamics air change rate per hour natural ventilation wind catcher tracer gas dispersion

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The Geology, Fluid Inclusions, and O-S Isotopes of the Mibei Gold Deposit, Hunan Province, Southern China

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 992-1006页

作者： XUE Wenhao LIANG yayun LI xiaofeng LI Mingyi XIE Wenbo PENG Xue xia Rui HE Hongsheng xiaO Jincheng School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Geophysical and Geochemical Survey Institute of Hunan Changsha 410116China New Geological Energy Exploration and Development Engineering Technology Research Center of Hunan Changsha 410116China State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences(Beijing)Beijing 100083China Comprehensive Survey Command Center for Natural Resources China Geological SurveyBeijing 100055China

The Mibei gold deposit,located in the southwestern part of the Xuefengshan uplift zone,the middle section of the Jiangnan orogenic belt in southern China,has estimated gold resources of approximately seven *** deposit is primarily a quartz vein-type gold deposit,with ore bodies occurring mainly within Neoproterozoic *** main metallic minerals in the ore are pyrite,chalcopyrite,and *** this study,the petrography and microthermometry of ore-forming fluid inclusions,oxygen isotopes of gold-bearing quartz,and sulfur isotopes of goldbearing sulfides and arsenopyrite were *** types of fluid inclusions were identified:type Ⅰa three-phase inclusions comprising vapor and two phases of liquids(V_(CO_(2))+L_(CO_(2))+L_(H2O)),type Ⅰb two-phase liquids(L_(CO_(2))+L_(H2O)),typeⅡ two-phase vapor-rich inclusions(V/V+L> 50%),and type Ⅲ pure liquid *** Ⅰ inclusions were heated uniformly to the liquid phase,type Ⅱ inclusions were heated uniformly to the gas phase,and type Ⅲ inclusions were heated without *** general,the temperature range of homogenization to liquid phase of fluid inclusions in the Mibei gold deposit is 204-227℃.The salinity of the inclusion ranges from 4.6 to 12.2 wt% NaCl *** δ~(18)O_(SMOW) of gold-bearing quartz varies from 16.9‰ to 17.5‰.The δ~(18)O_(H2O) of gold-bearing quartz are varied from 6.5‰ to 7.5‰.The δ~(34)S values of gold-bearing pyrite range from 1.7‰ to 6.8‰.The δ~(34)S values of gold-bearing arsenopy rite range from 5.6%o to 5.9‰.Theδ~(34)S values of pyrite from wall rocks slate range from 6.4‰ to 11.6‰.This evidence implies that the ore-forming fluids of the Mibei gold deposit originated from magmatic-hydrothermal processes,mixing with minor S from the surrounding *** with the evolution of the Jiangnan orogenic belt,due to the magmatic and tectonic activities of the Xuefengshan uplift during the Caledonian period,the fault seal mechanism controlled the ore-forming p

关键词： ore-forming fluid ore genesis Mibei gold deposit Xuefengshan uplift zone Jiangnan orogenic belt

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Developing a fluorescence substrate for HRP-based diagnostic assays with superiorities over the commercial ADHP

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Chinese Chemical Letters 2024年第6期35卷 439-444页

作者： Zhichao Zhou Fuqian Chen xiaotong xia Dong ye Rong Zhou Lei Li Tao Deng Zhenhua Ding Fang Liu Department of Radiation Medicine Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515China School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China Artemisinin Research Center Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Respiratory Disease the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510120China Guangzhou Laboratory Bio-IslandGuangzhou 510030China Nanshan Pharmaceutical Innovation Research Institute of Guangdong Province Foshan 528225China

The combination of horseradish peroxidase(HRP)and a fluorescence substrate has been attracting great interests in developing sensitive biochemical analysis and immunoassays.10-Acetyl-3,7-dihydroxyphenoxazine(ADHP or Amplex red)is the most sensitive fluorogenic substrate known for HRP in current market,however,it suffers from some drawbacks,such as non-specific reactivity to carboxylesterase and limited fluorescence *** the present study,a novel HRP substrate10-cyclopropylcarbonyl-dichloro-dihydroxyphenoxazine(AR-2),has been prepared,which exhibited improved sensitivity than ADHP in sensing ***,the fluorescence of AR-2/HRP demonstrated improved tolerance to physiological relevant p H fluctuation as compared to ADHP/*** detection of uric acid/urate oxidase reaction indicated excellent application prospect of AR-2/HRP for monitoring H_(2)O_(2)-generating biochemical *** interestingly,an enzyme-linked immunosorbent assay(ELISA)using AR-2 as the fluorescence reporter has been successfully used in detecting IgG against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)from human serum ***,AR-2 exhibits improved performances over the commercial ADHP,which will be an ideal alternative to ADHP in HRP-based fluorescence biochemical analysis and immunoassays.

关键词： Fluorescence immunoassay HRP fluorescence substrate Hydroresorufin Amplex red/ADHP SARS-CoV-2

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Extensive numerical simulations on competitive growth between the Edwards–Wilkinson and Kardar–Parisi–Zhang universality classes

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Chinese Physics b 2024年第6期33卷 298-307页

作者：余成志刘潇唐军夏辉 School of Materials Science and Physics China University of Mining and TechnologyXuzhou 221116China

Extensive numerical simulations and scaling analysis are performed to investigate competitive growth between the linear and nonlinear stochastic dynamic growth systems, which belong to the Edwards–Wilkinson(EW) and Kardar–Parisi–Zhang(KPZ) universality classes, respectively. The linear growth systems include the EW equation and the model of random deposition with surface relaxation(RDSR), the nonlinear growth systems involve the KPZ equation and typical discrete models including ballistic deposition(bD), etching, and restricted solid on solid(RSOS). The scaling exponents are obtained in both the(1 + 1)-and(2 + 1)-dimensional competitive growth with the nonlinear growth probability p and the linear proportion 1-p. Our results show that, when p changes from 0 to 1, there exist non-trivial crossover effects from EW to KPZ universality classes based on different competitive growth rules. Furthermore, the growth rate and the porosity are also estimated within various linear and nonlinear growths of cooperation and competition.

关键词： competitive growth scaling behavior discrete growth model Kardar–Parisi–Zhang universality class

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