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frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov x.C.Ai l.p.An R.Aliberti Q.An x.Z.bai y.bai O.bakina A.barnyakov V.blinov V.bobrovnikov D.bodrov A.bogomyagkov A.bondar I.boyko Z.H.bu f.M.Cai H.Cai j.j.Cao Q.H.Cao x.Cao Z.Cao Q.Chang K.t.Chao D.y.Chen H.Chen H.x.Chen j.f.Chen K.Chen l.l.Chen p.Chen S.l.Chen S.M.Chen S.Chen S.p.Chen W.Chen x.Chen x.f.Chen x.R.Chen y.Chen y.Q.Chen H.y.Cheng j.Cheng S.Cheng t.G.Cheng j.p.Dai l.y.Dai x.C.Dai D.Dedovich A.Denig I.Denisenko j.M.Dias D.Z.Ding l.y.Dong W.H.Dong V.Druzhinin D.S.Du y.j.Du Z.G.Du l.M.Duan D.Epifanov y.l.fan S.S.fang Z.j.fang G.fedotovich C.Q.feng x.feng y.t.feng j.l.fu j.Gao y.N.Gao p.S.Ge C.Q.Geng l.S.Geng A.Gilman l.Gong t.Gong b.Gou W.Gradl j.l.Gu A.Guevara l.C.Gui A.Q.Guo f.K.Guo j.C.Guo j.Guo y.p.Guo Z.H.Guo A.Guskov K.l.Han l.Han M.Han x.Q.Hao j.b.He S.Q.He x.G.He y.l.He Z.b.He Z.x.Heng b.l.Hou t.j.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.j.Hu W.H.Hu x.H.Hu y.C.Hu j.Hua G.S.Huang j.S.Huang M.Huang Q.y.Huang W.Q.Huang x.t.Huang x.j.Huang y.b.Huang y.S.Huang N.Hüsken V.Ivanov Q.p.ji j.j.jia S.jia Z.K.jia H.b.jiang j.jiang S.Z.jiang j.b.jiao Z.jiao H.j.jing x.l.Kang x.S.Kang b.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.lei E.levichev C.H.li C.li D.y.li f.li G.li G.li H.b.li H.li H.N.li H.j.li H.l.li j.M.li j.li l.li l.li l.y.li N.li p.R.li R.H.li S.li t.li W.j.li x.li x.H.li x.Q.li x.H.li y.li y.y.li Z.j.li H.liang j.H.liang y.t.liang G.R.liao l.Z.liao y.liao C.x.lin D.x.lin x.S.lin b.j.liu C.W.liu D.liu f.liu G.M.liu H.b.liu j.liu j.j.liu j.b.liu K.liu K.y.liu K.liu l.liu Q.liu S.b.liu t.liu x.liu y.W.liu y.liu y.l.liu Z.Q.liu Z.y.liu Z.W.liu I.logashenko y.long C.G.lu j.x.lu N.lu Q.f.lü y.lu y.lu Z.lu p.lukin f.j.luo t.luo x.f.luo y.H.luo H.j.lyu x.R.lyu j.p.Ma p.Ma y.Ma y.M.Ma f.Maas S.Malde D.Matvienko Z.x.Meng R.Mitchell A.Nefediev y.Nefedov S.l.Olsen Q.Ouyang p.pakhlov G.pakhlova x.pan y.pan E.passemar y.p.pei H.p.peng l.peng x.y.peng x.j.peng K.peters S.pivovarov E.pyata b.b.Qi y.Q.Qi W.b.Qian y.Qian C.f.Qiao j.j.Qin j.j.Qin l.Q.Qin x.S.Qin t.l.Qiu j.Rademacker C.f.Redmer H.y.Sang Anhui university Hefei 230039China beihang university Beijing 100191China budker Institute of Nuclear physics Novosibirsk 630090Russia CAS Key laboratory of theoretical physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central china Normal university Wuhan 430079China Central South university Changsha 410083China china university of Geosciences Wuhan 430074China china university of Mining and technology Xuzhou 221116China École polytechnique fédérale de lausanne(Epfl) LausanneSwitzerland fudan university Shanghai 200433China Goethe university frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal university Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal university Shijiazhuang 050024China Hebei university Baoding 071002China Hefei university of technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal university Xinxiang 453007China Henan university Kaifeng 475004China High Energy physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 pokrovsky bulvar Moscow 109028Russia Huangshan university Huangshan 245000China Hubei university of Automotive technology Shiyan 442002China Hunan Normal university Changsha 410081China Hunan university of Science and technology Xiangtan 411201China Hunan university Changsha 410082China Indiana university BloomingtonIndiana 47405USA Inner Mongolia university Hohhot 010021China Institute of Advanced Science facilities Shenzhen 518107China Institute of High Energy physics Chinese Academy of SciencesBeijing 100049China Institute of Modern physics Chinese Academy of SciencesLanzhou 730000China Institute of physics Academia SinicaTaipeiTaiwan 11529China Institute of theoretical physics Chinese Academy of SciencesBeijing 100190China jilin university Changch

the superτ-charm facility(StCf)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** StCf will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the bEpCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** StCf project in china is under development with an extensive R&D *** document presents the physics opportunities at the StCf,describes conceptual designs of the StCf detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity StCf detector conceptual design

In situ tEM investigation of electron irradiation and aging-induced high-density nanoprecipitates in an Mg-10Gd-3y-1Zn-0.5Zr alloy

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journal of Magnesium and Alloys 2024年第5期12卷 1841-1853页

作者： M.lv H.l.Ge Q.Q.jin x.H.Shao y.t.Zhou b.Zhang x.l.Ma Shenyang National laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Materials Science and Engineering Research Center Guangxi University of Science and TechnologyLiuzhou 545006China

In-situ electron irradiation and aging are applied to introduce high-density precipitates in an Mg-10Gd-3y-1Zn-0.5Zr(GWZ1031K,wt.%)alloy to improve the *** results show that the hardness of the Mg alloy after irradiation for 10 h and aging for 9 h at 250℃ is 1.64 Gpa,which is approximately 64% higher than that of the samples before being *** is mainly attributed to γ'precipitates on the basal plane after irradiation and the high-density nanoscale β'precipitates on the prismatic plane after aging,which should be closely related to the irradiation-induced homogenous *** latter plays a key role in precipitation *** result paves a way to improve the mechanical properties of metallic materials by tailoring the precipitation through irradiation and aging.

关键词： Mg alloy Electron beam irradiation Hardening precipitates In-situ tEM

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov p.Adlarson O.Afedulidis x.C.Ai R.Aliberti A.Amoroso Q.An y.bai O.bakina I.balossino y.ban H.-R.bao V.batozskaya K.begzsuren N.berger M.berlowski M.bertani D.bettoni f.bianchi E.bianco A.bortone I.boyko R.A.briere A.brueggemann H.Cai x.Cai A.Calcaterra G.f.Cao N.Cao S.A.Cetin j.f.Chang W.l.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.l.Chen S.j.Chen S.l.Chen S.M.Chen t.Chen x.R.Chen x.t.Chen y.b.Chen y.Q.Chen Z.j.Chen Z.y.Chen S.K.Choi x.Chu G.Cibinetto f.Cossio j.j.Cui H.l.Dai j.p.Dai A.Dbeyssi R.E.de boer D.Dedovich C.Q.Deng Z.y.Deng A.Denig I.Denysenko M.Destefanis f.De Mori b.fang S.S.fang W.x.fang y.fang y.Q.fang R.farinelli l.fava f.feldbauer G.felici C.Q.feng j.H.feng y.t.feng K.fischer M.fritsch C.D.fu j.l.fu y.W.fu H.Gao y.N.Gao yang Gao S.Garbolino I.Garzia p.t.Ge Z.W.Ge C.Geng E.M.Gersabeck b.Ding x.x.Ding y.Ding y.Ding j.Dong l.y.Dong M.y.Dong x.Dong M.C.Du S.x.Du Z.H.Duan p.Egorov y.H.fan j.fang jA.Gilman K.Goetzen l.Gong W.x.Gong W.Gradl S.Gramigna M.Greco M.H.Gu y.t.Gu C.y.Guan Z.l.Guan A.Q.Guo l.b.Guo M.j.Guo R.p.Guo y.p.Guo A.Guskov j.Gutierrez K.l.Han t.t.Han x.Q.Hao f.A.Harris K.K.He K.l.He f.H.Heinsius C.H.Heinz y.K.Heng C.Herold t.Holtmann p.C.hong G.y.Hou x.t.Hou y.R.Hou Z.l.Hou b.y.Hu H.M.Hu j.f.Hu t.Hu y.Hu G.S.Huang K.x.Huang l.Q.Huang x.t.Huang y.p.Huang t.Hussain f.H\"olzken N.H\"usken N.in der Wiesche M.Irshad j.jackson S.janchiv j.H.jeong Q.ji Q.p.ji W.ji x.b.ji x.l.ji y.y.ji x.Q.jia Z.K.jia D.jiang H.b.jiang p.C.jiang S.S.jiang t.j.jiang x.S.jiang y.jiang j.b.jiao j.K.jiao Z.jiao S.jin y.jin M.Q.jing x.M.jing t.johansson S.Kabana N.Kalantar-Nayestanaki x.l.Kang x.S.Kang M.Kavatsyuk b.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.b.Kolcu b.Kopf M.Kuessner x.Kui A.Kupsc W.K\"uhn j.j.lane p.larin l.lavezzi t.t.lei Z.H.lei H.leithoff M.lellmann t.lenz C.li C.li C.H.li Cheng li D.M.li f.li G.li H.li H.b.li H.j.li H.N.li Hui li j.R.li j.S.li K.li l.j.li l.K.li lei li M.H.li p.R.li Q.M.li Q.x.li R.li S.x.li t.li W.D.li W.G.li x.li x.H.li x.l.li x.y.li y Institute of High Energy physics Chinese Academy of SciencesBeijing 100049China beihang university Beijing 100191China bochum Ruhr-university D-44780 BochumGermany budker Institute of Nuclear physics Sb RAS(bINp) Novosibirsk 630090Russia Carnegie Mellon university PittsburghPennsylvania 15213USA Central china Normal university Wuhan 430079China Central South university Changsha 410083China china Center of Advanced Science and technology Beijing 100190China china university of Geosciences Wuhan 430074China Chung-Ang university Seoul06974Republic of Korea COMSAtS university Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan fudan university Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal university Guilin 541004China Guangxi university Nanning 530004China Hangzhou Normal university Hangzhou 310036China Hebei university Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal university Xinxiang 453007China Henan university Kaifeng 475004China Henan university of Science and technology Luoyang 471003China Henan university of technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal university Changsha 410081China Hunan university Changsha 410082China Indian Institute of technology Madras Chennai 600036India Indiana university BloomingtonIndiana 47405USA INfN laboratori Nazionali di frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INfN laboratori Nazionali di frascati INFN Sezione di PerugiaI-06100PerugiaItaly INfN laboratori Nazionali di frascati University of PerugiaI-06100PerugiaItaly INfN Sezione di ferrara INFN Sezione di FerraraI-44122FerraraItaly INfN Sezione di ferrara University of FerraraI-44122FerraraItaly Inner Mongolia university Hohhot 010021China Institute of Modern physics Lanzhou 730000China Institute of physics and technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the bESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).the fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the Cp-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the b^(−)→DK^(−)decay.

关键词： bESIII D^(0)meson decays amplitude analysis Cp-even fraction

prestoring lithium into SnO_(2)coated 3D carbon fiber cloth framework as dendrite-free lithium metal anode

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particuology 2024年第1期84卷 89-97页

作者： tao Wei yanyan Zhou Cheng sun lesheng liu Sijia Wang Mengting Wang ye liu Qing Huang Quanchao zhuang yongfu tang School of Energy and power Jiangsu University of Science and TechnologyZhenjiang212003China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing210037China li-ion batteries lab School of Materials Science and EngineeringChina University of Mining and TechnologyXuzhouChina Hebei Key laboratory of Applied Chemistry School of Environmental and Chemical EngineeringYanshan UniversityQinhuangdao066004China

for several decades,the promise of implementing of lithium(li)metal anodes has been regarded as the"holy grail"for li-based ***,we have proposed a facile design of a carbon fiber cloth(CfC)framework coated with SnO_(2)nanoparticles through a hydrothermal process,which served as a reliable host for prestoring molten li to produce a CfC@SnO_(2)@li composite ***,tEM,HRtEM,xpS and different electrochemical characterizations were carried *** to the synergetic effects of the 3D conductive CfC and the coated lithiophilic SnO_(2)nanoparticles,the designed CfC@SnO_(2)@li electrodes can buffer the volume changes and reduce the local current density,thus suppress the li dendrites during ***,the CfC@SnO_(2)electrodes showed a high and stable CE of 98.6%for 1000 cycles at a current density of 1 mA cm^(-2)(1 mAh cm^(-2)).What is more,at a high current density of 5 mA cm^(-2)and a high areal capacity of 5 mAh cm^(-2),the symmetric cell displayed relatively low overpotential and long cycling lifetime of 1600 *** results confirm its great potential as lithium metal anodes in practical battery applications.

关键词： lithiophilic lithium metal anodes SnO_(2) 3D anode Dendrite-free

Construction of 2D/2D ti_(3)C_(2)t_(x)Mxene/CdS heterojunction with photothermal effect for efficient photocatalytic hydrogen production

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journal of Materials Science & technology 2024年第4期171卷 1-9页

作者： t.y.Huang Z.yang S.y.yang Z.H.Dai y.j.liu j.H.liao G.y.Zhong Z.j.xie y.p.fang S.S.Zhang Key laboratory for biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China School of physics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Chemical Engineering and Energy technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

the insensitivity of semiconductors to visible and infrared light is a key constraint on the utilization of light energy in photocatalytic *** photocatalysts with full-spectrum absorption through surface engineering is an effective approach to fully harnessing light energy in semiconductor ***,a novel stable ti_(3)C_(2)t_(x)Mxene/CdS heterojunction catalyst is obtained by in-situ epitaxial growth of two-dimensional(2D)CdS nanosheets on 2D Mxene interface via a solvothermal *** exceptional light absorption properties of Mxene confer outstanding full-spectrum driven photocat-alytic hydrogen evolution capability upon the heterogeneous *** unique 2D/2D structure effectively mitigated the recombination of photogenerated carriers,enhancing the photocatalytic performance of the ***,the composite catalyst exhibits a significantly higher surface temperature of 80.4℃under visible light irradiation at an intensity of 0.1 W/cm^(2),which is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite catalyst with photothermal ef-fect demonstrates a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is 7.2 times higher than that of CdS *** study introduces a novel approach for constructing full-spectrum absorption catalysts and expands the application of the photothermal effect in photocatalytic hydrogen evolution research.

关键词： two-dimensional structure Heterostructure photothermal effect photocatalyst Hydrogen evolution

Nanoscale precise Editing of Multiple Immune Stimulating ligands on DNA Origami for t Cell Activation and Cell-based Cancer Immunotherapy

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CCS Chemistry 2024年第3期6卷 719-732页

作者： lele sun fengyun Shen Zijian xiong yu Chao Chunhai fan zhuang liu Institute of functional Nano&Soft Materials(fUNSOM) Jiangsu Key Lab Carbon Based Functional Materials and DevicesSoochow UniversitySuzhou 215123Jiangsu School of life Sciences Shanghai UniversityShanghai 200444 School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 201240

the spatial arrangement of activating ligands is known to have great influence on t cell ***,independently studying each ligand’s spatial organization parameter that affects t cell activation remains a great ***,with DNA origami,we precisely organized the CD3ɛantibodies simulating t cell receptor(tCR)ligands and CD28 antibodies simulating co-stimulatory ligands to interrogate the independent role of tCR-ligand spacing and local copy numbers as well as the spacing between tCR ligands and co-stimulatory ligands on t cell *** found that t cell activation benefited fromlocally concentrated tCR ligands with a shorter spacing and was maximized by an∼38 nm spacing between tCR ligands and co-stimulatory *** t cell expander constructed based on our findings could efficiently expand CD8+t cells for tumor ***,the DNA nanostructurebased ligands’precise arrangement can be a unique tool in studying immune cell activations and cellbased immunotherapies.

关键词： DNA origami t cell activation t cell receptor immune cancer immunotherapy

biomolecular condensates and disease pathogenesis

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Science china life Sciences 2024年第9期67卷 1792-1832页

作者： Ke Ruan Ge bai yanshan fang Dan li tingting li xingguo liu boxun lu Qing lu Zhou Songyang Shuguo sun Zheng Wang xin Zhang Wen Zhou hong Zhang Neurology Department at Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science School of Life Sciences Fudan University Key laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education Bio-X Institutes Shanghai Jiao Tong University State Key laboratory of biocontrol MOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging Research School of Life Sciences Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Human Anatomy Histology and Embryology School of Basic Medicine Tongji Medical College Huazhong University of Science and Technology the Second Affiliated Hospital School of Basic Medical Sciences Institute of Biomedical Innovation Jiangxi Medical College Nanchang University Westlake laboratory of life Sciences and biomedicine Department of Immunology and Microbiology School of Life Sciences Southern University of Science and Technology National laboratory of biomacromolecules Institute of Biophysics Chinese Academy of Sciences College of life Sciences University of Chinese Academy of Sciences the first Affiliated Hospital & School of life Sciences Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics Hefei National Research Center for Interdisciplinary Sciences at the Microscale Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and Medicine University of Science and Technology of China Nanhu brain-computer Interface Institute Department of Neurology of Second Affiliated Hospital and School of brain Science and brain Medicine Zhejiang University School of Medicine Interdisciplinary Research Center on biology and Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences university of Chinese Academy of Sciences bio-x Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of

biomolecular condensates or membraneless organelles(MlOs) formed by liquid-liquid phase separation(llpS) divide intracellular spaces into discrete compartments for specific functions. Dysregulation of llpS or aberrant phase transition that disturbs the formation or material states of MlOs is closely correlated with neurodegeneration, tumorigenesis, and many other pathological processes. Herein, we summarize the recent progress in development of methods to monitor phase separation and we discuss the biogenesis and function of MlOs formed through phase separation. We then present emerging proof-of-concept examples regarding the disruption of phase separation homeostasis in a diverse array of clinical conditions including neurodegenerative disorders, hearing loss, cancers, and immunological diseases. finally, we describe the emerging discovery of chemical modulators of phase separation.

关键词： liquid-liquid phase separation biomolecular condensate membraneless organelle

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A novel high-Cr CoNi-based superalloy with superior high-temperature microstructural stability, oxidation resistance and mechanical properties

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International journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1373-1381页

作者： xiaorui Zhang Min Zou Song lu longfei li xiaoli zhuang Qiang feng beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced MetalsUniversity of Science and Technology BeijingBeijing 100083China

A novel multicomponent high-Cr CoNi-based superalloy with superior comprehensive performance was prepared,and the evaluation of its high-temperature microstructural stability,oxidation resistance,and mechanical properties was conducted mainly using its cast polycrystalline *** results disclosed that the morphology of theγ′phase remained stable,and the coarsening rate was slow during the long-term aging at 900–1000℃.the activation energy forγ′precipitate coarsening of alloy 9CoNi-Cr was(402±51)kj/mol,which is higher compared with those of CMSx-4 and some other Ni-based and Co-based ***,there was no indica-tion of the formation of topologically close-packed phases during this *** these factors demonstrated the superior microstructural stability of the *** mass gain of alloy 9CoNi-Cr was 0.6 mg/cm^(2) after oxidation at 1000℃ for 100 h,and the oxidation resistance was comparable to advanced Ni-based superalloys CMSx-4,which can be attributed to the formation of a continuous Al_(2)O_(3) protective ***,the compressive yield strength of this cast polycrystalline alloy at high temperatures is clearly higher than that of the conventional Ni-based cast superalloy and the compressive minimum creep rate at 950℃ is comparable to that of the conventional Ni-based cast superalloy,demonstrating the alloy’s good mechanical properties at high *** is partially because high Cr is bene-ficial in improving theγandγ′phase strengths of alloy 9CoNi-Cr.

关键词： CoNi-based superalloys microstructure coarsening oxidation mechanical properties

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Advances in the treatment of IgA nephropathy with biological agents

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Chronic Diseases and translational Medicine 2024年第1期10卷 1-11页

作者： yongze zhuang Hailing lu junxia li Department of Nephrology 900 Hospital of the Joint Logistics TeamPLAFuzhou General Clinical Medical CollegeFujian Medical UniversityFuzhouFujianChina

Immunoglobulin A nephropathy(IgAN)is the most common primary glomerular disease,and the“four-hit”theory represents its currently accepted pathogenic *** immunity triggered by infections in the respiratory tract,intestines,or other areas leads to antigen presentation,t cell stimulation,b cell maturation,and the production of IgA-producing plasma *** proteins b-lymphocyte stimulator(blyS)and a proliferation-inducing ligand(ApRIl)are involved in this process,and alternative complement and lectin pathway activation are also part of the pathogenic *** Disease Improving Global Outcomes guidelines indicate that a specific effective treatment for IgAN is lacking,with renin-angiotensin-aldosterone system inhibitors being the primary *** research shows that biological agents can significantly reduce proteinuria,stabilize the estimated glomerular filtration rate,and reverse some pathological changes,such as endocapillary proliferation and crescent *** are four main categories of biological agents used to treat IgA nephropathy,specifically anti-CD20 monoclonal antibodies,anti-blyS or ApRIl monoclonal antibodies,monoclonal antibodies targeting both blyS and ApRIl(telitacicept and atacicept),and monoclonal antibodies inhibiting complement system activation(narsoplimab and eculizumab).However,further research on the dosages,treatment duration,long-term efficacy,and safety of these biological agents is required.

关键词： anti-CD20 monoclonal antibodies ApRIl biological agents blyS complement IgAnephropathy

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