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健康人感染HBV或HCV中动脉硬化的研究

世界核心医学期刊文摘（胃肠病学分册） 2006年第5期2卷 47-47页

作者： Moritani M. Adachi K. arima N. 孟欣颖(译) 纪泛扑(校) K. Adachi Department of Gastroenterology and Hepatology Shimane University School of Medicine 89-1 Enya-cho Izumo 693-8501 Japan 不详

Abstract Abstract Background: It is unclear whether infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) affects arteioscle-rosis. We performed a cross-sectional study to clarify the effect of HBV and HCV infection on arteriosclerosis. Methods: The study subjects were 1806 healthy individuals who visited Shimane Environment and Health Public Corporation for routine medical check-ups. Serum levels of total cholesterol, high-density lipoprotein (HDL) cholest-erol, triglycerides, and blood glucose were investigated inll subjects. The degree of arteriosclerosis was assessed using systolic blood pressure, the bilateral ankle brachial index (ABI), the heart-carotid pulse wave velocity (HCPWV), and the heart-ankle PWV(HAPWV). These cardiovascular parameters were compared between control subjects and subjects with HBV and HCV infection, using analysis of covariance to adjust for confounding factors (sex, age, body mass index, and smoking and drinking). Results: Of the 1806 subjects, 39 and 31 were diagnosed as positive for HBV and HCV infection, respectively. The remaining 1736 were considered to be the controls. Adjusted serum lipid levels in the subjects with HBV and those with HCV infection tended to be lower than those in the control subjects. Adjusted arteriosclerotic parameters in the subjects with HBV and HCV infectionwere similar to those in the control subjects, even after adjusting for serum lipid levels. Conclusions: Infection with HBV or HCV does not influence the severity of arteriosclerosis in healthy subjects.

关键词： HCV感染动脉硬化 HBV 健康人踝臂指数(ABI) HDL-胆固醇动脉脉搏波血清总胆固醇横断面研究心血管参数

妊娠期饮酒与妊娠期高血压疾病的关系:日本环境与儿童研究

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中华高血压杂志 2018年第11期26卷 1094-1094页

作者：刘青叶鹏 Iwama N Metoki H Nishigori H Mizuno S Takahashi F Tanaka K Watanabe Z Saito M Sakurai K Ishikuro M Obara T Tatsuta N Nishijima I Sugiyama T Fujiwara I Kuriyama S arima T Nakai K yaegashi N

该研究在日本环境和儿童研究中调查了母亲孕期饮酒与妊娠期高血压疾病的关系。这是一项全国范围的出生队列研究,共有76940名孕妇被纳入分析。使用两份问卷获得有关怀孕期间饮酒量的信息:T1和T2。T1和T2问卷的平均孕龄分别为(16.5±5.8)... 详细信息

该研究在日本环境和儿童研究中调查了母亲孕期饮酒与妊娠期高血压疾病的关系。这是一项全国范围的出生队列研究,共有76940名孕妇被纳入分析。使用两份问卷获得有关怀孕期间饮酒量的信息:T1和T2。T1和T2问卷的平均孕龄分别为(16.5±5.8)和(27.9±3.7)周。饮酒作为暴露,妊娠高血压疾病作为结果,并将可能的混杂因素纳入具有logit连接功能的广义线性混合效应模型中。

关键词：妊娠期高血压疾病饮酒量儿童环境日本广义线性混合效应模型妊娠高血压疾病出生队列研究

Relationship of meteorological factors and human brucellosis in Hebei province,China

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Relationship of meteorological factors and human brucellosis...

高糖对系膜细胞金属蛋白酶表达的影响及肝素的干预作用

安徽省2019年度流行病与卫生统计学学术年会

作者：操龙挺 Liu HH Li J yin XD Duan y Wang J 安徽医科大学公共卫生学院

BACKGROUND:Brucellosis has always been one of the major public health problems in China.Investigating the influencing factors of brucellosis is conducive to its prevention and control.The incidence trend of brucellosis shows an obvious seasonality,suggesting that there may be a correlation between brucellosis and meteorological factors,but related studies were few.We aimed to use the autoregressive integrated moving average(arima) model to analyze the relationship between meteorological factors and brucellosis.METHODS:The data of monthly incidence of brucellosis and meteorological factors in Hebei province from January 2004 to December 2015 were collected from the Chinese Public Health Science Data Center and Chinese meteorological data website.An arima model incorporated with covariables was conducted to estimate the effects of meteorological variables on brucellosis.RESULTS:There was a highest peak from May to July every year and an upward trend during the study period.Atmospheric pressure,wind speed,mean temperature,and relative humidity had significant effects on brucellosis.The arima(1,0,0)(1,1,0)12 model with the covariates of atmospheric pressure,wind speed and mean temperature was the optimal model.The results showed that the atmospheric pressure with a 2-month lag(β=-0.004,p=0.037),the wind speed with a 1-month lag(β=0.030,p=0.035),and the mean temperature with a 2-month lag(β=-0.003,p=0.034) were significant predictors.CONCLUSION:Our study suggests that atmospheric pressure,wind speed,mean temperature,and relative humidity have a significant impact on brucellosis.Further understanding of its mechanism would help facilitate the monitoring and early warning of brucellosis.

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肾脏病与透析肾移植杂志 2004年第1期13卷 25-29页

作者：周巧玲保元裕一郎塚本雅俊野畸刚曾我部笃原田幸治有馬晖勝中南大学湘雅医院肾内科长沙410008 日本鹿儿岛大学医学部第二内科

目的：研究高糖对正常人类系膜细胞(NHMC)增殖及金属蛋白酶2(MMP2)和金属蛋白酶。(MMP9)表达的影响及肝素对其的干预作用。方法：NHMC在含和(或)小含肝索的高糖培养基中培养，以正常糖培养基作对照。采用WST-1法测定NHMC增殖状况；用wes... 详细信息

目的：研究高糖对正常人类系膜细胞(NHMC)增殖及金属蛋白酶2(MMP2)和金属蛋白酶。(MMP9)表达的影响及肝素对其的干预作用。方法：NHMC在含和(或)小含肝索的高糖培养基中培养，以正常糖培养基作对照。采用WST-1法测定NHMC增殖状况；用western Blot技术分析MMP2、MMP9表达情况。结果：高糖组NHMC增殖明显高于对照组，二组问有显著性差异(P<0.05)。用肝素十预后，高糖组肝素浓度为50μg/ml时，NHMC增殖开始受到抑制，且随着肝素浓度递增，NHMC增殖抑制更明显(肝素50～400μg／ml各浓度组与未加肝素组比较，均P<0．05或P<0.01)。而对照组肝素浓度为200μg／ml时，NHMC增殖才出现抑制(肝素200～40μg／ml组与未加肝素组比较，均P<0.05)。另外，高糖与对照组NHMC均有一定量MMP2、MMP9表达，加入肝素后MMP2、MMP9出现高表达，特别是在高糖组尤为明显。结论：肝素能抑制高糖刺激下NHMC增殖并能使体外NHMC中的MMP2、MMP9出现高表达，推测MMPs町能参与了高糖状态下NHMC的细胞外基质的降解过程并且肝素有肾保护作用。

关键词：高糖系膜细胞金属蛋白酶肝素糖尿病肾病慢性肾功能衰竭细胞增殖