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Journal of Innovative Optical Health Sciences 2022年第1期15卷 90-102页

作者： P.A.Dyachenko(Timoshina) A.N.Bashkatov D.A.alexandrov V.I.Kochubey V.V.Tuchin Saratov State University SaratovRussia Laboratories of Biophotonics and Laser Molecular Imaging and Machine Learning National Research Tomsk State University TomskRussia Saratov State Medical University SaratovRussia Institute of Precision Mechanics and Control Russian Academy of SciencesRussia A.N.Bach Institute of Biochemistry Research Center of Biotechnology of the Russian Academy of Sciences MoscowRussia

The influence of ischemia-reperfusion(I/R)action on pancreatic blood flow(PBF)and the development of acute pancreatitis(AP)in laboratory rats is evaluated in vivo by using the laser speckle contrast imaging(LSCI).Additionally,the optical properties in norm and under condition of AP in rats were assessed using a modied integrating sphere spectrometer and inverse Monte Carlo(IMC)*** results of the experimental study of microcirculation of the pancreas in 82 rats in the ischemic model are *** data obtained conrm the fact that local ischemia and changes in the blood°ow velocity of the main vessels cause and provoke acute pancreatitis.

关键词： Laser speckles contrast of speckle images adaptive algorithm microcirculation blood flow acute pancreatitis pancreas rats optical properties integrating sphere spectroscopy

Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

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World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

Mn微合金化对Ti-Al-Mo-Zr-Fe-B合金组织演变和力学性能的影响

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稀有金属材料与工程 2024年第6期53卷 1555-1565页

作者：何苗霞燕迟董月成常辉 alexandrov Igor V 南京工业大学材料科学与工程学院新材料研究院江苏南京211816 乌法理工大学材料科学与金属物理系俄罗斯乌法450008

通过OM、EBSD和TEM等研究了Mn微合金化对新型近αTi-Al-Mo-Zr-Fe-B合金微观组织和力学性能的影响。结果表明:添加0.5%(质量分数)的Mn元素可以将合金的铸态微观组织从3.28μm细化到2.65μm,使其抗拉伸强度从882 MPa提高到966 MPa,但延伸... 详细信息

通过OM、EBSD和TEM等研究了Mn微合金化对新型近αTi-Al-Mo-Zr-Fe-B合金微观组织和力学性能的影响。结果表明:添加0.5%(质量分数)的Mn元素可以将合金的铸态微观组织从3.28μm细化到2.65μm,使其抗拉伸强度从882 MPa提高到966 MPa,但延伸率从7.8%下降到5.1%。锻造后的2种合金的晶粒尺寸趋于一致,微观组织趋于等轴化且Mn微合金化后的组织更加均匀。锻造后,Ti-Al-Mo-Zr-Fe-B合金的抗拉伸强度和延伸率增加到966 MPa和16.4%,而含有0.5%(质量分数)Mn元素的合金具有更高的抗拉伸强度,达到了1079 MPa,同时延伸率达到了15.8%。结论表明,强度的提高可以归因于Mn元素的固溶强化效应,同时Mn微合金化处理使合金中的Al元素富集于α相,有利于提高合金的强度和塑性。

关键词： Mn微合金化近α钛合金组织演变力学性能

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赋范空间中一个二次方程解的个数（英文）

黑龙江大学自然科学学报 2016年第1期33卷 1-5,141页

作者： alexandrov Victor 俄罗斯索伯列夫数学研究所新西伯利亚630090 俄罗斯新西伯利亚国立大学物理系新西伯利亚630090

研究方程Q(u)=g,其中Q是映射一个赋范空间到另一个的连续二次算子。显然,若u是该方程的一个解,则-u也是一个解。给出没有其它解的条件,并应用其研究偏微方程uΔu=g的Dirichlet边值问题。

关键词：二次算子二次泛函方程向量空间

Net biome production of managed forests in Japan

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Science China(Life Sciences) 2002年第Z1期45卷 109-115页

作者： alexandrov Georgii yamagata yoshiki National Institute for Environmental Studies Tsukuba Ibaraki 305-8506 Japan

Net biome production (NBP) is considered as the most appropriate concept for analyzing long-term and large-scale changes of the carbon cycle induced by land use. We have estimated NBP potential of Japanese managed forests, based on their age structure, to be 16 Mt C/a. Fifty-nine percent of this sink is located in the warm-temperate broadleaf forest zone and the remaining 39% is located in the cool-temperate broadleaf forest zone. This potential of NBP could be achieved under a long rotation period (70 a) and may serve as a target for sink enhancement efforts with the potential to uptake up to 4% of current fossil fuel emissions.

关键词： aboveground biomass, carbon sinks, land use.

Molecular Dynamics Simulation of Behaviours of Non-Polar Droplets Merging and Interactions with Hydrophobic Surfaces

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Journal of Bionic Engineering 2008年第4期5卷 271-281页

作者： y.y. yan C.y. Ji School of the Built Environment University of Nottingham Nottingham NG7 2RD UK

This paper presents a molecular dynamics simulation of the behaviours of non-polar droplets merging and also the fluid molecules interacting with a hydrophobic surface. Such behaviours and transport phenomena are popular in general microchannel flow boiling and two-phase flow. The droplets are assumed to be composed of Lennards-Jones type molecules. Periodic boundary conditions are applied in three coordinate directions of a 3-D system, where there exist two liquid droplets and their vapour. The two droplets merge when they come within the prescribed small distance. The merging of two droplets apart from each other at different initial distances is tested and the possible larger （or critical） non-dimensional distance, in which droplets merging can occur, is discussed. The evolution of the merging process is simulated numerically by employing the Molecular Dynamics （MD） method. For interactions with hydrophobic solid wall, a system with fluid confined between two walls is used to study the wetting phenomena of fluid and solid wall. The results are compared with those of hydrophilic wall to show the unique characteristics of hydrophobic interactions by microscopic methods.

关键词： molecular dynamics simulation mist flow droplets merging hydrophobic wetting

Simulation of plastic deformation induced texture evolution using the crystallographic homogenization finite element method

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Acta Mechanica Solida Sinica 2017年第1期30卷 51-63页

作者： y.P.Chen y.y.Cai Department of Mechanics Huazhong University of Science and Technology

A semi-implicit elastic/crystalline viscoplastic finite element（FE） method based on a ＂crystallographic homogenization＂ approach is formulated for a multi-scale analysis. In the formulation, the asymptotic series expansion is introduced to define the displacement in the micro-continuum. This homogenization FE analysis is aimed at predicting the plastic deformation induced texture evolution of polycrystalline materials, the constituent microstructure of which is represented by an assembly of single crystal grains. The rate dependent crystal plasticity model is adopted for the description of microstructures. Their displacements are decomposed into two parts： the homogenized deformation defined in the macrocontinuum and the perturbed one in the micro-continuum. This multi-scale formulation makes it possible to carry out an alternative transition from a representative micro-structure to the macro-continuum. This homogenization procedure satisfies both the compatibility and the equilibrium in the micro-structure. This developed code is applied to predict the texture evolution, and its performance is demonstrated by the numerical examples of texture evolution of FCC polycrystalline metals.

关键词： Homogenization Local periodicity Crystalline plasticity Texture Finite element

Recent Advances in Computational Simulation of Macro-,Meso-,and Micro-Scale Biomimetics Related Fluid Flow Problems

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Journal of Bionic Engineering 2007年第2期4卷 97-107页

作者： y. y. yan School of the Built Environment The University of Nottingham Nottingham NG7 2RD UK

Over the last decade, computational methods have been intensively applied to a variety of scientific researches and engineering designs. Although the computational fluid dynamics （CFD） method has played a dominant role in studying and simulating transport phenomena involving fluid flow and heat and mass transfers, in recent years, other numerical methods for the simulations at meso- and micro-scales have also been actively applied to solve the physics of complex flow and fluid-interface interactions. This paper presents a review of recent advances in multi-scale computational simulation of biomimetics related fluid flow problems. The state-of-the-art numerical techniques, such as lattice Boltzmann method （LBM）, molecular dynamics （MD）, and conventional CFD, applied to different problems such as fish flow, electro-osmosis effect of earthworm motion, and self-cleaning hydrophobic surface, and the numerical approaches are introduced. The new challenging of modelling biomimetics problems in developing the physical conditions of self-clean hydrophobic surfaces is discussed.

关键词： biomimetics computational simulation macro- meso- micro-scale hydrophobic surfaces

Large Scale and Performance tests of the ATLAS Online Software

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International Conference on Computing in High Energy and Nuclear Physics 2001年第1期 572-576页

作者： alexandrov H.Wolters 等 JointInstituteforNuclearResearch DubnaRussia FCUL，UiversityofLisboa LisbonPortugal

One of the sub-systems of the Trigger/DAQ system of the future ATLAS experiment is the Online Software *** encompasses the functionality needed to configure,control and monitor the *** architecture is based on a component structure described in the ATLAS Trigger/DAQ technical *** integration tests ensure its smooth operation in test beam setups during its evolutionary development towards the final ATLAS online *** is received and returned into the development *** of the *** have been performed on a set of up to 111 PCs on a configuration which is getting closer to the final size,Large scale and performance tests of the integrated system were performed on this setup with emphasis on investigating the aspects of the inter-dependence of the components and the performance of the communication *** particular interest were the run control state transitions in various configurations of the run control *** the purpose of the tests,the software from other Trigger/DAQ sub-systems has been *** paper presents a brief overview of the online system structure,its components and the large scale integration tests and their results.

关键词： ATLAS实验软件开发脱机软件

Interest of D-dimer level,severity of COVID-19 and cost of management in Gabon

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World Journal of Critical Care Medicine 2025年第1期14卷 91-99页

作者： Berthe A Iroungou Arnaud Nze O Helga M Kandet y Neil-Michel Longo-Pendy Nina D Mezogho-Obame Annicet-Clotaire Dikoumba Guignali L Mangouka UnitéMixte de Recherche Centre International de Recherches Médicales de Franceville et le Service de SantéMilitaireLibreville 20404EstuaireGabon AP-HP Health Economics Research UnitHtel Dieu HospitalParis 75004Ilede-FranceFrance Laboratory Hôpital D'Instruction des Armées D'AkandaLibreville 20404EstuaireGabo Unitéde Recherche enÉcologie de la Santé Centre Interdisciplinaire de Recherches Médicales de FrancevilleFranceville 769Gabon Laboratory Hôpital D'Instruction des Armées Omar Bongo OndimbaLibreville 20404EstuaireGabon Department of Medecine Polyvalente Hôpital D'Instruction des Armées Omar Bongo OndimbaLibreville 20404EstuaireGabon

BACKGROUND Coronavirus disease 2019(COVID-19)is strongly associated with an increased risk of thrombotic events,including severe outcomes such as pulmonary *** D-dimer levels are a critical biomarker for assessing this *** Gabon,early implementation of anticoagulation therapy and D-dimer testing has been crucial in managing *** study hypothesizes that elevated Ddimer levels are linked to increased COVID-19 *** To determine the impact of D-dimer levels on COVID-19 severity and their role in guiding clinical *** This retrospective study analyzed COVID-19 patients admitted to two hospitals in Gabon between March 2020 and December *** study included patients with confirmed COVID-19 diagnoses and available D-dimer measurements at *** on demographics,clinical outcomes,D-dimer levels,and healthcare costs were ***-19 severity was classified as non-severe(outpatients)or severe(inpatients).A multivariable logistic regression model was used to assess the relationship between D-dimer levels and disease severity,with adjusted odds ratios(OR)and 95%*** A total of 3004 patients were included,with a mean age of 50.17 years,and the majority were female(53.43%).Elevated D-dimer levels were found in 65.81%of patients,and 57.21%of these experienced severe *** analysis showed that patients with elevated D-dimer levels had 3.33 times higher odds of severe COVID-19(OR=3.33,95%CI:2.84-3.92,Pysis,adjusted for age,sex,and year of *** financial analysis revealed a substantial burden,particularly for uninsured *** D-dimer predicts COVID-19 severity and guides treatment,but the high cost of anticoagulant therapy highlights the need for policies ensuring affordable access in resource-limited settings like Gabon.

关键词： D-dimers COVID-19 Management Disease severity Healthcare costs Gabon