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农业译文 1989年第2期 10-20页

作者： Elad,y. 杨景华

干扰素和利巴韦林联合治疗慢性丙型肝炎老年患者的局限性

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世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 47-48页

作者： Iwasaki y. Ikeda H. Araki y. 陈云茹 Department of Gastroenterology.and Hepatology Okayama UniversityGraduate School of MedicineDentistryand Pharmaceutical Sciences2-5-1Shikata-choOkayama 700-8558Japan

In contrast to the United States, Japanese patients with chronic hepatitis C currently.treated with interferon are generally.10 to 15 y.ars older. Older patients, however, tend to experience more frequent adverse events. This study.was conducted to clarify.the effect of patient age on the efficacy.and safety.of combination therapy. We consecutively.enrolled 208 patients with nave chronic hepatitis C. Patients were classified into three groups according to age: y.unger than 50 y.ars of age (n = 52); 50 to 59 y.ars old (n = 83); and 60 y.ars of age or older (n = 73). Interferon alpha-2b therapy.was administered daily.for 2 weeks, followed by.3 times per week for 22 weeks, while ribavirin was administered daily. Of the 208 study.patients, discontinuation of therapy.or dose reduction was required in 116 (56%) and was more frequent in older patient groups: 38%, 48%, and 77%for the y.ar-old patient groups, respectively.(P riate analy.is showed patient age to be independently.associated with adherence to therapy. A sustained virological response was achieved in 77 (37%) patients, with genoty.e, viral load, and adherence to therapy.associated with this achievement. A tendency.toward a lower sustained virological response rate was seen in the older patients. In conclusion, patient age is an important factor contributing to the safety.of combination therapy. Thus, treatment schedule should be modified, or other therapeutic modalities should be considered for older patients with chronic hepatitis C.

关键词：慢性丙型肝炎干扰素α 持续病毒学应答不良反应率应答率病毒载量依从性多变量分析

Sy.ErGIC　EFFECT　OF　POLy.Er　SUPPOrTED　Pd－Pt　BIMETALLIC　CATALy.TS　ON　THE　Hy.rOGENATION　OF　NITrOArOMATICS

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Chinese Chemical Letters 1996年第7期7卷 663-664页

作者： y.ng, B y., ZK Xu, y.Liao, SJ y., Dr CHINESE ACAD SCI DALIAN INST CHEM PHYSDALIAN 116023PEOPLES R CHINA

s: Hy.rogenation of nitroaromatics has been carried out under mild conditions using poly.N-viny.-2-py.rolidone supported Pd-Pt bimetallic cataly.ts (PdCl2 and H2PtCl6 as cataly.t precursors).The cataly.ic activities of the bimetallic cataly.ts are significantly.higher than those of themonometallic Pd or Pt cataly.t especially.in the case of the hy.rogenation of substitutednitroaromatics due to a remarkable sy.ergic effect. The ratio of Pd to Pt in the cataly.t influences theactivity.of the cataly.t.

关键词： SELECTIVE Hy.rOGENATION

THE NATUrAL INFECTION AND SEASONAL PrEVALENCE OF ANOPHELES MOSQUITOES IN CHEFANG AND VICINITy. y.NNAN-BUrMA BOrDEr*

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中华医学杂志(英文版) 1949年第8期67卷 413-413页

作者： C. y. CHOW M. C. BALFOUr

A preliminary.study.of the anophelines of the Chefang valley.and their relation to malaria has already.been published (1). The present paper is a study.of natural infection and seasonal prevalence of Anopheles mosquit... 详细信息

关键词： MOSQUITOES

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Early.stage colon cancer: Current treatment standards, evolving paradigms, and future directions

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World Journal of Gastrointestinal Oncology 2020年第8期12卷 808-832页

作者： Sakti Chakrabarti Carrie y.Peterson Deepika Sriram Amit Mahipal Division of Hematology.Oncology Medical College of WisconsinMilwaukeeWI 53226United States Department of Surgery Medical College of WisconsinMilwaukeeWI 53226United States Division of Medical Oncology Mayo ClinicRochesterMN 55905United States

Colon cancer continues to be one of the leading causes of mortality.and morbidity.throughout the world despite the availability.of reliable screening tools and effective *** majority.of patients with colon cancer are diagnosed at an early.stage(stages I to III),which provides an opportunity.for *** current treatment paradigm of early.stage colon cancer consists of surgery.followed by.adjuvant chemotherapy.in a select group of patients,which is directed at the eradication of minimal residual disease to achieve a *** alone is curative for the vast majority.of colon cancer ***,surgery.and adjuvant chemotherapy.can achieve long term survival in about two-thirds of colon cancer patients with nodal *** chemotherapy.is recommended for all patients with stage III colon cancer,while the benefit in stage II patients is not unequivocally.established despite several large clinical *** research in early.stage colon cancer is focused on minimally.invasive surgical techniques,strategies to limit treatment-related toxicities,precise patient selection for adjuvant therapy.utilization of molecular and clinicopathologic information to personalize therapy.and exploration of new therapies exploiting the evolving knowledge of tumor *** this review,we will discuss the current standard treatment,evolving treatment paradigms,and the emerging biomarkers,that will likely.help improve patient selection and personalization of therapy.leading to superior outcomes.

关键词： Adjuvant Circulating tumor DNA Immunoscore Minimally.invasive Neoadjuvant FOxTrOT Minimal residual disease International duration evaluation of adjuvant chemotherapy

BAND ELECTrONIC STrUCTUrES OF Sy.THETIC METAL BISDITHIOLENE DErIVATIVES 　

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Chinese Chemical Letters 1995年第7期6卷 633-636页

作者： Zhang, y.Li, LF y.u, XZ Sun, y. Nanjing Univ Inst Coordinat Chem State Key Lab Coordinat Chem Nanjing 210093 Peoples R China

Energy.band calculations of tetrathiafulvalene-metal bisdithiolenes (C6S8M)∞ (M= Ni, Pt) with the extended Huckel molecular orbital (EHMO) method show that the multiple overlaps among frontier molecular orbitals (FMO) and the small band gap account for their conducting properties. Their estimated conductivities are in good agreement with experimental data. FMO are mainly.composed of ligand *** of the band structures betWeen poly.ers and lay.red salts with the same building block are revealed.

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Improvement in the mechanical properties of Al/SiC nanocomposites fabricated by.severe plastic deformation and friction stir processing

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International Journal of Minerals,Metallurgy.and Materials 2017年第3期24卷 297-308页

作者： M.Sarkari Khorrami M.Kazeminezhad y.Miy.shita A.H.Kokabi Department of Materials Science and Engineering Sharif University of Technology Department of Mechanical Engineering Nagaoka University of Technology

Severely.deformed aluminum sheets were processed by.friction stir processing(FSP) with Si C nanoparticles under different conditions to improve the mechanical properties of both the stir zone and the heat affected zone(HAZ).In the case of using a simple probe and the same rotational direction(rD) of the FSP tool between passes,at least three FSP passes were required to obtain the appropriate distribution of ***,after three FSP passes,fracture occurred outward from the stir zone during transverse tensile tests;thus,the strength of the specimen was significantly.lower than that of the severely.deformed base material because of the softening phenomenon in the *** improve the mechanical properties of the HAZ,we investigated the possibility.of achieving an appropriate distribution of nanoparticles using fewer FSP *** results indicated that using the threaded probe and changing the rD of the FSP tool between the passes effectively.shattered the clusters of nanoparticles and led to an acceptable distribution of Si C nanoparticles after two FSP *** these cases,fracture occurred at the HAZ with higher strength compared to the specimen processed using three FSP passes with the same rD between the passes and with the simple *** fracture behaviors of the processed specimens are discussed in detail.

关键词： friction stir processing plastic deformation aluminum silicon carbide nanocomposites mechanical properties

A NEW CHrOME GLy.OSIDE FrOM SMILAX GLABrA rOXB

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Chinese Chemical Letters 1995年第7期6卷 587-588页

作者： Cao, ZZ y., y. Cao, y.Leng, ZK Nanjing Inst Mat Med Nanjing 210009 Peoples R China

A new chrome gly.oside, 5,7-dihy.roxy.hromone-3-O-L-rhamnopy.anoside, named smiglanin, was isolated from the root of Smilax glabra collected in Lanxi, Zhejiang province. Its structure was elucidated by.special data an...

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A NEW SESQUITErPENE FrOM LIGULArIA NELUMBIFOLIA

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Chinese Chemical Letters 1995年第7期6卷 583-584页

作者： Peng, Hr Jia, ZJ y.ng, L Zhao, y Lanzhou Univ Inst Organ Chem State Key Lab Appl Organ Chem Lanzhou 730000 Peoples R China

A new guaiane sesquiterpene was isolated from Ligularia Nelumbifolia. Its structure was elucidated by.spectroscopic methods including 2D-NMr techniques and showed to be 4 alpha ,9 alpha ,10 beta -tri-acetoxy.1 beta, 5...

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日本社区内首次卒中患者的10年卒中复发情况:福冈研究

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 22-23页

作者： Hata J. Tanizaki y. Kiy.hara y. 胡慧敏 Dept.of Med. and Clinical Science Graduate School of Medical Sciences Kyushu University Maidashi 3-1 -1 Higashi-kuFukuoka 812-8582 Japan Dr.

Background: Very.few population based cohort studies have focused on the long term recurrence of stroke. Objective: To examine 10 y.ar c umulative recurrence rates for stroke in a Japanese cohort according to patholog ical ty.e and clinical subty.e of brain infarction. Methods: During a 32 y.ar fo llowup of 1621 subjects ≥40 y.ars of age, 410 developed first ever *** were followed up prospectively.for 10 y.ars after stroke onset. results: During follow up, 108 (26%) experienced recurrent stroke. The cumulative recurrence r ates were 35.3%atfive y.ars and 51.3%at 10 y.ars. The 10 y.ar recurrence rates of subarachnoid haemorrhage (SAH), brain haemorrhage, and brain infarction were 70.0%, 55.6%, and 49.7%, respectively.the difference between SAH and brain i nfarction was significant (p = 0.004). Most recurrent episodes after SAH or brai n haemorrhage happened within a y.ar after the index stroke, whereas recurrence of brain infarction increased consistently.throughout the observation period. Ca rdioembolic stroke had a higher recurrence rate (75.2%) than lacunar infarction (46.8%) (p =0.049). The 10 y.ar risk of stroke recurrence increased with age a fter lacunar or atherothrombotic brain infarction, but not after the other ty.es or subty.es. After atherothrombotic brain infarction, cardioembolic stroke, or SAH, the ty.e and subty.e of most recurrent strokes were the same as for the ind ex stroke,but recurrence after lacunar infarction or brain haemorrhage showed di vergent patterns. Conclusions: Japanese people have higher recurrence rates of s troke than other populations. recurrence rate after a first brain infarct increa ses consistently.through the next 10 y.ars.

关键词：首次卒中脑梗死复发复发率 recurrence 福冈卒中发作队列研究临床亚型 infarct 蛛网膜下腔出血