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Motion reconstruction of the small carry.on impactor aboard Hay.busa2

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Astrody.amics 2020年第4期4卷 289-308页

作者： Takanao Saiki y.y. Mimasu y.to Takei Manabu y.mada Hirotaka Sawada K azunori Ogawa Naoko Ogawa Hiroshi Takeuchi Akira Miura y.ri Shimaki Koji Wada Rie Honda y.suhiro y.kota Kei Shirai Naruhisa Sano Hirohito ohtsuka Go Ono Kent y.shikawa Shota Kikuchi Chikako Hirose y.kio y.mamoto Takahiro Iwata Masahiko Arakawa Seiji Sugita Satoshi Tanaka Fuy.to Terui Makoto y.shikawa Satoru Nakazawa Sei-ichiro Watanabe y.ichi Tsuda Japan Aerospace Exploration Agency Sagamihara 252-5210Japan Chiba Institute of Technology Narashino 275-0016Japan Kobe University K obe 657-8501Japan The Graduate University.for Aduanced Studies Sagamihara 252-5210Japan Kochi University Kochi 780-8520Japan IHI Aerospace Co. LtdTomioka 370-2398Japan The University.of Toky. Tokyo 113-0033Japan Nagoy. University Nagoya 464-8601Japan

Subsurface exploration is one of the most ambitious scientific objectives of the Hay.busa2 mission.A small device called small carry.on impactor(SCI)was developed to create an artificial crater on the surface of asteroid *** enables us to sample subsurface materials,which will provide a window to the *** phy.ical properties of the resulting crater are also useful for understanding the internal structure of *** understanding of the crater and ejecta properties,including the depth of excavation of subsurface materials,requires accurate information on impact *** particular,the impact angle is a critical factor because it greatly.influences the size and shape of the *** April 5,2019,the Hay.busa2 spacecraft deploy.d the SCI at 500 m of altitude above the asteroid *** SCI gradually.reduced its altitude,and it shot a 2 kg copper projectile into the asteroid 40 min after *** the position of the released SCI is essential for determining the impact *** study.describes the motion reconstruction of the SCI based on the actual operation *** results indicate that the SCI was released with high accuracy.

关键词： small body.exploration Hay.busa2 kinetic impact artificial crater motion reconstruction

1例Wernicke脑病患者从上视性到下视性眼球震颤的转变

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 52-52页

作者： Suzuki y. Matsuda T. Washio N. ohtsuka K. 潘佳鸿 Department of Ophthalmol ogy Sapporo Medical University School of Medicine S1W16 Chuo-ku Sapporo 06 0-8543 Japan

Background: We report an unusual case of Wernicke’s encephalopathy.presenting with transient upbeat ny.tagmus that changed to a persistent downbeat ny.tagmus . Case: A 27-y.ar-old man presented with upbeat ny.tagmus. Three months earlie r, he had been diagnosed with Wernicke’s encephalopathy.after fasting for a mon th. Observations: This diagnosis was supported by.his sy.ptoms (ataxia, a confus ed state). Clinical recovery.followed thiamine therapy. His upbeat ny.tagmus had linear slow phases with average amplitude and frequency.(±SD) during fixation straight ahead of 2.8±0.7°and 4.6±2.2Hz. respectively. Two months later, the primary.position upbeat ny.tagmus had diminished and down beat ny.tagmus (0.9 + 0.5°and 3.2±0.7 Hz on average) for a 20°downward gaze had developed. Then, 8 months later, he showed only.downbeat ny.tagmus, which obey.d Alexander’s law. His primary.position downbeat ny.tagmus was completely.suppressed by.clonazepam, a γ-aminobuty.ic acid (GABA) agonist. Conclusions: Owing to an underly.ng cen tral vestibular imbalance, even after the recovery.of acute neurological sy.ptom s, Wernicke’s encephalopathy.can be complicated by.persistent downbeat ny.tagmu s, which can be treated by.a GABA agonist.

关键词： Wernicke 下视性眼球震颤脑病患者上视共济失调前庭功能眼位激动剂临床康复氯硝西泮

Tm(0．1)y.(5)：FOV纳米相氟氧化物玻璃陶瓷的紫外和可见上转换发光

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中国科学（G辑） 2008年第7期38卷 817-824页

作者：陈晓波宋增福吴瑾光 N. Sawanobori M. ohtsuka 李永良周静王策刘金英田强孙萍景红梅应用光学北京市重点实验室北京师范大学物理系和分析测试中心北京100875 北京大学物理学院化学学院北京100871 Sumita Optical Glass Inc. 4-7-25 Harigaya Urawa Saitama338 Japan

研究了在975nm半导体激光激发下纳米相氟氧化物玻璃陶瓷Tm(0.1)y.(5):FOV里y.3+敏化Tm3+的紫外和可见上转换发光.发现了位于363.6nm的一条紫外上转换发光线,它是Tm3+离子的1D2→3H6的荧光跃迁.还发现了位于450.7nm,(477.0,462.5nm),648.... 详细信息

研究了在975nm半导体激光激发下纳米相氟氧化物玻璃陶瓷Tm(0.1)y.(5):FOV里y.3+敏化Tm3+的紫外和可见上转换发光.发现了位于363.6nm的一条紫外上转换发光线,它是Tm3+离子的1D2→3H6的荧光跃迁.还发现了位于450.7nm,(477.0,462.5nm),648.5nm,(680.5,699.5nm)和(777.2,800.7nm)的几条上转换发光线,它们是Tm3+离子的1D2→3F4,1G4→3H6,1G4→3F4,3F3→3H6和3H4→3H6的荧光跃迁.通过对上转换发光强度F随975nm抽运激光功率P改变详细地测量和分析证实了1D2能级的上转换发光部分是五光子上转换发光,而1G4能级和3H4能级的上转换发光则是三光子和双光子上转换发光.初步的理论分析建议1D2能级的上转换发光机理部分是Tm3+离子之间{3H4(Tm3+)→3F4(Tm3+),1G4(Tm3+)→1D2(Tm3+)}和{1G4(Tm3+)→3F4(Tm3+),3H4(Tm3+)→1D2(Tm3+)}的交叉能量传递.而1G4能级和3H4能级的上转换发光机理则是y.3+离子到Tm3+离子的{2F5/2(y.3+)→2F7/2(y.3+),3H4(Tm3+)→1G4(Tm3+)}和{2F5/2(y.3+)→2F7/2(y.3+),3F4(Tm3+)→3F2(Tm3+)}的相继的能量传递。

关键词：上转换发光紫外纳米相氟氧化物玻璃陶瓷饱和 Tm^3+离子 y.^3+离子能量传递

1例Hailey.Hailey.日本患者ATP2C1基因的新突变

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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 50-51页

作者： ohtsuka T. Okita H. Hama N. y.mazaki S. 罗素菊徐波 Department of Dermatology Koshigaya Hospital Dokkyo University School of Medicine 2- 1- 50Minami- Koshigaya Koshigaya Saitama 343- 8555 Japan

Hailey. Hailey.disease (HHD) is an autosomal dominant disorder with recurrent eruption of vesicles and bullae involving predominantly.the neck, groin and axillary.regions. Histopathology.shows suprabasal cleavage in epidermal cells. Recent studies have revealed that HHD is caused by.mutations in the ATP2C1 gene encoding a novel Ca2+ pump. We analy.ed mutations of the ATP2C1 gene in 2 Japanese patients with HHD. The diagnosis of HHD was made based on the characteristic clinical features and histopathological evidence. All 27 exons and flanking intron boundaries were amplified by.poly.erase chain reaction and products analy.ed by.sequencing. As a result, we identified a novel missense mutation (A1087G) in exon 13 of the ATP2C1 gene in a patient. This mutation led the amino acid change from Thr to Ala in the phosphory.ation protein domain. Another patient showed no mutation of the gene. These results demonstrate that a spectrum of ATP2C1 gene mutations is present in Japanese HHD patients.

关键词：基因突变 ATP2C1 Hailey.Hailey 磷酸化蛋白病理学检查组织病理学水疱疹突变

Endocy.oscopic narrow-band imaging efficiency.for evaluation of inflammatory.activity.in ulcerative colitis

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World Journal of Gastroenterology 2015年第7期21卷 2108-2115页

作者： y.suharu Maeda Kazuo ohtsuka Shin-ei Kudo Kunihiko Wakamura y.ichi Mori Noriy.ki Ogata y.shiki Wada Masashi Misawa Akihiro y.mauchi Seiko Hay.shi Toy.ki Kudo Takemasa Hay.shi Hidey.ki Miy.chi Fuy.hiko y.mamura Fumio Ishida Haruhiro Inoue Shigeharu Hamatani Digestive Disease Center Showa University Northern Yokohama Hospital Department of Gastroenterology.and Hepatology Tokyo Medical and Dental University Hospital Endoscopy.Center Showa Hospital Department of Pathology Showa University Northern Yokohama Hospital

AIM:To assess the efficacy.of endocy.oscopic narrowband imaging(EC-NBI)for evaluating the severity.of inflammation in ulcerative colitis(UC).METHODS:This retrospective study.was conducted at a single tertiary.care referral *** included UC patients who underwent colonoscopy.with endocy.oscopy.from July.2010 to December *** was performed,and the images were evaluated by.assessing visibility.increased vascularization,and the increased calibers of capillaries and were classified as Obscure,Visible or *** was indicative of inactive disease,while Visible and Dilated were indicative of acute *** study.received Institutional Review Board *** primary.outcome measures included the diagnostic ability.of EC-NBI to distinguish between active and inactive UC on the basis of histological *** conventional endoscopic images were classified according to the May. endoscopic score.A score of 0 or 1 indicated inactive disease,whereas a score of 2 indicated active ***:Fifty.two patients were *** was a strong correlation between the EC-NBI findings and the histological assessment(r=0.871,Py.specificity.positive predictive value,negative predictive value,and accuracy.of EC-NBI for diagnosing acute inflammation were 84.0%,100%,87.1%,100%,and 92.3%,respectively.while those for the May. endoscopic score were 100%,40.7%,100%,61.0%,and 69.2%,*** with conventional endoscopy.EC-NBI was superior in diagnostic specificity.negative predictive value,and accuracy.Py..CONCLUSION:The EC-NBI finding of capillaries in the rectal mucosa was strongly.correlated with histological inflammation and aided in the differential diagnosis between active and inactive UC.

关键词： Endosy.oscopy Narrow-band imaging Magnified endosc

Blue Upconversion Luminescence from y.3+-doped Oxy.luoride Vitroceramics Excited by.960nm Laser

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Chinese Journal of Lasers 2001年第5期 50-53页

作者： CHEN Xiaobo 1 Masaaki ohtsuka 2 WANG Guowen 3 1Beijing Normal University.Optics Center, Beijing 100875, China 2Sumita Optical Glass, INC. , Japan 3Phy.ics Department, Peking University. Beijing 100871, China

This paper investigates the upconversion luminescence of y. 3+ doped oxy.luoride vitroceramics excited by.960 nm diode laser. A new upconversion cooperative radiation luminescence is found, which is rather strong and positioned at 479 5 nm. It comes from a coupled state of two y. 3+ ion cluster. It is of significance due to the effective method to obtain compact blue light.

关键词： upconversion luminescence y. 3+ doped oxy.luoride ion cluster

Uncovering the roles of CAST/ELKS protein family.in the regulation of sy.aptic transmission and plasticity

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Uncovering the roles of CAST/ELKS protein family in the regu...

Diagnostic and therapeutic single-operator cholangiopancreatoscopy.in biliopancreatic diseases:Prospective multicenter study.in Japan

中国神经科学学会第十二届全国学术会议

作者： Wei Dong Monica Montesinos Matthias Lübbert R.Oliver Goral Travis Putzke Kevin Goff Debbie Guerrero-Given Akari Hagiwara May. y.mazaki Manabu Abe Kenji Sakimura Naomi Kamasawa Toshihisa ohtsuka Samuel M.y.ung,Jr Key.Laboratory.of Medical Electrophy.iology Ministry of Education Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research Southwest Medical University

Sy.apses utilize a network of proteins, the cy.omatrix at the active zone(CAZ) to tightly.regulate sy.aptic strength and SV release kinetics to match the changing needs of the neuronal circuit. The CAST/ELKS family. central components of the CAZ, have been implicated as key.proteins that regulate sy.aptic function. However, their functional roles in the regulation of neuronal circuits remain unresolved. Using a newly.created CAST KO/ELKS conditional KO mouse line which overcomes the embry.nic lethality.associated with constitutive KO of ELKS proteins, we analy.ed the role of the CAST/ELKS protein family.in regulation of presy.aptic function to match the needs of the neuronal circuit. To do so, we utilized the caly. of Held, a large excitatory.presy.aptic terminal located in the auditory.brainstem and the dominant input for driving postsy.aptic spiking in the Medial Nucleus of the trapezoid body.MNTB) to help encode sound information. We carried out electrophy.iological and ultrastructural analy.is in both the immature(prehearing postnatal day.(P9-11) and functionally.mature(hearing, P16-P21) caly. to elucidate the roles of the CAST/ELKS proteins. Here we identify.for the first time, that the CAST/ELKS protein family.regulates voltage gated Ca channel abundance in the presy.aptic terminal. In addition, loss of CAST/ELKS proteins did not affect basal sy.aptic transmission. However, loss of CAST/ELKS resulted in increased release probability.while decreasing the size of the RRP available for action potential mediated release in the functionally.mature caly.. Therefore, we conclude that the CAST/ELKS proteins are critical molecules that differentially.control key.parameters of sy.aptic function in response to the changing neuronal circuit demand.

关键词： caly. of Held sy.aptic transmission plasticity pre-sy.aptic terminal CAST/ELKS

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World Journal of Gastroenterology 2016年第5期22卷 1891-1901页

作者： Toshio Kurihara Ichiro y.suda Hiroy.ki Isay.ma Toshio Tsuy.guchi Taketo y.maguchi Ken Kawabe y.shinobu Okabe Keiji Hanada Tsuy.shi Hay.shi Takao ohtsuka Sy.hei Oana Hiroshi Kawakami y.shinori Igarashi Kazuy. Matsumoto Kiichi Tamada Shomei Ry.zawa Hiroki Kawashima y.taka Okamoto Iruru Maetani Hiroy.ki Inoue Takao Itoi Department of Gastroenterology.and Hepatology Tokyo Medical University6-7-1 NishishinjukuShinjuku-kuTokyo 160-0023Japan First Department of Internal Medicine Gifu University HospitalGifu 501-1194Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Gastroenterology.and Nephrology Chiba University Graduate School of MedicineChiba 260-8677Japan Department of Gastroenterology Chiba Cancer CenterFunabashi Municipal HospitalChiba 260-8717Japan Department of Gastroenterology Clinical Research InstituteNational Hospital OrganizationKyushu Medical CenterFukuoka 810-8563Japan Division of Gastroenterology Department of MedicineKurume University School of MedicineKurume 830-0011Japan Department of Gastroenterology Onomichi General HospitalOnomichi 722-8508Japan Department of Medical Oncology.and Hematology Sapporo Medical University School of MedicineSapporo 060-8543Japan Department of Surgery.and Oncology Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan Department of Gastroenterology Iwate Medical UniversityMorioka 020-0023Japan Department of Gastroenterology.and Hepatology Graduate School of MedicineHokkaido UniversitySapporo 060-8648Japan Division of Gastroenterology.and Hepatology Omori Medical CenterToho UniversityTokyo 143-0015Japan Department of Gastroenterology Tottori University HospitalYonago 683-8504Japan Department of Internal Medicine Division of GastroenterologyJichi Medical UniversityShimotsuke 329-0498Japan Department of Gastroenterology Digestive Disease CenterShowa UniversityNorthern Yokohama HospitalYokohama 224-0032Japan Department of Gastroenterology.and Hepatology Graduate School of MedicineNagoya UniversityNagoya 466-8550Japan Department of Gastroenterology Mutsu General HospitalMutsu 035-0071Japan Division of Gastroenterology Department of Internal MedicineOhashi Medical CenterToho UniversityTokyo 153-0044Japan Department of Gastroenterology Mie University

AIM: To assess the utility.and safety.of single-operator cholangiopancreatoscopy.SOCPS) using the Spy.Glass sy.tem in widespread clinical application for biliary.and pancreatic ***: This study.was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary.diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy.for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary.and pancreatic lesions or treatment of biliary.and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy.under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy.of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy.of SOCPS visual impression of intraductal papillary.mucinous neoplasm was 87.5%(14/16). Stone therapy. complete biliary.and pancreatic stone clearance combined with SOCPS-directed stone therapy.using electrohy.raulic lithotripsy.or laser lithotripsy.was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy.Glass sy.tem was used in cannulation of the cy.tic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary.stricture in two

关键词： Cholangioscopy Endoscopic retrogradecholangiopancreatography Pancreatoscopy Singleoperator Spy.lass

泡盛曲霉对高温环境中肉鸡生长性能和抗氧化能力的影响

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饲料博览 2014年第9期24卷 44-44页

作者： El-Deep M H Ijiri D Eid y.Z y.manaka H ohtsuka A

文章旨在研究日粮中添加泡盛曲霉对处于高温环境下的雄性肉鸡生长性能和抗氧化能力的影响。试验将15日龄的雄性肉鸡24只随机分为两组,分别饲喂玉米-豆粕型基础日粮(对照组)和在基础日粮中添加泡盛曲霉0.05%。分别将6只肉鸡处于温度适中... 详细信息

文章旨在研究日粮中添加泡盛曲霉对处于高温环境下的雄性肉鸡生长性能和抗氧化能力的影响。试验将15日龄的雄性肉鸡24只随机分为两组,分别饲喂玉米-豆粕型基础日粮(对照组)和在基础日粮中添加泡盛曲霉0.05%。分别将6只肉鸡处于温度适中的条件下(22℃),6只处于热应激条件下(35℃),试验期15 d。饲喂泡盛曲霉处于22℃肉鸡的采食量下降,但其饲料转化率升高了;处于热应激状态的肉鸡体增重和饲料摄入量显著下降。饲喂泡盛曲霉对热应激状态下的肉鸡生长性能无有利影响。尽管泡盛曲霉组热应激条件下丙二醛(脂质过氧化的指标)含量增加,但泡盛曲霉可以降低22℃环境下肉鸡骨骼肌中丙二醛的含量。在热应激条件下,α-生育酚的含量降低,并且泡盛曲霉组的α-生育酚含量同样也减少。但两个条件下肝脏中的谷胱甘肽过氧化物酶mRNA的表达量均有所增加。研究表明,饲喂泡盛曲霉可以通过改善抗氧化酶的表达来提高热应激状态下肉鸡的抗氧化能力。

关键词：抗氧化酶泡盛曲霉肉鸡热应激丙二醛