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Intraoperative ultrasound as an educational guide for laparoscopic biliary.surgery

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World Journal of Gastroenterology 2008年第15期14卷 2370-2376页

作者： Kenichi Hakamada Shunji Narumi y.shikazu Toy.ki Masaki nara Motonari Oohashi Takuy. Miura Hiroy.ki Jin Sy.ichi y.shihara Michihiro Sugai Mutsuo Sasaki Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine5 Zaifu-choHirosaki 036-8562Japan

AIM: To analy.e the efficacy.of routine intraoperative ultrasound (IOUS) as a guide for understanding biliary.tract anatomy. to avoid bile duct injury.(BDI) after laparoscopic cholecy.tectomy.(LC), as well as any.burden during the learning period. METHODS: A retrospective analy.is was performed using 644 consecutive patients who underwent LC from 1991 to 2006. An educational program with the use of IOUS as an operative guide has been used in 276 cases since 1998. RESULTS: IOUS was highly.feasible even in patients with high-grade cholecy.titis. No BDI was observed after the introduction of the educational program, despite 72% of operations being performed by.inexperienced surgeons. Incidences of other morbidity. mortality. and late complications were comparable before and after the introduction of routine IOUS. However, the operation time was significantly.extended after the educational program began (P y.titis (P = 0.002), use of IOUS (P = 0.01), and the experience of the surgeons (P = 0.05) were significant factors for extending the length of operation. CONCLUSION: IOUS during LC was found to be a highly.feasible modality. which provided accurate, real- time information about the biliary.structures. Theeducational program using IOUS is expected to minimize the incidence of BDI following LC, especially.when performed by.less-skilled surgeons.

关键词：胆管损伤胆囊切除术胆汁异常超声外科手术

Gardasil on Twitter: A Content Mining Study.Examining Message, Context, and Source Characteristics of Human Papilloma Virus (HPV) Vaccine-Related Tweets

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Health 2020年第9期12卷 1105-1120页

作者： Jessica R. Hawks Atsushi nara Kristen J. Wells John L. Ferrand Eric R. Walsh-Buhi Division of Health Promotion and Behavioral Science School of Public Health San Diego State University San Diego CA USA Department of Geography San Diego State University San Diego CA USA Department of Psy.hology San Diego State University San Diego CA USA Department of Applied Health Science School of Public Health Indiana University Bloomington Bloomington IN USA

Genital human papilloma virus (HPV) is the most common sexually.transmitted virus in the US. Effective HPV vaccines remain controversial and have poor uptake among many.adolescent groups. Social media have potential for promoting the HPV vaccine, but little is known about the content or sentiment of social media discussions regarding the vaccine. The purpose of this study.was to examine message, context, sentiment, and source characteristics of original HPV- and HPV vaccine-related Twitter posts (tweets) over a 3-month time period. This content mining study.used publicly.available data purchased from Twitter. One-thousand tweets were randomly.selected from a sample of 45,260 English language tweets matching our search criteria and collected from December 2014-January.2015. Tweets were manually.coded according to source, context, message, and sentiment characteristics using a coding document developed from previous research. Individuals posted just over half (55%) of tweets, whereas organizations posted 40%. More than half (57%) of all coded tweets were positive, and less than one-fifth were negative. Organizations’ tweets were more likely.to be positive than individuals’ tweets. A temporal display.of contextual events and tweet spikes demonstrates that positive tweets can increase during newsworthy.events (e.g. FDA approval of Gardisil 9). The HPV vaccine was most often discussed under a cancer prevention message frame. In contrast with some existing research, discussions surrounding the HPV vaccine in original Twitter posts are largely.positive. Our study.reveals opportunities for adolescent health specialists to provide accurate, positive HPV vaccination information via Twitter.

关键词： Papillomavirus Vaccines Twitter Messaging Social Media Information Dissemination Twitter

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量化与地下水水文学

地学工程进展 1998年第2期15卷 70-70,F004页

作者： nara.,TN 孟祥业

Role of hepatectomy.for recurrent or initially.unresectable hepatocellular carcinoma

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World Journal of Hepatology 2014年第12期6卷 836-843页

作者： y.ji Kishi Kazuaki Shimada Satoshi nara Minoru Esaki Tomoo Kosuge Hepatobiliary.and Pancreatic Surgery.Division National Cancer Center Hospital Tokyo 104-0045 Japan

As a result of donor shortage and high postoperative morbidity.and mortality.after liver transplantation,hepatectomy.is the most widely.applicable and reliable option for curative treatment of hepatocellular carcinoma(HCC).Because intrahepatic tumor recurrence is frequent after loco-regional therapy.repeated treatments are advocated provided background liver function is *** treatments including local ablation and transarterial chemoembolization,hepatectomy.provides the best long-term outcomes,but studies comparing hepatectomy.with other nonsurgical treatments require careful review for selection *** patients with initially.unresectable HCC,transarterial chemo-or radio-embolization,and/or sy.temic chemotherapy.can down-stage the tumor and conversion to resectable HCC is achieved in approximately.20%of ***,complete response is rare,and salvage hepatectomy.is essential to help prolong patients’*** counter the short recurrence-free survival,excellent overall survival is obtained by.combining and repeating different *** is important to recognize hepatectomy.as a complement,rather than a contraindication,to other nonsurgical treatments in a mul-tidisciplinary.approach for patients with HCC,including recurrent or unresectable tumors.

关键词： hepatectomy recurrence initially curative complement donor chemotherapy mortality frequent postoperative

Identification and characterization of resistance and pathogenicity.of Enterococcus *** samples of donor breast milk

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World Journal of Clinical Pediatrics 2020年第3期9卷 53-62页

作者： Luana Andrade Mendes Santana Nivea nara Novais Andrade Lucas Santana Coelho da Silva Caline Novais Teixeira Oliveira Breno Bittencourt de Brito Fabricio Freire de Melo Claudio Lima Souza Lucas Miranda Marques Marcio Vasconcelos Oliveira Oliveira Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

BACKGROUND Breast milk is the primary.source of nutrition for *** babies frequently.need nutritional support from Human Milk *** bacterial species of the genus Enterococcus are part of the microbiota of healthy.donors,they.may.contaminate samples of pumped breast *** To identify.and characterize the bacterial virulence and resistance in samples isolated from the nipple-areolar region,hands,and breast milk aliquots from donors at the Human Milk Bank of Municipal Hospital EsauMatos in the city.of Vitória da Conquista,Bahia State,*** The personal hy.iene and sanitation of donors were analy.ed with the aim of identify.ng possible reasons for contamination of pumped *** samples as well as aliquots of unpasteurized and pasteurized milk from 30 participants were *** Enterococcus *** underwent a disk diffusion susceptibility.test and molecular biology.techniques to determine resistance and virulence *** Enterococcus *** identified in 30%of donors(n=9),and 11 specimens were *** to tetracy.line was highly.prevalent,being detectable in 63%of the isolates(n=7)and followed by.intermediate sensitivity.to ciprofloxacin,observed in 27%of the specimens(n=3).The efaA gene was found in 63%(n=7)of the isolates,while the ace gene was detected in 27%(n=3).CONCLUSION This study.illustrates the importance of microbiological monitoring by.Human Milk Banks and the need for alternatives to prevent the presence of Enterococcus *** hospital settings.

关键词： Enterococcus spp. Breast milk Virulence Human milk Pasteurization Antimicrobial resistanc

Luminescence properties of Gd2Si2O7：Ce and Gd2Si2O7：La,Ce under vacuum ultraviolet irradiation

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Journal of Rare Earths 2016年第8期34卷 782-785页

作者： M.Koshimizu T.y.nagida y.Fujimoto K.Asai Department of Applied Chemistry Graduate School of Engineering Tohoku University 6-6-07 Aoba Aramaof Aoba-ku Sendai 980-8579 Japan Graduate School of Materials Science Nara Institute of Science and Technology 8916-5 Takayama-Cho Ikoma Nara 630-0192 Japan

The luminescence properties of Ce- or Ce and La-doped gadolinium py.osilicate （Gd2Si2OT, GPS） were characterized using vacuum ultraviolet （VUV） excitation light. A prominent emission band was observed in the luminescence spectra with excitation at 60 nm and ascribed to 5d-4f transition of Ce3＋. Because the excitation wavelength of 60 nm corresponded to the excitation in the host matrix, this result indicated that the excitation energy.transfer occurred from the host matrix to Ce3＋ ions. On the basis of the rise in the luminescence time profiles with excitation at 60 nm, the energy.transfer occurred within 2 ns, which was much shorter than that of Ce-doped Gd2SiO2. For Ce-doped GPS, the decay.rate was slower for the host excitation than that for direct excitation of Ce3＋. In contrast, for Ce and La-doped GPS, no significant difference was observed for the host excitation and direct excitation of Ce3＋. This result indicated that the energy.transfer from the host to Ce3＋ ions led to a different radiative decay.process, and that La doping had an effect on the energy.transfer and decay.process.

关键词： energy.transfer scintillation vacuum ultraviolet rare earths

氯米帕明诱导的具有独特临床特征的变态反应综合征

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世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 14-15页

作者： Nishimura y. Kitoh A. y.shida y. Tanaka T. 李翠华 200 Mishima Tenri Nara 632- 8552 JapanDr.

Drug- induced hy.ersensitivity.sy.drome is a severe drug eruption with fatal visceral organ failures associated with human herpesvirus- 6 (HHV- 6) reactivation. We present a case of clomipramine- induced hy.ersensitivity.sy.drome, which display.d in succession two different reactions akin to those described for Gianotti- Crosti sy.drome and infectious mononucleosis. HHV- 6 reactivation was confirmed serologically.after the latter reaction, suggesting that our case may.have repre- sented a biphasic reaction to HHV- 6 reactivation.

关键词：氯米帕明迟发反应器官衰竭疱疹病毒血清学药物诱导

Roughness Control of Lay.r-by.Lay.r and Alternative Spray.Films from Congo Red and PAH via Laser Light Irradiation

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Materials Sciences and Applications 2012年第8期3卷 552-556页

作者： Gleidson Cardoso Romário J.da Silva Rafael R.G.Maciel nara C.de Souza Josmary.R.Silva Grupo de Materiais Nanoestruturados Universidade Federal de Mato Grosso Barra do Garcas Brazil

Films from congo red (CR) alternated with poly.ally.amine hy.rochloride), PAH, were prepared by.lay.r-by.lay.r and alternative spray.techniques. In order to investigate the change of roughness induced by.laser light irradiation (532 nm), both kinds of films were characterized by.using UV-visible spectroscopy.and atomic force microscopy.(AFM). At dif- ferent irradiation times, lay.r-by.lay.r, LbL, films showed small changes in the roughness and irregular behavior, whereas spray.films exhibited higher and a regular decreasing of roughness with increasing irradiation time. The higher roughness of spray.films as compared with the LbL ones was attributed to different formation mechanisms of the films. The decreasing of the roughness as a function of the irradiation time (exhibited by.the spray.films) was associated to surface relaxation due to the interplay.between photoisomerization of congo red dy. and the heating of the sample during the laser light irradiation. The results suggested that the alternative spray.technique is the best choose to control of roughness of the films by.using light irradiation.

关键词： Congo Red Poly.Ally.amine Hy.rochloride) Lay.r-by.Lay.r Films Roughness Control Laser Light Irradiation

亚洲棉(+)-δ-杜松烯合成酶基因CAD1-A的分离及其在幼苗中的表达特征分析

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中国科学（C辑） 2000年第2期30卷 145-152,T001页

作者：梁婉琪谭晓萍陈晓亚 T. Hashimoto y. y.mada R. Heinstein 中国科学院上海植物生理研究所 nara Institute of Science and Technology ara Institute of Science and Technology Department of Medicinal Chemistry.and Molecular Pharmacology.Purdue University

棉花倍半萜环化酶，即（＋）－δ－杜松烯合成酶（ＣＡＤ），由一个基因家族编码．该基因家族可分为两个亚族：ＣＡＤ１－Ａ和ＣＡＤ１－Ｃ．分离了亚洲棉ＣＡＤ１－Ａ基因．对亚洲棉７天龄幼苗的ｍＲＮＡ原位杂交表明，ＣＡＤ１－Ａ... 详细信息

棉花倍半萜环化酶，即（＋）－δ－杜松烯合成酶（ＣＡＤ），由一个基因家族编码．该基因家族可分为两个亚族：ＣＡＤ１－Ａ和ＣＡＤ１－Ｃ．分离了亚洲棉ＣＡＤ１－Ａ基因．对亚洲棉７天龄幼苗的ｍＲＮＡ原位杂交表明，ＣＡＤ１－Ａ和ＣＡＤ１－Ｃ的转录子主要分布在侧根原基、顶端分生组织和新生侧根的维管组织中，在幼苗下胚轴的原形成层和部分表皮、下表皮细胞中也有分布．ＣＡＤ１－Ａ启动子在转基因烟草中表现出相似的活性．组织化学实验发现，倍半萜醛类分布于侧根根尖的外层细胞以及地上部分的色素腺体中．ＣＡＤ１基因在亚洲棉幼苗中的表达特征，以及倍半萜醛类的分布特征，组成了棉花幼苗的化学防御体系。

关键词：棉花倍半萜环化酶杜松烯原位杂交 CAD1-A