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Impacts of COVID-19 on children and adolescents:A sy.tematic review analy.ing its psy.hiatric effects

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World Journal of Psy.hiatry 2022年第11期12卷 1313-1322页

作者： Italo Wanderson de Moura Gabriel Danielly.Gonçalves Sombra Lima Jeully.Pereira Pires Nélio Barreto Vieira Aloisio Antonio Gomes de Matos Brasil y.ra Talita Gomes Pereira Erika Galvao de Oliveira HildsonLeandro de Menezes Nadia nara Rolim Lima Alberto Olavo Advíncula Reis Ruan Neto Pereira Alves Uanderson Pereira da Silva Jucier Gonçalves Junior Modesto Leite Rolim-Neto School of Medicine Faculty of Medicine of Juazeiro do Norte-FMJ/IDOMEDJuazeiro do Norte 63040-360CearaBrazil School of Medicine Federal University of CaririBarbalha 63048-080CearaBrazil Mais Médicos Program Federal Government of Brazil-Ministry of HealthIguatu 63048-080CearaBrazil Julio Alves de Lira Hospital and Maternity.Hospital HALHMBelo Jardim 55157-290PernambucoBrazil Nursing Department Doctor Leão Sampaio University Center-UNILEAOJuazeiro do Norte 63.041-140CearaBrazil Julio Alves de Lira Hospital and Maternity.Hospital JALHMBelo Jardim 55157-290PernambucoBrazil Graduate Program(Post-Doctoral)in Neuro-Psy.hiatry UFPERecife 50670-901PernambucoBrazil Postgraduate Program(Master’s and Doctorate)in Public Health University of São Paulo-USPSão Paulo 01246-904São PauloBrazil School of Education USPSão Paulo 05508-040São PauloBrazil Internal Medicine-Division of Rheumathology.at Hospital das Clínicas São Paulo UniversitySão Paulo 01246-903São PauloBrazil

OBJECTIVE To summarize the most relevant data from a sy.tematic review on the impact of COVID-19 on children and adolescents,particularly.analy.ing its psy.hiatric *** This review was conducted according to the Preferred Reporting Items for Sy.tematic Reviews and Meta-analy.es(PRISMA)guidelines and included experimental studies(randomized-individually.or pooled-and non-randomized controlled trials),observational studies with a group for internal comparison(cohort studies-prospective and retrospective-and case-control)and qualitative studies in the period from 2021 to *** The search identified 325 articles;we removed 125 *** selected 200 manuscripts,chosen by.title and selected *** excluded 50 records after screening titles and abstracts,as they.did not meet the inclusion *** retrieved 150 records selected for a full *** excluded 90 text articles and we selected 25 records for the(n)***:Due to the short period of data collection,from 2021 to 2022,there is a possibility.of lack of relevant studies related to the mental health care of children and *** addition,there is the possibility.of publication bias,such as only.significant findings being *** The impact of COVID-19 on the mental health of children and adolescents is of great concern to child and y.uth *** such as fear,anxiety.panic,depression,sleep and appetite disorders,as well as impairment in social interactions caused by.psy.hic stress,are punctual markers of pain and psy.hic suffering,which have increasing impacts on the mental health panorama of children and adolescents globally.particularly.in vulnerable and socially.at-risk populations.

关键词： Child psy.hiatry Adolescent psy.hiatry Mental health COVID-19 Kids Teens

Hemosuccus pancreaticus: Problems and pitfalls in diagnosis and treatment

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World Journal of Gastroenterology 2008年第17期14卷 2776-2779页

作者： y.shikazu Toy.ki Kenichi Hakamada Shunji Narumi Masaki nara Keinosuke Ishido Mutsuo Sasaki Department of Gastroenterological Surgery Hirosaki University School of Medicine

Hemosuccus pancreaticus is a rare cause of intermittent upper gastrointestinal bleeding. We report two cases of hemosuccus pancreaticus with multiple episodes of upper gastrointestinal bleeding. The causes of hemorrhage were rupture of pseudoaneury.m of the splenic artery.and bleeding from the wall of pancreatic pseudocy.t. Interventional radiology.is the first modality.for early.diagnosis and possible treatment of hemosuccus pancreaticus. When angiography.shows no abnormal findings or interventional radiological therapy.can not be successful, surgery.should be considered without delay. Our patients herein underwent surgery.without recurrence or sequelae. Intraoperative ultrasonography.and pancreatoscopy.were helpful modalities for confirming the source of hemorrhage and determining the cutting line of the pancreas. When we encounter intermittent upper gastrointestinal bleeding with an obscure source, hemosuccus pancreaticus should be included in differential diagnoses especially.in patients with chronic pancreatitis, which would lead to a prompt and proper treatment.

关键词：胰性血液症状治疗方法疗效

Risk of complications and urinary.incontinence following cy.oreductive prostatectomy. a multi-institutional study

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Asian Journal of Andrology 2018年第1期20卷 9-14页

作者： Dae Keun Kim Jaspreet Singh Parihar y.ung Suk Kwon Sinae Kim Brian Shinder nara Lee Nicholas Farber Thomas Ahlering Douglas Skarecky.Bertram y.h Nora Ruel Wun-lae Kim Koon Ho Rha Isaac y. Kim Department of Urology CHA Seoul Station Medical Center CHA University CHA Medical School Seou104637 Korea Department of Urology School of Medicine Graduate School Hanyang University Seou104763 Korea Section of Urologic Oncology Rutgers Cancer Institute of New Jersey and Division of Urology Rutgers Robert Wood Johnson Medical School Rutgers The State University of New Jersey New Brunswick 08901 USA Department of Biostatistics Rutgers School of Public Health The State University of New Jersey New Brunswick NJ Piscataway 08854 USA Department of Internal Medicine Rutgers Robert Wood Johnson Medical School Rutgers The State University of New Jersey New Brunswick 08901 USA Department of Urology University of California Irvine School of Medicine Orange 92687 USA Division of Urology.and UroLogic Oncology City of Hope National Medical Center Duarte 91010 USA Department of Urology Chungbuk National University College of Medicine Cheongju 28644 Korea Department of Urology.and Urological Science Institute College of Medicine Yonsei University Seou103722. Korea

Emerging evidence has suggested that cy.oreductive prostatectomy.（CRP） allows superior oncologic control when compared to current standard of care androgen deprivation therapy.alone. However, the safety.and benefit of cy.oreduction in metastatic prostate cancer （mPCa） has not been proven. Therefore, we evaluated the incidence of complications following CRP in men newly.diagnosed with mPCa. A total of 68 patients who underwent CRP from 2006 to 2014 at four tertiary.surgical centers were compared to 598 men who underwent radical prostatectomy.for clinically.localized prostate cancer （PCa）. Urinary.incontinence was defined as the use of any.pad. CRP had longer operative times （200 min vs 140 min, P 〈 0.0001） and higher estimated blood loss （250 ml vs 125 ml, P 〈 0.0001） compared to the control group. However, both overall （8.82% vs 5.85%） and major complication rates （4.41% vs 2.17%） were comparable between the two groups. Importantly. urinary.incontinence rate at 1-y.ar after surgery.was significantly.higher in the CRP group （57.4% vs 90.8%, P 〈 0.0001）. Univariate logistic analy.is showed that the estimated blood loss was the only.independent predictor of perioperative complications both in the unadjusted model （OR： 1.18; 95% Ch 1.02-1.37; P= 0.025） and surgery.ty.e-adjusted model （OR： 1.17; 95% Ch 1.01-1.36; P= 0.034）. In conclusion, CRP is more challenging than radical prostatectomy.and associated with a notably.higher incidence of urinary.incontinence. Nevertheless, CRP is a technically.feasible and safe surgery.for selecting PCa patients who present with node-positive or bony.metastasis when performed by.experienced surgeons. A prospective, multi-institutional clinical trial is currently.underway.to verify.this concept.

关键词： cy.oreductive surgical procedures metastatic prostate cancer outcome radical prostatectomy

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曼谷买手——购物龙头聚集地——SIAM区

世界 2007年第7期 144-147页

作者： nara

如果你的购物欲望比热带的温度更高，那么，带一只空箱子到曼谷去。老牌购物狂都知道，在这里——单位时间内的购物效率总是最高的。以下是本文作者在曼谷48小时内的购物清单，它证明，这种旅行是“赚了”。

关键词：购物欲望曼谷聚集购物效率单位时间

拉萨藏族人群尿电解质及氨基酸排泄与血压水平的关系

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西藏医药 1995年第3期16卷 1-4页

作者：孙新甫庄建国 y.y.monri y.nara 西藏医学科学研究所 WHO心血管疾病原发性预防协作研究中心

随机抽取拉萨市49—54岁年龄组108名(男性42人,女性66人)藏族人群,测定身高、体重、血压及24小时尿钠、钾、钙、镁和氨基酸等生物学指标,以评价藏族人群独特的饮食习惯与血压水平之关系.结果显示:平均收缩压、舒张压、尿钠和钠/钾比高;... 详细信息

随机抽取拉萨市49—54岁年龄组108名(男性42人,女性66人)藏族人群,测定身高、体重、血压及24小时尿钠、钾、钙、镁和氨基酸等生物学指标,以评价藏族人群独特的饮食习惯与血压水平之关系.结果显示:平均收缩压、舒张压、尿钠和钠/钾比高;尿钾、钙、镁、牛磺酸及1—甲基组氨酸排泄量低.尿镁与收缩压呈负相关;3—甲基组氨酸与舒张压呈负相关.尿镁及3—甲基组氨酸作为独立因素分别进入收缩压及舒张压多元回归方程.收缩压、舒张压与尿钠呈负相关、与体重指数呈正相关,但相关系数均无显著意义.结果提示:饮食中的多种营养因素包括低钾、低镁和低3—甲基组氨酸摄入可能与血压水平和高血压患病率高有一定关系.改善饮食结构可有利于正常血压的调节和高血压的防治.

关键词：尿电解质尿氨基酸血压

高脂饮食诱导的巨噬细胞抑制因子-1通过激活肿瘤间质细胞产生促肿瘤细胞因子促进前列腺癌的进展

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癌症 2022年第2期41卷 65-79页

作者： Mingguo Huang Shintaro Narita Atsushi Koizumi Taketoshi nara Kazuy.ki Numakura Shigeru Satoh Hiroshi Nanjo Tomonori Habuchi Department of Urology Akita University Graduate School of Medicine1-1-1 HondoAkita 010-8543Japan Department of Clinical Pathology Akita University Graduate School of Medicine1-1-1 HondoAkita 010-8543Japan

背景与目的最近研究表明高脂饮食(high-fat diet,HFD)和/或HFD诱导的肥胖可影响前列腺癌(prostate cancer,PCa)的进展,但HFD在PCa微环境中的作用尚不清楚。本研究旨在阐明HFD环境下PCa进展的分子机制,描述以巨噬细胞抑制因子-1(macroph... 详细信息

背景与目的最近研究表明高脂饮食(high-fat diet,HFD)和/或HFD诱导的肥胖可影响前列腺癌(prostate cancer,PCa)的进展,但HFD在PCa微环境中的作用尚不清楚。本研究旨在阐明HFD环境下PCa进展的分子机制,描述以巨噬细胞抑制因子-1(macrophage inhibitory.cy.okine-1,MIC-1)活性为主的肿瘤间质微环境的特征。方法我们利用HFD或正常饮食的PC-3M-luc-C6 PCa小鼠模型,研究了HFD对PCa间质微环境和MIC-1信号活性的影响。我们分离了原发PCa患者来源的前列腺周围脂肪细胞,并研究了其对前列腺间质成纤维细胞活性及其分泌细胞因子的影响。进一步研究了MIC-1信号的表达模式及其对人PCa间质活性和肿瘤进展的影响。结果在PC-3M-luc-C6 PCa小鼠模型中,HFD通过上调前列腺间质成纤维的MIC-1信号通路活性,增加了白介素(interleukin,IL)-8和IL-6的分泌,促进了PCa细胞的生长和侵袭。另外,前列腺周围脂肪细胞通过增加脂肪分解和游离脂肪酸的释放,直接促进了PC-3细胞产生MIC-1和前列腺间质成纤维细胞分泌IL-8。前列腺癌患者血清MIC-1水平增高与人PCa间质活性、高血清IL-8、IL-6水平、脂肪酶高活性、PCa患者疾病进展及高体重指数具有显著相关性。胶质细胞源性神经营养因子受体α(glial-derived neurotrophic factor receptor α-like,GFL)是MIC-1的特异性受体,在PCa细胞和癌周间质成纤维细胞中都出现高表达,雄激素去势治疗和化疗都降低了其表达水平。结论 HFD通过增加游离脂肪酸水平,在代谢水平上调了MIC-1信号活性,从而激活了PCa间质微环境,这可能是HFD和/或脂肪诱导的PCa进展的关键机制。

关键词：巨噬细胞抑制因子-1 肿瘤微环境高脂饮食前列腺癌代谢

Anaplastic carcinoma associated with a mucinous cy.tic neoplasm of the pancreas during pregnancy.Report of a case and a review of the literature

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World Journal of Gastroenterology 2008年第1期14卷 132-135页

作者： Kenichi Hakamada Takuy. Miura Akitoshi Kimura Masaki nara y.shikazu Toy.ki Shunij Narumi Mutsuo Sasak Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine Hirosaki 036-8562 Japan

Oncogenesis of anaplastic carcinoma of the pancreas is a subject of controversy. because it shows sarcomatous nature with extremely.poor prognosis. We herein report an unusual case of anaplastic carcinoma occurring with a recurrent mucinous cy.tic neoplasm in a 38-y.ar-old female. A 10-cm retroperitoneal cy.tic mass was pointed out in the first pregnancy.and a probable diagnosis of mucinous cy.tic neoplasm was made in October 2000. She refused surgery.first and delivered her baby.uneventfully. During her second pregnancy.in 2002, however, she presented hematemesis and underwent urgent distal pancreatectomy. splenectomy.and partial resection of the gastric wall where the tumor perforated. A diagnosis of borderline-ty.e mucinous cy.tic neoplasm with ovarian-like stroma was made. Nine months later, CT visualized a recurrent cy.tic tumor near the pancreatic stump, which was subsequently.resected. Pathology.revealed that the tumor was composed of two different components of borderline-ty.e mucinous cy.tic neoplasm and anaplastic carcinoma. The latter was intensely.positive for vimentin, CD68, p53 and focally.for cy.okeratin, suggesting both sarcomatous and carcinomatous differentiation. She survived four y.ars after the second surgery.without tumor recurrence. Although the origin of anaplastic carcinoma has not been determined y.t, it should be remembered that anaplastic carcinoma can occur in association with mucinous cy.tic neoplasm of more benign histology.

关键词：胆囊肿瘤整形术癌科胰腺肿瘤怀孕

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聚乙烯醇中的紫外偏振线性聚炔分子（英文）

Chinese Journal of Chemical Phy.ics 2019年第2期32卷 175-181,I0002页

作者： R. Sata H. Suzuki N. Ueno y. Morisawa M. Hatanaka T. Wakabay.shi 日本近畿大学化学系东大阪577-8502 日本奈良科学技术研究所生驹630-0192 日本科学技术厅川口332-0012

本文通过研究共轭线性碳链分子,聚炔H(C≡C)nH (n=5∽7)的电子吸收带,设计了适用于UV的光偏振膜.激光烧蚀的聚炔分子被分散在聚乙烯醇膜中.结构各向异性的性质使得多炔分子的UV吸收跃迁偶极子与分子轴平行,并且吸收仅发生在沿着分子轴... 详细信息

本文通过研究共轭线性碳链分子,聚炔H(C≡C)nH (n=5∽7)的电子吸收带,设计了适用于UV的光偏振膜.激光烧蚀的聚炔分子被分散在聚乙烯醇膜中.结构各向异性的性质使得多炔分子的UV吸收跃迁偶极子与分子轴平行,并且吸收仅发生在沿着分子轴具有电子矢量幅度的电磁波上.多炔分子在固体聚乙烯醇膜中作为特定波长入射光的偏振分量之一的选择性吸收剂.使用可旋转的偏振UV光研究包含聚炔分子的拉伸聚乙烯醇膜的吸收强度的角度依赖性,并根据线性二向色性理论中有序参数进行分析.

关键词：聚炔紫外线吸收聚乙烯醇线性二向色性线性偏振光偏振片

A case of invasive hemoly.phangioma of the pancreas

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World Journal of Gastroenterology 2008年第18期14卷 2932-2934页

作者： y.shikazu Toy.ki Kenichi Hakamada Shunji Narumi Masaki nara Daisuke Kudoh Keinosuke Ishido Mutsuo Sasaki Department of Gastroenterological Surgery Hirosaki University School of Medicine 5 Zaifu-cho Hirosaki Aomori 0368652 Japan

Hemoly.phangioma of the pancreas is a very.rare benign tumor. There were only.five reports of this disease until March 2008. Herein, we report a case of hemoly.phangioma of the pancreas with gastrointestinal bleeding due to duodenal invasion. A 53-y.ar-old man had been admitted a referral hospital because of severe anemia due to gastrointestinal bleeding in December 2005. He was then transferred to our institute with a diagnosis of a tumor of the head of the pancreas with duodenal invasion in January.2006. No abnormalities were revealed except for anemia in laboratory.data including CEA and CA19-9. Gastrointestinal endoscopy.revealed bleeding at the duodenum. Computed tomography.also demonstrated a heterogenous mass at the pancreatic head and suspected invasion to the duodenal wall. Ultrasonography.showed a huge mass at the pancreatic head with a mixture of high and low echoic areas. Py.orous-preserving pancreatoduodenectomy.was performed. The pancreatic tumor was soft and had invaded to the duodenum. The pathological diagnosis was a hemoly.phangioma of the pancreas invaded to the duodenum. His postoperative course was uneventful and he was discharged on the 26th d after surgery. Hemoly.phangioma of the pancreas is a very.rare benign tumor. In a literature review until March 2008, we found five case reports. Major sy.ptoms are abdominal pain and distension due to the enlarged tumor. However, we experienced a case of hemoly.phangioma of the pancreas with gastrointestinal bleeding due to invasion to the duodenum. This disease is a very.rare entity. but should be considered when patients have gastrointestinal bleeding.

关键词：血管淋巴管瘤十二指肠侵入出血胰腺疾病