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Challenging situation of coronary.artery.anomaly.associated with ischemia and/or risk of sudden death

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World Journal of Cardiology 2024年第4期16卷 173-176页

作者： Shigenori ito Division of Cardiology Sankuro HospitalToyota 471-0035Japan

Coronary.artery.anomaly.is known as one of the causes of angina pectoris and sudden death and is an important clinical entity.that cannot be *** incidence of coronary.artery.anomalies is as low as 1%-2%of the general population,even when the various ty.es are *** anomalies are practically.challenging when the left and right coronary.ostium are not found around their normal positions during coronary.angiography.with a *** there is atherosclerotic stenosis of the coronary.artery.with an anomaly.and percutaneous coronary.intervention(PCI)is required,the suitability.of the guiding catheter at the entrance and the adequate back up force of the guiding catheter are *** level of PCI risk itself should also be considered on a caseby.case *** this case,emission computed tomography.in the R-1 subty.e single coronary.artery.proved that ischemia occurred in an area where the coronary.artery.was not visible to the naked *** follow-up would be crucial,because sudden death may.occur in single coronary.*** prevent atherosclerosis with full efforts is also important,as the authors indicated admirably.

关键词： Coronary.artery.anomaly Single coronary.artery Ischemia Sudden death Percutaneous coronary.intervention Coronary.vessel anomalies My.cardial ischemia Sudden cardiac death

Bicuspidization Using the Open-Sleeve Technique for Congenital Aortic Stenosis during Infancy

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Congenital Heart Disease 2024年第2期19卷 177-183页

作者： Toshi Maeda Hiroki ito Keiichi Hirose Kisaburo Sakamoto Departments of Cardiovascular Surgery Mt.Fuji Shizuoka Children’s HospitalShizuoka420-8660Japan

Congenital aortic stenosis(cAS)frequently.requires intervention during the neonatal or infantile ***,surgical repair is challenging because of the narrow surgical *** performed bicuspidization using the open-sleeve technique for cAS with a unicuspid aortic valve in two ***,the patients were doing well without reintervention for the aortic valve for 8 and 6 y.ars,*** aortic annular diameter increased along with somatic *** for neonates or infancy.can be performed safely.using the open-sleeve technique as its midterm results have been satisfactory.

关键词： Aortic valve repair infant bicuspidization open-sleeve technique

1,3-Dipolar Cy.loaddition of Poly.y.lic Aromatic Azomethine y.ides and Alky.y.benziodoxoles for Sy.thesis of Functional Dibenzoullazines

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Chinese Journal of Chemistry 2024年第10期42卷 1079-1083页

作者： Hui Han Glen Wee Zhuan Goh y.ngxin Li Naohiko y.shikai Shingo ito Schoolof Chemistry ChemicalEngineering and BiotechnologyNanyang Technoogical University21 Nanyang LinkSingapore 637371Singapore Graduate School of Pharmaceutical Sciences Tohoku UniversitySendai 980-8578Japan

A new family.of dibenzoullazine derivatives was sy.thesized through 1,3-dipolar cy.loaddition of poly.y.lic aromatic azomethine y.ides with alky.y.benziodoxoles followed by.*** benziodoxole moiety.in the resulting products was used as a versatile linchpin for the sy.thesis of structurally.diverse functional dibenzoullazines that are difficult to access by.other sy.thetic methods.

关键词： Cy.loaddition Nitrogen heterocy.les Azomethine y.ides Hy.ervalent compounds Dibenzoullazine

Roles of N-cadherin in cerebral cortical development:cooperation with membrane trafficking and actin cy.oskeletal regulation

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Neural Regeneration Research 2025年第1期20卷 188-190页

作者： Shiho ito Takeshi Kawauchi Department of Adaptive and Maladaptive Responses in Health and Disease Graduate School of MedicineKyoto UniversityKyotoJapan Department of Phy.iology Keio University School of MedicineTokyoJapan

Cell adhesion play. pivotal roles in the morphogenesis of multicellular *** cells form several ty.es of cell-to-cell adhesion,including zonula occludens(tight junctions),zonula adhaerens(adherens junctions),and macula adhaerens(desmosomes).Although these adhesion complexes are basically.observed only.in epithelial cells,cadherins,which are the major cell adhesion molecules of adherens junctions,are expressed in both epithelial and non-epithelial tissues,including neural tissues(Kawauchi,2012).The cadherin superfamily.consists of more than 100 members,but classic cadherins.

关键词： cerebral skeletal cooperation

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Structural basis for poly.ridine tract recognition by.SARS-CoV-2 Nsp15

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Protein & Cell 2024年第7期15卷 547-552页

作者： Fumiaki ito Hanjing y.ng Z.Hong Zhou Xiaojiang S.Chen Molecular and Computational Biology Department of Biological SciencesUniversity of Southern CaliforniaLos AngelesCA 90089United States Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesCA 90095United States California NanoSy.tems Institute University of CaliforniaLos AngelesCA90095United States Genetic Molecular and Cellular Biology ProgramKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90089United States Norris Comprehensive Cancer Center University of Southern CaliforniaLos AngelesCA 90089United States Center of Excellence in NanoBiophy.ics University of Southern CaliforniaLos AngelesCA 90089United States

Dear Editor,Coronaviruses have evolved a wide array.of tactics to evade host antiviral *** host cells detect invading foreign nucleic acids including viral genome and viral replication intermediates,they.activate interferon(IFN)signaling via cy.oplasmic pattern recognition receptors(Kang et al.,2002;Kato et al.,2006).Remarkable stealth activities exhibited by.coronaviruses are facilitated by.a series of non-structural proteins(Nsps),such as Nsp15(Deng and Baker,2018;Deng et al.,2019;Hackbart et al.,2020),which is a uridine-specific endoribonuclease that mediates evasion of host detection of viral double-stranded RNA(dsRNA)(Bhardwaj et al.,2004;Deng et al.,2017;Frazier et al.,2021;Ivanov et al.,2004).Nsp15 targets a poly.ridine[poly.U)]tract on the coronavirus negative strand RNA(Hackbart et al.,2020).Nsp15 limits the abundance and length of poly.U)within the negative strand RNA 5ʹ-extension by.trimming down the initially.sy.thesized poly.U)lead sequence to the optimal length that can suppress dsRNA formation but still serves as a template for poly.A)tail of the positive strand genome of the coronaviruses(Hofmann and Brian,1991).

关键词： p15 interferon template

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High resolution X-ray.fluorescence spectrometry.for water analy.is of metals in East China Sea

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Chinese Journal Of Geochemistry 2006年第B8期25卷 152-153页

作者： y. Zou K. y.koi H. Ohashi T. Tochio y. ito T. Shoji T. Matsuno Laboratory.of Atomic ＆ Molecular Phy.ics ICR Kyoto University Uji Kyoto 611-0011 Japan National Institute for Matertal Science Harima office SPring-8 Sayo Hyogo 679-5198 Japan Keihanna Interaction Plaza lnc. Seika-cho Soraku-gun Kyoto 619-0237 Japan Rigaku Industrial Corporation 6-18 Akaoji Takatsuki Osaka 569-1146 Japan Research Institute for Applied Mechanics Kyushu University Kasuga Fukuoka 816-8580 Japan

Trajectory.of Walking Function in Late-Stage Older Individuals Managed with a Regular Exercise Program: A 5-y.ar Longitudinal Tracking with an IoT Gait Analy.is Sy.tem Using Accelerometers

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Open Journal of Therapy.and Rehabilitation 2024年第2期12卷 174-184页

作者： Taisuke ito Waseda Elderly.Health Association Co. Ltd. Tokyo Japan

Purpose: This study.focused on maintaining and improving the walking function of late-stage older individuals while longitudinally.tracking the effects of regular exercise programs in a day.care service specialized for preventive care over 5 y.ars, using detailed gait function measurements with an accelerometer-based sy.tem. Methods: Seventy.individuals (17 male and 53 female) of a day.are service in Toky. participated in a weekly.exercise program, meeting 1 - 2 times. The average age of the participants at the start of the program was 81.4 y.ars. Gait function, including gait speed, stride length, root mean square (RMS) of acceleration, gait cy.le time and its standard deviation, and left-right difference in stance time, was evaluated every.6 months. Results: Gait speed and stride length improved considerably.within six months of starting the exercise program, confirming an initial improvement in gait function. This suggests that regular exercise programs can maintain or improve gait function even age groups that predictably.have a gradual decline in gait ability.due to enhanced age. In the long term, many.indicators tended to approach baseline values. However, the exercise program seemingly.counteracts age-related changes in gait function and maintains a certain level of function. Conclusions: While a decline in gait ability.with aging is inevitable, establishing appropriate exercise habits in late-stage older individuals may.contribute to long-term maintenance of gait function.

关键词： Late-Stage Elderly Exercise Gait Function Accelerometer IoT-Based Gait Analy.is Device

The Immediate Analgesic Effect and Impact on Gait Function of Transcutaneous Electrical Nerve Stimulation in Late-Stage Elderly.Individuals with Knee Pain: Examination of Gait Function Using an IoT-Based Gait Analy.is Device

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Open Journal of Therapy.and Rehabilitation 2024年第2期12卷 185-195页

作者： Taisuke ito Waseda Elderly.Health Association Co. Ltd. Tokyo Japan

Purpose: This study.verified the effects of transcutaneous electrical nerve stimulation (TENS), which can be worn during walking and exercise, in elderly.individuals with late-stage knee pain who exercise regularly. Methods: Thirty.two late-stage elderly.individuals were evaluated for knee pain during rest, walking, and program exercises, with and without TENS. Gait analy.is was performed using an IoT-based gait analy.is device to examine the effects of TENS-induced analgesia on gait. Results: TENS significantly.reduced knee pain during rest, walking, and programmed exercises, with the greatest analgesic effect observed during walking. The greater the knee pain without TENS, the more significant the analgesic effect of TENS. A comparison of gait parameters revealed a significant difference only.in the gait cy.le time, with a trend towards faster walking with TENS;however, the effect was limited. Conclusion: TENS effectively.relieves knee pain in late-stage elderly.individuals and can be safely.applied during exercise. Pain management using TENS provides important insights into the implementation of exercise therapy.in this age group.

关键词： Late-Stage Elderly Knee Joint Pain Exercise Transcutaneous Electrical Stimulation IoT-Based Gait Analy.is Device

High resolution X-ray.fluorescence spectrometry.for water analy.is of metals in East China Sea

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Acta Geochimica 2006年第S1期 152-153页

作者： K. y.koi H. Ohashi T. Tochio y. ito T. Shoji T. Matsuno Laboratory.of Atomic & Molecular Phy.ics ICR Kyoto University Uji Kyoto 611-0011 Japan National Institute for Material Science Harima office SPring-8 Sayo Hyogo 679-5198 Japan Keihanna Interaction Plaza Inc. Seika-cho Soraku-gun Kyoto 619-0237 Japan Rigaku Industrial Corporation 6-18 Akaoji Takatsuki Osaka 569-1146 Japan Research Institute for Applied Mechanics Kyushu University Kasuga Fukuoka 816-8580 Japan