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Atomistic Simulation of the Orientation-dependent Plastic deformation Mechanisms of Iron Nanopillars

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journal of Materials Science & Technology 2012年第2期28卷 164-168页

作者： y. zhang d.j. y. K.M. Wang Anshan-Normal University 43 Pingan Street Anshanll4005 China University.of Science and Technology.LiaoNing Anshanll4051 China

Tensile tests were performed on iron nanopillars oriented along [001] and [110] directions at a constant temperature of 300 K through molecular dy.amics simulations with an embedded-atom interatomic potential for iron. The nanopillars were stretched until y.elding to investigate the onset of their plastic deformation behaviors. y.elding was found to occur through two different mechanisms for [001] and [110] tensions. In the former case, plastic deformation is initiated by.dislocation nucleation at the edges of the nanopillar, whereas in the latter case by.phase transformation inside the nanopillar. The details during the onset of plastic deformation under the two different orientations were analy.ed. The vary.ng mechanisms during plastic deformation initiation are bound to influence the mechanical behavior of such nanoscale materials, especially.those strongly.textured.

关键词： Iron Molecular dy.amics simulation Nanopillar Plastic deformation

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： y.jun Zhu Xiaoguo Li Xingwei Lei Liuy.ng Tang daochen wen Bo Zeng Xiaofeng zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may.be related to neuroinflammation, cellular immunity. apoptosis, and autophagy. the exact underly.ng molecular mechanisms are unclear. This review summarizes the current status of different ty.es of remote ischemic conditioning methods in animal and clinical studies and analy.es their commonalities and differences in neuroprotective mechanisms and signaling pathway.. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury.owing to its simplicity. non-invasiveness, safety. and patient tolerability. different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically. remote ischemic conditioning can exert neuroprotective effects by.activating the Notch1/phosphatidy.inositol 3-kinase/Akt signaling pathway. improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy. and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not y.t been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

Cortico-striatal gamma oscillations are modulated by.dopamine d3 receptors in dy.kinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang y.ewei Bi Min Li jiazhi Chen Zhuy.ng Wang Huantao wen Ming Zhou Minjie Luo Wangming zhang Neurosurgery.Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely.recognized hallmark of abnormal neural electrical activity.in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophy.iological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine d3 receptor,which is implicated in levodopa-induced dy.kinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity.of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary.motor cortex(M1)↔dorsolateral striatum gamma *** of Pd128907(a selective dopamine d3 receptor agonist)induced dy.kinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine d3 receptor antagonist)attenuated dy.kinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality.in the M1→dorsolateral striatum *** findings suggest that the dopamine d3 receptor play. a role in dy.kinesia-related oscillatory.activity.and that it has potential as a therapeutic target for levodopa-induced dy.kinesia.

关键词： aperiodic components dopamine d3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dy.kinesia local field potentials neuromodulation Parkinson’s disease primary.motor cortex

INTERMETALLICS AS SUBSTITUTES FOR SUPERALLOy.

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Acta Metallurgica Sinica(English Letters) 2005年第4期18卷 463-467页

作者： j. zhang d. Feng Z. y. Zhong High Temperature Materials division Central Iron and Steel Research Institute Beijing 100081China

The application advances of TiAl, Ti3Al and Ni3Al base aUoy. were denumstrated by.Central Iron and Steel Research Institute, China. The recent research progresses on improving the reliability.of cast TiAI were mainly.presented and discussed. The characteristics of the self-oriented lamellar microstructure in cast TiAI were investigated in both as cast and as HlPed states. Based on the mechanical anisotropy.of the cast lamellar microstructure, the component specific microstrueture design was proposed for a better performance and reliability.of cast TiAl.

关键词： intermetallic application TiAl alloy microstructure design

Targeting TrkB–PSd-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin y.ng y.-wen Alvin Huang john Marshall department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomy.sin receptor kinase B(TrkB)signaling play. a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity.dependent release of brain-derived neurotrophic factor at sy.apses binds to pre-or postsy.aptic TrkB resulting in the strengthening of sy.apses,reflected by.long-term ***,the association of postsy.aptic density.protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidy.inositol 3-kinase-mechanistic target of rapamy.in signaling required for long-term *** this review,we discuss TrkB-postsy.aptic density.protein-95 coupling as a promising strategy.to magnify.brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsy.aptic density.protein-95 association with TrkB signaling could mitigate the observed deficiency.of neuronal connectivity.in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively.investigated,they.cannot distinguish the multiple human TrkB splicing isoforms or cell ty.e-specific *** TrkB–postsy.aptic density.protein-95 coupling provides an alternative approach to specifically.boost TrkB signaling at localized sy.aptic sites versus global stimulation that risks many.adverse side effects.

关键词： Angelman sy.drome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsy.aptic density.protein-95 sy.aptic plasticity TrkB

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas M.Brandon Westover Can zhang department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(Ad) is a common neurodegenerative disorder and the primary.cause of dementia. Considerable evidence supports the “amy.oid hy.othesis,” stating that the pathogenesis of Ad is primarily.caused by.the deposition of amy.oid-β(Aβ), which drives tau phosphory.ation, neuroinflammation, and neurodegeneration in the brain. The amy.oid hy.othesis is strengthened by.the significant and moderate benefit of lecanemab, a humanized antibody.through an anti-amy.oid mechanism,showing slowed clinical decline(van dy.k et al.,2023). The recent positive results of anti-amy.oid trials have brought back focus on the amy.oid hy.othesis through biochemical, genetic, and pharmacological approaches(zhang, 2023).

关键词： Alzheimer inflammation hy.othesis

dielectric-ion-conductive ZnNb2O6 lay.r enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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journal of Energy.Chemistry 2025年第1期100卷 693-701页

作者： Haifeng y.ng jian Wang Panpan zhang Xiaomin Cheng Qinghua Guan jing dong Bixian Chen Lujie jia jing zhang y.ngzheng zhang y.njian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key.Laboratory.of Nanophotonic Materials and devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology.(KIT) School of Materials Science and Engineering Xi'an University of Technology State Key.Laboratory.of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy.storage sy.tems due to their low cost and high ***,their performance and sustainability.are significantly.hindered by.the sluggish desolvation kinetics at the electrode/electroly.e interface and the corresponding hy.rogen evolution reaction where active water molecules tightly.participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electroly.e interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial lay.r is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB lay.r accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by.electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cy.ling stability.of over 2000 h and robust reversibility.（99.54%） even under high current density.and depth of discharge ***,the assembled ZNB@Zn-based full cell display. high capacity.retention rate of 80.21%after 3000 cy.les at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cy.les,highlighting the bright prospects of the dielectric but ion-conductive lay.r in further application of AZMBs.

关键词： Zn metal battery dielectric artificial lay.r Rapid ion diffusion Zincophilic diffusion Active water inhibition

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缺陷对单层硅烯纳米梁振动频率的影响

原子与分子物理学报 2025年第6期42卷 76-82页

作者：张文博王静新疆大学物理科学与技术学院乌鲁木齐830017

由于硅纳米谐振器在量子计算、传感器、医学等方面存在广泛的应用,使其物理性质的研究具有重要意义.本文通过分子动力学模拟方法研究了掺杂元素、空位缺陷、掺杂浓度对单层硅烯纳米梁振动特性的影响.研究结果表明,单层硅烯纳米梁的振动... 详细信息

由于硅纳米谐振器在量子计算、传感器、医学等方面存在广泛的应用,使其物理性质的研究具有重要意义.本文通过分子动力学模拟方法研究了掺杂元素、空位缺陷、掺杂浓度对单层硅烯纳米梁振动特性的影响.研究结果表明,单层硅烯纳米梁的振动频率随着纳米梁长度的增加而减小.单元素、双元素掺杂均会导致单层硅烯纳米梁的振动频率的增加,且随着掺杂浓度的增加纳米梁的振动频率整体呈现增大的趋势.此外,单空位缺陷会导致单层硅烯纳米梁的振动频率随着缺陷浓度的增加而减小.掺杂-单空位缺陷的单层硅烯纳米梁的振动频率则呈现了随着掺杂浓度的增加先减小后增加的变化趋势.这些变化规律均是由掺杂元素、空位缺陷以及它们共同作用的结果.此研究结果对硅烯纳米谐振器,振荡器等纳米器件的设计具有一定的理论指导意义.

关键词：硅烯掺杂振动频率分子动力学

STUdy.ON THE HOT dEFORMATION BEHAVIORS OF Al-Zn-Mg-Cu-Cr ALUMINUM ALLOy

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Acta Metallurgica Sinica(English Letters) 2008年第2期21卷 109-115页

作者： G. y. Lin Z.F. zhang H. zhang d.S. Peng j. Zhou School of Materials Science and Engineering Central South University Changsha 410083 China

The hot deformation behaviors and microstructures of A1-Zn-Mg-Cu-Cr aluminum alloy.have been studied using thermal simulation test, optical microscopy.and transmission electron microscopy. As a result, the true stress versus true strain curves and the microstructures under various deformation conditions are obtained. The microstructures gradually.incline to dy.amic-recry.tallization with the deformation temperature rising and the recry.tallization grains refine with the decrease of deformation temperature or with raising the strain rates. The quantitative relationship between the Zener-Hollomon parameter （Z） and average recry.tallization grain size in the subsequent heat treatment is set up.

关键词： A1-Zn-Mg-Cu-Cr aluminum alloy Hot deformation True stressvs true strain curve Microstructure