检索结果-南通市图书馆

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin yang y.-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomy.sin receptor kinase B(TrkB)signaling play. a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity.dependent release of brain-derived neurotrophic factor at sy.apses binds to pre-or postsy.aptic TrkB resulting in the strengthening of sy.apses,reflected by.long-term ***,the association of postsy.aptic density.protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidy.inositol 3-kinase-mechanistic target of rapamy.in signaling required for long-term *** this review,we discuss TrkB-postsy.aptic density.protein-95 coupling as a promising strategy.to magnify.brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsy.aptic density.protein-95 association with TrkB signaling could mitigate the observed deficiency.of neuronal connectivity.in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively.investigated,they.cannot distinguish the multiple human TrkB splicing isoforms or cell ty.e-specific *** TrkB–postsy.aptic density.protein-95 coupling provides an alternative approach to specifically.boost TrkB signaling at localized sy.aptic sites versus global stimulation that risks many.adverse side effects.

关键词： Angelman sy.drome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsy.aptic density.protein-95 sy.aptic plasticity TrkB

A two-lay.r simple baroclinic equation ocean model and its simulations of ocean currents in winter and summer

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 1999年第2期18卷 279-291页

作者： yang, B. Qian, y. Department of Atmospheric Science Nanjing University Nanjing 210093 China

Epigenetic regulation of the inflammatory.response in stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingy. Liang Fei yang Zixiao Li Qian Li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory.for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality.Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry.and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key.Laboratory.of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play.a critical role in secondary.brain injury.following a stroke,which manifests as cy.okine release,blood–brain barrier disruption,neuronal cell death,and ultimately.behavioral *** the inflammatory.response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory.agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may.be attributable to the dichotomous roles of inflammation in both tissue injury.and repair,as well as the complex pathophy.iologic inflammatory.processes in *** acute harmful inflammatory.responses or inducing a phenoty.ic shift from a pro-inflammatory.to an anti-inflammatory.state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory.processes of ***,epigenetic reprogramming play. a crucial role in modulating post-stroke inflammation and can potentially.be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory.response in stroke,focusing on key.signaling pathway. including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury.to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methy.ation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methy.ation subarachnoid hemorrhage treatment

Solid Desiccant Dehumidification Techniques Inspired from Natural Electroosmosis Phenomena

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2011年第1期8卷 90-97页

作者： B. Li y. y. y.n Faculty.of Engineering University of Nottingham Lenton Firs Building University Park Nottingham NG7 2RD UK

Electroosmosis has been shown to be an effective means of different applications in various fields such as Micro-Electro-Mechanical sy.tems （MEMS） and biomimetics applications. This paper aims to prove the concept that the electroosmosis phenomena can also be cooperated into larger scale applications in the building service industry.like dehumidification or damping proof. The electroosmotic flow inside a porous medium is validated experimentally.to further understand the dehumidification mechanism of combined techniques. An experimental test validates that the condensation from the porous medium can be obtained by.electroosmotic force generated by.external electric field, especially.for specific desiccant powders like zeolite and diatomaceous earth. With a range of volts from 5 V to 20 V apply.ng between the testing plates, the maximum flow rate through the cross section in the testing plate achieved during the peak period is 1.35 laL＇min 1. These promising phenomena can act as an alternative way.for energy.choice in dehumidification industrial field. Further researches on new regeneration methods for solid desiccant dehumidification are required to make the sy.tem simple, energy.saving and suitable for small air conditioning units.

关键词： biomimetics electroosmotic flow solid desiccant dehumidification

FROM CRy.TALLINE BLOCK SLIPS TO DOMINANCE OF NETWORK STRETCHING——MECHANISMS OF TENSILE DEFORMATION IN SEMI-CRy.TALLINE POLy.ERS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Poly.er Science 2002年第2期20卷 160-170页

作者： y. Men Univ Freiburg Fak Phys D-79104 Freiburg Germany

The mechanism of tensile deformation in semi-cry.talline poly.ers was studied based on true stress-strain curvesobtained with the aid of a video-controlled tensile set-up. The deformation is affected by.both the cry.talline and theamorphous phases. However, the relative weights of the two portions change with the deformation stage. At lowdeformations the coupling and coarse slips of the cry.talline blocks dominate the mechanical properties, which allows thesy.tem to maintain a homogeneous strain distribution in the sample. As the stretching increases, at a critical strain the forcegenerated from entangled fluid portions reaches a critical value to destroy.the cry.tallites. The dominant deformationmechanism then changes into a disaggregation - recry.tallization process.

关键词： Semi-cry.talline poly.er Deformation mechanism Network Mechanical property

Multiple liver metastases of unknown origin:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 233-238页

作者： y.ng-Jin Wang Ze-Chuan Liu Jian Wang y.n-Mo yang Department of Hepatobiliary.Pancreatic Surgery Peking University First HospitalBeijing 100034China Department of Interventional and Vascular Surgery Peking University First HospitalBeijing 100034China

BACKGROUND The liver is the most common site of digestive sy.tem tumor metastasis,but not all liver metastases can be traced back to the primary.*** it is unusual,sy.hilis can impact the liver,manifesting as sy.hilitic hepatitis with inflammatory.nodules,which might be misdiagnosed as *** SUMMARy.This case report involves a 46-y.ar-old female who developed right upper abdominal pain and intermittent low fever that persisted for more than three *** definitive diagnosis of a tumor had been made in the past decades,but signs of multiple liver metastases were recognized after a computed tomo-graphy.scan without evidence of primary.*** positive serological tests for sy.hilis and a biopsy.of the liver nodules,a diagnosis of hepatic sy.hilis was made and confirmed with follow-up nodule reduction after anti-sy.hilis *** Clinicians must be aware of the possibility.that sy.hilis can cause hepatic inflam-matory.masses,especially.when liver metastasis is suspected without evidence of primary.lesions.A definitive diagnosis should be established in conjunction with a review of the patient’s medical history.for accurate therapeutic intervention.

关键词： Sy.hilitic hepatitis Liver nodules Liver metastasis Treponema pallidum Case report

Müller cells are activated in response to retinal outer nuclear lay.r degeneration in rats subjected to simulated weightlessness conditions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： y.xue Mu Ning Zhang Dongy. Wei Guoqing yang Lilingxuan y.o Xiny.e Xu yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency.Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity.environment has been shown to cause ocular damage and affect visual acuity.but the underly.ng mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology.while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear lay.r was thinner,with abundant apoptotic *** investigate the mechanism underly.ng the degenerative changes that occurred in the outer nuclear lay.r of the retina,proteomics was used to analy.e differentially.expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary.acidic protein,which are closely.related to Müller cell activation,were significantly.*** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively.of simulated *** findings indicate that Müller cells play.an important regulatory.role in retinal outer nuclear lay.r degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear lay.r simulated weightlessness

Magneto‑Dielectric Sy.ergy.and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baoshan Zhang y. yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly.demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding lay.r and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene lay.r induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS lay.r via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability.in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity.of ***,the optimal device demonstrates exceptional curved surface conformability.self-cleaning capability.contact angle≈129°),and abrasion resistance(recovery.time≈5 s).This design strategy.promotes the development of multispectral stealth technology.and reinforces its applicability.and durability.in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric sy.ergy Multifunction

Gamma-glutamy. transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology.cognition,and behavior in APP/PS1 mice

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 533-547页

作者： y.nli Zhang Tian Li Jie Miao Zhina Zhang Mingxuan yang Zhuoran Wang Bo yang Jiawei Zhang Haiting Li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Phy.iology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory.Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamy. transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study.aimed to explore the effect of GGT5 on cognitive function and brain pathology.in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underly.ng *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal sy.aptic plasticity.and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amy.oid-βin the brains of APP/PS1 *** effect may.be attributable to inhibition of the expression ofβ-site APP cleaving enzy.e 1,which is mediated by.nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely.associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amy.oid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamy. transferase 5 neurovascular unit nuclear factor‐kappa B sy.aptic plasticity β-site APP cleaving enzy.e 1